SI2717883T1 - Zaščita pred motnjo endotelijske pregrade z inhibicijo tirozin kinaze ABL-sorodnega gena (ARG) - Google Patents

Zaščita pred motnjo endotelijske pregrade z inhibicijo tirozin kinaze ABL-sorodnega gena (ARG)

Info

Publication number
SI2717883T1
SI2717883T1 SI201131153A SI201131153A SI2717883T1 SI 2717883 T1 SI2717883 T1 SI 2717883T1 SI 201131153 A SI201131153 A SI 201131153A SI 201131153 A SI201131153 A SI 201131153A SI 2717883 T1 SI2717883 T1 SI 2717883T1
Authority
SI
Slovenia
Prior art keywords
arg
inhibition
tyrosine kinase
protection against
related gene
Prior art date
Application number
SI201131153A
Other languages
English (en)
Inventor
Nieuw Amerongen Geerten P. Van
Noordegraaf Anton Vonk
Jurjan Aman
Hinsbergh Victor W. M. Van
Original Assignee
Stichting Vumc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Vumc filed Critical Stichting Vumc
Publication of SI2717883T1 publication Critical patent/SI2717883T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201131153A 2011-05-02 2011-05-02 Zaščita pred motnjo endotelijske pregrade z inhibicijo tirozin kinaze ABL-sorodnega gena (ARG) SI2717883T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11731142.3A EP2717883B1 (en) 2011-05-02 2011-05-02 Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (arg)
PCT/NL2011/050299 WO2012150857A1 (en) 2011-05-02 2011-05-02 Protection against endothelial barrier dysfunction through inhibition of the tyrosine kinase abl-related gene (arg)

Publications (1)

Publication Number Publication Date
SI2717883T1 true SI2717883T1 (sl) 2017-06-30

Family

ID=44583314

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201131153A SI2717883T1 (sl) 2011-05-02 2011-05-02 Zaščita pred motnjo endotelijske pregrade z inhibicijo tirozin kinaze ABL-sorodnega gena (ARG)

Country Status (10)

Country Link
US (1) US9290765B2 (sl)
EP (1) EP2717883B1 (sl)
DK (1) DK2717883T3 (sl)
ES (1) ES2622112T3 (sl)
HR (1) HRP20170553T1 (sl)
LT (1) LT2717883T (sl)
PL (1) PL2717883T3 (sl)
PT (1) PT2717883T (sl)
SI (1) SI2717883T1 (sl)
WO (1) WO2012150857A1 (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2717883T3 (pl) 2011-05-02 2017-07-31 Stichting Vumc Ochrona przed zaburzeniami bariery śródbłonkowej poprzez hamowanie kinazy tyrozynowej Abl-related gene (ARG)
US9994514B2 (en) 2012-05-08 2018-06-12 Aeromics, Inc. Methods of treating cerebral edema and spinal cord edema
JP6535338B2 (ja) 2013-11-06 2019-06-26 エアロミクス・インコーポレイテッドAeromics,Inc. 新規製剤
WO2018013912A1 (en) * 2016-07-15 2018-01-18 The Board Of Regents Of The University Of Oklahoma Anti-arid3a treatments for inflammatory disorders
CN112852853B (zh) * 2021-01-08 2023-06-02 重庆医科大学附属儿童医院 一种高强度聚焦超声生物靶向增效剂及运用
EP4046639A1 (en) 2021-02-22 2022-08-24 Stichting VUmc Prevention of pulmonary vascular leak in covid-19
GB202204070D0 (en) 2022-03-23 2022-05-04 Exvastat Ltd Treatment
US11752152B1 (en) 2022-04-25 2023-09-12 Exvastat Ltd Pharmaceutical formulations of imatinib and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
US6774288B1 (en) 1997-07-07 2004-08-10 Basf Plant Science L.L.C. Animal feed with low phytic acid, oil, burdened and protein laden grain
KR100722344B1 (ko) 1999-04-15 2007-05-29 브리스톨-마이어스스퀴브컴파니 환형 단백질 티로신 키나제 억제제
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
EP2213738B1 (en) 2002-11-14 2012-10-10 Dharmacon, Inc. siRNA molecules targeting Bcl-2
US7846906B2 (en) 2003-02-28 2010-12-07 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
US8106180B2 (en) 2003-08-07 2012-01-31 Whitehead Institute For Biomedical Research Methods and products for expression of micro RNAs
CA2687336C (en) 2007-05-23 2014-12-23 Dharmacon, Inc. Micro-rna scaffolds and non-naturally occurring micro-rnas
UA100253C2 (uk) 2007-11-26 2012-12-10 Сантаріс Фарма А/С Lna-антагоністи андрогенного рецептора
PL2717883T3 (pl) 2011-05-02 2017-07-31 Stichting Vumc Ochrona przed zaburzeniami bariery śródbłonkowej poprzez hamowanie kinazy tyrozynowej Abl-related gene (ARG)

Also Published As

Publication number Publication date
US9290765B2 (en) 2016-03-22
DK2717883T3 (en) 2017-04-24
PL2717883T3 (pl) 2017-07-31
WO2012150857A1 (en) 2012-11-08
EP2717883A1 (en) 2014-04-16
HRP20170553T1 (hr) 2017-06-02
ES2622112T3 (es) 2017-07-05
EP2717883B1 (en) 2017-03-22
LT2717883T (lt) 2017-04-25
PT2717883T (pt) 2017-04-19
US20140187605A1 (en) 2014-07-03

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