TR199901542T2 - 2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists. - Google Patents

2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists.

Info

Publication number
TR199901542T2
TR199901542T2 TR1999/01542T TR9901542T TR199901542T2 TR 199901542 T2 TR199901542 T2 TR 199901542T2 TR 1999/01542 T TR1999/01542 T TR 1999/01542T TR 9901542 T TR9901542 T TR 9901542T TR 199901542 T2 TR199901542 T2 TR 199901542T2
Authority
TR
Turkey
Prior art keywords
alpha
imidazolinylaminoindazole
compounds useful
adrenoceptor agonists
compounds
Prior art date
Application number
TR1999/01542T
Other languages
Turkish (tr)
Inventor
Lee Cupps Thomas
Eva Bogdan Sophie
Todd Henry Raymond
James Sheldon Russell
Lee Seibel William
Joseph Ares Jeffrey
Original Assignee
The Procter & Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Publication of TR199901542T2 publication Critical patent/TR199901542T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)

Abstract

Bu bulus istemlerde tanimlandigi gibi (I) yapisini haiz bilesiklere; bunlarin enantiomerleri, optik izomerleri, stereoizomerleri, diastereomerleri, totomerleri, ilave tuzlari, biyohidrolize edilebilir amitleri ve esterlerine ve bu yeni bilesikleri içeren farmasötik bilesimlere iliskindir. Bulus ayrica bu bilesiklerin alfa-2 adrenoseptörleri tarafindan degistirilmis bozukluklari önlemek veya tedavi etmek için kullanimina iliskindir.As described in the claims, these inventions have compounds (I); their enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters, and pharmaceutical compositions containing these novel compounds. The invention also relates to the use of these compounds to prevent or treat altered disorders by alpha-2 adrenoceptors.

TR1999/01542T 1996-11-25 1997-11-21 2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists. TR199901542T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3174096P 1996-11-25 1996-11-25

Publications (1)

Publication Number Publication Date
TR199901542T2 true TR199901542T2 (en) 2000-01-21

Family

ID=21861136

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01542T TR199901542T2 (en) 1996-11-25 1997-11-21 2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists.

Country Status (20)

Country Link
EP (1) EP0944620A1 (en)
JP (1) JP2001506599A (en)
KR (1) KR20000069104A (en)
CN (1) CN1244864A (en)
AR (1) AR010643A1 (en)
AU (1) AU5433998A (en)
BR (1) BR9713535A (en)
CA (1) CA2272644A1 (en)
CO (1) CO4910166A1 (en)
CZ (1) CZ183999A3 (en)
HU (1) HUP9904660A3 (en)
ID (1) ID22676A (en)
IL (1) IL130067A0 (en)
NO (1) NO992502L (en)
NZ (1) NZ335882A (en)
PE (1) PE47099A1 (en)
SK (1) SK69699A3 (en)
TR (1) TR199901542T2 (en)
WO (1) WO1998023609A1 (en)
ZA (1) ZA9710576B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9908175D0 (en) * 1999-04-09 1999-06-02 Lilly Co Eli Method of treating neurological disorders
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
EP2226315A4 (en) 2007-12-28 2012-01-25 Carna Biosciences Inc 2-aminoquinazoline derivative
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
CN112538074A (en) * 2020-12-24 2021-03-23 艾希尔（深圳）药物研发有限公司 Preparation method of debrominated impurities of brimonidine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH641782A5 (en) * 1978-12-07 1984-03-15 Siegfried Ag 1H- and 2H-indazole derivatives
US4526898A (en) * 1980-09-05 1985-07-02 Siegfried Aktiengesselschaft Antihypertensive 4-(2-imidazolin-2-yl-amino)-2-methyl-indazole
ES2150546T3 (en) * 1993-12-17 2000-12-01 Procter & Gamble COMPOUNDS OF 6- (2-IMIDAZOLINYLAMINE) QUINOXALINE USEFUL AS ALPHA-2-ADRENOCEPTOR AGONISTS.
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists

Also Published As

Publication number Publication date
HUP9904660A2 (en) 2000-06-28
CO4910166A1 (en) 2000-04-24
PE47099A1 (en) 1999-06-12
BR9713535A (en) 2000-03-21
NO992502D0 (en) 1999-05-25
CN1244864A (en) 2000-02-16
KR20000069104A (en) 2000-11-25
ID22676A (en) 1999-12-09
CA2272644A1 (en) 1998-06-04
ZA9710576B (en) 1998-09-16
SK69699A3 (en) 2000-06-12
WO1998023609A1 (en) 1998-06-04
NO992502L (en) 1999-07-26
AU5433998A (en) 1998-06-22
CZ183999A3 (en) 1999-11-17
NZ335882A (en) 2000-12-22
HUP9904660A3 (en) 2002-02-28
JP2001506599A (en) 2001-05-22
AR010643A1 (en) 2000-06-28
IL130067A0 (en) 2000-02-29
EP0944620A1 (en) 1999-09-29

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