US3956315A - Herbicidal N-(3-cyano-4-alkylthien-2-yl) ureas - Google Patents

Herbicidal N-(3-cyano-4-alkylthien-2-yl) ureas Download PDF

Info

Publication number
US3956315A
US3956315A US05/453,231 US45323174A US3956315A US 3956315 A US3956315 A US 3956315A US 45323174 A US45323174 A US 45323174A US 3956315 A US3956315 A US 3956315A
Authority
US
United States
Prior art keywords
cyano
urea
herbicidal
carbon atoms
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US05/453,231
Inventor
John W. Kobzina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chevron USA Inc
Original Assignee
Chevron Research Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chevron Research Co filed Critical Chevron Research Co
Priority to US05/453,231 priority Critical patent/US3956315A/en
Priority to CA220,886A priority patent/CA1040208A/en
Priority to DE19752510936 priority patent/DE2510936A1/en
Priority to FR7507935A priority patent/FR2264814B1/fr
Priority to JP50055557A priority patent/JPS50154427A/ja
Priority to GB1203775A priority patent/GB1462570A/en
Application granted granted Critical
Publication of US3956315A publication Critical patent/US3956315A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Definitions

  • the thienyl ureas of the invention may be represented by the following formula (I): ##SPC1##
  • X is hydrogen, fluoro, chloro or bromo
  • R 1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, or phenyl substituted with up to 2 (0 to 2) fluoro, chloro or bromo
  • R 2 is hydrogen or alkyl of 1 to 6 carbon atoms
  • R 3 is hydrogen or alkyl of 1 to 6 carbon atoms.
  • Representative alkyl groups which R 1 , R 2 and R 3 may represent are methyl, ethyl, n-propyl, isopropyl and butyl.
  • Representative cycloalkyl groups which R 1 may represent are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl.
  • Representative halophenyl groups which R 1 may represent are 2-fluorophenyl, 4-fluorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl and 3-bromophenyl.
  • the preferred X group is hydrogen or chloro.
  • the most preferred X group is hydrogen.
  • the preferred R 1 group is alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, or phenyl.
  • the most preferred R 1 group is alkyl of 3 to 6 carbon atoms.
  • the preferred R 2 group is hydrogen.
  • the preferred R 3 group is alkyl of 1 to 6 carbon atoms, more preferably of 1 to 3 carbon atoms.
  • the preferred thienyl ureas of formula (I) are therefore those wherein X is hydrogen or chloro, R 1 is alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or phenyl; R 2 is hydrogen, and R 3 is alkyl of 1 to 6 carbon atoms, and the most preferred thienyl ureas of formula (I) are those wherein X is hydrogen, R 1 is alkyl of 3 to 6 carbon atoms, R 2 is hydrogen and R 3 is alkyl of 1 to 3 carbon atoms.
  • Illustrative thienyl ureas of formula (I) are:
  • the thienyl ureas of formula (I) are prepared by reacting a 2-aminothiophene (II), phosgene (III) and an amine (IV) according to the following reaction: ##SPC2##
  • the above reaction is conducted by more or less conventional procedures.
  • the aminothiophene can be reacted with phosgene, and the resulting carbamoyl chloride product can be reacted with the amine (IV) to produce the product (I).
  • the entire amounts of reactants (II), III) and (IV) can be reacted together.
  • substantially equimolar amounts of reactants (II), (III) and (IV) are employed, although an excess of phosgene or the amine (IV) also can be employed.
  • at least 2 to 3 mols of acid acceptor is employed per mol of phosgene.
  • Suitable acid acceptors are trialkylamines, such as triethylamines, or a pyridine compound, such as pyridine or ⁇ -picoline. Reaction temperatures generally vary from 0°C. to 50°C.
  • the product (I) is isolated by conventional procedures such as extraction, distillation, chromatography and crystallization.
  • the thienyl ureas of formula (I) wherein R 2 is hydrogen and R 3 is alkyl can also be prepared by reacting the 2-aminothiophene (II) and an alkyl isocyanate (III) according to the following reaction: ##SPC3##
  • This second reaction is conducted by the conventional procedures generally employed for the reaction of amines and isocyanates.
  • this reaction is generally conducted with substantially equimolar amounts of the reactants (II) and (V) or with an excess of the isocyanate (V), preferably in the presence of an inert solvent such as dimethoxyethane or dimethylformamide, and optionally in the presence of a small amount of a basic catalyst such as a tertiary trialkylamine, e.g., triethylamine, or dialkyl tin dialkanoates, e.g., dibutyl tin dilaurate.
  • Suitable reaction temperatures vary from about 0°C. to 150°C., preferably from about 50°C. to 125°C.
  • the product (VI) is isolated and purified by conventional procedures such as distillation, crystallization and chromatography.
  • 2-Amino-3-cyano-4-sec-butylthiophene was prepared from sulfur and 1,1-dicyano-2-methyl-2-sec-butylethylene by the procedure described in Chem. Ber. 99, 2712 (1966).
  • 2-Amino-3-cyano-4-cyclopropylthiophene was prepared from sulfur and 1,1-dicyano-2-methyl-2-cyclopropylethylene in diethylamine by the procedure described in Chem. Ber. 99, 2171 (1966).
  • the compounds of the present invention are, in general, herbicidal in both pre- and post-emergent applications.
  • the herbicidal compounds will be applied in herbicidally effective amounts to the environment or growth medium of the vegetation, e.g., soil infested with seeds and/or seedlings of such vegetation. Such application will inhibit the growth of or kill the seeds, germinating seeds and seedlings.
  • the herbicidal compounds will be applied directly to the foliage and other plant parts.
  • the herbicidal compounds of the invention are effective against weed grasses as well as broadleaf weeds. Some may be selective with respect to the type of application and/or type of weed.
  • the compounds of the present invention can be used alone as herbicides. However, it is generally desirable to apply the compounds in herbicidal compositions comprising one or more of the herbicidal compounds intimately admixed with a biologically inert carrier.
  • the carrier may be a liquid diluent or a solid, e.g., in the form of dust powder or granules.
  • the active herbicidal compounds can be from about 0.01 to 95% by weight of the entire composition.
  • Suitable liquid diluent carriers include water and organic solvents, e.g., hydrocarbons such as benzene, toluene, kerosene, diesel oil, fuel oil, and petroleum naphtha.
  • Suitable solid carriers are natural clays such as kaolinite, atalpulgite, and montmorillonite.
  • talcs, pyrophillite, diatomaceous silica, synthetic fine silicas, calcium aluminosilicate and tricalcium phosphate are suitable carriers.
  • Organic materials such as walnut-shell flour, cottonseed hulls, wheat flour, wood flour, or redwood-bark flour may also be used as solid carriers.
  • the herbicidal composition will also usually contain a minor amount of a surface-active agent.
  • a surface-active agent are those commonly known as wetting agents, dispersing agents and emulsifying agents, and can be anionic, cationic or nonionic in character.
  • the herbicidal compositions may also contain other pesticides, adjuvants, stabilizers, conditioners, fillers, and the like.
  • the amount of herbicidal compound or composition administered will vary with the particular plant part or plant growth medium which is to be contacted, the general location of application -- i.e., sheltered areas such as greenhouses, as compared to exposed areas such as fields -- as well as the desired type of control. Generally, for both pre- and post-emergent control, the herbicidal compounds of the invention are applied at rates of 0.2 to 60 kg/ha., and the preferred rate is in the range 0.5 to 40 kg/ha.
  • An acetone solution of the test compound was prepared by mixing 750 mg of the compound, 220 mg of a nonionic surfactant and 25 ml of acetone. This solution was added to approximately 125 ml of water containing 156 mg of surfactant.
  • Seeds of the test vegetation were planted in a pot of soil and the test solution was sprayed uniformly onto the soil surface at a dose of 33 ⁇ /cm 2 .
  • the pot was watered and placed in a greenhouse.
  • the pot was watered intermittently and was observed for seedling emergence, health of emerging seedlings, etc., for a 3-week period. At the end of this period, the herbicidal effectiveness of the compound was rated based on the physiological observations. A 0-to-100 scale was used, 0 representing no phytotoxicity, 100 representing complete kill.
  • the test compound was formulated in the same manner as described above for the pre-emergence test.
  • the concentration of the test compound in this formulation was 5000 ppm.
  • This formulation was uniformly sprayed on 2 similar pots of 24-day-old plants (approximately 15 to 25 plants per pot) at a dose of 33 ⁇ /cm 2 . After the plants had dried, they were placed in a greenhouse and then watered intermittently at their bases, as needed. The plants were observed periodically for phytotoxic effects and physiological and morphological responses to the treatment. After 3 weeks, the herbicidal effectiveness of the compound was rated based on these observations. A 0-to-100 scale was used, 0 representing no phytotoxicity and 100 representing complete kill. The results of these tests appear in Table II.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Novel N-(3-cyano-4-alkylthien-2-yl) ureas are selective pre- and/or post-emergent herbicides.

Description

DESCRIPTION OF THE PRIOR ART
Thienyl-substituted ureas are disclosed in German Offen. No. 2,040,579, published Feb. 25, 1971; French Pat. No. 2,084,629, issued Jan. 29, 1972; and German Offen. No. 2,122,636, published Dec. 2, 1971.
DESCRIPTION OF THE INVENTION
The thienyl ureas of the invention may be represented by the following formula (I): ##SPC1##
wherein X is hydrogen, fluoro, chloro or bromo; R1 is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, or phenyl substituted with up to 2 (0 to 2) fluoro, chloro or bromo; R2 is hydrogen or alkyl of 1 to 6 carbon atoms and R3 is hydrogen or alkyl of 1 to 6 carbon atoms.
Representative alkyl groups which R1, R2 and R3 may represent are methyl, ethyl, n-propyl, isopropyl and butyl. Representative cycloalkyl groups which R1 may represent are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl. Representative halophenyl groups which R1 may represent are 2-fluorophenyl, 4-fluorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl and 3-bromophenyl.
The preferred X group is hydrogen or chloro. The most preferred X group is hydrogen. The preferred R1 group is alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, or phenyl. The most preferred R1 group is alkyl of 3 to 6 carbon atoms. The preferred R2 group is hydrogen. The preferred R3 group is alkyl of 1 to 6 carbon atoms, more preferably of 1 to 3 carbon atoms.
The preferred thienyl ureas of formula (I) are therefore those wherein X is hydrogen or chloro, R1 is alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or phenyl; R2 is hydrogen, and R3 is alkyl of 1 to 6 carbon atoms, and the most preferred thienyl ureas of formula (I) are those wherein X is hydrogen, R1 is alkyl of 3 to 6 carbon atoms, R2 is hydrogen and R3 is alkyl of 1 to 3 carbon atoms.
Illustrative thienyl ureas of formula (I) are:
N-(3-cyano-4-methylthien-2-yl) urea,
N-(3-cyano-4-ethyl-5-chlorothien-2-yl) urea,
N-(3-cyano-4-isopropyl-5-bromothien-2-yl) urea,
N-(3-cyano-4-n-propylthien-2-yl)-N'-methyl urea,
N-(3-cyano-4-t-butylthien-2-yl)-N'-methyl urea,
N-(3-cyano-4-sec-butyl-5-bromothien-2-yl)-N'-methyl urea,
N-(3-cyano-4-cyclopentyl-5-chlorothien-2-yl)-N'-methyl urea,
N-(3-cyano-4-o-bromophenyl-5-chlorothien-2-yl)-N'-hexyl urea,
N-(3-cyano-4-isopropylthien-2-yl)-N' ,N'-dimethyl urea,
N-(3-cyano-4-cyclopropyl-5-chlorothien-2-yl)-N',N'-diethyl urea,
N-(3-cyano-4-o-fluorophenylthien-2-yl)-N',N'-dimethyl urea, and
N-(3-cyano-4-o,p-dichlorophenylthien-2-yl)-N',N'-dimethyl urea.
The thienyl ureas of formula (I) are prepared by reacting a 2-aminothiophene (II), phosgene (III) and an amine (IV) according to the following reaction: ##SPC2##
wherein X, R1, R2 and R3 have the same significance as previously defined and B is an acid acceptor.
The above reaction is conducted by more or less conventional procedures. For example, the aminothiophene can be reacted with phosgene, and the resulting carbamoyl chloride product can be reacted with the amine (IV) to produce the product (I). Alternatively, the entire amounts of reactants (II), III) and (IV) can be reacted together. Generally, substantially equimolar amounts of reactants (II), (III) and (IV) are employed, although an excess of phosgene or the amine (IV) also can be employed. Generally, at least 2 to 3 mols of acid acceptor is employed per mol of phosgene. Suitable acid acceptors are trialkylamines, such as triethylamines, or a pyridine compound, such as pyridine or α-picoline. Reaction temperatures generally vary from 0°C. to 50°C. The product (I) is isolated by conventional procedures such as extraction, distillation, chromatography and crystallization.
The thienyl ureas of formula (I) wherein R2 is hydrogen and R3 is alkyl can also be prepared by reacting the 2-aminothiophene (II) and an alkyl isocyanate (III) according to the following reaction: ##SPC3##
wherein X, R1 and R3 have the same significance as previously defined.
This second reaction is conducted by the conventional procedures generally employed for the reaction of amines and isocyanates. Thus, this reaction is generally conducted with substantially equimolar amounts of the reactants (II) and (V) or with an excess of the isocyanate (V), preferably in the presence of an inert solvent such as dimethoxyethane or dimethylformamide, and optionally in the presence of a small amount of a basic catalyst such as a tertiary trialkylamine, e.g., triethylamine, or dialkyl tin dialkanoates, e.g., dibutyl tin dilaurate. Suitable reaction temperatures vary from about 0°C. to 150°C., preferably from about 50°C. to 125°C. The product (VI) is isolated and purified by conventional procedures such as distillation, crystallization and chromatography.
EXAMPLES
The preparation of the thienyl ureas of the invention is illustrated by the following examples.
Example 1-- Preparation of N-(3-cyano-4-sec-butylthien-2-yl)-N'-methyl urea
2-Amino-3-cyano-4-sec-butylthiophene was prepared from sulfur and 1,1-dicyano-2-methyl-2-sec-butylethylene by the procedure described in Chem. Ber. 99, 2712 (1966).
A solution of 5 g 2-amino-3-cyano-4-sec-butylthiophene and 10 ml methyl isocyanate in 20 ml dimethoxyethane was stirred at about 25°C. for 2 days and then at reflux for 6 hours. The reaction mixture was evaporated under reduced pressure and the residue was chromatographed on a silica-gel column. The product, a white solid melting at 149°-152°C., was eluted with 70% ether-30% hexane. The infrared spectrum of the product showed cyano absorption at 4.5 microns. Sulfur analysis for the product is tabulated in Table I.
Example 2 -- Preparation of N-(3-cyano-4-cyclopropylthien-2-yl)-N'-methyl urea
2-Amino-3-cyano-4-cyclopropylthiophene was prepared from sulfur and 1,1-dicyano-2-methyl-2-cyclopropylethylene in diethylamine by the procedure described in Chem. Ber. 99, 2171 (1966).
A solution of 10 g 2-amino-3-cyano-4-cyclopropylthiophene, 6.94 g methyl isocyanate and 0.1 g dibutyl tin dilaurate in 20 ml dimethoxyethane was refluxed for 7 hours and then allowed to stand at about 25°C. overnight. The reaction mixture was evaporated and the resulting residue was chromatographed on silica gel. The product, a pale-green solid melting at 169°-172°C., was eluted with 1:1 ether-hexane. Sulfur analysis for the product is tabulated in Table I.
Example 3 -- Preparation of N-(3-cyano-4-t-butylthien-2-yl)-N'-methyl urea
A solution of 4 g 2-amino-3-cyano-4-t-butylthiophene, 1.27 g methyl isocyanate and 3 ml triethylamine in 20 ml dimethylformamide was heated at 130°C. for 3 hours and then allowed to stand at about 25°C. overnight. The dimethylformamide was removed by distillation and the residue was crystallized from ether to give the product, as a tan solid, m.p. 212°-214°C. The infrared spectrum of the product showed cyano absorption at 4.6 microns. Sulfur analysis for the product is tabulated in Table I.
Example 4 -- Preparation of N-(3-cyano-4-t-butyl-5-chlorothien-2-yl)-N'-methyl urea
Gaseous hydrogen chloride was bubbled into a cooled (0°C.) solution of 5 g of 2-amino-3-cyano-4-5-butylthiophene in 20 ml chloroform for 5 minutes. To the resulting mixture was then added dropwise 3.81 g sulfuryl chloride over a 10-minute period. After stirring at 0°C. for 2 hours, the reaction mixture was placed under reduced pressure (water aspirator) at 0°C. to remove gaseous by-products. The reaction mixture was then diluted with 10 ml of a 25% (weight) aqueous sodium hydroxide solution and 5 ml of methylene chloride. The organic layer was separated, dried over magnesium sulfate and evaporated under reduced pressure to give an oil residue. The oil was chromatographed on silica gel (1:1 ether-hexane elution) to give 3.7 g of 3-cyano-4-t-butyl-5-chlorothiophene, as a semi-solid. Elemental analysis showed: %S, calc. 14.93, found 15.0; %Cl, calc. 16.5, found 15.8.
A solution of 6.4 g 3-cyano-4-t-butyl-5-chlorothiophene, prepared as described above, 1.71 g methyl isocyanate and 20 drops triethylamine in 20 ml dimethylformamide was heated at 120°-125°C. for 3 hours. The reaction mixture was diluted with 250 ml ice water and extracted with chloroform. The chloroform extracts were dried over magnesium sulfate and evaporated to give an oil. The oil was chromatographed on silica gel (1:1 ether-hexane eluant) to give the product as a brown solid, m.p. 215°-217°C. Sulfur analysis for the product is tabulated in Table I.
Example 5 -- Preparation of N-(3-cyano-4-t-butylthien-2-yl)-N',N'-dimethyl urea
A solution of 3.04 g phosgene in about 25 ml benzene was added to a cooled (0°C.) solution of 5 g 2-amino-3-cyano-4-t-butylthiophene, 5 g diethylamine and 8.4 g triethylamine in 100 ml benzene. The reaction mixture was warmed to about 25°C. and maintained at this temperature for about 16 hours. The reaction mixture was filtered and the filtrate was evaporated to give a black oil. The oil was chromatographed on silica gel. The product, a brown solid melting at 120°-125°C., was eluted from the silica gel with 1:1 ether-hexane. The infrared spectrum of the product showed strong cyano absorption at 4.6 microns and strong carbonyl absorption at 6.0 microns. Sulfur analysis for the product is tabulated in Table I.
UTILITY
The compounds of the present invention are, in general, herbicidal in both pre- and post-emergent applications. For pre-emergent control of undesirable vegetation, the herbicidal compounds will be applied in herbicidally effective amounts to the environment or growth medium of the vegetation, e.g., soil infested with seeds and/or seedlings of such vegetation. Such application will inhibit the growth of or kill the seeds, germinating seeds and seedlings. For post-emergent applications, the herbicidal compounds will be applied directly to the foliage and other plant parts. Generally, the herbicidal compounds of the invention are effective against weed grasses as well as broadleaf weeds. Some may be selective with respect to the type of application and/or type of weed.
The compounds of the present invention can be used alone as herbicides. However, it is generally desirable to apply the compounds in herbicidal compositions comprising one or more of the herbicidal compounds intimately admixed with a biologically inert carrier. The carrier may be a liquid diluent or a solid, e.g., in the form of dust powder or granules. In the herbicidal composition, the active herbicidal compounds can be from about 0.01 to 95% by weight of the entire composition.
Suitable liquid diluent carriers include water and organic solvents, e.g., hydrocarbons such as benzene, toluene, kerosene, diesel oil, fuel oil, and petroleum naphtha. Suitable solid carriers are natural clays such as kaolinite, atalpulgite, and montmorillonite. In addition, talcs, pyrophillite, diatomaceous silica, synthetic fine silicas, calcium aluminosilicate and tricalcium phosphate are suitable carriers. Organic materials such as walnut-shell flour, cottonseed hulls, wheat flour, wood flour, or redwood-bark flour may also be used as solid carriers.
The herbicidal composition will also usually contain a minor amount of a surface-active agent. Such surface agents are those commonly known as wetting agents, dispersing agents and emulsifying agents, and can be anionic, cationic or nonionic in character. The herbicidal compositions may also contain other pesticides, adjuvants, stabilizers, conditioners, fillers, and the like.
The amount of herbicidal compound or composition administered will vary with the particular plant part or plant growth medium which is to be contacted, the general location of application -- i.e., sheltered areas such as greenhouses, as compared to exposed areas such as fields -- as well as the desired type of control. Generally, for both pre- and post-emergent control, the herbicidal compounds of the invention are applied at rates of 0.2 to 60 kg/ha., and the preferred rate is in the range 0.5 to 40 kg/ha.
Pre- and post-emergent herbicidal tests on representative compounds of the invention were made using the following methods:
Pre-Emergent Test
An acetone solution of the test compound was prepared by mixing 750 mg of the compound, 220 mg of a nonionic surfactant and 25 ml of acetone. This solution was added to approximately 125 ml of water containing 156 mg of surfactant.
Seeds of the test vegetation were planted in a pot of soil and the test solution was sprayed uniformly onto the soil surface at a dose of 33 μ/cm2. The pot was watered and placed in a greenhouse. The pot was watered intermittently and was observed for seedling emergence, health of emerging seedlings, etc., for a 3-week period. At the end of this period, the herbicidal effectiveness of the compound was rated based on the physiological observations. A 0-to-100 scale was used, 0 representing no phytotoxicity, 100 representing complete kill.
Post-Emergence Test
The test compound was formulated in the same manner as described above for the pre-emergence test. The concentration of the test compound in this formulation was 5000 ppm. This formulation was uniformly sprayed on 2 similar pots of 24-day-old plants (approximately 15 to 25 plants per pot) at a dose of 33 μ/cm2. After the plants had dried, they were placed in a greenhouse and then watered intermittently at their bases, as needed. The plants were observed periodically for phytotoxic effects and physiological and morphological responses to the treatment. After 3 weeks, the herbicidal effectiveness of the compound was rated based on these observations. A 0-to-100 scale was used, 0 representing no phytotoxicity and 100 representing complete kill. The results of these tests appear in Table II.
                                  TABLE I                                 
__________________________________________________________________________
                                            Melting Point                 
                                                     Sulfur Analysis      
No.           Compound                      °C.                    
                                                     Calc. Found          
__________________________________________________________________________
1   N-(3-cyano-4-sec-butylthien-2-yl)-N'-methyl urea                      
                                            149-152  13.51 13.7           
2   N-(3-cyano-4-cyclopropylthien-2-yl)-N'-methyl urea                    
                                            169-172  14.49 13.6           
3   N-(3-cyano-4-sec-butylthien-2-yl)-N'-methyl urea                      
                                            212-214  13.51 12.92          
4   N-(3-cyano-4-t-butyl-5-chlorothien-2-yl)-N'-methyl urea               
                                            215-217  11.80 11.40          
5   N-(3-cyano-4-t-butylthien-2-yl)-N',N'-dimethyl urea                   
                                            120-125  12.75 12.68          
6   N-(3-cyano-4-isopropylthien-2-yl)-N'-methyl urea                      
                                            177-178  14.36 14.28          
7   N-(3-cyano-4-t-butylthien-2-yl)-N'-propyl urea                        
                                            154-158  12.08 12.07          
8   N-(3-cyano-4-isopropylthien-2-yl)-N',N'-dimethyl urea                 
                                            113-116  17.7                 
                                                         N 17.8           
9   N-(3-cyano-4-phenylthien-2-yl)-N'-methyl urea                         
                                            190-194  12.46 11.8           
10  N-(3-cyano-4-cyclopropylthien-2-yl)-N',N'-dimethyl urea               
                                            171-172  13.63 13.6           
11  N-(3-cyano-4-isopropylthien-2-yl) urea  190-192  15.32 18.7           
12  N-(3-cyano-4-sec-butylthien-2-yl)-N'-ethyl urea                       
                                            104-106  12.76 13.2           
13  N-(3-cyano-4-cyclopropylthien-2-yl)-N'-ethyl urea                     
                                            174-180  13.63 13.0           
14  N-(3-cyano-4-cyclopropylthien-2-yl)-N'-t-butyl urea                   
                                            227-230  12.18 12.1           
15  N-(3-cyano-4-cyclohexylthien-2-yl)-N'-methyl urea                     
                                            225-226  12.17 12.1           
__________________________________________________________________________

                                  TABLE II                                
__________________________________________________________________________
Herbicidal Effectiveness                                                  
Pre/Post                                                                  
Compound No.                                                              
        O    W    C     M     P    L                                      
__________________________________________________________________________
1       0/80 15/85                                                        
                  30/95 100/100                                           
                              75/100                                      
                                   75/100                                 
2       0/45  0/45                                                        
                   0/85  80/100                                           
                              55/100                                      
                                   60/100                                 
3       25/75                                                             
             60/75                                                        
                  50/60 100/100                                           
                              0/90 95/100                                 
4       0/25  0/20                                                        
                   --/10                                                  
                         90/100                                           
                              70/95                                       
                                   100/100                                
5       0/90  0/90                                                        
                   0/85  0/100                                            
                              0/95  0/100                                 
6       15/94                                                             
             95/89                                                        
                  100/95                                                  
                        100/100                                           
                              65/100                                      
                                   95/100                                 
7       0/0  0/0  0/0    95/100                                           
                              0/35 95/100                                 
8       13/--                                                             
             27/--                                                        
                  27/-- 93/-- 73/--                                       
                                   99/--                                  
9       10/20                                                             
              0/20                                                        
                   --/10                                                  
                        80/95 80/90                                       
                                   80/90                                  
10      0/15  0/15                                                        
                   0/15  0/25 0/25 0/25                                   
11      20/0 10/0 0/0   70/0  0/0  70/0                                   
12      0.45  0/35                                                        
                   0/10 100/100                                           
                              15/40                                       
                                   100/100                                
13      0/0   0/35                                                        
                  0/0   100/90                                            
                              95/40                                       
                                   100/78                                 
14      0/0  0/0  15/0   0/35 0/20 100/0                                  
15      0/25  0/60                                                        
                   0/25 95/95 70/65                                       
                                   100/100                                
__________________________________________________________________________
 O = Wild Oats (Avenua fatua)                                             
 M = Mustard (Brassica arvensis)                                          
 W = Watergrass (Echinochloa crusgalli)                                   
 P = Pigweed (Amaranthus retroflexus)                                     
 C = Crabgrass (Digitaria sanguinalis)                                    
 L = Lambsquarter (Chenopodium album)

Claims (3)

What is claimed is:
1. A compound of the formula ##SPC4##
wherein X is hydrogen; R1 is alkyl of 3 to 6 carbon atoms; R2 is hydrogen; and R3 is alkyl of 1 to 6 carbon atoms.
2. N-(3-cyano-4-isopropylthien-2-yl)-N'-methyl urea, according to claim 1.
3. N-(3-cyano-4-sec-butylthien-2-yl)-N'-methyl urea, according to claim 1.
US05/453,231 1974-03-21 1974-03-21 Herbicidal N-(3-cyano-4-alkylthien-2-yl) ureas Expired - Lifetime US3956315A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US05/453,231 US3956315A (en) 1974-03-21 1974-03-21 Herbicidal N-(3-cyano-4-alkylthien-2-yl) ureas
CA220,886A CA1040208A (en) 1974-03-21 1975-02-27 Herbicidal n-(3-cyano-4-alkylthien-2-yl) ureas
DE19752510936 DE2510936A1 (en) 1974-03-21 1975-03-13 THIENYL URNANE
FR7507935A FR2264814B1 (en) 1974-03-21 1975-03-13
JP50055557A JPS50154427A (en) 1974-03-21 1975-03-20
GB1203775A GB1462570A (en) 1974-03-21 1975-03-21 Cyanothienyl ureas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/453,231 US3956315A (en) 1974-03-21 1974-03-21 Herbicidal N-(3-cyano-4-alkylthien-2-yl) ureas

Publications (1)

Publication Number Publication Date
US3956315A true US3956315A (en) 1976-05-11

Family

ID=23799705

Family Applications (1)

Application Number Title Priority Date Filing Date
US05/453,231 Expired - Lifetime US3956315A (en) 1974-03-21 1974-03-21 Herbicidal N-(3-cyano-4-alkylthien-2-yl) ureas

Country Status (6)

Country Link
US (1) US3956315A (en)
JP (1) JPS50154427A (en)
CA (1) CA1040208A (en)
DE (1) DE2510936A1 (en)
FR (1) FR2264814B1 (en)
GB (1) GB1462570A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130414A (en) * 1976-05-03 1978-12-19 Schering Ag 1,2,3-Thiadiazole-5-yl-urea derivatives, process for making the same and plant retardation and defoliation composition containing same
US4240820A (en) * 1978-04-21 1980-12-23 Bayer Aktiengesellschaft Method of regulating the growth of plants
US5422335A (en) * 1990-12-13 1995-06-06 Basf Aktiengesellschaft Herbicides containing substituted 2-aminothiophenes
US20020165398A1 (en) * 1998-03-12 2002-11-07 Lone Jeppesen Modulators of protein tyrosine phosphatases (PTPases)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3529247A1 (en) * 1985-05-17 1986-11-20 Bayer Ag, 5090 Leverkusen USE OF THIENYL UREAS AND ISOHARNS AS AN PERFORMANCE DRIVER IN ANIMALS, NEW THIENYL URINS AND ISOHARNS AND THEIR PRODUCTION
DE3541628A1 (en) * 1985-11-26 1987-05-27 Bayer Ag THIENYL URINE DERIVATIVES
EP0273602A1 (en) * 1986-12-05 1988-07-06 Eli Lilly And Company 3-Cyano-4-arylthiophenes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
DE2040579A1 (en) * 1969-08-14 1971-02-25 May & Baker Ltd New thiophene derivatives
FR2084629A5 (en) * 1970-03-16 1971-12-17 Shell Int Research Herbicidal thiophenes - eg amide, urea and carbamate derivs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
DE2040579A1 (en) * 1969-08-14 1971-02-25 May & Baker Ltd New thiophene derivatives
FR2084629A5 (en) * 1970-03-16 1971-12-17 Shell Int Research Herbicidal thiophenes - eg amide, urea and carbamate derivs

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130414A (en) * 1976-05-03 1978-12-19 Schering Ag 1,2,3-Thiadiazole-5-yl-urea derivatives, process for making the same and plant retardation and defoliation composition containing same
US4240820A (en) * 1978-04-21 1980-12-23 Bayer Aktiengesellschaft Method of regulating the growth of plants
US5422335A (en) * 1990-12-13 1995-06-06 Basf Aktiengesellschaft Herbicides containing substituted 2-aminothiophenes
US20020165398A1 (en) * 1998-03-12 2002-11-07 Lone Jeppesen Modulators of protein tyrosine phosphatases (PTPases)

Also Published As

Publication number Publication date
FR2264814B1 (en) 1979-06-08
GB1462570A (en) 1977-01-26
CA1040208A (en) 1978-10-10
FR2264814A1 (en) 1975-10-17
DE2510936A1 (en) 1975-10-09
JPS50154427A (en) 1975-12-12

Similar Documents

Publication Publication Date Title
US3637847A (en) N-haloalkyl-anilides
US3536721A (en) Substituted-sulfonyl glycolamide compositions
US3865863A (en) 2-(Benzoyl)-3-dimethylaminoacrylonitriles
US3956315A (en) Herbicidal N-(3-cyano-4-alkylthien-2-yl) ureas
US3944607A (en) Herbicidal N-(N'-alkynylcarbamylmethyl)-2,6-dialkyl-α-haloacetanilides
US3301885A (en) Phenyl nu-hydrocarboxy nu-hydrocarbyl thiocarbamates
US3279907A (en) Herbicidal method utilizing aromatic nitrogen-containing herbicides
US3238222A (en) (n-3, 4-disubstituted phenyl-3 and/or omega methyl-2-pyrrolidinones and piperidones)
US3812209A (en) 1-hydrocarbyldithio-3-aryl ureas
US4205168A (en) N-Carbamylalkyl-2,6-dialkyl-α-haloacetanilides
US3158624A (en) Preparation of trichlorofuroylchloride
US3872157A (en) Substituted anilide carbamates
US3819626A (en) Substituted triazines
EP0196570B1 (en) Benzoaxazine derivatives and herbicidal composition
US3892775A (en) 3,5-Dimethyl-2-thienyl-(n-haloalkylthiocarboxanilide) herbicides
US4097265A (en) 3,5-Dimethyl-2-thienylcarboxanilide and 3,5-dimethyl-2-thienyl-(N-haloalkylthiocarboxanilide) herbicides
US4012436A (en) Carbamoyl chlorides
US4326876A (en) 2-Aminosubstituted-5-methylene-thiazole and 3-aminosubstituted-1 methylene-2,4-thiazaspiro[5.4]decane herbicides
CA1116604A (en) FUNGICIDAL AND HERBICIDAL 2-SUBSTITUTED-3-OXA- 3A.lambda..SUB.4,4-DITHIA-6-HALO-1,5-DIAZAPENTALENE
US3266883A (en) Herbicidal method
US3997324A (en) Herbicidal N- oxythio-substituted ureas
US3948633A (en) 3,5-Dimethyl-2-thienylcarboxanilide and 3,5-dimethyl-2-thienyl-(N-haloalkylthiocarboxanilide) herbicides
US3997326A (en) Herbicidal N-(N'-alkynylcarbamylmethyl) 2,6-dialkyl-alpha-haloacetanilides
US3544305A (en) Herbicidal n-formyl alpha-haloacetanilides
US3824281A (en) 1-carboxamidothio-3-aryl ureas