US3342183A - Absorbent adhesive patch impregnated with a vasoconstrictor - Google Patents

Absorbent adhesive patch impregnated with a vasoconstrictor Download PDF

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US3342183A
US3342183A US389275A US38927564A US3342183A US 3342183 A US3342183 A US 3342183A US 389275 A US389275 A US 389275A US 38927564 A US38927564 A US 38927564A US 3342183 A US3342183 A US 3342183A
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adhesive
patch
vasoconstrictor
cut
bleeding
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US389275A
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Edenbaum Martin
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Johnson and Johnson
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Johnson and Johnson
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/025—Adhesive bandages or dressings characterised by the skin-adhering layer having a special distribution arrangement of the adhesive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A61F13/0253—Adhesive bandages or dressings characterised by the skin-adhering layer characterized by the adhesive material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00463—Plasters use haemostatic
    • A61F2013/00472—Plasters use haemostatic with chemical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Definitions

  • the present invention relates to an applicator for vasoconstrictive substances. More particularly, it relates to absorbent patches impregnated with a vasoconstrictor.
  • vasoconstrictors to retard or stop the bleeding of surface cuts is well known and widely applied in cases where rapid termination of bleeding is imperative for medical reasons or is otherwise desirable.
  • vasoconstrictors While it has been possible to obtain vasoconstrictors in liquid form for application to these cuts, such liquids have not eliminated these problems.
  • substantial bleeding occurs, and after vasoconstrictor application, the same unsightly splotches of hardened blood are formed on the skin surrounding the cut. If the skin is washed, bleeding is likely to resume- In addition, liquid applications are extremely messy because of the tendency of the solution to run.
  • Vasoconstrictor have sometimes been applied to the surface of the skin by impregnating a cotton wadding with the substance and then pressing the cotton against the cut. This type of application was time consuming since the cotton had to be held in place while waiting for the bleeding to stop, thus preventing the user from proceeding with his normal course of activity. In shaving, where numerous cuts are likely to occur, this lost time could be substantial.
  • an applicator in the form of a small patch of absorbent sheet material containing a vasoconstrictor on at least one surface thereof, and an adhesive printed thereon in an open pattern so as to leave numerous areas free from adhesive.
  • the adhesive acts to hold the patch in intimate contact with the wound.
  • This adhesive is printed onto the surface of the patch in an open pattern so that substantial areas of absorbent sheet material remain free of adhesive. Thus the blood from the cut will be quickly absorbed by the absorent sheet through these open areas.
  • vasoconstrictor and adhesive may be printed together on the pad in the open pattern.
  • the blood will simultaneously soften and activate the adhesive and effect release of vasoconstrictor from the printed areas.
  • Means can be provided for easy removal of the patch by shaping the patch so as to present a small tab of sheet material free from adhesive. The patch is then removed by grasping the tab and peeling. The same effect may be obtained by printing the adhesive so that a small margin of the sheet material at the periphery remains adhesive free.
  • FIGURES 1 through 5 are views in perspective of the various applicators of this invention.
  • FIGURE 1 illustrates a patch 10 of the present invention.
  • An absorbent sheet 11 has been impregnated with a vasoconstrictor, and an adhesive has been applied to the impregnated sheet material in an open substantially rectangular pattern of small discrete dots 13.
  • a tab like appendage 12 of the patch is left free of adhesive so as to provide a tab for the user to grasp while peeling the bandage from the skin after use.
  • FIGURE 2 illustrates another patch 10a of this invention.
  • An open pattern of discrete spots 13aof ahesive has been deposited on impregnated absorbent sheet 11a in a diamond formation.
  • a tab like appendage 12a of the patch remains free of adhesive.
  • the patch 1% illustrated in FIGURE 3 contains an adhesive in an open grid-like pattern 13b on the impregnated absorbent sheet 111).
  • a small tab like appendage 12b again remains free of adhesive.
  • the patch in FIGURE 4 is another patch of the invention, having a different shape from those hereinbefore described, wherein the adhesive is applied to the impregnated absorbent sheet in an open pattern of small discrete dots 13c in diamond formation. Tab like appendage remains free of adhesive.
  • the rectangular patch 10d illustrated in FIGURE 5 contains an adhesive in an open pattern of discrete dots 13d, on impregnated absorbent material 11d.
  • a margin 14 around the periphery of the patch is left free of adhesive so that the user may easily grab hold of the edge of the patch and facilitate its removal.
  • vasoconstrictor components gives the patch its a bleeding retarding characteristics. While many vasoconstrictors may be used in the system, methylaminoacetocatechol -HC1 (sold by Winthrop Laboratories as Stryphnon-HCI), has been found to possess particularly high vasoconstrictive activity when subjected to the conditions under which the patch is used.
  • the vasoconstrictor may be present on the sheet in any amount greater than about one percent (1%) by weight of the dry weight of the absorbent sheet material, and preferably in amounts from about three percent (3%) to about five percent (5%) of the weight of the absorbent sheet material.
  • the vasoconstrictor should be present in an amount greater than about one (1) milligram per square inch of surface area and preferably in amounts of from about three (3) to about five (5) miligrams per square inch of surface area.
  • the concentration of the vasoconstrictor in the printing solution therefore, must be adjusted relative to the amount of printing solution to be applied to the pad. While greater concentrations of vasconstrictor may be used, they do not substantially increase the speed of bleeding retardation.
  • the adhesive used is preferably a remoistenable adhesive. This classification includes any water soluble adhesive; however, polyvinyl alcohol, polyvinyl acetate, and methyl cellulose are preferred since they are approached by the Food and Drug Administration for cosmetic use.
  • the adhesive component usually is present on the patch in amounts of from about one (1) milligram to about five (5) milligrams per square inch of surface area. If too much adhesive is applied, the adhesive areas may be raised with respect to the adhesive free areas to the point that the adhesive free areas will not be in intimate contact with the skin. This is generally to be avoided as it interferes with the absorption of blood from the cut.
  • a normally tacky and pressure sensitive adhesive may be substituted for the remoistenable adhesive.
  • the absorbent backing may consist of any absorbent material that is substantially nap free.
  • Standard filter paper such as Whatman #3, has been found to be particularly useful because it is clean, cheap, and possesses considerable stiffness.
  • any conventional antiseptic may be added to the solution printed onto the pad in any amount consistent with the printability requirements mentioned earlier. Normal vegetable colorings may be similarly added.
  • the applicator of this invention may be produced by impregnating the sheet material with the vasoconstrictor and then over-printing with the adhesive in the desired open pattern.
  • a moisture activatable adhesive is used, a solution containing both the adhesive and the vasoconstrictor can be printed on the absorbent sheet material in the desired pattern. This latter procedure is preferred Where possible, since impregnation of the entire pad with vasconstrictor impedes its absorbency.
  • the concentration of the various printing solutions must be adjusted in the light of the amount of each material desired on the patch and the amount of solution to be applied to the patch.
  • the pattern of adhesive printed on the patch may be any pattern consistent with the concentration of adhesive desired on the pad, proper pressure sensitive adhesive properties, and retention of a requisite amount of absorbency. Anywhere up to ninety percent (90%) of the surface area of the applicator may be so printed while still retaining sufficient absorbency; but about thirty percent (30%) is preferred. If the preferred pattern of small discrete spots is used, the patch preferably contains from about seventy-five (75) to about one hundred twenty-five (125) spots of about one-sixteenth A inch diameter per square inch of surface area.
  • EXAMPLE I A solution containing ten (10) parts of StryphnonHCl and ten (10) parts of a cold-water soluble polymer of vinyl alcohol, is formulated in sixty (60) parts cold water. The solution is silk-screened on a six (6) inch Whatman #3 filter paper at an eight-tenth (0.8) gram wet pick-up. The dry filter paper weighs three and twotenths 3.2) grams. The silk screen contains one hundred (100) holes per square inch, each hole being about onesixteenth A inch in diameter.
  • the printed pad is dried for fifteen minutes at 250 Fahrenheit, and is then sterilized under steam for twenty minutes at 250 Fahrenheit.
  • the pad contains five and sixty-six hundredths (5.66) milligrams Stryphnon-Hcl per square inch of surface area.
  • the pad is then cut into one (1) inch by one-quarter A) inch strips.
  • the strips are tested for hemostatic activity on a dog by applying them to a small bleeding cut.
  • the strips on being moistened by the blood, adhere to the skin on contact.
  • the patches are removed after one (1) minute, bledeing has ceased and the area surrounding the wound is clean of blood, the same having been absorbed by the patch.
  • EXAMPLE II A solution containing ten (10) parts of Stryphnon-Hcl and ten (10) parts of a cold-water soluble polymer of vinyl alcohol, is formulated in two hundred eighty (280) parts cold water. The solution is silk-screened on a six (6) inch Whatman #3 filter paper at an eight-tenths (0.8) gram wet pick-up. The dry filter paper weighs three and two-tenths (3.2) grams. The silk screen contains one hundred holes per square inch, each hole being onesixteenth inch in diameter.
  • the printed pad is dried for fifteen (15 minutes at 250 Fahrenheit, and is then sterilized under steam for twenty (20) minutes at 250 Fahrenheit.
  • the pad contains one and forty-four hundredths (1.44) milligrams Stryphnon-HCI per square inch of surface area.
  • the pad is then cut into one (1) inch by one-quarter A) inch strips.
  • the strips are tested for hemostatic activity on a dog by applying them to a small cut.
  • the strips on being moistened by the blood, adhere to the skin on contact. When the patches are removed after one (1) minute, bleeding has ceased and the wound is clean of blood, the same having been absorbed by the patch.
  • EXAMPLE III A solution is formulated containing ten (10) parts of Stryphnon-HCl and seven hundred (700) parts cold water. A six (6) inch circle of Whatman #3 filter paper is placed in a beaker of the solution and is impregnated to one hundred percent (100%) wet pick-up. Two (2) grams of solution are absorbed by the filter paper. The filter paper is dried for fifteen (15) minutes at 250 Fahrenheit.
  • a solution is formulated containing ten (10) parts of a cold-water soluble polymer of vinyl alcohol in two hundred (200) parts water. This solution is silk-screened on the impregnated filter paper at an eight-tenths (0.8) gram wet pick-up.
  • the silk screen contains one hundred (100) holes per square inch, each hole being one-sixteenth inch diameter.
  • the impregnated, imprinted pad is dried for fifteen (15 minutes at 250 Fahrenheit and is then sterilized under steam for twenty (20) minutes at 250 Fahrenheit.
  • the filter paper is then cut into one (1) inch by one-quarter A1) inch strips, each strip containing one and one-half percent (1.5%) Stryphnon'HCl by weight of the weight of the absorbent backmg.
  • the strips are tested for hemostatic activity on a dog by applying them to a small cut.
  • the strips on being moistened by the blood, adhere to the skin on contact.
  • the patches are removed after one (1) minute, bleeding has ceased and the wound site is clean of blood, the same having been absorbed by the patch.
  • a patch for application to small cuts to prevent bleeding comprising a dry absorbent sheet impregnated with a vasoconstrictor and containing on at least one surface an adhesive, said adhesive being present in an open pattern extending across at least a large portion of said sheet inward of its periphery leaving numerous adhesive free areas distributed over the surface of said patch whereby, when said patch is adhesively applied to a bleeding cut, blood from the cut is absorbed by the adhesive free areas of said sheet and effects the release of said vasoconstrictor from said sheet into said cut to thus retard further bleeding.
  • vasoconstrictor is present on the patch in an amount greater than 1 milligram per square inch of the surface area of the absorbent sheet material.
  • the patch of claim 4 in which the moisture activatable adhesive is chosen from the group consisting of polyvinyl alcohol, polyvinyl acetate, and methyl cellulose.
  • vasoconstrictor is methylaminoacetocatechal.
  • a patch for application to small cuts to prevent bleeding comprising an absorbent sheet containing on one surface thereof a mixture of a vasoconstrictor and a dry moisture activatable adhesive, said mixture of vasoconstrictor and adhesive being present in an open pattern extending across at least a large portion of said sheet inward of its periphery leaving numerous adhesive free areas distributed over the surface of said patch whereby,
  • the blood from the cut activates said remoistenable adhesive and effects release of said vasoconstrictor into said cut to thus retard further bleeding while blood from the cut is absorbed by the adhesive free areas of said sheet.
  • vasoconstrictor is present on the patch in an amount greater than 1 milligram per square inch of the surface area of the absorbent sheet.
  • said moisture activatable adhesive is chosen from the group consisting of polyvinyl alcohol, polyvinyl acetate, and methyl cellulose.
  • vasoconstrictor is methylaminoacetocatechal.

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  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
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Description

Sept. 19, 1967 M. EDENBAUM 3, ABSORBENT ADHESIVE PATCH IMPREGNATED WITH A VASOCONSTRICTOR Filed Aug. l5, 1964 INVENTOR. 4%,??? 5091/54 (/M VMXM ATTORNEY 3,342,183 ABSORBENT ADHESIVE PATCH IMPREGNATED WITH A VASOCONSTRICTOR Martin Edenbaurn, New Brunswick, NJ., assignor to Johnson & Johnson, a corporation of New Jersey Filed Aug. 13, 1964, Ser. No. 389,275 14 Claims. (Cl. 128-268) The present invention relates to an applicator for vasoconstrictive substances. More particularly, it relates to absorbent patches impregnated with a vasoconstrictor.
The use of vasoconstrictors to retard or stop the bleeding of surface cuts is well known and widely applied in cases where rapid termination of bleeding is imperative for medical reasons or is otherwise desirable.
Many small cuts occur during daily activity which clot quickly leaving only a small scab. Since, with these cuts, the rapid stoppage of bleeding is not imperative for medical reasons, vasoconstrictors are not usually applied. However, when these small cuts occur in the area of the face or legs during such activities as shaving, the rapid stoppage of blood, minimization of scab size, and elimination of blood from the surrounding areas of the skin become important for cosmetic reasons.
If these cuts are allowed to clot by the natural processes, not only do substantial scabs form, but the area surrounding the wound site becomes covered by hardened blood. When the surface is washed with water to remove the blood from areas surrounding the cut, invariably the scab will also be removed and bleeding will resume.
While it has been possible to obtain vasoconstrictors in liquid form for application to these cuts, such liquids have not eliminated these problems. During the time required for liquid application, substantial bleeding occurs, and after vasoconstrictor application, the same unsightly splotches of hardened blood are formed on the skin surrounding the cut. If the skin is washed, bleeding is likely to resume- In addition, liquid applications are extremely messy because of the tendency of the solution to run.
Vasoconstrictor have sometimes been applied to the surface of the skin by impregnating a cotton wadding with the substance and then pressing the cotton against the cut. This type of application was time consuming since the cotton had to be held in place while waiting for the bleeding to stop, thus preventing the user from proceeding with his normal course of activity. In shaving, where numerous cuts are likely to occur, this lost time could be substantial.
It is therefore an object of this invention to provide an applicator which will allow quick and easy application of vasoconstrictive material to these small cuts and will at the same time remove blood from the surface of the skin, thus eliminating any evidence of the cut, Without hindering the action of the vasoconstrictor.
It has been discovered that this object can be obtained by an applicator in the form of a small patch of absorbent sheet material containing a vasoconstrictor on at least one surface thereof, and an adhesive printed thereon in an open pattern so as to leave numerous areas free from adhesive.
When the patch is applied to a bleeding cut, the adhesive acts to hold the patch in intimate contact with the wound. This adhesive is printed onto the surface of the patch in an open pattern so that substantial areas of absorbent sheet material remain free of adhesive. Thus the blood from the cut will be quickly absorbed by the absorent sheet through these open areas.
This absorption of blood in turn effects a rapid and positive release of vasoconstrictor onto the wound site. When the pad is removed, the site is clean due to the United States Patent absorption of the blood into the pad, and the cut will not bleed again due to the action of the vasoconstrictor.
When a moisture activata'ble adhesive is used, the vasoconstrictor and adhesive may be printed together on the pad in the open pattern. When such a pad is applied to a bleeding cut, the blood will simultaneously soften and activate the adhesive and effect release of vasoconstrictor from the printed areas.
Means can be provided for easy removal of the patch by shaping the patch so as to present a small tab of sheet material free from adhesive. The patch is then removed by grasping the tab and peeling. The same effect may be obtained by printing the adhesive so that a small margin of the sheet material at the periphery remains adhesive free.
The invention may be more easily understood by reference to the drawings wherein FIGURES 1 through 5 are views in perspective of the various applicators of this invention.
Referring now to the drawings, FIGURE 1 illustrates a patch 10 of the present invention. An absorbent sheet 11 has been impregnated with a vasoconstrictor, and an adhesive has been applied to the impregnated sheet material in an open substantially rectangular pattern of small discrete dots 13. A tab like appendage 12 of the patch is left free of adhesive so as to provide a tab for the user to grasp while peeling the bandage from the skin after use.
FIGURE 2 illustrates another patch 10a of this invention. An open pattern of discrete spots 13aof ahesive has been deposited on impregnated absorbent sheet 11a in a diamond formation. A tab like appendage 12a of the patch remains free of adhesive.
The patch 1% illustrated in FIGURE 3 contains an adhesive in an open grid-like pattern 13b on the impregnated absorbent sheet 111). A small tab like appendage 12b again remains free of adhesive.
The patch in FIGURE 4 is another patch of the invention, having a different shape from those hereinbefore described, wherein the adhesive is applied to the impregnated absorbent sheet in an open pattern of small discrete dots 13c in diamond formation. Tab like appendage remains free of adhesive.
The rectangular patch 10d illustrated in FIGURE 5 contains an adhesive in an open pattern of discrete dots 13d, on impregnated absorbent material 11d. A margin 14 around the periphery of the patch is left free of adhesive so that the user may easily grab hold of the edge of the patch and facilitate its removal.
The vasoconstrictor components gives the patch its a bleeding retarding characteristics. While many vasoconstrictors may be used in the system, methylaminoacetocatechol -HC1 (sold by Winthrop Laboratories as Stryphnon-HCI), has been found to possess particularly high vasoconstrictive activity when subjected to the conditions under which the patch is used.
For the rapid clotting desired, the vasoconstrictor may be present on the sheet in any amount greater than about one percent (1%) by weight of the dry weight of the absorbent sheet material, and preferably in amounts from about three percent (3%) to about five percent (5%) of the weight of the absorbent sheet material. When a remoistenable adhesive is used and the vasoconstrictor and adhesive are both printed on the pad, the vasoconstrictor should be present in an amount greater than about one (1) milligram per square inch of surface area and preferably in amounts of from about three (3) to about five (5) miligrams per square inch of surface area. The concentration of the vasoconstrictor in the printing solution, therefore, must be adjusted relative to the amount of printing solution to be applied to the pad. While greater concentrations of vasconstrictor may be used, they do not substantially increase the speed of bleeding retardation.
The adhesive used is preferably a remoistenable adhesive. This classification includes any water soluble adhesive; however, polyvinyl alcohol, polyvinyl acetate, and methyl cellulose are preferred since they are approached by the Food and Drug Administration for cosmetic use. The adhesive component usually is present on the patch in amounts of from about one (1) milligram to about five (5) milligrams per square inch of surface area. If too much adhesive is applied, the adhesive areas may be raised with respect to the adhesive free areas to the point that the adhesive free areas will not be in intimate contact with the skin. This is generally to be avoided as it interferes with the absorption of blood from the cut.
In an alternate embodiment of the invention, a normally tacky and pressure sensitive adhesive may be substituted for the remoistenable adhesive.
The absorbent backing may consist of any absorbent material that is substantially nap free. Standard filter paper, such as Whatman #3, has been found to be particularly useful because it is clean, cheap, and possesses considerable stiffness.
If desired, any conventional antiseptic may be added to the solution printed onto the pad in any amount consistent with the printability requirements mentioned earlier. Normal vegetable colorings may be similarly added.
The applicator of this invention may be produced by impregnating the sheet material with the vasoconstrictor and then over-printing with the adhesive in the desired open pattern. When a moisture activatable adhesive is used, a solution containing both the adhesive and the vasoconstrictor can be printed on the absorbent sheet material in the desired pattern. This latter procedure is preferred Where possible, since impregnation of the entire pad with vasconstrictor impedes its absorbency.
As previously mentioned, the concentration of the various printing solutions must be adjusted in the light of the amount of each material desired on the patch and the amount of solution to be applied to the patch. The pattern of adhesive printed on the patch may be any pattern consistent with the concentration of adhesive desired on the pad, proper pressure sensitive adhesive properties, and retention of a requisite amount of absorbency. Anywhere up to ninety percent (90%) of the surface area of the applicator may be so printed while still retaining sufficient absorbency; but about thirty percent (30%) is preferred. If the preferred pattern of small discrete spots is used, the patch preferably contains from about seventy-five (75) to about one hundred twenty-five (125) spots of about one-sixteenth A inch diameter per square inch of surface area.
The invention will be further illustrated in greater detail by the following examples. It should be understood that although these examples may describe some of the more specific features of the invention, they are given only for the purpose of illustration and the invention should not be construed as limited thereto.
EXAMPLE I A solution containing ten (10) parts of StryphnonHCl and ten (10) parts of a cold-water soluble polymer of vinyl alcohol, is formulated in sixty (60) parts cold water. The solution is silk-screened on a six (6) inch Whatman #3 filter paper at an eight-tenth (0.8) gram wet pick-up. The dry filter paper weighs three and twotenths 3.2) grams. The silk screen contains one hundred (100) holes per square inch, each hole being about onesixteenth A inch in diameter.
The printed pad is dried for fifteen minutes at 250 Fahrenheit, and is then sterilized under steam for twenty minutes at 250 Fahrenheit. The pad contains five and sixty-six hundredths (5.66) milligrams Stryphnon-Hcl per square inch of surface area.
The pad is then cut into one (1) inch by one-quarter A) inch strips. The strips are tested for hemostatic activity on a dog by applying them to a small bleeding cut. The strips, on being moistened by the blood, adhere to the skin on contact. When the patches are removed after one (1) minute, bledeing has ceased and the area surrounding the wound is clean of blood, the same having been absorbed by the patch.
EXAMPLE II A solution containing ten (10) parts of Stryphnon-Hcl and ten (10) parts of a cold-water soluble polymer of vinyl alcohol, is formulated in two hundred eighty (280) parts cold water. The solution is silk-screened on a six (6) inch Whatman #3 filter paper at an eight-tenths (0.8) gram wet pick-up. The dry filter paper weighs three and two-tenths (3.2) grams. The silk screen contains one hundred holes per square inch, each hole being onesixteenth inch in diameter.
The printed pad is dried for fifteen (15 minutes at 250 Fahrenheit, and is then sterilized under steam for twenty (20) minutes at 250 Fahrenheit. The pad contains one and forty-four hundredths (1.44) milligrams Stryphnon-HCI per square inch of surface area. The pad is then cut into one (1) inch by one-quarter A) inch strips. The strips are tested for hemostatic activity on a dog by applying them to a small cut. The strips, on being moistened by the blood, adhere to the skin on contact. When the patches are removed after one (1) minute, bleeding has ceased and the wound is clean of blood, the same having been absorbed by the patch.
EXAMPLE III A solution is formulated containing ten (10) parts of Stryphnon-HCl and seven hundred (700) parts cold water. A six (6) inch circle of Whatman #3 filter paper is placed in a beaker of the solution and is impregnated to one hundred percent (100%) wet pick-up. Two (2) grams of solution are absorbed by the filter paper. The filter paper is dried for fifteen (15) minutes at 250 Fahrenheit.
A solution is formulated containing ten (10) parts of a cold-water soluble polymer of vinyl alcohol in two hundred (200) parts water. This solution is silk-screened on the impregnated filter paper at an eight-tenths (0.8) gram wet pick-up. The silk screen contains one hundred (100) holes per square inch, each hole being one-sixteenth inch diameter. The impregnated, imprinted pad is dried for fifteen (15 minutes at 250 Fahrenheit and is then sterilized under steam for twenty (20) minutes at 250 Fahrenheit. The filter paper is then cut into one (1) inch by one-quarter A1) inch strips, each strip containing one and one-half percent (1.5%) Stryphnon'HCl by weight of the weight of the absorbent backmg.
The strips are tested for hemostatic activity on a dog by applying them to a small cut. The strips, on being moistened by the blood, adhere to the skin on contact. When the patches are removed after one (1) minute, bleeding has ceased and the wound site is clean of blood, the same having been absorbed by the patch.
Although several specific examples of the inventive concept have been described, the same should not be construed as limited thereby to the specific features mentioned therein, but to include various other equivalent features and should be limited only in accordance with the claims appended hereto. It is understood that any suitable changes may be made without departing from the spirit and scope of the invention.
What is claimed is:
1. A patch for application to small cuts to prevent bleeding comprising a dry absorbent sheet impregnated with a vasoconstrictor and containing on at least one surface an adhesive, said adhesive being present in an open pattern extending across at least a large portion of said sheet inward of its periphery leaving numerous adhesive free areas distributed over the surface of said patch whereby, when said patch is adhesively applied to a bleeding cut, blood from the cut is absorbed by the adhesive free areas of said sheet and effects the release of said vasoconstrictor from said sheet into said cut to thus retard further bleeding.
2. The patch of claim 1 wherein said open pattern of adhesive covers les than 90% of the surface area of the patch.
3. The patch of claim 2 wherein said vasoconstrictor is present on the patch in an amount greater than 1 milligram per square inch of the surface area of the absorbent sheet material.
4. The patch of claim 3 in which the adhesive is a moisture activatable adhesive.
5. The patch of claim 4 in which the moisture activatable adhesive is chosen from the group consisting of polyvinyl alcohol, polyvinyl acetate, and methyl cellulose.
6. The patch of claim 5 wherein said vasoconstrictor is methylaminoacetocatechal.
7. The patch of claim 3 in which said adhesive is a pressure sensitive adhesive.
8. A patch for application to small cuts to prevent bleeding comprising an absorbent sheet containing on one surface thereof a mixture of a vasoconstrictor and a dry moisture activatable adhesive, said mixture of vasoconstrictor and adhesive being present in an open pattern extending across at least a large portion of said sheet inward of its periphery leaving numerous adhesive free areas distributed over the surface of said patch whereby,
when said patch is applied to a bleeding cut, the blood from the cut activates said remoistenable adhesive and effects release of said vasoconstrictor into said cut to thus retard further bleeding while blood from the cut is absorbed by the adhesive free areas of said sheet.
9. The patch of claim 8 wherein said open pattern of adhesive covers less than of the surface area of the patch.
10. The patch of claim 9 wherein said vasoconstrictor is present on the patch in an amount greater than 1 milligram per square inch of the surface area of the absorbent sheet.
11. The patch of claim It) in which said moisture activatable adhesive is chosen from the group consisting of polyvinyl alcohol, polyvinyl acetate, and methyl cellulose.
12. The patch of claim 11 in which said vasoconstrictor is methylaminoacetocatechal.
13. A patch for application to small cuts to prevent bleeding of claim 1 in which said patch contains. an area at the periphery free of adhesive whereby the removal of the patch from the surface of the wound is facilitated.
14. The patch of claim 13 where said adhesive free area at the periphery is a tab like appendage.
References Cited UNITED STATES PATENTS 2,160,503 5/1939 Herrmann l67-58 2,669,720 2/1954 Vandekerck 128-132 ADELE M. EAGER, Primary Examiner.
UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 3,342,183 September 19, 1967 Martin Edenbaum It is hereby certified that error appears in the above numbered patent requiring correction and that the said Letters Patent should read as corrected below.
Column 3, line 75, for "Hcl" read HCl column 4, line 6, for "bleding" read bleeding line 10, for "Hcl" read HCl column 5, line 9, for "les" read less column 5, line 28, strike out "dry" and insert the same after "a", first occurrence, in line 27, same column 5.
Signed and sealed this 29th day of October 1968.
(SEAL) Attest:
Edward M. Fletcher, Jr. EDWARD J. BRENNER Attesting Officer Commissioner of Patents

Claims (1)

1. A PATCH FOR APPLICATION TO SMALL CUTS TO PREVENT BLEEDING COMPRISING A DRY ABSORBENT SHEET IMPREGNATED WITH A VASOCONSTRICTOR AND CONTAINING ON AT LEAST ON SURFACE AN ADHESIVE, SAID ADHESIVE BEING PRESENT IN AN OPEN PATTERN EXTENDING ACROSS AT LEAST A LARGE PORTION OF SAID SHEET INWARD OF ITS PERIPHERY LEAVING NUMEROUS ADHESIVE FREE AREAS DISTRIBUTED OVER THE SURFACE OF SAID PATCH WHEREBY, WHEN SAID PATCH IS ADHESIVELY APPLIED TO A BLEEDING CUT, BLOOD FROM THE CUT IS ABSORBED BY THE ADHESIVE FREE AREAS OF SAID SHEET AND EFFECTS THE RELEASE OF SAID VASOCONSTRICTOR FROM SAID SHEET INTO SAID CUT TO THUS RETARD FURTHER BLEEDING.
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Cited By (45)

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US3439676A (en) * 1966-12-01 1969-04-22 Dow Corning Wound dressing
US4233976A (en) * 1978-07-06 1980-11-18 Minnesota Mining And Manufacturing Company Styptic device
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
US4457756A (en) * 1982-04-14 1984-07-03 Kern Eugene B Nose bleed clip
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
US4614787A (en) * 1984-11-13 1986-09-30 Thermedics, Inc. Drug dispensing wound dressing
US4638043A (en) * 1984-11-13 1987-01-20 Thermedics, Inc. Drug release system
US4727868A (en) * 1984-11-13 1988-03-01 Thermedics, Inc. Anisotropic wound dressing
US4751133A (en) * 1984-11-13 1988-06-14 Thermedics, Inc. Medical patches and processes for producing same
US4773408A (en) * 1985-01-04 1988-09-27 E. R. Squibb & Sons, Inc. Wound dressing
EP0288749A2 (en) * 1987-04-30 1988-11-02 Lohmann GmbH & Co. KG Adhesive bandages
US4820266A (en) * 1986-01-27 1989-04-11 Berry Yale J Method of stopping nose bleeds
USRE32991E (en) * 1984-11-13 1989-07-18 Thermedics, Inc. Drug dispensing wound dressing
US4880690A (en) * 1984-11-13 1989-11-14 Thermedics, Inc. Perfume patch
US4883668A (en) * 1986-04-24 1989-11-28 Kabushiki Kaisya Advance Material for endermic administration pre-treatment
US5051259A (en) * 1987-12-15 1991-09-24 Coloplast A/S Skin barrier product with discontinuous adhesive layer
US5064422A (en) * 1990-10-18 1991-11-12 Bertek, Inc. Twin patch applicator
US6191338B1 (en) * 1998-11-19 2001-02-20 Kurt Haller Adhesive bandage, matrix, and methods of removal
US6213993B1 (en) 1994-10-28 2001-04-10 Kimberly-Clark Worldwide, Inc. Self-adhering absorbent article
US20030149387A1 (en) * 2000-08-09 2003-08-07 The Procter & Gamble Company Anti-snoring device comprising a skin compatible adhesive
US6736141B2 (en) * 2000-12-15 2004-05-18 David L. Freedman Surgical aid
EP1293185A3 (en) * 2001-09-18 2005-01-26 Johnson & Johnson Consumer Companies, Inc. Adhesive bandage
US20070026028A1 (en) * 2005-07-26 2007-02-01 Close Kenneth B Appliance for delivering a composition
US20080102093A1 (en) * 2006-10-31 2008-05-01 Close Kenneth B Appliance for delivering a composition, the appliance having an elastic layer and a shielding layer
US20080103461A1 (en) * 2006-10-31 2008-05-01 Johnson Kroy D Appliance for delivering a composition, the appliance having an outer fibrous layer and inner liquid-impermeable layer
US20080103460A1 (en) * 2006-10-31 2008-05-01 Close Kenneth B Method for making an appliance for delivering a composition, the appliance having an elastic layer and a shielding layer
US20080116096A1 (en) * 2006-11-17 2008-05-22 Johnson Kroy D Liquid-permeable appliance for delivering a composition
US20090041824A1 (en) * 2007-08-07 2009-02-12 Arsenal Medical, Inc. Method and apparatus for composite drug delivery medical devices
USD679820S1 (en) * 2010-10-15 2013-04-09 Smith & Nephew Plc Medical dressing
USD679819S1 (en) * 2010-10-15 2013-04-09 Smith & Nephew Plc Medical dressing
US20150351622A1 (en) * 2014-06-06 2015-12-10 Randolph P. Nopasri Blade aid
USD749071S1 (en) * 2014-05-15 2016-02-09 Nick Moore Control interface shield
USD768945S1 (en) * 2015-10-12 2016-10-11 Yu-Hua Chen Anti-mildew and antiseptic sticker
USD784961S1 (en) * 2015-06-05 2017-04-25 Logitech Europe, S.A. Ear cushion
USD798462S1 (en) * 2016-04-01 2017-09-26 Parapatch, Inc. Clitoral adhesive device
USD806242S1 (en) 2012-05-23 2017-12-26 Smith & Nephew Plc Flexible port used to connect a wound dressing to a source of negative pressure
US9855054B1 (en) 2015-06-15 2018-01-02 Tony Stcyr Nose bleed arrest implement
US9967988B1 (en) * 2016-11-04 2018-05-08 Henge Docks Llc Retention system for an electronic device
USD868133S1 (en) * 2018-01-17 2019-11-26 Palma Disciullo Camera cover
USD913605S1 (en) * 2019-03-29 2021-03-16 Monty L. Ruetenik Equine rocker shoe
USD914216S1 (en) * 2018-06-29 2021-03-23 3M Innovative Properties Company Nose tab
USD934415S1 (en) * 2019-05-03 2021-10-26 Coloplast A/S Cold sore patch applicator
US20220023229A1 (en) * 2018-12-10 2022-01-27 Dermal Diagnostics Ltd Attachment of membranes for transdermal devices
USD983380S1 (en) * 2019-04-19 2023-04-11 Suturegard Medical Inc. Wound closure device
US11730874B2 (en) 2004-04-05 2023-08-22 Smith & Nephew, Inc. Reduced pressure treatment appliance

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Cited By (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3439676A (en) * 1966-12-01 1969-04-22 Dow Corning Wound dressing
US4233976A (en) * 1978-07-06 1980-11-18 Minnesota Mining And Manufacturing Company Styptic device
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
US4457756A (en) * 1982-04-14 1984-07-03 Kern Eugene B Nose bleed clip
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
US4880690A (en) * 1984-11-13 1989-11-14 Thermedics, Inc. Perfume patch
USRE32991E (en) * 1984-11-13 1989-07-18 Thermedics, Inc. Drug dispensing wound dressing
US4727868A (en) * 1984-11-13 1988-03-01 Thermedics, Inc. Anisotropic wound dressing
US4751133A (en) * 1984-11-13 1988-06-14 Thermedics, Inc. Medical patches and processes for producing same
US4638043A (en) * 1984-11-13 1987-01-20 Thermedics, Inc. Drug release system
US4614787A (en) * 1984-11-13 1986-09-30 Thermedics, Inc. Drug dispensing wound dressing
US4773408A (en) * 1985-01-04 1988-09-27 E. R. Squibb & Sons, Inc. Wound dressing
US4820266A (en) * 1986-01-27 1989-04-11 Berry Yale J Method of stopping nose bleeds
US4883668A (en) * 1986-04-24 1989-11-28 Kabushiki Kaisya Advance Material for endermic administration pre-treatment
EP0288749A3 (en) * 1987-04-30 1989-06-07 Lohmann GmbH & Co. KG Adhesive bandages
EP0288749A2 (en) * 1987-04-30 1988-11-02 Lohmann GmbH & Co. KG Adhesive bandages
US5051259A (en) * 1987-12-15 1991-09-24 Coloplast A/S Skin barrier product with discontinuous adhesive layer
US5064422A (en) * 1990-10-18 1991-11-12 Bertek, Inc. Twin patch applicator
US6213993B1 (en) 1994-10-28 2001-04-10 Kimberly-Clark Worldwide, Inc. Self-adhering absorbent article
US6191338B1 (en) * 1998-11-19 2001-02-20 Kurt Haller Adhesive bandage, matrix, and methods of removal
US20030149387A1 (en) * 2000-08-09 2003-08-07 The Procter & Gamble Company Anti-snoring device comprising a skin compatible adhesive
US7055526B2 (en) * 2000-08-09 2006-06-06 Mohamed Ali Bakarat Anti-snoring device comprising a skin compatible adhesive
US6736141B2 (en) * 2000-12-15 2004-05-18 David L. Freedman Surgical aid
EP1293185A3 (en) * 2001-09-18 2005-01-26 Johnson & Johnson Consumer Companies, Inc. Adhesive bandage
AU2002301029B2 (en) * 2001-09-18 2007-12-20 Johnson & Johnson Consumer Companies, Inc. Adhesive Bandage With Improved Comfort And Fit
US11730874B2 (en) 2004-04-05 2023-08-22 Smith & Nephew, Inc. Reduced pressure treatment appliance
US20070026028A1 (en) * 2005-07-26 2007-02-01 Close Kenneth B Appliance for delivering a composition
US20080102093A1 (en) * 2006-10-31 2008-05-01 Close Kenneth B Appliance for delivering a composition, the appliance having an elastic layer and a shielding layer
US20080103461A1 (en) * 2006-10-31 2008-05-01 Johnson Kroy D Appliance for delivering a composition, the appliance having an outer fibrous layer and inner liquid-impermeable layer
US20080103460A1 (en) * 2006-10-31 2008-05-01 Close Kenneth B Method for making an appliance for delivering a composition, the appliance having an elastic layer and a shielding layer
US20080116096A1 (en) * 2006-11-17 2008-05-22 Johnson Kroy D Liquid-permeable appliance for delivering a composition
US20090041824A1 (en) * 2007-08-07 2009-02-12 Arsenal Medical, Inc. Method and apparatus for composite drug delivery medical devices
WO2009020607A3 (en) * 2007-08-07 2009-04-16 Arsenal Medical Inc Method and apparatus for composite drug delivery medical devices
WO2009020607A2 (en) * 2007-08-07 2009-02-12 Arsenal Medical, Inc. Method and apparatus for composite drug delivery medical devices
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USD749071S1 (en) * 2014-05-15 2016-02-09 Nick Moore Control interface shield
US20150351622A1 (en) * 2014-06-06 2015-12-10 Randolph P. Nopasri Blade aid
US10039443B2 (en) * 2014-06-06 2018-08-07 Randolph P Nopasri Blade aid
USD784961S1 (en) * 2015-06-05 2017-04-25 Logitech Europe, S.A. Ear cushion
US9855054B1 (en) 2015-06-15 2018-01-02 Tony Stcyr Nose bleed arrest implement
USD768945S1 (en) * 2015-10-12 2016-10-11 Yu-Hua Chen Anti-mildew and antiseptic sticker
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