SG11201600479WA - Therapeutically active compounds and their methods of use - Google Patents

Therapeutically active compounds and their methods of use

Info

Publication number
SG11201600479WA
SG11201600479WA SG11201600479WA SG11201600479WA SG11201600479WA SG 11201600479W A SG11201600479W A SG 11201600479WA SG 11201600479W A SG11201600479W A SG 11201600479WA SG 11201600479W A SG11201600479W A SG 11201600479WA SG 11201600479W A SG11201600479W A SG 11201600479WA
Authority
SG
Singapore
Prior art keywords
methods
active compounds
therapeutically active
therapeutically
compounds
Prior art date
Application number
SG11201600479WA
Inventor
Samuel V Agresta
Chong-Hui Gu
David Schenkein
Hua Yang
Liting Guo
Zhen Tang
Jianming Wang
Yanfeng Zhang
Yan Zhou
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2013/081170 external-priority patent/WO2015018060A1/en
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of SG11201600479WA publication Critical patent/SG11201600479WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201600479WA 2013-08-02 2014-08-01 Therapeutically active compounds and their methods of use SG11201600479WA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361861884P 2013-08-02 2013-08-02
PCT/CN2013/081170 WO2015018060A1 (en) 2013-08-09 2013-08-09 Crystalline forms of therapeutically active compounds and use thereof
US201461939098P 2014-02-12 2014-02-12
US201461975448P 2014-04-04 2014-04-04
US201462011948P 2014-06-13 2014-06-13
PCT/US2014/049469 WO2015017821A2 (en) 2013-08-02 2014-08-01 Therapeutically active compounds and their methods of use

Publications (1)

Publication Number Publication Date
SG11201600479WA true SG11201600479WA (en) 2016-02-26

Family

ID=52432592

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201709187TA SG10201709187TA (en) 2013-08-02 2014-08-01 Therapeutically active compounds and their methods of use
SG11201600479WA SG11201600479WA (en) 2013-08-02 2014-08-01 Therapeutically active compounds and their methods of use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201709187TA SG10201709187TA (en) 2013-08-02 2014-08-01 Therapeutically active compounds and their methods of use

Country Status (21)

Country Link
US (5) US9738625B2 (en)
EP (3) EP3566706B1 (en)
JP (3) JP6742905B2 (en)
CN (3) CN110386922A (en)
AU (2) AU2014295938B2 (en)
BR (1) BR112016002287A2 (en)
CA (1) CA2919382A1 (en)
CL (2) CL2016000263A1 (en)
EA (1) EA030428B1 (en)
ES (1) ES2886211T3 (en)
IL (2) IL243833A0 (en)
MX (2) MX2020011397A (en)
MY (1) MY177994A (en)
NI (1) NI201600022A (en)
PE (1) PE20160840A1 (en)
PH (1) PH12016500164A1 (en)
SA (1) SA516370523B1 (en)
SG (2) SG10201709187TA (en)
TW (2) TWI666208B (en)
UA (1) UA121021C2 (en)
WO (1) WO2015017821A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI666208B (en) 2013-08-02 2019-07-21 美商阿吉斯藥品有限公司 Therapeutically active compounds and their methods of use
AU2015324158A1 (en) * 2014-09-29 2017-04-13 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2016126798A1 (en) 2015-02-04 2016-08-11 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2016177347A1 (en) * 2015-05-07 2016-11-10 Teligene Ltd Heterocyclic compounds as idh2 inhibitors
KR102303011B1 (en) * 2015-07-30 2021-09-16 치아타이 티안큉 파마수티컬 그룹 주식회사 1,3,5-triazine derivatives and methods of use thereof
EP3331866B1 (en) 2015-08-05 2023-07-26 Les Laboratoires Servier Methods of preparing a 6-heteroaryl-1,3,5-triazine-2,4-diol and a 6-heteroaryl-1,3,5-triazine-2,4-diamine
KR102701893B1 (en) * 2015-10-15 2024-09-03 셀진 코포레이션 Combination therapy for treating malignant tumors
BR112018007304A2 (en) * 2015-10-15 2018-10-23 Agios Pharmaceuticals Inc Combination therapy for treatment of malignancies
MA43848A (en) * 2015-10-21 2018-11-21 Neuform Pharmaceuticals Inc DEUTERATED COMPOUNDS FOR THE TREATMENT OF MALIGNANT HEMOPATHIES, ASSOCIATED COMPOSITIONS AND PROCEDURES
IL299563A (en) 2015-12-04 2023-02-01 Agios Pharmaceuticals Inc Methods of treatment of acute myeloid leukemia characterized by the presence of a mutant allele of idh2 and the absence of a mutant allele of nras
WO2017140758A1 (en) 2016-02-19 2017-08-24 Debiopharm International S.A. Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers
EP3419593B1 (en) 2016-02-26 2022-03-23 Celgene Corporation Enasidenib for use in the treatment of relapsed or refractory acute myeloid leukaemia
JP7093764B2 (en) * 2016-08-03 2022-06-30 セルジーン コーポレイション How to treat myelodysplastic syndrome
US20180042930A1 (en) 2016-08-03 2018-02-15 Celgene Corporation Methods of treatment of malignancies
SG11201901873PA (en) * 2016-09-07 2019-03-28 Celgene Corp Tablet compositions
ES2924500T3 (en) 2017-01-22 2022-10-07 Chia Tai Tianqing Pharmaceutical Group Co Ltd 1,3,5-triazine derivative salt, crystal, preparation method, pharmaceutical composition and use thereof
JP2020518629A (en) * 2017-05-05 2020-06-25 メモリアル スローン ケタリング キャンサー センター How to treat myeloproliferative tumors
SG11201913008TA (en) 2017-06-30 2020-01-30 Celgene Corp Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-doxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide
CN109467538A (en) 2017-09-07 2019-03-15 和记黄埔医药(上海)有限公司 The heteroaryl cyclics and application thereof that cycloolefin replaces
US20210403452A1 (en) * 2018-11-02 2021-12-30 Celgene Corporation Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol
WO2020092915A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Solid dispersions for treatment of cancer
US20220017490A1 (en) 2018-11-02 2022-01-20 Celgene Corporation Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof
EP4058028A1 (en) 2019-11-14 2022-09-21 Celgene Corporation Pediatric formulations for treatment of cancer
CN114773320A (en) * 2022-05-29 2022-07-22 重庆医科大学 1,3,5-triazine compound, preparation method and application thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2390529A (en) 1942-02-03 1945-12-11 Ernst A H Friedheim Hydrazino-1,3,5-triazino derivatives of substituted phenylarsenic compounds
JPS58186682A (en) 1982-04-27 1983-10-31 日本化薬株式会社 Dyeing of cellulose or cellulose containing fiber material
DE3512630A1 (en) 1985-04-06 1986-10-23 Hoechst Ag, 6230 Frankfurt METHOD FOR COLORING OR PRINTING CELLULOSE FIBERS OR CELLULOSE MIXED FIBERS
ATE130882T1 (en) 1990-07-12 1995-12-15 Ciba Geigy Ag METHOD FOR THE PHOTOCHEMICAL AND THERMAL STABILIZATION OF POLYAMIDE FIBER MATERIALS.
JPH11158073A (en) 1997-09-26 1999-06-15 Takeda Chem Ind Ltd Adenosine a3 antagonist
US6274620B1 (en) 1999-06-07 2001-08-14 Biochem Pharma Inc. Thiophene integrin inhibitors
WO2003037346A1 (en) * 2001-10-31 2003-05-08 Cell Therapeutics, Inc. 6-phenyl-n-phenyl-(1,3,5) -triazine-2,4-diamine derivatives and related compounds with lysophphosphatidic acid acyltransferase beta (lpaat-beta) inhibitory activity for use in the treatment of cancer
US7205298B2 (en) 2002-07-18 2007-04-17 Janssen Pharmaceutica N.V. Substituted triazine kinase inhibitors
EP2152676B1 (en) 2007-04-30 2013-04-03 ProMetic BioSciences Inc. "triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives"
GB0805477D0 (en) 2008-03-26 2008-04-30 Univ Nottingham Pyrimidines triazines and their use as pharmaceutical agents
AU2010259002B2 (en) * 2009-06-08 2014-03-20 Nantbio, Inc. Triazine derivatives and their therapeutical applications
CA2767008C (en) * 2009-07-07 2018-01-30 Pathway Therapeutics, Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
AU2013207289B2 (en) * 2012-01-06 2017-09-21 Les Laboratoires Servier Therapeutically active compounds and their methods of use
IN2014MN01897A (en) 2012-03-09 2015-07-10 Carna Biosciences Inc
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
CA2917592A1 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as idh2 mutants inhibitors for the treatment of cancer
TWI666208B (en) 2013-08-02 2019-07-21 美商阿吉斯藥品有限公司 Therapeutically active compounds and their methods of use
AU2015324158A1 (en) * 2014-09-29 2017-04-13 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
WO2016126798A1 (en) 2015-02-04 2016-08-11 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use

Also Published As

Publication number Publication date
TWI701242B (en) 2020-08-11
US20210155603A1 (en) 2021-05-27
TWI666208B (en) 2019-07-21
US20160194305A1 (en) 2016-07-07
AU2014295938B2 (en) 2018-07-19
WO2015017821A3 (en) 2015-04-09
AU2014295938A1 (en) 2016-02-18
NZ716226A (en) 2021-08-27
TW201932455A (en) 2019-08-16
AU2018247242B2 (en) 2020-03-12
EP3932408A1 (en) 2022-01-05
MY177994A (en) 2020-09-28
SG10201709187TA (en) 2017-12-28
PE20160840A1 (en) 2016-09-22
JP2019142930A (en) 2019-08-29
NI201600022A (en) 2016-03-16
EA201690322A1 (en) 2016-07-29
EP3027193A2 (en) 2016-06-08
CA2919382A1 (en) 2015-02-05
EA030428B1 (en) 2018-08-31
CL2017002240A1 (en) 2018-04-20
CN110372670A (en) 2019-10-25
US20240132474A1 (en) 2024-04-25
US10730854B2 (en) 2020-08-04
TW201524971A (en) 2015-07-01
CL2016000263A1 (en) 2016-08-19
SA516370523B1 (en) 2019-01-10
EP3566706A1 (en) 2019-11-13
US9738625B2 (en) 2017-08-22
US10093654B2 (en) 2018-10-09
WO2015017821A2 (en) 2015-02-05
EP3566706B1 (en) 2021-07-14
JP6742905B2 (en) 2020-08-19
MX2016001361A (en) 2016-06-14
US20170305885A1 (en) 2017-10-26
BR112016002287A2 (en) 2017-08-01
AU2018247242A1 (en) 2018-11-01
IL243833A0 (en) 2016-04-21
UA121021C2 (en) 2020-03-25
JP2016527279A (en) 2016-09-08
US20180370951A1 (en) 2018-12-27
CN105916507A (en) 2016-08-31
CN110386922A (en) 2019-10-29
ES2886211T3 (en) 2021-12-16
EP3027193A4 (en) 2017-04-26
CN110372670B (en) 2023-04-07
PH12016500164A1 (en) 2016-04-25
JP2021176893A (en) 2021-11-11
IL270347B (en) 2021-08-31
MX2020011397A (en) 2022-08-05

Similar Documents

Publication Publication Date Title
IL270347B (en) Therapeutically active compounds and their methods of use
ZA202100373B (en) Therapeutically active compounds and their methods of use
HK1217948A1 (en) Therapeutically active compounds and their methods of use
HK1203942A1 (en) Therapeutically active compounds and their methods of use
HK1204319A1 (en) Therapeutically active compounds and their methods of use
HK1223924A1 (en) Therapeutically active compounds and their methods of use
HK1223913A1 (en) Substituted benzamides and methods of use thereof
IL253796A0 (en) Therapeutically active compounds and their methods of use
IL251246A0 (en) Therapeutically active compounds and their methods of use
GB201320729D0 (en) Therapeutic compounds and their use
EP3024824A4 (en) Therapeutically active compounds and use thereof
EP2999474A4 (en) Therapeutic and method of use
HUE067381T2 (en) Dosage forms and therapeutic uses of l-4-chlorokynurenine
GB201311361D0 (en) Compounds and their therapeutic use
GB201308736D0 (en) Compounds and their therapeutic use
GB201317804D0 (en) Therapeutic compounds and their use
GB201316173D0 (en) Compounds and their therapeutic use
GB201307677D0 (en) Compounds and their therapeutic use