WO1990013314A3 - Antigenes of the envelope transmembrane glycoprotein of a human retrovirus of the hiv-2 type, and antigens presenting with them an immunological relationship - Google Patents

Antigenes of the envelope transmembrane glycoprotein of a human retrovirus of the hiv-2 type, and antigens presenting with them an immunological relationship Download PDF

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Publication number
WO1990013314A3
WO1990013314A3 PCT/FR1990/000336 FR9000336W WO9013314A3 WO 1990013314 A3 WO1990013314 A3 WO 1990013314A3 FR 9000336 W FR9000336 W FR 9000336W WO 9013314 A3 WO9013314 A3 WO 9013314A3
Authority
WO
WIPO (PCT)
Prior art keywords
glycoprotein
type
hiv
antigenes
transmembrane glycoprotein
Prior art date
Application number
PCT/FR1990/000336
Other languages
French (fr)
Other versions
WO1990013314A2 (en
Inventor
Ara Hovanessian
Maire-Anne Rey
Anne Laurent
Bernard Krust
Luc Montagnier
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8906322A external-priority patent/FR2646854A1/en
Priority claimed from US07/356,459 external-priority patent/US5208321A/en
Application filed by Pasteur Institut filed Critical Pasteur Institut
Priority to DE69026569T priority Critical patent/DE69026569T2/en
Priority to CA002032505A priority patent/CA2032505C/en
Priority to EP90908240A priority patent/EP0424519B1/en
Publication of WO1990013314A2 publication Critical patent/WO1990013314A2/en
Publication of WO1990013314A3 publication Critical patent/WO1990013314A3/en
Priority to HK219796A priority patent/HK219796A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to an antigenic glycoprotein gp80 characterized by the following properties: it has a molecular weight (PM) close to 80 kDa; it is recognized by polyclonal antibodies directed against the glycoprotein gp300; it includes in association in the form a dimer to entities of the envelope transmembrane glycoprotein gp36, coded by the genome of a human retrovirus of the type HIV-2, susceptible of causing SLA or AIDS in human beings, or any glycoprotein having a molecular weight of the same order of magnitude, capable of forming an immunological complex of the type antigene-antibody, with antibodies directed against said gp80. The invention also relates to antibodies directed against said glycoprotein. It also relates to diagnostic and vaccination applications.
PCT/FR1990/000336 1989-05-12 1990-05-11 Antigenes of the envelope transmembrane glycoprotein of a human retrovirus of the hiv-2 type, and antigens presenting with them an immunological relationship WO1990013314A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE69026569T DE69026569T2 (en) 1989-05-12 1990-05-11 ANTIGENS OF A TRANSMEMBRANE ENVELOPE GLYCOPROTEIN OF A HUMAN RETROVIRUS OF THE TYPE HIV-2 AND IMMUNOLOGELALLY RELATED ANTIGENS
CA002032505A CA2032505C (en) 1989-05-12 1990-05-11 Coat transmembrane glycoprotein antigens of a hiv-2 type human retrovirus and antigens sharing immunological similarities
EP90908240A EP0424519B1 (en) 1989-05-12 1990-05-11 Antigenes of the envelope transmembrane glycoprotein of a human retrovirus of the hiv-2 type, and antigens presenting with them an immunological relationship
HK219796A HK219796A (en) 1989-05-12 1996-12-24 Antigenes of the envelope transmembrane glycoprotein of a human retrovirus of the HIV-2 type and antigens presenting with them an immunological relationship

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR89/06322 1989-05-12
FR8906322A FR2646854A1 (en) 1989-05-12 1989-05-12 Antigens of the envelope transmembrane glycoprotein of a HIV-2 type human retrovirus, antigens exhibiting an immunological relationship with them
US356,459 1989-05-25
US07/356,459 US5208321A (en) 1988-06-09 1989-05-25 HIV-2 transmembrane glycoprotein homodimer (GP 80)

Publications (2)

Publication Number Publication Date
WO1990013314A2 WO1990013314A2 (en) 1990-11-15
WO1990013314A3 true WO1990013314A3 (en) 1990-12-27

Family

ID=26227325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1990/000336 WO1990013314A2 (en) 1989-05-12 1990-05-11 Antigenes of the envelope transmembrane glycoprotein of a human retrovirus of the hiv-2 type, and antigens presenting with them an immunological relationship

Country Status (11)

Country Link
EP (1) EP0424519B1 (en)
JP (5) JP3534746B2 (en)
AT (1) ATE136789T1 (en)
CA (1) CA2032505C (en)
DE (1) DE69026569T2 (en)
DK (1) DK0424519T3 (en)
ES (1) ES2085908T3 (en)
HK (1) HK219796A (en)
OA (1) OA09634A (en)
SG (1) SG48125A1 (en)
WO (1) WO1990013314A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256561A (en) * 1991-12-20 1993-10-26 Abbott Laboratories Monoclonal antibody to HIV-2 and uses thereof
FR2692898B1 (en) * 1992-06-30 1995-06-02 Centre Nat Rech Scient Method for obtaining membrane proteins, and use of these proteins for diagnostic or vaccination purposes.
JP2013040148A (en) * 2011-08-19 2013-02-28 Asahi Kasei Corp Sialyloligosaccharide peptide immobilization bead

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269520A2 (en) * 1986-11-21 1988-06-01 Institut Pasteur Retrovirus of the type HIV-2, susceptible to provoke AIDS, and its antigenic and nucleic-acid constituents
EP0283327A2 (en) * 1987-01-16 1988-09-21 Institut Pasteur Peptides with the immunological properties of HIV-2
EP0314534A1 (en) * 1987-09-07 1989-05-03 Transgene S.A. Expression vector for proteins from the HIV-2 virus, one of the agents that cause AIDS
EP0320495A1 (en) * 1986-01-22 1989-06-14 Institut Pasteur Retrovirus of the type HIV-2 capable of inducing AIDS, and the antigenic and nucleic acid components thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0320495A1 (en) * 1986-01-22 1989-06-14 Institut Pasteur Retrovirus of the type HIV-2 capable of inducing AIDS, and the antigenic and nucleic acid components thereof
EP0269520A2 (en) * 1986-11-21 1988-06-01 Institut Pasteur Retrovirus of the type HIV-2, susceptible to provoke AIDS, and its antigenic and nucleic-acid constituents
EP0283327A2 (en) * 1987-01-16 1988-09-21 Institut Pasteur Peptides with the immunological properties of HIV-2
EP0314534A1 (en) * 1987-09-07 1989-05-03 Transgene S.A. Expression vector for proteins from the HIV-2 virus, one of the agents that cause AIDS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 111, 1989, M.A. REY et al.: "On the Processing of HIV-2 Envelope Glycoproteins", voir page 364* Resume 150196t & Res. Virol. 1989, 140(3), 271-4 (Eng)* *

Also Published As

Publication number Publication date
JP4423374B2 (en) 2010-03-03
JP2005170949A (en) 2005-06-30
JP2006213702A (en) 2006-08-17
CA2032505C (en) 2001-07-10
WO1990013314A2 (en) 1990-11-15
OA09634A (en) 1993-04-30
CA2032505A1 (en) 1990-11-13
DK0424519T3 (en) 1996-05-13
JP4174591B2 (en) 2008-11-05
JP3833681B2 (en) 2006-10-18
EP0424519B1 (en) 1996-04-17
ES2085908T3 (en) 1996-06-16
EP0424519A1 (en) 1991-05-02
ATE136789T1 (en) 1996-05-15
JPH03506042A (en) 1991-12-26
JP3534746B2 (en) 2004-06-07
HK219796A (en) 1997-01-03
DE69026569D1 (en) 1996-05-23
SG48125A1 (en) 1998-04-17
DE69026569T2 (en) 1996-09-05
JP2003146999A (en) 2003-05-21
JP2008156350A (en) 2008-07-10

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