SU505362A3 - Способ получени оксипиримидинов - Google Patents

Способ получени оксипиримидинов

Info

Publication number
SU505362A3
SU505362A3 SU2008490A SU2008490A SU505362A3 SU 505362 A3 SU505362 A3 SU 505362A3 SU 2008490 A SU2008490 A SU 2008490A SU 2008490 A SU2008490 A SU 2008490A SU 505362 A3 SU505362 A3 SU 505362A3
Authority
SU
USSR - Soviet Union
Prior art keywords
oxypyrimidines
producing
sodium
atom
general formula
Prior art date
Application number
SU2008490A
Other languages
English (en)
Inventor
Эндрю Липински(Сша) Христофер
Джеррит Стам(Сша) Джон
Джорж Дианджемк(Сша) Джеральд
Юрген Эрнест Гесс(Фрг) Ганс
Original Assignee
Пфайзер Инк (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк (Фирма) filed Critical Пфайзер Инк (Фирма)
Application granted granted Critical
Publication of SU505362A3 publication Critical patent/SU505362A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Description

(54) СПОСОБ ПОЛУЧЕНИЯ ОКСИПИРИМИДИНОВ
где R, - атом водорода, атом rajioieiia, алкилрадикал с 1-3 атомами углерода, метокси или карбоксигруппа;
RI атом водорода, атом хлора, метилрадикал ,
или их солей, заключаетс  в том, что натриевую соль соединени  об1пей формулы ( II ) г
О I
/Ч
-0-С-С-ОН,
и снон
Соединени  общей формулы (II) пoJjyчaю при взаимодействии фенола или замещенного фе-.юла с эти лх лор ацетатом в присутствии этилата штри  с образованием феноксиацетата, который реашрует с металлическим натрием или гидридом натри  и метилформиатом в среде этилового эфира с образовашем натриевой соли этилфеноксиоксиакрилата .
Полученный акрилат затем нагревают с тиомочевиной в присутствии метилата натри  в среде этанола. Продукт подкисл ют, отфильтроньшают и пepeкpиcтaJUlизoвbшaют из смеси растворн1слей хлороформ (эшловый спирт) - уксусна  кислотас образованием фенокситиоурацила.
SU2008490A 1971-10-29 1974-03-26 Способ получени оксипиримидинов SU505362A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19400671A 1971-10-29 1971-10-29

Publications (1)

Publication Number Publication Date
SU505362A3 true SU505362A3 (ru) 1976-02-28

Family

ID=22715935

Family Applications (2)

Application Number Title Priority Date Filing Date
SU1839308A SU498908A3 (ru) 1971-10-29 1972-10-13 Способ получени производных пиримидинона
SU2008490A SU505362A3 (ru) 1971-10-29 1974-03-26 Способ получени оксипиримидинов

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU1839308A SU498908A3 (ru) 1971-10-29 1972-10-13 Способ получени производных пиримидинона

Country Status (25)

Country Link
JP (2) JPS5337870B2 (ru)
AR (2) AR198798A1 (ru)
AT (2) AT321308B (ru)
AU (1) AU467600B2 (ru)
BE (1) BE790125A (ru)
CA (1) CA980778A (ru)
CH (2) CH555832A (ru)
DE (3) DE2248741C3 (ru)
DK (1) DK131465B (ru)
EG (1) EG11013A (ru)
ES (2) ES407730A1 (ru)
FI (1) FI55503C (ru)
FR (1) FR2157865B1 (ru)
GB (2) GB1377308A (ru)
IE (1) IE37043B1 (ru)
IL (2) IL40458A (ru)
LU (1) LU66304A1 (ru)
NL (1) NL166470C (ru)
NO (1) NO136574C (ru)
PH (2) PH10129A (ru)
PL (2) PL84634B1 (ru)
SE (2) SE393376B (ru)
SU (2) SU498908A3 (ru)
YU (2) YU35125B (ru)
ZA (1) ZA727362B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151912U (ru) * 1979-04-17 1980-11-01
JPS5752409Y2 (ru) * 1979-11-05 1982-11-15
DE3222914A1 (de) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPH0655686B2 (ja) * 1988-08-30 1994-07-27 宇部興産株式会社 ｐ−ブロモフェノキシアセトアルデヒドジアルキルアセタール類の製造方法
ATE533488T1 (de) 2005-08-22 2011-12-15 Melior Pharmaceuticals I Inc Verfahren und formulierungen zur modulierung von lyn-kinaseaktivität und behandlung assoziierter erkrankungen
US8552184B2 (en) 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
US20130158055A1 (en) 2010-05-28 2013-06-20 Andrew G. Reaume Prevention Of Pancreatic Beta Cell Degeneration
EP3609500B1 (en) 2017-04-10 2024-11-13 Melior Pharmaceuticals I, Inc. Treatment of adipocytes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913462A (en) * 1959-11-17 Eahl h
GB951432A (en) * 1959-03-17 1964-03-04 Wellcome Found Pyrimidine derivatives and the manufacture thereof

Also Published As

Publication number Publication date
DE2264374A1 (de) 1973-05-24
SE393376B (sv) 1977-05-09
PH10129A (en) 1976-09-02
NL166470C (nl) 1981-08-17
YU36295B (en) 1982-06-18
YU255172A (en) 1980-03-15
FR2157865B1 (ru) 1975-10-31
PH11594A (en) 1978-03-31
DE2264374C3 (de) 1981-07-23
GB1377308A (en) 1974-12-11
JPS4852780A (ru) 1973-07-24
AU467600B2 (en) 1975-12-04
IE37043B1 (en) 1977-04-27
NL166470B (nl) 1981-03-16
AU4722872A (en) 1974-04-04
DE2264657C2 (de) 1982-09-16
EG11013A (en) 1976-11-30
AR198798A1 (es) 1974-07-24
CH555832A (fr) 1974-11-15
CH549579A (fr) 1974-05-31
DK131465C (ru) 1975-12-08
YU99179A (en) 1981-08-31
DE2248741A1 (de) 1973-05-03
JPS5422995B2 (ru) 1979-08-10
AT321308B (de) 1975-03-25
IL40458A0 (en) 1972-11-28
BE790125A (fr) 1973-04-16
SE7505279L (sv) 1975-05-06
SE397090B (sv) 1977-10-17
IL40458A (en) 1976-05-31
GB1377720A (en) 1974-12-18
DE2248741B2 (de) 1974-11-14
FI55503B (fi) 1979-04-30
ZA727362B (en) 1973-11-28
YU35125B (en) 1980-09-25
PL89852B1 (ru) 1976-12-31
DE2264657A1 (de) 1974-06-20
DK131465B (da) 1975-07-21
DE2248741C3 (de) 1975-06-26
JPS53116386A (en) 1978-10-11
FR2157865A1 (ru) 1973-06-08
ES436624A1 (es) 1977-02-01
CA980778A (en) 1975-12-30
JPS5337870B2 (ru) 1978-10-12
IE37043L (en) 1973-04-29
NL7213959A (ru) 1973-05-02
ES407730A1 (es) 1976-01-16
NO136574B (ru) 1977-06-20
IL48790A0 (en) 1976-03-31
NO136574C (no) 1977-09-28
IL48790A (en) 1976-05-31
AT320656B (de) 1975-02-25
SU498908A3 (ru) 1976-01-05
PL84634B1 (ru) 1976-04-30
FI55503C (fi) 1979-08-10
AR196263A1 (es) 1973-12-10
DE2264374B2 (de) 1980-08-07
LU66304A1 (ru) 1973-05-03

Similar Documents

Publication Publication Date Title
SU505362A3 (ru) Способ получени оксипиримидинов
ES391299A1 (es) Procedimiento para la preparacion de n-alil 2 - arilamino -imidazolinas (2) sustituidas.
ES456279A1 (es) Un procedimiento para preparar compuestos de cetofosfonato.
SU521846A3 (ru) Способ получени азаспирановых соединений,содержащих кремний или германий
GB1468270A (en) Substituted pyrimidine-thionothiolphosphoric acid esters process for their preparation and their use as insecticides or acaricides
ES408615A1 (es) Procedimiento para la preparacion de 4-amino-3,5-dihalogenofenil - etanolaminas.
SU498912A3 (ru) Способ получени триазолотиазоловых эфиров кислот фосфора
GB1095186A (en) Substituted cyanoacetic esters
ES423233A1 (es) Procedimiento para la preparacion de nuevas 2-fenilamino- imidazolinas-(2) sustituidas.
GB1420185A (en) Nitrile-substituted o-ethyl-s-n-propyl-o-vinylthionothiol phosphoric acid esters a process for their preparation and their use as insecticides or acaraicides
ES338638A1 (es) Procedimiento para la preparacion de nuevos esteres de aci-do fenilacetico sus tituidos.
ES8305727A1 (es) Procedimiento de preparacion de derivados del 3,4-difenil-5-metil pirazol.
ES425216A1 (es) Procedimiento para la preparacion de nuevas triazolo - 1,5 - benzodiazepinas sustituidas.
ES399873A1 (es) Procedimiento para la preparacion de nuevos i-fenoxi-2- idroxi-3-alcahilamino propanos recemicos u opticamenacti- vos.
GB1417174A (en) 1-2-delta2-imidazolinyl-2,2-diarylcoclopropanes
ES405646A1 (es) Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES446695A1 (es) Procedimiento para la preparacion de nuevos acidos 3-(4-bi- fenilil)-butiricos, sus esteres y amidas.
ES449425A1 (es) Procedimiento para preparar derivados de aminopirrol.
JPS5711981A (en) Theobromine derivative and its preparation
SE7605200L (sv) Sett att framstella 2-substituerade 1,4-bensodiazepin-derivat
GB1397997A (en) O-pyrazolo-pyrimidine-thiono-phsophoric -phosphinic- acid esters process for their production and their use as insecticides and acaricides
ES418283A1 (es) Un procedimiento para preparar compuestos organicos.
ES406367A1 (es) Procedimiento para la obtencion de derivados de la tiazo- lin-pirimidinona-5.
ES366534A1 (es) Procedimiento para la preparacion de nuevos acidos fenila- ceticos sustituidos.
ES406130A1 (es) Procedimiento para la preparacion de 4 - (4 - bifenilil) - butiricos y sus esteres.