SI2947072T1 - 1-(3-(6,7-dimetoksikinazolin-4-iloksi)fenil)-3-(5-1,1,1-trifluoro-2- metilpropan-2-il)izoksazol-3-il)urea kot modulator raf kinaze pri zdravljenju rakavih bolezni - Google Patents

1-(3-(6,7-dimetoksikinazolin-4-iloksi)fenil)-3-(5-1,1,1-trifluoro-2- metilpropan-2-il)izoksazol-3-il)urea kot modulator raf kinaze pri zdravljenju rakavih bolezni

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Publication number
SI2947072T1
SI2947072T1 SI200931598A SI200931598A SI2947072T1 SI 2947072 T1 SI2947072 T1 SI 2947072T1 SI 200931598 A SI200931598 A SI 200931598A SI 200931598 A SI200931598 A SI 200931598A SI 2947072 T1 SI2947072 T1 SI 2947072T1
Authority
SI
Slovenia
Prior art keywords
dimethoxyquinazolin
methylpropan
isoxazol
yloxy
trifluoro
Prior art date
Application number
SI200931598A
Other languages
English (en)
Inventor
Sunny Abraham
Shripad S. Bhagwat
Brian T. Campbell
Qi Chao
Raffaella Faraoni
Mark W. Holladay
Andiliy G. Lai
Martin W. Rowbottom
Eduardo Setti
Kelly G. Sprankle
Original Assignee
Ambit Biosciences Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambit Biosciences Corporation filed Critical Ambit Biosciences Corporation
Publication of SI2947072T1 publication Critical patent/SI2947072T1/sl

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    • C07ORGANIC CHEMISTRY
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    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
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    • A61K31/33Heterocyclic compounds
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D239/72Quinazolines; Hydrogenated quinazolines
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    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200931598A 2008-03-17 2009-03-17 1-(3-(6,7-dimetoksikinazolin-4-iloksi)fenil)-3-(5-1,1,1-trifluoro-2- metilpropan-2-il)izoksazol-3-il)urea kot modulator raf kinaze pri zdravljenju rakavih bolezni SI2947072T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6976308P 2008-03-17 2008-03-17
US11050808P 2008-10-31 2008-10-31
EP15166141.0A EP2947072B1 (en) 2008-03-17 2009-03-17 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea as raf kinase modulator in the treatment of cancer diseases

Publications (1)

Publication Number Publication Date
SI2947072T1 true SI2947072T1 (sl) 2017-03-31

Family

ID=40852165

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200931598A SI2947072T1 (sl) 2008-03-17 2009-03-17 1-(3-(6,7-dimetoksikinazolin-4-iloksi)fenil)-3-(5-1,1,1-trifluoro-2- metilpropan-2-il)izoksazol-3-il)urea kot modulator raf kinaze pri zdravljenju rakavih bolezni
SI200931239T SI2268623T1 (sl) 2008-03-17 2009-03-17 Derivati kinazolina kot modulatorji raf-kinaze in postopki uporabe le-teh

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200931239T SI2268623T1 (sl) 2008-03-17 2009-03-17 Derivati kinazolina kot modulatorji raf-kinaze in postopki uporabe le-teh

Country Status (23)

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US (5) US8618289B2 (sl)
EP (3) EP2268623B9 (sl)
JP (1) JP5542793B2 (sl)
KR (2) KR101601997B1 (sl)
CN (2) CN102026985B (sl)
AU (1) AU2009226136B2 (sl)
BR (1) BRPI0906186A2 (sl)
CA (2) CA2718123C (sl)
DK (2) DK2268623T3 (sl)
EA (1) EA019350B1 (sl)
ES (2) ES2547406T3 (sl)
HK (2) HK1151525A1 (sl)
HU (2) HUE032873T2 (sl)
IL (1) IL207793A (sl)
MX (1) MX2010010172A (sl)
MY (1) MY161576A (sl)
NZ (1) NZ587907A (sl)
PL (2) PL2947072T3 (sl)
PT (2) PT2947072T (sl)
SG (2) SG10201608813PA (sl)
SI (2) SI2947072T1 (sl)
WO (1) WO2009117080A1 (sl)
ZA (1) ZA201006524B (sl)

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