WO2002016929A3 - Urokinase peptide structure mimetics - Google Patents

Urokinase peptide structure mimetics Download PDF

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Publication number
WO2002016929A3
WO2002016929A3 PCT/EP2001/009668 EP0109668W WO0216929A3 WO 2002016929 A3 WO2002016929 A3 WO 2002016929A3 EP 0109668 W EP0109668 W EP 0109668W WO 0216929 A3 WO0216929 A3 WO 0216929A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide structure
urokinase peptide
structure mimetics
urokinase
plasminogen activator
Prior art date
Application number
PCT/EP2001/009668
Other languages
French (fr)
Other versions
WO2002016929A2 (en
Inventor
Olaf Wilhelm
Markus Buergle
Horst Kessler
Niko Schmiedeberg
Original Assignee
Wilex Ag
Olaf Wilhelm
Markus Buergle
Horst Kessler
Niko Schmiedeberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilex Ag, Olaf Wilhelm, Markus Buergle, Horst Kessler, Niko Schmiedeberg filed Critical Wilex Ag
Priority to US10/362,184 priority Critical patent/US20030232389A1/en
Priority to EP01980255A priority patent/EP1311856A2/en
Priority to AU2002212145A priority patent/AU2002212145A1/en
Publication of WO2002016929A2 publication Critical patent/WO2002016929A2/en
Publication of WO2002016929A3 publication Critical patent/WO2002016929A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972—Plasminogen activators
    • G01N2333/9723—Urokinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The NMR structure of the peptidic urokinase type plasminogen activator antagonist cyclo[21,29][D-Cys21Cys29]-uPA21-30 has been solved to identify design strategies for peptidomimetics that interfere with the binding of urokinase type plasminogen activator with its receptor.
PCT/EP2001/009668 2000-08-23 2001-08-21 Urokinase peptide structure mimetics WO2002016929A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/362,184 US20030232389A1 (en) 2000-08-23 2001-08-21 Urokinase peptide structure mimetics
EP01980255A EP1311856A2 (en) 2000-08-23 2001-08-21 Urokinase peptide structure mimetics
AU2002212145A AU2002212145A1 (en) 2000-08-23 2001-08-21 Urokinase peptide structure mimetics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00118099 2000-08-23
EP00118099.1 2000-08-23

Publications (2)

Publication Number Publication Date
WO2002016929A2 WO2002016929A2 (en) 2002-02-28
WO2002016929A3 true WO2002016929A3 (en) 2002-10-10

Family

ID=8169615

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009668 WO2002016929A2 (en) 2000-08-23 2001-08-21 Urokinase peptide structure mimetics

Country Status (4)

Country Link
US (1) US20030232389A1 (en)
EP (1) EP1311856A2 (en)
AU (1) AU2002212145A1 (en)
WO (1) WO2002016929A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2460915B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998021230A1 (en) * 1996-11-12 1998-05-22 Angstrom Pharmaceuticals, Inc. Cyclic peptides that bind to urokinase-type plasminogen activator receptor
WO1998046632A2 (en) * 1997-04-11 1998-10-22 Wilex Biotechnology Gmbh Inhibitors for urokinase receptor
WO2001005811A2 (en) * 1999-07-19 2001-01-25 Wilex Ag Cyclic peptidomimetic urokinase receptor antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998021230A1 (en) * 1996-11-12 1998-05-22 Angstrom Pharmaceuticals, Inc. Cyclic peptides that bind to urokinase-type plasminogen activator receptor
WO1998046632A2 (en) * 1997-04-11 1998-10-22 Wilex Biotechnology Gmbh Inhibitors for urokinase receptor
WO2001005811A2 (en) * 1999-07-19 2001-01-25 Wilex Ag Cyclic peptidomimetic urokinase receptor antagonists

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL CHEMISTRY (1997), 378(3/4), 231-237, 1997 *
BIOLOGICAL CHEMISTRY (2001), 382(8), 1197-1205, 2001 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BURGLE, MARKUS ET AL: "Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptides", XP002207723, retrieved from STN Database accession no. 127:77905 CA *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MAGDOLEN, VIKTOR ET AL: "Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87)", XP002207722, retrieved from STN Database accession no. 136:112295 CA *
NIENABER, VICKI L. ET AL: "Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite", STRUCTURE (LONDON) (2000), 8(5), 553-563, 3 May 2000 (2000-05-03), XP002207721 *
ZESLAWSKA, EWA ET AL: "Crystals of the Urokinase Type Plasminogen Activator Variant.beta.c-uPA in Complex with Small Molecule Inhibitors Open the Way towards Structure-based Drug Design", JOURNAL OF MOLECULAR BIOLOGY (2000), 301(2), 465-475, 11 August 2000 (2000-08-11), XP002207720 *

Also Published As

Publication number Publication date
WO2002016929A2 (en) 2002-02-28
EP1311856A2 (en) 2003-05-21
US20030232389A1 (en) 2003-12-18
AU2002212145A1 (en) 2002-03-04

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