SG11201806150RA - Psma and cd3 bispecific t cell engaging antibody constructs - Google Patents
Psma and cd3 bispecific t cell engaging antibody constructsInfo
- Publication number
- SG11201806150RA SG11201806150RA SG11201806150RA SG11201806150RA SG11201806150RA SG 11201806150R A SG11201806150R A SG 11201806150RA SG 11201806150R A SG11201806150R A SG 11201806150RA SG 11201806150R A SG11201806150R A SG 11201806150RA SG 11201806150R A SG11201806150R A SG 11201806150RA
- Authority
- SG
- Singapore
- Prior art keywords
- munich
- staffelseestrasse
- gmbh
- amgen
- research
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/134158 Al 10 August 2017 (10.08.2017) WIPO I PCT 11111111111111 0 111011111111111 010 11111 01110111 011111111 0111H110 111111111 0111111 (51) International Patent Classification: C07K 16/28 (2006.01) C07K 16/30 (2006.01) (21) International Application Number: PCT/EP2017/052239 (22) International Filing Date: 2 February 2017 (02.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/290,875 3 February 2016 (03.02.2016) US (71) Applicant: AMGEN RESEARCH (MUNICH) GMBH [DE/DE]; Staffelseestrasse 2, 81477 Munich (DE). (72) Inventors: RAUM, Tobias; c/o Amgen Research (Mu- nich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). MUENZ, Markus; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). BROZY, Jo- hannes; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). KUFER, Peter; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). HOFFMANN, Patrick; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Mu- nich (DE). FRIEDRICH, Matthias; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). RATTEL, Benno; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). BOGNER, Pamela; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). WOLF, Andreas; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). POMPE, Cornelius; c/o Amgen Re- search (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). (74) Agents: WEINZIERL, Gerhard et al.; Schiweck Weinzi- erl Koch, Landsberger Strasse 98, 80339 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 17 / 13 415 8 Al (54) Title: PSMA AND CD3 BISPECIFIC T CELL ENGAGING ANTIBODY CONSTRUCTS (57) : The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3 E chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662290875P | 2016-02-03 | 2016-02-03 | |
| PCT/EP2017/052239 WO2017134158A1 (en) | 2016-02-03 | 2017-02-02 | Psma and cd3 bispecific t cell engaging antibody constructs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201806150RA true SG11201806150RA (en) | 2018-08-30 |
Family
ID=57984927
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201806150RA SG11201806150RA (en) | 2016-02-03 | 2017-02-02 | Psma and cd3 bispecific t cell engaging antibody constructs |
| SG10202007331WA SG10202007331WA (en) | 2016-02-03 | 2017-02-02 | Psma and cd3 bispecific t cell engaging antibody constructs |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202007331WA SG10202007331WA (en) | 2016-02-03 | 2017-02-02 | Psma and cd3 bispecific t cell engaging antibody constructs |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US10781264B2 (en) |
| EP (2) | EP3411404B1 (en) |
| JP (2) | JP6954744B2 (en) |
| KR (1) | KR20180101623A (en) |
| CN (2) | CN109311979A (en) |
| AR (1) | AR107582A1 (en) |
| AU (1) | AU2017216237B2 (en) |
| BR (1) | BR112018015415A2 (en) |
| CA (1) | CA3011942A1 (en) |
| CL (1) | CL2018002063A1 (en) |
| CO (1) | CO2018008722A2 (en) |
| CR (1) | CR20180418A (en) |
| DK (1) | DK3411404T3 (en) |
| EA (1) | EA201891753A1 (en) |
| ES (1) | ES2935419T3 (en) |
| FI (1) | FI3411404T3 (en) |
| HK (1) | HK1257749A1 (en) |
| HU (1) | HUE060504T2 (en) |
| IL (1) | IL260920B (en) |
| LT (1) | LT3411404T (en) |
| MA (1) | MA43959A (en) |
| MX (1) | MX2018009386A (en) |
| MY (1) | MY195542A (en) |
| PH (1) | PH12018501558A1 (en) |
| PL (1) | PL3411404T3 (en) |
| PT (1) | PT3411404T (en) |
| SG (2) | SG11201806150RA (en) |
| SI (1) | SI3411404T1 (en) |
| TN (1) | TN2018000266A1 (en) |
| TW (1) | TWI767899B (en) |
| UA (1) | UA126656C2 (en) |
| UY (1) | UY37105A (en) |
| WO (1) | WO2017134158A1 (en) |
| ZA (1) | ZA201804829B (en) |
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| RU2559531C2 (en) * | 2008-10-01 | 2015-08-10 | Эмджен Рисерч (Мьюник)ГмбХ | Psma×cd3 bispecific single-chain antibody having interspecies specificity |
| KR102391731B1 (en) | 2013-01-14 | 2022-04-27 | 젠코어 인코포레이티드 | Novel heterodimeric proteins |
| JO3519B1 (en) | 2013-01-25 | 2020-07-05 | Amgen Inc | Antibody constructs for CDH19 and CD3 |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| CA2956471A1 (en) | 2014-07-31 | 2016-02-04 | Amgen Research (Munich) Gmbh | Optimized cross-species specific bispecific single chain antibody constructs |
| EP3223907A2 (en) | 2014-11-26 | 2017-10-04 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cd38 |
| IL252480B2 (en) | 2014-11-26 | 2023-12-01 | Xencor Inc | Heterodimeric antibodies that bind cd3 and tumor antigens |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| TW202346349A (en) | 2015-07-31 | 2023-12-01 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for dll3 and cd3 |
| TWI829617B (en) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for flt3 and cd3 |
| TWI744242B (en) * | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for egfrviii and cd3 |
| TWI796283B (en) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for msln and cd3 |
| TWI717375B (en) | 2015-07-31 | 2021-02-01 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for cd70 and cd3 |
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| EA039859B1 (en) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Bispecific antibody constructs binding egfrviii and cd3 |
| IL260920B (en) * | 2016-02-03 | 2022-09-01 | Amgen Res Munich Gmbh | Psma and cd3 bispecific t cell engaging antibody constructs, compositions comprising same and uses thereof |
| BR112018015715A2 (en) | 2016-02-03 | 2019-02-05 | Amgen Inc | bispecific bcma and cd3 t cell coupling antibody constructs |
| MX2018016265A (en) | 2016-06-28 | 2019-07-04 | Xencor Inc | Heterodimeric antibodies that bind somatostatin receptor 2. |
| JOP20190189A1 (en) * | 2017-02-02 | 2019-08-01 | Amgen Res Munich Gmbh | Low ph pharmaceutical composition comprising t cell engaging antibody constructs |
| CN111406068A (en) | 2017-05-16 | 2020-07-10 | 约翰霍普金斯大学 | MANAbody and methods of use |
| CN118126157A (en) | 2017-08-03 | 2024-06-04 | 美国安进公司 | Interleukin-21 muteins and methods of treatment |
| MA50077A (en) | 2017-09-08 | 2020-07-15 | Amgen Inc | KRAS G12C INHIBITORS AND THEIR PROCEDURES FOR USE |
| ES2941740T3 (en) | 2018-01-12 | 2023-05-25 | Amgen Inc | Anti-PD-1 antibodies and treatment methods |
| AU2019274657A1 (en) | 2018-05-24 | 2020-12-10 | Janssen Biotech, Inc. | PSMA binding agents and uses thereof |
| WO2020072306A1 (en) * | 2018-10-01 | 2020-04-09 | Amgen Inc. | Methods for reducing aggregation of bispecific antibodies |
| BR112021020532A2 (en) | 2019-04-19 | 2022-03-15 | Janssen Biotech Inc | Methods for treating prostate cancer with an anti-psma/cd3 antibody |
| US20220259329A1 (en) * | 2019-06-07 | 2022-08-18 | Amgen Inc. | Bispecific binding constructs |
| TWI809286B (en) | 2019-07-05 | 2023-07-21 | 日商小野藥品工業股份有限公司 | Treatment of hematological cancer with pd-1/cd3 bispecific protein |
| EP4004209A2 (en) * | 2019-07-26 | 2022-06-01 | Ixaka France | Anti-cd3 aptamers for use in cell targeting and labeling |
| US20230146593A1 (en) | 2020-03-12 | 2023-05-11 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecific antibodies binding to cds x cancer cell and tnf alpha or il-6 inhibitor |
| US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
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