UA97483C2 - Pyrimidine derivative as pi3k inhibitor and use thereof - Google Patents

Pyrimidine derivative as pi3k inhibitor and use thereof

Info

Publication number
UA97483C2
UA97483C2 UAA200902023A UAA200902023A UA97483C2 UA 97483 C2 UA97483 C2 UA 97483C2 UA A200902023 A UAA200902023 A UA A200902023A UA A200902023 A UAA200902023 A UA A200902023A UA 97483 C2 UA97483 C2 UA 97483C2
Authority
UA
Ukraine
Prior art keywords
pi3k inhibitor
pyrimidine derivative
formula
single bond
medical agent
Prior art date
Application number
UAA200902023A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Нобуо ШИММА
Хиросато ЭБИИКЕ
Джун Охвада
Хацуо КАВАДА
Кенджи Мориками
Мицуяки Накамура
Митюки Йошида
Нобуя Ишии
Масами ХАСЕГАВА
Шун Ямамото
Кохеи КОЯМА
Original Assignee
Чугай Сейяку Кабушики Кайша
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Чугай Сейяку Кабушики Кайша filed Critical Чугай Сейяку Кабушики Кайша
Priority claimed from PCT/JP2007/065396 external-priority patent/WO2008018426A1/en
Publication of UA97483C2 publication Critical patent/UA97483C2/en

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Abstract

Disclosed is a medical agent which is excellent in stability in living bodies and water solubility, while having excellent PI3K inhibitory activity. The medical agent is thus useful for prevention or treatment of cancers. Specifically disclosed is a compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. (I) (In the formula, X represents a single bond or the like; Y represents a single bond or the like (provided that X and Y are not single bonds at the same time); Z represents a hydrogen atom or the like; m represents an integer of 1 or 2; and Rrepresents a cyclic substituent.)(I)
UAA200902023A 2006-08-08 2007-08-07 Pyrimidine derivative as pi3k inhibitor and use thereof UA97483C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006216108 2006-08-08
PCT/JP2007/065396 WO2008018426A1 (en) 2006-08-08 2007-08-07 Pyrimidine derivative as pi3k inhibitor and use thereof

Publications (1)

Publication Number Publication Date
UA97483C2 true UA97483C2 (en) 2012-02-27

Family

ID=40947307

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200902023A UA97483C2 (en) 2006-08-08 2007-08-07 Pyrimidine derivative as pi3k inhibitor and use thereof

Country Status (3)

Country Link
CN (1) CN101501035B (en)
UA (1) UA97483C2 (en)
ZA (1) ZA200900907B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2799764A1 (en) * 2010-05-19 2011-11-24 Xcovery Holding Company, Llc. Mtor selective kinase inhibitors
JP6022691B2 (en) * 2012-08-30 2016-11-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Dioxino- and oxazine- [2,3-D] pyrimidine PI3K inhibitor compounds and methods of use
GB201514760D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
CN110563593A (en) * 2019-09-26 2019-12-13 新岸诺亚（北京）催化科技有限公司 Preparation method of N-methyl-4-bromoaniline
TW202128686A (en) * 2019-10-25 2021-08-01 大陸商江蘇恆瑞醫藥股份有限公司 A fused heteroaryl derivative, a preparation method and medical use thereof
CN113135942B (en) * 2020-01-17 2023-01-24 江苏恒瑞医药股份有限公司 Condensed pyrimidine derivative, preparation method and medical application thereof
CN111662185B (en) * 2020-06-18 2023-05-05 江苏富鼎化学有限公司 Synthesis method of N-methyl o-fluoroaniline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003291310A1 (en) * 2002-11-06 2004-06-03 Bristol-Myers Squibb Company Fused heterocyclic compounds and use thereof
PT2316831E (en) * 2002-11-21 2013-06-06 Novartis Ag 2-(morpholin-4-yl)pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer

Also Published As

Publication number Publication date
CN101501035A (en) 2009-08-05
CN101501035B (en) 2013-01-23
ZA200900907B (en) 2009-11-25

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