US4327079A - Dentifrice compositions - Google Patents

Dentifrice compositions Download PDF

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Publication number
US4327079A
US4327079A US06/201,727 US20172780A US4327079A US 4327079 A US4327079 A US 4327079A US 20172780 A US20172780 A US 20172780A US 4327079 A US4327079 A US 4327079A
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tooth
weight
sodium
powder
mgcl
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US06/201,727
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Hideki Aoki
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Sangi Co Ltd
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Dental Chemical Co Ltd
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Assigned to DENTAL CHEMICAL CO.LTD.A CORP. OF JAPAN reassignment DENTAL CHEMICAL CO.LTD.A CORP. OF JAPAN ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: AOKI HIDEKI
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the invention relates to dentifrice compositions.
  • a dentifrice composition containing synthetic hydroxyapatite powder and being neutral or weakly alkaline.
  • the dentifrice composition of the present invention is very effective in fortifying a surface of a tooth, promoting remineralization of the surface of the tooth and eliminating plaque (a colony of bacteria).
  • a conventional dentifrice contains, as a tooth-cleaning and abrading agent, a mineral, such as colloidal silica, calcium phosphate, calcium carbonate, magnesium carbonate, etc. While these abrading agents are used to remove contaminants on teeth, it is essential that they do not harm the teeth.
  • a mineral such as colloidal silica, calcium phosphate, calcium carbonate, magnesium carbonate, etc. While these abrading agents are used to remove contaminants on teeth, it is essential that they do not harm the teeth.
  • the dentifrice composition of the present invention contains a suitable amount of synthetic hydroxyapatite powder, plaque as well as substances contaminating teeth can be removed very effectively.
  • the synthetic hydroxyapatite has a hardness similar to that of the enamel portion of the tooth and it can impart an appropriate abrading effect on the enamel portion of the tooth in brushing the teeth.
  • the synthetic hydroxyapatite has a large surface area and an excellent absorptivity.
  • the synthetic hydroxyapatite powder has the effect of strengthening the coating on and remineralization the surface of the enamel of the tooth.
  • a dentifrice composition containing synthetic hydroxyapatite powder and, based on the weight of the composition, 0.1 to 20% by weight of NaCl and/or KCl and 0.003 to 3% by weight of MgCl 2 .
  • the latter dentifrice composition of the present invention can effectively deposit and coat crystals of hydroxyapatite on the surfaces of the teeth.
  • the solubility of hydroxyapatite in water is increased in the presence of the chlorides as specified above.
  • hydroxyapatite is a salt which only slightly soluble in water, the ion products of ions such as [Ca ++ ], [HPO 4 -- ], etc. ionized in the dentifrice are small. This means that the ion products for promoting coating on the surfaces of the teeth, i.e. deposition of the crystals of hydroxyapatite on the surfaces of the teeth are small.
  • the average particle size of the hydroxyapatite powder is preferably about 2 ⁇ and the maximum particle size thereof is preferably 10 ⁇ or less.
  • the dentifrice composition of the present invention may include various additives which are commonly employed in dentifrices and may further include, if desired, citric acid, lactic acid, acetic acid, pyrrolic acid, glutamine, proline, serine, glycine, etc.
  • Examples 1 to 7 and 11 to 17 respectively show formulations of the dentifrice compositions in accordance with the present invention in terms of parts by weight and Examples 8 to 10, 18 and 19 are to substantiate effects of the composition of the present invention.
  • An adult's permanent tooth was sliced in two using a prisma adamantinum to form a section having a thickness of about 200 ⁇ m.
  • a supernant saturated solution of a liquid prepared by stirring 1 g of hydroxyapatite powder with 100 ml of distilled water was passed over the thus formed section at a flow rate of 0.6 ml/min.
  • the section was observed continuously using a polarization microscope and it was confirmed that the section was coated with analogous apatite crystals about 1 ⁇ m thick after 14 hours.
  • hydroxyapatite powder 1 g was introduced into 100 ml of 37° C. distilled water and NaCl and MgCl 2 were added in various concentrations.
  • the calcium ion concentrations of the respective solutions were measured and it was confirmed that the solubility of hydroxyapatite was increased by adding NaCl and MgCl 2 .
  • the calcium ion concentrations 10 days after the preparation of the solutions were as follows:
  • An adult's permanent tooth was sliced in two using a prisma adamantinum to prepare a section about 200 ⁇ m thick.
  • the enamel portion was removed to expose the dentin portion.
  • a hydroxyapatite-saturated solution in distilled water containing 0.001% of MgCl 2 and 0.9% of NaCl was passed over the so prepared section at a flow rate of 0.6 ml/min.
  • the section was continuously observed using a polarization microscope and it was confirmed that all over the surfaces of the section were coated with analogous apatite crystals at a thickness of about 5 ⁇ m.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

A dentifrice composition containing synthetic hydroxyapatite powder which is neutral or weakly alkaline or contains 0.1 to 20% by weight of NaCl and/or KCl and 0.003 to 3% by weight of MgCl2. The dentifrice composition is very effective in fortifying a surface of a tooth, promoting remineralization of the surface of the tooth and eliminating plaque from the tooth.

Description

The invention relates to dentifrice compositions.
According to the present invention, there is provided a dentifrice composition containing synthetic hydroxyapatite powder and being neutral or weakly alkaline.
It has been found that the dentifrice composition of the present invention is very effective in fortifying a surface of a tooth, promoting remineralization of the surface of the tooth and eliminating plaque (a colony of bacteria).
In general, a conventional dentifrice contains, as a tooth-cleaning and abrading agent, a mineral, such as colloidal silica, calcium phosphate, calcium carbonate, magnesium carbonate, etc. While these abrading agents are used to remove contaminants on teeth, it is essential that they do not harm the teeth.
Since the dentifrice composition of the present invention contains a suitable amount of synthetic hydroxyapatite powder, plaque as well as substances contaminating teeth can be removed very effectively. We presume this is due to the fact that the synthetic hydroxyapatite has a hardness similar to that of the enamel portion of the tooth and it can impart an appropriate abrading effect on the enamel portion of the tooth in brushing the teeth. We further presume this is also due to the fact that the synthetic hydroxyapatite has a large surface area and an excellent absorptivity. We have further found that the synthetic hydroxyapatite powder has the effect of strengthening the coating on and remineralization the surface of the enamel of the tooth.
In accordance with the present invention, there is further provided a dentifrice composition containing synthetic hydroxyapatite powder and, based on the weight of the composition, 0.1 to 20% by weight of NaCl and/or KCl and 0.003 to 3% by weight of MgCl2.
It has also been found that the presence of a mixture of NaCl and/or KCl with MgCl2 in a dentifrice composition containing synthetic hydroxyapatite powder can effectively promote the elimination of plaque from teeth and the fortification and remineralization of the surfaces of the teeth.
More specifically, the latter dentifrice composition of the present invention can effectively deposit and coat crystals of hydroxyapatite on the surfaces of the teeth. We presume this is due to the fact that the solubility of hydroxyapatite in water is increased in the presence of the chlorides as specified above. More particularly, since hydroxyapatite is a salt which only slightly soluble in water, the ion products of ions such as [Ca++ ], [HPO4 -- ], etc. ionized in the dentifrice are small. This means that the ion products for promoting coating on the surfaces of the teeth, i.e. deposition of the crystals of hydroxyapatite on the surfaces of the teeth are small. However, if NaCl and/or KCl and MgCl2 are added to the dentifrice containing hydroxyapatite, it is presumed that the solubilities of Ca++ and HPO4 -- are increased very much and the coating on the teeth is enhanced.
In cases where the amounts of NaCl and/or KCl and MgCl2 contained in the dentifrice composition of the present invention are smaller than those specified above, a sufficient coating effect cannot be obtained, while in cases where such amounts are larger than those specified above, it becomes difficult to give a comfortable feeling in the use of the dentifrice composition.
To obtain a suitable abrading effect and desired plaque elimination, the average particle size of the hydroxyapatite powder is preferably about 2μ and the maximum particle size thereof is preferably 10μ or less.
The dentifrice composition of the present invention may include various additives which are commonly employed in dentifrices and may further include, if desired, citric acid, lactic acid, acetic acid, pyrrolic acid, glutamine, proline, serine, glycine, etc.
The invention will be further illustrated with reference to the following examples. Examples 1 to 7 and 11 to 17 respectively show formulations of the dentifrice compositions in accordance with the present invention in terms of parts by weight and Examples 8 to 10, 18 and 19 are to substantiate effects of the composition of the present invention.
EXAMPLE 1 
______________________________________                                    
Tooth Paste                                                               
______________________________________                                    
Apatite Powder     13.2                                                   
Calcium phosphate  25.0                                                   
CMC sodium salt    0.3                                                    
Carrageenan        1.2                                                    
Glycerin           10.0                                                   
Solbitol           15.0                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.2                                                    
Sodium saccharinate                                                       
                   0.1                                                    
Silicon dioxide    2.0                                                    
Water              30.0                                                   
______________________________________
EXAMPLE 2 
______________________________________                                    
Tooth Paste                                                               
______________________________________                                    
Apatite powder      7.2                                                   
Calcium phosphate   10.0                                                  
Calcium pyrophosphate                                                     
                    20.0                                                  
CMC Sodium salt     1.0                                                   
Sodium alginate     0.1                                                   
Glycerin            10.0                                                  
Solbitol            10.0                                                  
Sodium lauryl sulfate                                                     
                    1.5                                                   
Sodium lauryl sarcosinate                                                 
                    0.5                                                   
Flavor              0.5                                                   
Sodium saccharinate 0.1                                                   
Silicon dioxide     2.5                                                   
Sodium phosphate    1.0                                                   
Water               35.0                                                  
______________________________________
EXAMPLE 3 
______________________________________                                    
Tooth Paste                                                               
______________________________________                                    
Apatite powder     22.3                                                   
Calcium pyrophosphate                                                     
                   10.0                                                   
CMC sodium salt    0.5                                                    
Carrageenan        0.6                                                    
Glycerin           20.0                                                   
Solbitol           10.0                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.0                                                    
Sodium saccharinate                                                       
                   0.1                                                    
Silicon dioxide    2.0                                                    
Sodium phosphate   0.5                                                    
Water              30.0                                                   
______________________________________
EXAMPLE 4 
______________________________________                                    
Tooth Paste                                                               
______________________________________                                    
Apatite powder     38.1                                                   
CMC sodium salt    1.0                                                    
Carrageenan        0.3                                                    
Glycerin           35.0                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.0                                                    
Sodium saccharinate                                                       
                   0.1                                                    
Silicon dioxide    2.5                                                    
Water              20.0                                                   
______________________________________
EXAMPLE 5 
______________________________________                                    
Tooth Powder                                                              
______________________________________                                    
Apatite powder     96.3                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.5                                                    
Sodium saccharinate                                                       
                   0.2                                                    
______________________________________
EXAMPLE 6 
______________________________________                                    
Tooth Powder                                                              
______________________________________                                    
Apatite powder     40.7                                                   
Calcium pyrophosphate                                                     
                   50.0                                                   
Silicon dioxide    5.0                                                    
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             2.0                                                    
Sodium saccharinate                                                       
                   0.3                                                    
______________________________________
EXAMPLE 7 
______________________________________                                    
Wet Tooth Powder                                                          
______________________________________                                    
Apatite powder     65.38                                                  
Calcium phosphate  10.0                                                   
Solbitol           10.0                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.5                                                    
Calcium phosphate  1.0                                                    
Water              10.0                                                   
Sodium saccharinate                                                       
                   0.12                                                   
______________________________________
EXAMPLE 8
0.1% solution of Neutral Red was applied to the front teeth of each of three male adults A, B and C (22 to 25 years old), who had been using conventional commercially available dentifrices. Thereafter, similar dyeing operation was conducted one day after they started to use the dentifrice of Example 1 and the plaque-stained areas before and after the change of the dentifrices were compared. In the case of A, the stained area after the change was about 10% of the initial stained area and it was confirmed that the decontamination of the plaque area was about 90%. In cases of B and C, the decontamination of the plaque areas was about 50%.
EXAMPLE 9
Abrasive effects of dentifrices were tested using, for teeth, plate-form bodies made of sintered hydroxyapatite having a hardness similar to that of an enamel portion of a tooth. The plate-form bodies were each subjected to brushing using tooth brushes and different dentifrices for 60 minutes. The losses in weights of the respective plate-form bodies were measured. In the result, the abrasive effects of the dentrifrice composition of the present invention was similar to those of commercially available dentifrices (WHITE & WHITE and DENTER LION).
EXAMPLE 10
An adult's permanent tooth was sliced in two using a prisma adamantinum to form a section having a thickness of about 200 μm. A supernant saturated solution of a liquid prepared by stirring 1 g of hydroxyapatite powder with 100 ml of distilled water was passed over the thus formed section at a flow rate of 0.6 ml/min. The section was observed continuously using a polarization microscope and it was confirmed that the section was coated with analogous apatite crystals about 1 μm thick after 14 hours.
EXAMPLE 11 
______________________________________                                    
Tooth Paste                                                               
______________________________________                                    
Apatite powder     10.0                                                   
Calcium phosphate  25.0                                                   
CMC sodium salt    0.3                                                    
Carrageenan        1.2                                                    
Glycerin           10.0                                                   
Solbitol           15.0                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.2                                                    
Sodium saccharinate                                                       
                   0.1                                                    
Silicon dioxide    2.0                                                    
NaCl               0.27                                                   
MgCl.sub.2         0.01                                                   
Water              32.92                                                  
______________________________________
EXAMPLE 12 
______________________________________                                    
Tooth Paste                                                               
______________________________________                                    
Apatite powder      5.0                                                   
Calcium phosphate   10.0                                                  
Calcium pyrophosphate                                                     
                    20.0                                                  
CMC sodium salt     1.0                                                   
Sodium alginate     0.1                                                   
Glycerin            10.0                                                  
Solbitol            10.0                                                  
Sodium lauryl sulfate                                                     
                    1.5                                                   
Sodium lauryl sarcosinate                                                 
                    0.5                                                   
Flavor              0.5                                                   
Sodium saccharinate 0.1                                                   
Silicon dioxide     2.5                                                   
NaCl                3.0                                                   
MgCl.sub.2          0.2                                                   
Water               35.0                                                  
______________________________________
EXAMPLE 13 
______________________________________                                    
Tooth Paste                                                               
______________________________________                                    
Apatite powder     20.0                                                   
Calcium pyrophosphate                                                     
                   10.0                                                   
CMC sodium salt    0.5                                                    
Carrageenan        0.6                                                    
Glycerin           20.0                                                   
Solbitol           10.0                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.0                                                    
Sodium saccharinate                                                       
                   0.1                                                    
Silicon dioxide    2.0                                                    
KCl                2.0                                                    
MgCl.sub.2         0.3                                                    
Sodium phosphate   0.5                                                    
Water              30.0                                                   
______________________________________
EXAMPLE 14 
______________________________________                                    
Tooth Paste                                                               
______________________________________                                    
Apatite powder     35.0                                                   
CMC sodium salt    1.0                                                    
Carrageenan        0.3                                                    
Glycerin           35.0                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.0                                                    
Sodium saccharinate                                                       
                   0.1                                                    
Silicon dioxide    2.5                                                    
NaCl               2.0                                                    
MgCl.sub.2         0.1                                                    
KCl                1.0                                                    
Water              20.0                                                   
______________________________________
EXAMPLE 15 
______________________________________                                    
Tooth Powder                                                              
______________________________________                                    
Apatite powder     90.8                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.5                                                    
Sodium saccharinate                                                       
                   0.2                                                    
NaCl               5.0                                                    
MgCl.sub.2         0.5                                                    
______________________________________
EXAMPLE 16 
______________________________________                                    
Tooth Powder                                                              
______________________________________                                    
Apatite powder     38.0                                                   
Calcium pyrophosphate                                                     
                   50.0                                                   
Silicon dioxide    5.0                                                    
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             2.0                                                    
Sodium saccharinate                                                       
                   0.3                                                    
NaCl               1.8                                                    
MgCl.sub.2         0.2                                                    
Potassium phosphate                                                       
                   0.7                                                    
______________________________________
EXAMPLE 17 
______________________________________                                    
Wet Tooth Powder                                                          
______________________________________                                    
Apatite powder     63.0                                                   
Calcium phosphate  10.0                                                   
Solbitol           10.0                                                   
Sodium lauryl sulfate                                                     
                   2.0                                                    
Flavor             1.5                                                    
NaCl               3.3                                                    
MgCl.sub.2         0.08                                                   
Water              10.0                                                   
Sodium saccharinate                                                       
                   0.12                                                   
______________________________________
EXAMPLE 18
1 g of hydroxyapatite powder was introduced into 100 ml of 37° C. distilled water and NaCl and MgCl2 were added in various concentrations. The calcium ion concentrations of the respective solutions were measured and it was confirmed that the solubility of hydroxyapatite was increased by adding NaCl and MgCl2. The calcium ion concentrations 10 days after the preparation of the solutions were as follows:
______________________________________                                    
NaCl concentration;                                                       
               0     0.3    0.3  3.0  3.0  (%)                            
MgCl.sub.2 concentration;                                                 
               0     0.03   0.3  0.03 0.3  (%)                            
Ca.sup.++ concentration;                                                  
               4.9   26.0   31.2 31.5 36.7 (ppm)                          
______________________________________
EXAMPLE 19
An adult's permanent tooth was sliced in two using a prisma adamantinum to prepare a section about 200 μm thick. The enamel portion was removed to expose the dentin portion. A hydroxyapatite-saturated solution in distilled water containing 0.001% of MgCl2 and 0.9% of NaCl was passed over the so prepared section at a flow rate of 0.6 ml/min. The section was continuously observed using a polarization microscope and it was confirmed that all over the surfaces of the section were coated with analogous apatite crystals at a thickness of about 5 μm.

Claims (1)

I claim:
1. A dentifrice composition for tooth paste consisting essentially of: 30 to 35 parts by weight of an abrading agent containing 5 to 35 parts by weight of synthetic hydroxyapatite powder and the balance of at least one member selected from the group consisting of calcium phosphate and calcium pyrophosphate; 20 to 35 parts by weight of at least one filler selected from the group consisting of glycerin and sorbitol; 30 to 35 parts by weight of water; 0.27 to 3 parts by weight of at least one alkali metal chloride selected from the group consisting of NaCl and KCl; and, 0.01 to 0.3 parts by weight of MgCl2.
US06/201,727 1979-11-15 1980-10-29 Dentifrice compositions Expired - Lifetime US4327079A (en)

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Application Number Priority Date Filing Date Title
JP14701179A JPS5673014A (en) 1979-11-15 1979-11-15 Toothpaste composition
JP54/147011 1979-11-15

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Cited By (27)

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US4415550A (en) * 1983-03-04 1983-11-15 Pakhomov Gennady N Treatment-and-prophylactic tooth paste possessing anticarious effect
US4424203A (en) 1983-03-04 1984-01-03 Pakhomov Gennady N Gel for dental caries prevention
US4581227A (en) * 1982-11-03 1986-04-08 Staffan Kjelleberg Control of microflora
US4618489A (en) * 1983-09-02 1986-10-21 Research Foundation Of The State University Of New York Dental compositions and method of use therefor
US4631185A (en) * 1984-03-13 1986-12-23 The Trustees Of Columbia University In The City Of New York Method of desensitizing hypersensitive dentin employing compositions containing potassium salts
US4634589A (en) * 1984-05-18 1987-01-06 Wurttembergische Parfumerie-Fabrik Gmbh Dentifrice for hypersensitive teeth
US4701320A (en) * 1984-11-29 1987-10-20 Lederle (Japan), Ltd. Composition stably containing minocycline for treating periodontal diseases
GB2210265A (en) * 1987-10-02 1989-06-07 Richardson Vicks Ltd Dentifrice compositions
US4859656A (en) * 1985-01-10 1989-08-22 Chemical Dynamics Sweden Ab Method of detaching micro-flora and compositions therefor
EP0342746A1 (en) * 1988-05-19 1989-11-23 Unilever N.V. Oral compositions
EP0342380A1 (en) * 1988-05-19 1989-11-23 Württembergische Parfümerie-Fabrik GmbH Toothpastes and process to stabilize them
US4923683A (en) * 1987-06-27 1990-05-08 Kabushiki Kaisha Sangi Compositions for preventing tooth decay
US4933171A (en) * 1988-05-19 1990-06-12 Unilever Patent Holdings B.V. Oral compositions
US4933173A (en) * 1988-05-19 1990-06-12 Unilever Patent Holdings B.V. Oral preparations
US5009898A (en) * 1988-09-29 1991-04-23 Kabushiki Kaisha Sangi Antimicrobial hydroxyapatite powders and methods for preparing them
US5037639A (en) * 1989-05-24 1991-08-06 American Dental Association Health Foundation Methods and compositions for mineralizing calcified tissues
US5089254A (en) * 1990-01-08 1992-02-18 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Oral compositions
GB2206338B (en) * 1987-06-30 1992-03-04 Sangi Kk Fine filler dentifrice
US5112599A (en) * 1989-11-30 1992-05-12 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Oral compositions
US5468489A (en) * 1991-10-29 1995-11-21 Sangi Co., Ltd. Dentifrice containing antibacterial material
US5534244A (en) * 1989-05-24 1996-07-09 Tung; Ming S. Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds
US5833959A (en) * 1996-01-24 1998-11-10 Sangi Co., Ltd. Compositions for dental tissue
US6358494B1 (en) * 1997-03-26 2002-03-19 Tokyo Bioceramics Institute Co., Ltd. Composite toothpaste products
US6372198B1 (en) 2000-09-14 2002-04-16 Joseph M. Abbate Dentifrice for the mineralization and remineralization of teeth
US6610276B2 (en) 2001-01-12 2003-08-26 Steven A. Melman Multi-functional dental composition
US6919070B1 (en) * 1997-10-17 2005-07-19 Zakrytoe Aktsionernoe Obschestvo “OSTIM” Stomatic composition
US20150231060A1 (en) * 2013-03-14 2015-08-20 3 In 1 Dental Pllc Compositions for treatment of xerostomia and for tooth treatment

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* Cited by examiner, † Cited by third party
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JPS6470408A (en) * 1987-09-10 1989-03-15 Hairu Kk Dentifrice composition

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US3689636A (en) * 1969-10-24 1972-09-05 Bentex Pharm Co Composition and method for desensitizing sensitive teeth
US3691272A (en) * 1966-01-19 1972-09-12 Ciba Geigy Ag Tooth-paste
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US1817664A (en) * 1928-10-26 1931-08-04 Bernard B Badanes Dentifrice
US2658851A (en) * 1944-04-20 1953-11-10 Brandenberger Jacques Edwin Salt dentifrice
US2994642A (en) * 1954-10-16 1961-08-01 Bossard Francois Jean Sodium chloride toothpaste having a silica aerogel carrier
US3691272A (en) * 1966-01-19 1972-09-12 Ciba Geigy Ag Tooth-paste
US3689636A (en) * 1969-10-24 1972-09-05 Bentex Pharm Co Composition and method for desensitizing sensitive teeth
US3679360A (en) * 1970-06-26 1972-07-25 Nasa Process for the preparation of brushite crystals
US4048300A (en) * 1973-01-11 1977-09-13 Colgate-Palmolive Company Dental preparation containing materials having calcium and phosphate components
US4108980A (en) * 1973-01-11 1978-08-22 Colgate-Palmolive Company Process of preparing materials having calcium and phosphate components
US4080440A (en) * 1974-12-13 1978-03-21 The Procter & Gamble Company Method for remineralizing tooth enamel
US4083955A (en) * 1975-04-02 1978-04-11 The Procter & Gamble Company Processes and compositions for remineralization of dental enamel

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US4581227A (en) * 1982-11-03 1986-04-08 Staffan Kjelleberg Control of microflora
US4424203A (en) 1983-03-04 1984-01-03 Pakhomov Gennady N Gel for dental caries prevention
US4415550A (en) * 1983-03-04 1983-11-15 Pakhomov Gennady N Treatment-and-prophylactic tooth paste possessing anticarious effect
US4618489A (en) * 1983-09-02 1986-10-21 Research Foundation Of The State University Of New York Dental compositions and method of use therefor
US4751072A (en) * 1984-03-13 1988-06-14 The Trustees Of Columbia University In The City Of New York Method of desensitizing hypersensitive dentin employing compositions containing potassium chloride
US4631185A (en) * 1984-03-13 1986-12-23 The Trustees Of Columbia University In The City Of New York Method of desensitizing hypersensitive dentin employing compositions containing potassium salts
US4634589A (en) * 1984-05-18 1987-01-06 Wurttembergische Parfumerie-Fabrik Gmbh Dentifrice for hypersensitive teeth
US4710372A (en) * 1984-05-18 1987-12-01 Wurttembergische Parfumerie-Fabrik Gmbh Dentifrice for hypersensitive teeth
US4701320A (en) * 1984-11-29 1987-10-20 Lederle (Japan), Ltd. Composition stably containing minocycline for treating periodontal diseases
US4859656A (en) * 1985-01-10 1989-08-22 Chemical Dynamics Sweden Ab Method of detaching micro-flora and compositions therefor
US4923683A (en) * 1987-06-27 1990-05-08 Kabushiki Kaisha Sangi Compositions for preventing tooth decay
GB2206338B (en) * 1987-06-30 1992-03-04 Sangi Kk Fine filler dentifrice
GB2210265A (en) * 1987-10-02 1989-06-07 Richardson Vicks Ltd Dentifrice compositions
US4988499A (en) * 1988-05-19 1991-01-29 Unilever Patent Holdings, B.V. Oral compositions
EP0342746A1 (en) * 1988-05-19 1989-11-23 Unilever N.V. Oral compositions
US4933173A (en) * 1988-05-19 1990-06-12 Unilever Patent Holdings B.V. Oral preparations
EP0342380A1 (en) * 1988-05-19 1989-11-23 Württembergische Parfümerie-Fabrik GmbH Toothpastes and process to stabilize them
US4933171A (en) * 1988-05-19 1990-06-12 Unilever Patent Holdings B.V. Oral compositions
US5009898A (en) * 1988-09-29 1991-04-23 Kabushiki Kaisha Sangi Antimicrobial hydroxyapatite powders and methods for preparing them
US5437857A (en) * 1989-05-24 1995-08-01 American Dental Association Health Foundation Methods and compositions for mineralizing and fluoridating calcified tissues
US5037639A (en) * 1989-05-24 1991-08-06 American Dental Association Health Foundation Methods and compositions for mineralizing calcified tissues
US5534244A (en) * 1989-05-24 1996-07-09 Tung; Ming S. Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds
US5112599A (en) * 1989-11-30 1992-05-12 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Oral compositions
US5089254A (en) * 1990-01-08 1992-02-18 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Oral compositions
US5468489A (en) * 1991-10-29 1995-11-21 Sangi Co., Ltd. Dentifrice containing antibacterial material
US5833959A (en) * 1996-01-24 1998-11-10 Sangi Co., Ltd. Compositions for dental tissue
US6358494B1 (en) * 1997-03-26 2002-03-19 Tokyo Bioceramics Institute Co., Ltd. Composite toothpaste products
US6919070B1 (en) * 1997-10-17 2005-07-19 Zakrytoe Aktsionernoe Obschestvo “OSTIM” Stomatic composition
US6372198B1 (en) 2000-09-14 2002-04-16 Joseph M. Abbate Dentifrice for the mineralization and remineralization of teeth
US6610276B2 (en) 2001-01-12 2003-08-26 Steven A. Melman Multi-functional dental composition
US20150231060A1 (en) * 2013-03-14 2015-08-20 3 In 1 Dental Pllc Compositions for treatment of xerostomia and for tooth treatment
US9968547B2 (en) * 2013-03-14 2018-05-15 3 In 1 Dental Pllc Compositions for treatment of xerostomia and for tooth treatment
US10413503B2 (en) * 2013-03-14 2019-09-17 3 In 1 Dental Pllc Compositions for treatment of xerostomia and for tooth treatment

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