RU2575549C2 - Preset liquid drug dose injector (versions) - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: group of inventions refers to medical equipment, namely to devices for injection of a preset dose of a liquid drug, e.g. for injection of equal, fixed doses of a medicinal preparation or for injection of a limited amount of various doses of the medicinal preparation. The injector comprises a container of variable volume having an outlet, dose setting unit, injection unit, driving element, guide unit and power supply. The injection unit provides injecting a preset dose and comprises a rod toothed on at least one piece and configured to reduce a container volume. The driving element is configured movable in relation to the rod when setting a dose and transmitting a driving force onto the rod when injecting a medicinal preparation, and comprising a mating component for mating with the above rod. The guide is configured to rout the driving element and/or above rod. The power supply is functionally connected to the dose setting unit and injection unit and applicable to store and release power to actuate propulsion and rotation. When actuating the dose setting unit for the purpose of setting a dose, the mating component extends behind a tooth on the rod by means of a combined propulsion/rotation. In the second version, the injector also comprises a push button functionally connected to the dose setting unit and injection unit and configured axially movable between a first position with respect to the set dose, and a second position with respect to the actuation of the injection unit for the injection of the set dose. The actuation of the dose setting unit for the purpose of setting the dose effects as follows: the mating component extends behind the tooth on the above propulsion/rotation; the power supply accumulated power for the propulsion only released when the injection unit comes into action, and the push button switches from the second to first position.

EFFECT: increasing reliability and operational reproducibility of the above injector.

16 cl, 32 dwg

Description

Technical field

The invention relates to an injection device for injecting a fixed dose of a liquid drug (hereinafter referred to as the drug), for example for injecting the same, fixed doses of the drug or for injecting a limited number of different doses of the drug. More specifically, the invention relates to an injection device that minimizes the number of operations that must be performed by the user. This injection device is particularly effective when the user self-injects a liquid preparation, such as insulin, for diabetes.

State of the art

In some areas of therapy, the patient’s willingness to adhere to the prescribed course of treatment depends on the simplicity of the particular treatment regimen. For example, in many patients with type 2 diabetes, the disease is diagnosed at a relatively advanced age, when they are less likely to agree to a course of treatment that interferes too much with their normal lifestyle. Most of these people do not want to be constantly reminded of their illness; as a result, they do not want to deal with complex treatment regimens or waste time learning how to use inconvenient drug delivery systems.

Essentially, patients with diabetes should track fluctuations in glucose levels and minimize these fluctuations. A well-known agent for lowering glucose levels is insulin, which, in order to be effective, must be administered parenterally. Currently, subcutaneous injections are the most common method of administering insulin. Such injections were previously performed using a test tube and syringe; however, so-called injection devices, or injection pens, occupy an increasing market share. This is due, in particular, to the fact that for many people the use of such injection devices is easier, especially because they do not require the user to perform a separate filling operation before each injection.

In some known injection devices suitable for self-injection, the user must set the desired dose using the dose setting mechanism of the injection device, and then inject the previously set dose using the injection mechanism of the injection device. In such devices, the dose is variable, i.e. Before each injection, the user must determine the dose appropriate to the situation.

Other known injection devices are configured to inject a fixed dose at each actuation. In this case, the user must prepare the injection device by setting a fixed dose using the dose setting mechanism or the cocking mechanism of the device, and then administer this dose using the injection mechanism.

No. 4,973,318 describes a disposable syringe comprising a protective cap that is removably mounted to a first syringe housing element. The cap is configured to abut, being mounted on the first housing element, in the second housing element. The protective cap interacts with the first housing element so that the rotation of the cap relative to the second housing element causes the rotation of the first housing element relative to the second housing element. This relative rotation provides a variation in the set dose, i.e. a protective cap is used when setting the dose. However, in this case, the user, along with the operation of introducing the prescribed dose, must also perform the operation of its installation.

No. 5,674,204 describes a medication injection pen having a medication cartridge, a body assembly, and a cap. The housing unit contains a dose setting mechanism and a dose delivery mechanism, which are selectively disconnected and connected by respectively installing and removing a cap from a given injector handle. When the cap is attached to the injector, the user can easily set and adjust the set dose. When the cap is removed, the injector is ready for the introduction of a given dose. Thus, the installation / removal of the cap leads to the operation of the mechanism, which provides switching the handle-injector between the dose setting mode and the injection mode. In relation to this device, the user also needs to perform both the operation of setting the dose, and the operation of introducing the set dose.

US 7302948 describes an example from another field of medicine, a nasal applicator. In this applicator, the container with the drug can move forward and backward, depending on the cocking and actuation of the spring. The container with the drug is pushed back when a cap is attached to this applicator. A sharp stop during the movement of the container with the drug forward causes the piston to move, ejecting a dose of the drug through the exhaust nozzle.

No. 6,056,728 describes an injection device for automatically introducing a needle. It contains an intermediate chamber between the reservoir with the drug and the injection outlet for receiving a certain volume of the drug during preparation of the device for injection. The device has a rather bulky design, which reduces its attractiveness for carrying with you, for example, in a woman’s handbag.

It seems desirable to create an injection device that is easy to use and use which the patient could learn intuitively and easily. It is desirable, in particular, to create an injection device that allows you to enter a large number of doses of a liquid preparation and at the same time requiring the user to perform a minimum number of operations. It is also desirable to create an injection device that clearly shows the user when it is ready for injection and when the amount of the drug remaining in the tank is not enough to inject the full dose, after which the device automatically makes it impossible to further activate the injection mechanism. In addition, it is desirable to create an injection device having a compact design so that the user does not have the desire to leave him at home instead of carrying with him during the day.

Some well-known injection devices offer the so-called automatic administration of the drug. Such devices to ensure the supply of the piston in the tank use energy from an internal source (usually a spring). Automatic injection devices are designed to reduce the effort required by the user to remove the drug from the reservoir. An example of such a device is presented in US 5104380.

In a spring-loaded automatic injection device, in which, in preparation for injection, the mating component is axially discharged along the teeth of the piston rod, it is necessary to ensure that the spring is cocked and locked in response to the mating component engaging with the predetermined tooth on the piston rod. If this component engages with the specified tooth, but the spring was not blocked from being activated, the device will issue a dose at an undesirable moment. On the other hand, if the spring has been cocked and locked without the mating component engaging with the tooth on the piston rod, no dose will be given when the injection mechanism is activated.

Therefore, it seems desirable to create an automatic

an injection device, by using which the user is guaranteed that the dose is either set correctly, with the guarantee that it will not be displayed until the user activates the injection mechanism, or is not installed at all.

US 6193698 uses a spring to apply force to the button and hold the drive mechanism of the injection device in a proximal position. During the injection, the metering button and the drive mechanism are squeezed into a distal position. To prevent uncontrolled injections, the blocking element prevents the backward movement of the metering button and the drive mechanism to overcome the force exerted by the spring. To release the metering button, the user must press the shutter button, which becomes available only after manually installing two bushings in the "zero" position relative to one another.

With this in mind, it seems desirable to create an injection device that, after the injection, blocks the metering button in the distal position and which automatically releases the button and moves it along the axis back to the proximal position when the device is prepared for injection, so that the user can verify that the device.

EP 1304129 describes an injection device which comprises a mechanism for automatically locking the dose setting scale from unintentional injection after this scale has been retracted to set the dose. The locking mechanism provides a blocking pairing between the flexible fingers formed on the scale and the groove in the device body. These fingers must be able to withstand large compressive forces to prevent the scale from shifting in the event of improper or accidental use of the device.

US 2007/0135767 describes yet another example of an injection device that includes a mechanism for preventing accidental release of the release button.

It is also desirable to create an injection device that is free from the risk of unintentional actuation by the user to withdraw a dose of the drug when the device has a protective cap and which at the same time does not require a mechanical lock that can withstand heavy loads.

In addition, it is desirable to create an injection device that can be safely and effectively used and carried safely.

In the General case, in the manufacture of injection devices that contain a piston rod, configured to move the piston in the tank for removal from the reservoir of the drug, it is necessary that the piston rod is in conjunction with the piston throughout the injection. Otherwise, there is a risk that the amount of the drug injected by the user will be less than the specified value. However, for several reasons, it is undesirable for the drug to be pressurized in the reservoir when the user uses the injection device for the first time. Therefore, injection devices are often made, especially leaving a small gap between the piston rod and the piston, so that the rod has free play during transportation. For injection devices with a variable dose, the first time you use the device, the user sets a small dose and introduces it into the air. This provides initial preparation (“priming”) of the device, so that when setting the next dose, the user is confident in injecting the required amount of the drug, since the piston rod and piston are now connected. In some fixed-dose injection devices, the piston rod travels a considerable distance with each injection. If, in this case, the user first sets the dose and releases it into the air to prime the device, a significant amount of the drug may be lost. This is especially undesirable when the drug is expensive.

In connection with the foregoing, it is desirable to create an injection device with a fixed dose, the priming of which the user can perform without spending an almost complete dose of the drug.

Disclosure of invention

The invention is directed to the creation of an injection device for which the number of operations performed by the user is reduced in comparison with similar known injection devices.

Another problem solved by the invention is the creation of an injection device, the use of which the patient could learn intuitively and easily.

The next task is to create an injection device in which the procedure for setting the dose is simplified in comparison with similar known injection devices.

Another task is to create an injection device that gives the user clear signals about his readiness for an injection.

A further task is to create an injection device that gives the user clear signals when the amount of the drug remaining in the tank is not enough to ensure a full dose, and which automatically makes further use of the device impossible.

The next task is to create an injection device in which the injection means is automatically deactivated when the protective cap is on the device and automatically switches to the working state when the protective cap is removed. This reliably eliminates the risk that the user will inadvertently withdraw a dose of the drug inside the cap, for example, when he carries the device in his bag.

Another challenge is to create an injection device that automatically sets the correct dose, eliminating the risk of the user setting the wrong dose.

A further task is to create an injection device capable of injecting a given dose and performing priming, allowing the user to make the first withdrawal of the drug from the injection device when the volume of the drug being withdrawn is less than the specified dose.

In the following description will be disclosed various aspects and variations of the invention, providing a solution to the problems or tasks that will become clear from the description, including from consideration of specific options.

According to a first aspect of the invention, there is provided a mechanical injection device for injecting prescribed doses of a liquid drug. This device. contains a means for setting a dose, providing a dose setting, an injection means for conducting an injection of a prescribed dose, a removable cap and a receiving part made with the possibility of stop in the cap or pair with it when it is installed on the injection device. Moreover, the means for setting the dose is functionally connected with the receiving part in such a way that the installation of the cap on the injection device and / or its removal from the specified device provides the installation of a single dose of the means for setting the dose.

The injection device may, for example, relate to the type of devices that provide multiple installation and delivery of a given dose.

In the context of the invention, the term "mechanical injection device" should be interpreted as encompassing injection devices operated mechanically (manually), in contrast to injection devices equipped with drives.

The term "liquid preparation" should be interpreted as encompassing various drugs (drugs) in a liquid state, for example, in the form of a solution or suspension.

The term "target dose" means that when the means for setting the dose is triggered, a specific, fixed dose will be set, without the possibility of setting an arbitrary dose. However, the preset dose can be varied in the sense that it is possible to initially adjust the injection device to the selected dose, and the means for setting the dose will then set the selected dose at each of its activation. It should also be noted that the term "predetermined dose" does not exclude the presence of the priming function of the injection device before first use.

The injection device is preferably capable of multiple doses of a liquid preparation.

The dose setting agent is part of an injection device that is actuated during the dose setting process. Likewise, an injection agent is part of an injection device, the actuation of which enables the injection of a prescribed dose. The injection means often comprises a movable piston rod adapted to interact with the piston located in the cartridge containing the liquid preparation. In this case, the actuation of the injection means causes the piston rod to move in such a way that the piston moves inside the cartridge in a direction that displaces the liquid preparation from the cartridge through a needle capable of penetrating through the cartridge shell.

The injection device contains a removable cap, which can be configured to close the part of the injection device that carries the needle when this device is not used. Thus, the removable cap can protect the needle installed in the corresponding part of the device, eliminating the risk of needle sticks and preventing accidental removal of the liquid preparation. When it is desired to inject the dose, the cap can be removed and the part carrying the needle can be opened.

The receiving part is part of an injection device configured to receive and hold the removable cap when it is mounted on the injection device. It may comprise means for holding the cap, for example a bayonet connector, a threaded portion or a snap lock. The receiving part may receive the cap when it is mounted on the injection device to close the distal portion of this device. Alternatively, the receiving part may be configured to receive a cap mounted on the proximal portion of the injection device.

The means for setting the dose is functionally associated with the receiving part, i.e. the execution of the receiving part of certain operations affects the means for setting the dose. More specifically, the dose setting means and the receiving part are connected in such a way that the installation and / or removal of the cap results in a dose setting by the dose setting means. The means for setting the dose and the receiving part can be connected mechanically, directly or through one or more intermediate parts, or in any other suitable way, provided that certain operations performed by the receiving part affect the means for setting the dose, leading to the setting of the dose. So, the dose can be set when installing the cap or when removing it. Alternatively, part of the dose setting process can be performed when the cap is installed, and the rest of the process later when the cap is removed. In any case, the cycle of operations involving the installation and removal of the cap leads to the fact that the dose will be set by the means for setting the dose, preferably automatically.

As a rule, while the injection device is not used, a removable cap is inserted into the receiving part, preferably covering the part of the device carrying the needle or nozzle opening. When it is desired to inject, by means of an injection device, the dose of the drug, the cap is removed. After the dose has been injected, the cap is again mounted on the receiving part. Therefore, each new injection following the previous one is accompanied by the installation and removal of the cap. Since the means for setting the dose and the receiving part are connected as described above, such a cycle of installation / removal of the cap automatically leads to the fact that the dose will be set. Therefore, when the user removes the cap to inject the dose, the dose is already set and the user does not need to perform additional operations to set the dose. This reduces the number of operations performed by the user. In addition, since the dose is set automatically, the risk of errors during dose setting is reduced.

In accordance with one particular embodiment of the invention, an injection device for injecting a fixed dose of a liquid preparation is provided, comprising a dose setting means, an injection means for administering a fixed dose injection, a removable cap and a receiving part configured to abut or pair with the cap when mounted on injection device. Moreover, the means for setting the dose is functionally connected with the receiving part in such a way that the installation of the cap on the injection device and / or its removal from the specified device ensures the installation of a single dose of the means for setting the dose.

In the context of the invention, the term "setting a single dose" should be interpreted in accordance with the above explanation, i.e. when installing the cap on the injection device and / or removing it from the specified device, the dose setting means sets one dose, which can be withdrawn when the injection means is triggered. Thanks to this embodiment, it is impossible to sequentially inject two doses without completing the installation and removal of the cap. This gives the device a safety feature, since if it is possible to repeatedly administer a dose, for example of the same dose, without performing a cap installation / removal cycle, the user would have to count the number of injections that were triggered. This could lead to confusion and uncertainty regarding the actual dose administered.

The means for setting the dose can set the dose in response to the essentially linear (translational) movement of the cap, i.e. to trigger the means for setting the dose, the movement of the cap may have a substantially linear component. According to this embodiment, the cap is mounted and / or removed by means of essentially linear motion. In this case, the cap is preferably held in position by means of a latch based on the coordination of the dimensions of the parts, bayonet lock or similar means. In this embodiment, the cap during its movement during installation or removal can move essentially in the axial direction, the corresponding element, the movement of which can lead to the installation of the dose, for example under the action of energy stored in the spring component, and / or due to axial movement release button.

Alternatively or additionally, the dose setting means may set the dose in response to the rotational movement of the cap, i.e. to trigger the means for setting the dose, the movement of the cap may have a rotational component. According to this embodiment, the cap is mounted and / or removed by means of a movement that is at least partially rotational, for example a purely rotational or spiral movement. In this case, the cap may be held on the receiving part by means of a threaded connection, a bayonet lock or the like. Only the rotational component of the movement can be responsible for setting the dose, for example, forcing the corresponding element of the injection device to rotate. Thus, the rotational component of the operation of installing or removing the cap can provide rotation of the corresponding element if the cap is fixed by means of a bayonet lock. It is also possible that the cap is installed by means of a substantially linear movement, with its passage beyond the threaded section, and when removed, the cap must be rotated to pass through the threaded section. In this case, it is the rotational component of this movement that can be effectively used to set the dose. The advantage of this embodiment is that the dose will be established only immediately before its intentional injection, i.e. you will not need to carry a cocked injection device in your pocket or purse. This will minimize the risk of accidental, early withdrawal of the prescribed dose in the cap. However, the same effect can be achieved by a suitable blocking mechanism that prevents the injection of a prescribed dose until the cap is removed.

An alternative to purely rotational motion is a combination of linear and rotational motions, i.e. dose setting means for setting the dose can be initiated by a spiral motion.

In a specific embodiment of the invention, the installation of the cap on the injection device causes the element interacting with it to move along the axis relative to the piston rod, shifting the conjugated component along the rod in the proximal direction. Thus, at each dose setting, by installing the cap on the injection device, this conjugate component moves ever further along the piston rod to its proximal end.

According to one embodiment of the invention, there is provided an injection device for injecting a predetermined dose of a liquid preparation containing a proximal part and a distal part opposite it, a cartridge for placing a liquid preparation in it and containing a movable piston, a dose setting means, an injection means providing an injection the established dose and containing the piston rod, providing discrete movement of the piston inside the cartridge, with each discrete change schenie corresponds to the set dose, a removable cap adapted to cover the distal part of the injection device, and a receiving part adapted to abut a cap or conjugation with it when it is mounted on the injection device. Moreover, the means for setting the dose is functionally connected with the receiving part in such a way that the installation of the cap on the injection device and / or its removal from the specified device provides the dose setting by the means for setting the dose. Since the drug is removed from the reservoir in the distal part of the injection device, a removable cap is able to close and protect the outlet channel.

The injection device may further comprise energy supply means associated with the dose setting means and the injection means so that energy is stored in the energy supply means during the dose setting and the stored energy is released by the dose injection, thereby providing an injection. The energy supply means may be a spring component configured to be cocked by axial action, for example by compressing or stretching a spring. The spring component may be a compressible or torsion spring. If it is a compressible spring, the injection device can function effectively as follows. When the cap is inserted into or removed from the receiving part, the component compressing the spring is driven (preferably along the axis) and compresses the spring. After this, the specified component is locked in this position, holding the spring in a compressed state. When the injection needle is inserted into the selected injection zone, press the shutter release button. This causes the component compressing the spring to move out of its blocking position, and the energy stored in the spring is released in such a way that it moves the piston rod, which presses the cartridge piston in the forward direction, allowing the dose to be removed from the cartridge through the injection needle.

According to a second aspect of the invention, there is provided an injection device comprising a housing, a dose setting means, an injection means providing an injection of a predetermined dose and comprising a rod with teeth, at least on one of its parts, a drive component configured to move relative to said rod the time of setting the dose, as well as the transmission of the drive force to the specified rod during the injection and containing a mating element designed to interface with the specified current guiding means configured to guide movement of the actuating member and / or said rod, and energy supply means operatively associated with the means for the dose setting and injection means and adapted to store and release energy for translational and rotational motion.

The drive component may be coupled to the power supply means such that, as a result of the movement of the drive component, the power supply means stores and / or releases energy and, conversely, the release of energy by the power supply means drives the drive component. The energy supply means may comprise a compressible spring in which a rotational stress is preliminarily created in order to act on the drive component to give it rotation in a certain direction.

When the dose setting means is actuated to set the dose, the drive component will move relative to the piston rod, as a result of which the mating element will be disengaged from the tooth on the rod and advanced along it with the passage for the next tooth in the proximal direction. This relative movement is guided by a guiding means, which may form part of the housing or be a separate element associated with the housing. When, after this, the injection means is activated to inject the set dose, the mating element will mesh with the tooth that it just passed, and the drive component will move distally relative to the body, forcing the rod to be moved. This movement is also guided by a guiding means.

In the context of the invention, the expression “dose setting means is actuated to provide a dose setting” should be interpreted as meaning that the dose setting means that has been activated actually sets the dose. As will become clear from the following description, simply bringing the means for setting the dose does not necessarily lead to setting the dose.

Further, in the context of the invention, the term "tooth" should be interpreted as meaning any structurally irregular transverse member of the stem (including both a protrusion and a recess) capable of engaging with the mating member and allowing mutual axial movement of the stem and mating member.

In one embodiment of the invention, the guiding means comprises a structure that allows the drive component and the shaft provided with teeth to perform a purely translational relative displacement during one part of their relative displacement and a combined translational / rotational relative displacement during the other part of this displacement. In this particular embodiment, the guiding means is provided with a first, longitudinal guiding surface substantially parallel to said rod and providing a purely translational relative movement of the drive component and the rod. The guiding means is further provided with a second, inclined guiding surface, which is connected to the first guiding surface at the transition point and which provides a combined translational / rotational relative movement of the drive component and the rod. The second and first guide surfaces preferably form an angle between 180 ° and 270 °, preferably between 225 ° and 270 °, more preferably between 240 ° and 270 °. In any case, the angle between the first and second guide surfaces and the size of the second guide surface, within which the indicated movement is possible, are two parameters that must be coordinated so that when the drive component passes along the second guide surface during dose setting, this component and the rod made a combined translational / rotational relative movement, during which the mating element passes by a tooth on the rod.

The energy supply means may comprise a compressible spring in which rotational stress is preliminarily created in order to provide a constant force to the drive component, which tends to rotate it in a certain direction. In the spring, stress can also be created by axially compressing it so that it constantly acts on the drive component in the distal direction. As a result, when the drive component extends along the first guide surface of the guide means, an axial force acts on it from the side of the spring, tending to displace it distally inside the injection device. Thus, during dose setting, the drive component can pass along the first guide surface, overcoming the force of the spring, while during injection it can pass along this surface under the action of the spring. Moreover, when the drive component passes along the first guide surface, the rotational force of the spring may act on it. However, during the passage along the first guide surface, the drive component cannot rotate under this force due to the fact that the first guide surface is oriented longitudinally and substantially parallel to the stem.

The transition point defines the place where the first and second guide surfaces meet, i.e. the point at which the drive component moves from movement along the first guide surface to movement along the second guide surface, or vice versa. When the drive component passes along the second guide surface, axial and rotational forces generated by the spring can act on it. Since the second guide surface is inclined, these forces make possible the combined translational / rotational movement of the drive component relative to the rod. During dose setting, the drive component can pass along the second guide surface under the action of the rotational force of the spring, but with overcoming its axial force. During the actuation of the injection means, the drive component can pass along the second guide surface, overcoming the rotational force of the spring.

The spring parameters and the angle of inclination of the second guide surface are preferably matched so that the rotational force of the spring is capable of moving the drive component along the second guide surface to overcome the axial force generated by it.

The guiding means is preferably provided with a abutment surface adapted to stop the combined translational / rotational movement of the drive component when it comes to a position in which the mating element has just passed the tooth on the tooth-provided rod. In this position, the spring is cocked and locked in response, since the rotational force created by it is able to overcome its axial force and thereby keep the drive component in a stable stationary state.

The guiding means is preferably also provided with a thrust surface adapted to stop the translational movement of the drive component during the injection, thereby indicating the end of the dose delivery, i.e. to the position of the drive component corresponding to the end of the elimination of the established dose. The actual dose can be determined by the distance between two adjacent teeth on the stock. This distance exceeds the axial movement of the drive component along the first guide surface of the guide means, but less than the total axial movement of the drive component after activation of the injection means, i.e. smaller than the total axial dimension of the first and second guide surfaces. Alternatively, the actual withdrawal dose may be determined by the total axial distance that the drive component travels after the injection agent is activated.

The described embodiment is particularly effective because when the user actuates the dose setting means to set the dose, the last part of the dose setting operation can be performed automatically by the injection device. This is achieved by the fact that during the first part of the dose setting, the user manually activates the dose setting means to move the drive component proximally along the first guide surface, overcoming the linear force of the spring. If the spring is pre-applied with rotational stress, it creates a force that constantly acts on the drive component and therefore is able to press it against the first guide surface. Therefore, while the drive component is guided by the first guide surface, it cannot rotate and therefore performs a purely translational motion, while the mating element slides along the stem. When the user moves the drive component proximally so far that it reaches the transition point at the junction of the first and second guide surfaces, the rotational force of the spring can begin to deploy the drive component and force it to pass along the second guide surface until it stops, reaching the abutment surface. Since the second guide surface is inclined, the drive component will perform a combined rotational / translational motion relative to the rod. The configurations of the first and second guide surfaces can be such that the distance along the axis that the drive component travels from the transition point to stop at the abutment surface allows the mating element to move from a position immediately below (distal) relative to a specific tooth on the rod to a position directly above (proximally ) relative to this tooth. This ensures that when the injection means is actuated, the mating element will be able to mesh with this tooth and thereby provide for axial forced movement of the stem towards the distal end of the injection device. While the drive component is moving along the second guide surface, the spring can release rotational energy while simultaneously storing translational energy. In this case, when the drive component stops at the abutment surface, the spring will be charged and locked from the release of energy until the next injection means activation.

The dose setting means preferably operates in such a way that while the drive component passes along the first guide surface, the dose is not set, so that if the user stops exposing the dose setting means before the drive component reaches the transition point, the translational force of the spring can return drive component to the starting point, i.e. to the end position of the dose. However, if the dose setting means is moved so that the drive component reaches the transition point, the remainder of the dose setting can be controlled by a spring, which ensures that the dose is actually set, i.e. that the mating element will actually pass beyond the required tooth on the rod and that the drive component will be fixed in a state from which it cannot be removed until the injection means is actuated. Thus, the last part of the dose setting process is performed automatically by the injection device, and the user has no way to intervene in this process.

When the user actuates the injection means to inject the set dose, the drive component may first be forced to move along the second guide surface, overcoming the rotational force of the spring. At some point during this movement, the mating element will engage with the tooth on the stem. When the drive component reaches the transition point, the translational force of the spring can move the drive component and stem distally along the axis until the drive component comes into contact with the abutment surface.

A serrated rod may be operatively coupled to the reservoir of the injection device containing the preparation such that the distance along the axis that the rod passes correlates with the dose actually withdrawn from the reservoir. This tank can be made rigid, for example, in the form of a cartridge containing a piston movable along the axis, and the specified rod can be functionally connected to the tank through the piston. Alternatively, the tank may be flexible, i.e. capable of undergoing controlled deformation when the rod moves along the axis of the injection device. In any case, the axial movement of the rod can lead to a decrease in the volume of the reservoir containing the drug, in accordance with the displayed dose.

The dose setting means may be actuated by pushing the metering button out of the housing in the proximal direction. Alternatively, the agent may be actuated as follows. The injection device may further comprise a removable cap and a receiving part configured to contact or mate with the cap when it is mounted on the injection device. The means for setting the dose can be functionally connected with the receiving part so that the installation of the cap on the injection device will force the drive component to move along the axis of the rod, and in this movement it will be guided by means of supplying energy and geometry of the guiding means, as described above. In this particular embodiment, the installation of the cap on the injection device provides automatic dose setting. The guide means can be configured so that with each installation of the cap on the injection device, the drive component moves proximally at the same distance, and with each activation of the injection means, at the same distance distally. In this case, the injection device is a fixed dose device. However, alternatively or additionally, the guiding means and / or the rod can be configured to allow pre-calibration, before setting the dose, the position corresponding to the zero dose. This will allow you to implement a device that produces a variable dose, capable of issuing a limited number of different dose options for the drug. This option can be implemented, for example, by introducing means for adjusting the axial dimension of the first guide surface.

The energy supply means may comprise a compressible spring in which rotational stress has been previously created, as described above. However, you can use another suitable means of supplying energy, for example in the form of two or more springs, each of which is able to provide the energy necessary for translational and rotational motion. So, you can use a compressible spring to provide energy for the implementation of translational motion, and a torsion spring to provide energy for the implementation of rotational motion, a torsion bar, compressible in the axial direction, or a device based on a tension spring.

According to a third aspect of the invention, there is provided an injection device for injecting predetermined doses of a liquid preparation, comprising a dose setting means, an injection means providing an injection of a predetermined dose and comprising a rod with teeth in at least one of its parts, and a drive component configured to movement relative to the specified rod during dose setting and transmission of the drive force to the specified rod during injection. In this case, the injection device is equipped with a priming means enabling the user to prime the injection device without removing a substantially complete predetermined dose.

The priming means can be implemented using a guide means described in the context of the second aspect of the invention and containing a second longitudinal guide surface. This second longitudinal guide surface may be identical to the abutment surface configured to stop the movement of the drive component along the inclined guide shelf during dose setting. Alternatively, it may be another longitudinal surface physically connected to an inclined guide surface. In any case, the second longitudinal guide surface is preferably connected to the support shelf in such a way that prior to the first practical use of the injection device by the user, for example, when the injection device comes from the manufacturer, the drive component rests on the support shelf. In this case, when the user first injects the injection means, the drive component is automatically moved along the second longitudinal guide surface when it comes to a position on the inclined guide shelf. If the injection device further comprises an energy supply means operably coupled to the dose setting means and the injection means for storing and releasing energy to provide translational and rotational movement, then when the user first drives the injection means, the energy supply means may be activated to effect the initial movement of the drive component.

The longitudinal dimension of the second longitudinal guide surface is smaller than the longitudinal dimension of the first guide surface that guides the drive component between the transition point and the dose end position. This means that the initial axial movement of the drive component will be less than its axial movement during normal injection. In other words, since the drive component forces the rod during the injection, the first time the injection means is activated, the rod moves along the axis by a smaller distance than the subsequent activation of this means, which leads to the delivery of the set dose. Thus, it is possible to perform priming of the injection device without spending the drug in an amount approximately equal to a predetermined dose.

The injection device may be provided with a safety tape that the user can remove to perform priming. The safety belt may, for example, be located at the distal end of the housing or simply distal to the release button. Alternative to activating priming by pressing the shutter button, priming can be activated by turning the shutter button clockwise or counterclockwise to a certain angle to move the slider (slider) from the starting position on the shelf.

According to a fourth aspect of the invention, there is provided a mechanical injection device for injecting fixed doses of a liquid preparation, comprising a dose setting means for setting a dose, an injection means for administering a fixed dose injection, a release button operably connected to the dose setting means and the injection means, and with the possibility of axial movement between the first position corresponding to the set dose and the second position, corresponding which activates the injection means for injecting the prescribed dose; and a holding means for holding the release button in the second position when the injection means is actuated in order to inject the prescribed dose. As a result, when the user moves his finger away from the release button after the injection, it remains in the second position. This will indicate to the user that the injection device is not yet ready for the next injection.

In this context, the expression "second position corresponding to the actuation of the injectable agent for administering the prescribed dose" should be interpreted as meaning the position in which the injectable agent has been activated to a degree sufficient to complete the injection of the prescribed dose.

The injection device comprises a proximal part and an opposing distal part and preferably has an elongated shape defining an axis that virtually connects the proximal and distal parts. In this context, expressions of the type “element moving along the axis” or “element moving along the axis” should be interpreted as characterizing an element that is capable of moving exactly along the specified axis of the injection device.

The restraining means may be operatively coupled to the dose setting means such that when the dose setting means is activated to set the dose, the holding means is automatically deactivated. This will allow the release button to move from the second position back to the first position. In a specific embodiment, when the means for setting the dose is activated to set the dose, the release button automatically moves from the second to the first position. As a result, the user is instructed that the injection device is ready for the injection.

The second position may correspond to a position in which the release button is fully recessed into the housing or pressed against it and in which only the upper part or the pressing surface of the release button is visible and / or accessible for pressing by the user. On the contrary, the first position may be a position in which the release button clearly protrudes from the housing. The axial distance that it travels between the first and second positions is large enough so that it can be easily distinguished whether the injection device is ready for injection or not.

When the dose setting means is actuated to set the dose, the release button can be moved from the second to the first position by a force transmitting component in contact or mating with the release button so that the translational, rotational or spiral movement of the component causes the release button to move. The release button can move between the first and second positions, essentially linearly (translationally), i.e. without rotation. Alternatively or additionally, this movement may include the rotation of the release button.

The holding means that locks the shutter release button in the second position when the injection tool is actuated to inject the set dose can create a simple friction pairing between the shutter release button and the case or force transmitting component, for example, between the outer surface of the release button and the inner surface of the case. Alternatively or additionally, the holding means may interface between the release button and the housing or the force transmitting component by matching the dimensions of the mating components. The shutter release button may include a latch for interlocking with the locking structure on the housing, for example, on its inner surface. Alternatively, the housing may include a latch for interlocking with the locking structure on the release button. During the injection, when the shutter release button comes to the second position, the latch engages with the locking structure and holds the shutter release button away. When actuating the dose setting means, the pairing can be eliminated by another force transmitting component that moves the latch away from the locking structure.

The means of supplying energy can act on the shutter button, trying to shift it to the first position. In this case, the deactivation of the holding means may lead to the automatic release of energy by the energy supply means for moving the release button to the first position. In one embodiment, the energy supply means comprises a spring which is compressed during an injection as a result of the release of the shutter button from the first to the second position. Deactivating the holding means when the dose setting means is activated to set the dose causes the spring to push the release button back to the first position. This will indicate that the dose is set appropriately and that the injection device is ready for injection.

In a specific embodiment, an injection device for injecting a fixed dose of a liquid preparation is provided, comprising a reservoir for containing a liquid preparation and containing a movable piston, a dose setting means for setting a dose, an injection means for administering a set dose and containing a piston rod, providing discrete movement of the piston inside the tank, and each discrete movement corresponds to a set dose, and a trigger button y, functionally associated with the means for setting the dose and with the injecting means and made with the possibility of axial movement between the first position corresponding to the set dose (and the readiness of the injection device for injection) and the second position corresponding to actuating the injection means for carrying out the injection doses. The device also contains a holding means for holding the push button in the second position when the injection means is actuated in order to inject the set dose, a removable cap and a receiving part adapted to abut the cap or pair with it when it is mounted on the injection device. In this case, the means for setting the dose is functionally connected with the receiving part in such a way that installing the cap on the injection device and / or removing it from the specified device forces the means for setting the dose, essentially at the same time as setting the dose, to deactivate the holding means and to release the release button from second to first position.

In another embodiment, the injection device comprises a variable volume reservoir, a dose setting means, an injection means providing an injection of a predetermined dose and comprising a rod with teeth, at least on one of its parts, configured to reduce the volume of the reservoir, a drive component made with the ability to move relative to the specified rod during dose setting and transmission of the drive force to the specified rod during injection, a removable cap, the receiving part, flush with the possibility of stopping in the cap or pairing with it when it is installed on the injection device, the release button, functionally connected with the means for setting the dose and with the injection means and made with the possibility of axial movement between the first position corresponding to the established dose (and the readiness of the injection device to injection), and a second provision corresponding to the actuation of the injection agent for the injection of the prescribed dose. The device also comprises means for supplying energy, functionally connected with the means for setting the dose and with the injection means and designed to store and release energy to ensure translational and rotational motion. Moreover, the piston rod contains a structural element designed to interface with the drive component in order to prevent rotation of the drive component when actuating the dose setting means when the amount of the drug remaining in the tank is not sufficient to provide a full dose. This provides an indication of the exhaustion of the contents of the device.

In this embodiment, when the piston moves to a position where an insignificant or insufficient amount of the drug remains in the reservoir, the drive component will still be able to move along the axis of the piston rod during dose setting, but is blocked from rotation with respect to the piston rod. In the event that the installation of the cap on the injection device acts on the means for setting the dose, causing the drive component to move relative to the piston rod, the installation of the cap on the injection device remains possible. However, only translational movement will not lead to a dose setting, so that the device will not be able to be used for further injections.

As described above, the shutter release button can be automatically moved from the second to the first position when the dose setting means is activated to set the dose. However, when the dose setting tool is triggered without actually setting the dose, the shutter button will not go into the first position, and this situation will indicate to the user installing the cap on the receiving part after injecting the last dose that there are no more doses left in the injection device.

The structural element on the piston rod may be a protrusion, for example in the form of a hammer head or other shape, suitable for interfacing with the drive component to prevent rotation of the drive component with respect to the piston rod. If the piston rod is provided with teeth, this element is preferably located at the proximal end of the rod in order to fix the drive component from rotation after passing and activating the most proximal tooth on the piston rod.

According to a fifth aspect of the invention, there is provided an injection device comprising a blocking mechanism preventing an established dose from being injected. Such a mechanism is preferably used to prevent accidental, early withdrawal of the established dose, for example, before the needle or discharge nozzle is properly positioned (positioned) in the desired injection zone. This embodiment is especially effective when the installation of the cap causes the means for setting the dose to set the dose, since in this case some time will elapse between the setting of the dose and its injection, during which it may be necessary to carry the injection device, for example in a pocket or purse.

The locking mechanism can be activated automatically when the cap is installed on the injection device. According to this embodiment, it is desirable that the installation of the cap leads to both dose setting and activation of the blocking mechanism. Alternatively, this mechanism may be actuated manually and / or independently. For example, it can be automatically activated by other actions, and not by installing a cap.

Thus, according to one embodiment, there is provided an injection device for injecting a fixed dose of a liquid preparation, comprising a variable volume reservoir into which a liquid preparation can be placed, a dose setting means, an injection means for conducting a fixed dose injection, a removable cap and a receiving part made with the possibility of emphasis in the cap or pair with it when it is installed on the injection device. At the same time, the injection agent is functionally connected with the receiving part in such a way that it is deactivated by installing the cap on the injection device, thereby preventing the removal of the drug from the reservoir. This embodiment is effective because it eliminates the risk of the user inadvertently activating an injection agent, for example, when carried in a pocket or purse.

In one embodiment, the blocking mechanism must be switched to a non-blocking state prior to the injection. This switching can be carried out manually and / or as a separate operation. Alternatively, the blocking mechanism is automatically deactivated when the cap is removed from the injection device. If the installation of the cap activates the blocking mechanism, and the removal of the cap switches it to a non-blocking state, the cap can be considered as part of the blocking mechanism. This option is highly safe, since the blocking mechanism is activated and deactivated automatically, so the user does not need to think about it, i.e. to remember to activate / deactivate the blocking mechanism.

The reservoir may be a rigid cartridge containing a piston movable along the axis, or it may be a flexible reservoir providing a controlled reduction in volume. The injection means may comprise a piston rod that is movable along the axis and capable of acting on the reservoir directly or through a component associated with it, in order to reduce the volume of the reservoir, thereby removing the preparation from it. The installation of the cap on the receiving part can act on the injection agent directly or indirectly, through the element associated with it. In any case, the cap, preferably its edge, mechanically acts on the injection agent in such a way that it cannot be activated even if the user applies a lot of force to the injection device.

The injection device may comprise a drive component capable of forcibly moving the piston rod during its axial forward movement, i.e. towards the distal end of the injection device. In this case, the cap, when mounted on the receiving part, can physically block the drive component in relation to the axial movement forward, for example by means of thrust surfaces. At the same time, the cap may allow rotational movement of the drive component.

In a specific embodiment, the injection device further comprises a guide means configured to direct the movement of the drive component and / or the specified rod, and a release button operatively associated with the means for setting the dose and the injection means and configured to axially move between the first position corresponding to the established dose, and the second position corresponding to the actuation of the injection means for the injection of the prescribed dose. In this case, the release button is capable of essentially seamlessly moving from the first to the second position and back to the first position when the cap is mounted on the injection device. In other words, with the cap installed on the device, the trigger button can be manipulated, for example, recessed into the housing. This embodiment allows you to get an injection device that is guaranteed from premature operation of the injection mechanism, without embedding a mechanical lock that can withstand significant forces exerted on the release button, for example, if the user plays with it, mishandles or drops.

If the guiding means comprises a first, longitudinal guiding surface and a second, inclined guiding surface, as described in the context of the second aspect of the invention, this means can be implemented by making the drive component so that part of it abuts against the edge of the cap when it is mounted on the injection device. As a result, the cap blocks the drive component from moving along the axis, thereby also preventing axial movement of the piston rod, i.e. removing the dose from the reservoir.

Brief Description of the Drawings

The invention will now be described in more detail with reference to the accompanying drawings.

Figure 1 is a longitudinal sectional view, in an unbroken state, of an injection device according to a first embodiment of the invention.

In Fig.2, the injection device of Fig.1 is presented in a longitudinal section, in a cocked state.

Figure 3 is a perspective view of an injection device according to a second embodiment of the invention.

Figure 4 is a perspective view of the injection device of Figure 3, some parts of which are removed.

Figure 5 shows a portion of the injection device of figures 3 and 4.

6 is a longitudinal sectional view showing an injection device according to a third embodiment of the invention.

Fig. 7 is a longitudinal sectional view showing an injection device according to a fourth embodiment of the invention.

On Fig in a perspective image, in longitudinal section shows the body of the injection device to show the guide means in detail.

9, the housing is shown in perspective in order to illustrate the position of the guide means in the housing.

10a and 10b show, respectively, the first and second sides of the piston rod of the injection device.

11, a perspective image shows a drive component of an injection device.

12 is a two-dimensional view of the guide means and the drive component, the drive component being shown in two different positions with respect to the guide means.

On Fig shows a two-dimensional representation of the guide means containing a support shelf, providing the possibility of priming.

On Fig in a perspective image presents the push button of the injection device.

On Fig in a perspective image shows the mating element of the injection device.

On Fig in a perspective image presents a means for securing the spring injection device.

On Fig in a perspective image presents a node containing a drive component, a spring and means for securing the spring.

Fig. 18 is a perspective view illustrating the functional relationship between the push button and the drive component.

Fig. 19 is a perspective view illustrating an injection device with the housing removed, illustrating the interaction between the drive component and the protective cap.

On Fig in longitudinal section presents a mechanism that works when the content in the injection device is exhausted.

On Fig in longitudinal section presents an injection device according to the fifth embodiment of the invention.

On Fig in a perspective image, in side view, shows the guide means.

On Fig guide means shown in a perspective image, in a view from the distal end.

On Fig in a perspective image shows a drive component.

On Fig in a perspective image shows a push button.

26 is a perspective view illustrating a functional relationship between a push button and a drive component.

On Fig presents a perspective image illustrating the interface between the drive component and the piston rod.

On Fig in a perspective image shows a node containing the piston rod, the drive component, the guide means and the spring, in a situation where the drive component is supported on the metering shelves of the guide means, which corresponds to the charged state of the injection device.

On Fig in a perspective image shows the mechanism of the injection device that is triggered when the contents of the device are exhausted.

On Fig in a perspective image shows the injection device with the housing removed to illustrate the interaction between the drive component and the protective cap.

On Fig in longitudinal section presents an injection device according to the sixth embodiment of the invention.

On figa-32c illustrates in detail the release mechanism of the push button of the injection device.

Similar elements in the drawings, as a rule, have similar designations.

The implementation of the invention

Figure 1 shows in longitudinal section an injection device 1 according to a first embodiment of the invention. In Fig. 1, this device is shown in an uninitiated state when the dose has not yet been established.

The injection device 1 comprises a housing 2, a cartridge holder 3 with a cartridge 4 installed in it, and a trigger (in particular a push) button 5. An injection needle 6 is fixed to the distal end of the cartridge holder 3. The piston rod 7 is mounted with a stop in the piston 8 located inside the cartridge 3; so that the movement of the piston rod 7 in the distal direction causes the movement of the piston 8 also in the distal direction, leading to the expulsion of the liquid preparation from the cartridge 4 through the injection needle 6.

After the user completes the injection, a cap is installed on the injection device 1 (not shown in FIG. 1), inserting it into the receiving part 9 to close the injection needle 6. When the cap is mounted on the receiving part 9, he clicks on the slider (slider) 10, displacing it in the proximal direction. This leads to compression of the spring 11 and to the storage, thereby energy in it, as well as to the movement of the latches 12 in the proximal direction, with the approach for the protrusions 13 made on the housing 2. The presence of the protrusions 13 ensures that the latches 12 are held in this position.

The slider 10 is connected to the piston rod 7 by means of teeth (not shown) made on the piston rod 7 and a portion 14 interacting with them formed on the slider. These teeth and the portion 14 interacting with them are designed so that the portion 14 can pass by the teeth when the slider 10 moves relative to the piston rod 7 in the proximal direction. However, when the slider 10 moves in the opposite direction, the piston rod 7 must move with it. Therefore, with the mentioned movement of the slider 10 in the proximal direction, the slider 10 should move relative to the piston rod 7, and the magnitude of this movement corresponds to a given dose, since with the subsequent movement of the slider 10 in the opposite direction, the piston rod 7 and, therefore, the piston 8 will move the same distance .

The described movement of the slider 10 in the proximal direction, in addition, will cause the trigger button 5 to move in the proximal direction so that it will protrude from the housing 2. This will indicate to the user that the injection device 1 is cocked, i.e. dose set.

Figure 2 in longitudinal section shows the injection device 1 of figure 1 in a cocked state. In figure 2, the cap 15 is shown inserted into the receiving part 9 of the injection device 1. It can be seen that the release button 5 has shifted in the proximal direction compared to the position shown in figure 1. It can also be seen that the latches 12 have moved in the proximal direction beyond the protrusions 13 and that the protrusions 13 hold the latches 12 in this position.

The user who wishes to inject the prescribed dose removes the cap 15 by opening the injection needle 6 and inserts it into the selected injection zone. Then he presses the release button 5 in the distal direction, i.e. towards the housing 2 (in the position shown in figure 1). This forces the pressure surfaces 16 to press the latches 12 to the axis of the injection device 1, thereby removing them from the protrusions 13. Accordingly, the slider 10 can move in the distal direction, and the energy stored in the spring 11 during setting the dose will ensure this movement. Due to the adhesion of the tooth of the piston rod 7 and the interacting section 14 of the slider 10, the piston rod 7 moves with the slider. As a result, the piston 8 also moves in the distal direction, ensuring the removal of a given dose from the cartridge 4 through the injection needle 6.

Upon completion of the injection, the cap 15 is again placed on the receiving part 9 of the injection device 1, providing a new dose, as described above. It should be noted that since the slider 10 moves the same distance each time, each time the cap 15 is placed on the injection device 1, the same fixed fixed dose is set.

3, a perspective view illustrates an injection device 100 according to a second embodiment of the invention. You can see the housing 102 and the release button 105, as well as the cap 115 placed on the injection device 100. The release button 105 is relatively close to the housing 102. This means that the injection device 100 is not cocked, i.e. dose not established.

FIG. 4 shows the injection device 100 of FIG. 3, also in a perspective view. For clarity, some parts, namely the cap and housing, are removed. This allows you to see the cartridge holder 103 and the release button 105. The injection device 100 of FIGS. 3, 4 preferably works as follows. When it is desired to inject the dose, the cap 115 is removed from the injection device 100 by rotating the cap 115 relative to the housing 102, thereby opening the injection needle (not shown). The cap 115 is connected to the cartridge holder 103 by means of teeth 117 formed on the receiving part 109 so that when the cap 115 is rotated, the cartridge holder 103 also rotates. Such rotation of the cartridge holder 103 causes a portion 118 to rotate with a helical guide, which actually forms part of the cartridge holder 103. The inclined part of the guide of this section 118 interacts with a protrusion (not shown) formed on the inside of the housing, so that the rotation of section 118 makes it move relative to the housing in the proximal direction along the axis.

In addition, the rotation of the cartridge holder 103 causes the piston rod 107 to rotate. The release button 105 is associated with a thread on the piston rod 107, so rotating this rod will elongate the piston rod 107 / release button assembly 105. Since the piston rod 107 is distally blocked, this extension causes the release button 105 to move proximal direction i.e. out of the case. As a result, the injection device 100 is cocked.

Finally, the axial movement of the driven portion 118 causes the cap 115 to be pushed out of the injection device 100.

After the cap 115 has been removed and the injection device 100 cocked (as described above), the injection needle is mounted on a suitable injection zone. Then, the shutter button 105 is pressed distally, i.e. toward the housing 102. Since the shutter release button 105 and the piston rod 107 are blocked from mutual axial movement, the movement of the button causes the piston rod 107 to move and thereby inject.

Upon completion of the injection, the cap 115 is again placed on the injection device 100, pushing it on this device 100, essentially in the axial direction. In order for the cap 115 to fit exactly on the injection device 100, you must simultaneously press the release button 105 in the distal direction.

Figure 5 shows on an enlarged scale a part of the device of figure 4, in order to more clearly show the receiving part 109, the teeth 117 and the driven section 118.

6 is a longitudinal sectional view showing an injection device 200 according to a third embodiment of the invention, in a cocked state. The injection device 200 functions similarly to the injection device 1 of FIGS. 1 and 2. However, in this embodiment, there is no spring for storing energy, so in order to bring the set dose, the user must manually press the release button 205 to its original position.

Upon completion of the injection, the cap 215 is inserted into the receiving part 209 of the injection device 200. In this case, the cap presses the slider 210, moving it in the proximal direction, so that the slider 210 pushes in the proximal direction (i.e. from the housing 202, to the position shown in 6) release button 205.

The slider 210 and the piston rod 207 are connected to each other by teeth 219 formed on the piston rod 207 and interacting with these teeth sections 214 formed on the slider 210. These teeth 219 and sections 214 are made and arranged so that the sections interacting with the teeth 214 can pass past the teeth 219 when the slider 210 moves relative to the piston rod 207 in the proximal direction. However, when the slider 210 moves in the opposite direction, the piston rod 207 must move with it. Therefore, with said movement of the slider 210 in the proximal direction, the slider 210 must move relative to the piston rod 207, the magnitude of this movement corresponding to a predetermined dose, as described above.

The user who wishes to inject the prescribed dose removes the cap 215 by opening the injection needle 206 and inserts it into the selected injection zone. Then he moves the shutter release button 205 in the distal direction, i.e. toward the housing 202. This makes the slider 210 also move in the distal direction, and, due to the interaction between the teeth 219 and the sections 214 interacting with them, the piston rod 207 moves with it. As a result, the piston 208 also moves in the distal direction, ensuring the removal of a given dose through the injection needle 206.

Fig. 7 is a longitudinal sectional view showing an injection device 300 according to a fourth embodiment of the invention. This device includes a housing 302 and a cartridge holder 303 with a cartridge 304 installed in it, which contains a liquid preparation located between the piston 308, capable of axially moving inside the cartridge 304, the cartridge tubular wall 340 and the self-sealing baffle 342 that overlaps the outlet channel 341, through which should flow out the liquid preparation when displacing the piston moving inside the cartridge 304, provided that the injection needle (not shown) is attached to the outlet channel 341 through the interface 343 for and ly. The cap 315 is inserted into the receiving part 309, mounted in the housing 302, and protects the cartridge 304 and the exhaust channel 341. The trigger button 305, made with the possibility of reciprocating axial movement relative to the housing 302, is shown in the position in which it protrudes from the distal end of the housing . This indicates that the injection device 300 is in a cocked state, i.e. that the dose is established and that the injection device 300 is ready for injection (after removing the cap 315), as will be explained in more detail below.

The piston rod 307 is attached to the piston 308 through the stem leg 347 and is operatively connected to the trigger button 305. Therefore, when the cap 315 is removed, the injection needle is attached to the needle interface 343 and the trigger button 305 is pushed towards the body 302, the piston rod 307 will move to a certain the axial distance inside the housing 302, moving the piston 308 inside the cartridge 304 to an equivalent distance to allow injection of the desired amount of drug through the outlet channel 341.

The movement of the piston rod 307 is ensured by the interaction of the connecting ring 330, which interacts with the spiral path 351 made in the release button 305, and the drive component 310, which is connected to the connecting ring 330 and is configured to interact with the piston rod 307 and transmit the drive force thereto. The drive component 310 receives energy from a prestressed spring 311, capable of storing and releasing energy for both translational and rotational motion. One end of the spring 311 is held at its base 360, and the other is connected to the drive component 310 so that the spring 311 and the drive component 310 can exchange forces and torques. Due to this, the drive component 310 is capable of performing both translational and rotational movements relative to the housing 302. In particular, during the assembly of the injection device 300, torsion stress can be generated in the spring 311, for example, by reversing its end sections by half a revolution or a full revolution . When cap 315 is removed from the injection device 300, the path of movement of the drive component 310 will be defined by the guide component 320.

Two radially opposite openings 361 are made in the housing 302, into each of which a hook 362, available on the spring base 360, can be inserted to keep this base from translational and rotational movements relative to the housing 302. The housing 302 is also provided with a window 399 through which the current position can be monitored a drive component 310 in an injection device 300.

8, the housing 302 is shown in perspective, in longitudinal section, to show the guide component 320 in more detail. For greater clarity, the proximal end 344 of the cartridge holder 303 is not shown. The guide component 320 includes a metering shelf 323 configured to support and guide the drive component 310 during the second part of the dose setting and the first part of the injection. The longitudinal guide surface 324 extends from the dispensing shelf 323 to the stopper 325 defining the end of the dose (hereinafter, the end stop of the dose). The dispensing shelf 323 is in the form of a spiral guide segment, which extends along the side surface from the junction with the longitudinal guide surface 324 to the limiter 322 of longitudinal movement. On the guide component there is a dog 326, the tip 327 of which is designed to interact with the piston rod 307.

In Fig.9, the housing 302 is presented in a perspective image, in a view from its distal end. The position of the guide component 320 within the housing 302 is shown. For clarity, the proximal end 344 of the cartridge holder 303 is not shown again. The guide component 320, having a substantially tubular structure, is aligned with the housing 302 and connected to it by spacers 386. Such communication with the housing 302 provides a tubular gap 389 between the outer wall 329 of the guide component 320 and the inner surface of the housing 302. part of this gap is occupied by the tubular proximal end 344 of the cartridge holder 303. The receiving part 309 overlaps the rest of the tubular gap 389 and the distal edge 385 of the housing. There is also a central channel 380 that allows the piston rod 307 to pass through the guide component 320 and serves as a guide for axial movements of the rod.

On figa shows the first side of the piston rod 307, along the length of which are the teeth 319. The distance between two adjacent teeth 319 is constant along the entire length of their location. The teeth 319 are able to interact with the drive component 310 during injection of a predetermined dose when the drive component 310 acts on the teeth 319 and causes the piston rod 307 to move forward. At its proximal end, the piston rod 307 has a locking face 393 designed to limit the movement of the drive component 310 in a situation of exhausting the contents of the device.

10b shows a second side of the piston rod 307. Smaller teeth 396 are distributed along this side. The distance between two adjacent teeth 396 is equal to the distance between two adjacent teeth 319 on the first side of the piston rod 307. Between two adjacent teeth 396 are even smaller teeth 395, and the distance between two adjacent teeth 395 is constant over the entire area of their location. The teeth 395 and 396 are made such that when the piston rod 307 is advanced through the central channel 380, the tip 327 of the dog 326 slips over them. At its proximal end, the piston rod 307 is provided with a longitudinal track 394 configured to restrict, preferably together with the stop face 393, the movement of the drive component 310 in a situation of exhausting the contents of the device.

11, a perspective view shows a drive component 310 having a substantially tubular body 370 with two radially opposite longitudinal grooves 371 extending from its proximal end, and with a pair of jumpers 377 connecting the tubular body 370 to the distal portion, which contains various elements for interacting with other components. Two legs 372 protrude from the jumpers 377, which can move in a tubular gap 389. Each leg 372 has a lower part, the end surface of which forms a contact face 374. The distal part of the drive component 310 also contains two runners 373, made with the possibility of sliding along the guide surfaces a guide component 320. One runner 373 is provided with a latch 375. The tooth engaging member 376 is located on the same circle as the two runners 373 between them. This element is rigidly connected with the skids, so that it performs the same translational and / or rotational movements as the skids 373, and vice versa. During dose setting, the tooth engaging member 376 is able to axially move relative to the piston rod 307, while during injection, this member may come into contact with the tooth 319 on the piston rod 307 and move the piston rod 307 in the axial direction along the housing 302. The jumpers 377 act as a reference plane for the spring 311 and, therefore, form an interface for the exchange of axial forces between the spring 311 and the drive component 310. A supporting surface 378 is adjacent to one of the jumpers 377, which may abut against the distal end of the spring 311 to exchange torques between the spring 311 and the drive component 310.

12 shows a two-dimensional representation of the guide component 320 and the drive component 310. One of the runners 373 is shown in two different positions on the guide component 320. It should be understood that the guide component 320 contains two groups of guide surfaces along which two runners 373 pass simultaneously. However, since the motions of the runners 373 along the respective guide surfaces are identical, only one of them is represented. The metering shelf 323 and the longitudinal guide surface 324 converge at an angle 6. The connection of the metering shelf 323 and the longitudinal guide surface 324 (edge 328 of the guide surface) forms the transition point between the sliding movements of the slide 373 along the longitudinal guide surface 324 and along the inclined metering shelf 323 The movement of the slide 373 in a spiral along the dispensing shelf 323 is limited by the stop 322, and the axial movement of the slide 373 along the longitudinal guide surface 324 is limited by the end of the stopper 325 end of dose. The length of the longitudinal guide surface 324 along the axis is H, so that when the runner 373 is located exactly on the edge 328, it is at a distance H from the end of the stopper 325 of the end of the dose. Due to the inclination of the metering shelf 323, the slide 373, moving along the metering shelf 323 from the edge 328 to the stop 322, in addition to the rotational movement, also moves along the axis by a distance D. Thus, when the slide 373 is at the stop 322, it is removed from the end of the stopper 325 end of dose along the axis at a distance of H + D. The axial distance H + D is significantly greater than the distance between two adjacent teeth 319 on the piston rod 307, which exceeds the axial dimension H or is equal to it.

Due to the torsion interference of the prestressed spring 311, the slide 373 is pressed with force against the stop 322 when it is on the dispensing shelf 323, and against the longitudinal guide surface 324 when it is at the end of the dose end stopper 325 (it is actually pressed against the longitudinal guide surface 324 in any position below the edge 328). The spring 311 is also prestressed in the axial direction, so that it depresses the slide 373 towards the end of the stop of the end of the dose 325. The characteristics of the spring 311 and the slope of the metering shelf 323, however, are selected such that when the skid 373 is above the edge 328, the torque generated by the spring 311 can overcome the axial force generated by it, so that the skid 373 is pressed against the limiter 322.

13 is a two-dimensional view of the guide component 320 and the drive component 310 in the embodiment where the guide component 320 further comprises a support shelf 321 for supporting the runner 373 prior to the first use of the injection device 300. Under the influence of the torque generated by the spring 311, the runner 373 is fixed on support shelf 321 before using the device. The runner 373 is capable of sliding sliding along the support shelf 321 and the stop 322 to go to the dispensing shelf 323 in the same way as it moves from the dispensing shelf 323 to the end of the stop of the dose end stop 325. However, the slide 373 cannot move from the metering shelf 323 back to the support shelf 321. Thus, after the slide 373 has been retracted from the support shelf 321, it can only move between the metering shelf 323 and the end of the stopper 325 of the dose end. The length of the limiter 322 along the axis is P, i.e. the runner 373, moving from the support shelf 321 to the dispensing shelf 323, travels a distance P. The value of P is substantially less than H; in addition, when the injection device 300 is supplied by the manufacturer, there may be a small axial clearance between the piston rod 307 and the piston 308. Therefore, when the injection device 300 is used for the first time, the axial movement of the piston rod 307 will be much smaller than in subsequent applications. This allows you to carry out a trial delivery of a liquid preparation without spending its full dose.

On Fig in a perspective image presents the trigger (push) button 305 having a push surface 352 for acting on it by the operator of the injection device 300. The trigger button 305 also contains two segments 353, each of which is equipped with a spiral path 351 and has two side side 354.

On Fig in a perspective image shows the connecting ring 330 associated with the release button 305 and with the drive component 310. This ring has a proximal and distal sides 331, 332 and two radially opposite tabs 333 for interaction with grooves 371 in the tubular body 370 of the drive component 310 to allow joint rotation of the connecting ring 330 and the drive component 310. The tabs 333 can also mate with the spring base 360 to block the connecting ring 330 from translational escheniya relative to the base 360 of the spring. The connecting ring 330 and the drive component 310 are capable of reciprocal movement limited by the length of the grooves 371. Two protrusions 334 are also provided for insertion into the spiral tracks 351 and for movement within these tracks to convert the rotational movement of the connecting ring 330 into the translational movement of the release button 305 and vice versa.

Fig. 16 shows a perspective view of a spring base 360 configured to hold one end of the spring 311 in a fixed position relative to the housing 302. At the spring base 360 there are two radially opposed struts 364, each of which is provided with a hook 362 for engaging with respective openings 361 in the housing 302, and two contact sides 365, made with the possibility of abutment on the sides 354 segments, preventing the rotation of the shutter button 305 relative to the base 360 of the spring. As a result of the interaction between the hooks 362 and the holes 361, the spring base 360 is rigidly fixed relative to the housing 302, i.e. it is blocked from both rotational and translational motion relative to the housing. To fix the proximal end of the spring 311, a groove 366 is provided. At the base 360 of the spring there is also a proximal side 363, which is capable of abutting against the distal side 332 of the connecting ring 330, and two peripheral grooves 367, which are adapted to interact with the tongues 333 and their fixation from the axial displacement. Thus, the connecting ring 330 is rigidly connected with the base 360 of the spring with respect to axial movement, but is able to rotate relative to it within the limits limited by the circumference of the peripheral grooves 367.

On Fig in a perspective image presents the Assembly of the node containing the drive component 310, the spring 311 and the base 360 of the spring. The proximal end 397 of the spring is secured to the base 360 of the spring, and its distal end 398 is connected to the drive component 310. Since the base 360 of the spring is attached to the housing 302 and therefore cannot move, the torsion interference applied to the spring 311 tends to rotate the drive component 310 counterclockwise (when viewed from the base of the 360 spring).

Fig. 18 is a perspective view illustrating a functional relationship between the release button 305 and the actuating component 310. Pressing the pressure surface 352 will cause the release button 305 to lower toward the spring base 360. Since the shutter release button 305 is locked from rotation relative to a given base, its downward movement is purely translational. With the translational movement of the release button 305, the protrusions 334 move along the spiral paths 351. This converts the movement of the release button 305 into the rotational movement of the connecting ring 330, and since the connecting ring 330 is fixed from rotational movement relative to the drive component 310, it will also rotate. The spiral tracks 351 are made such that when the shutter release button 305 is pressed towards the spring base 360, the connecting ring 330 and, therefore, the drive component 310 will rotate clockwise (when viewed from the spring base 360), i.e. opposite to the force exerted by the spring 311.

FIG. 19 shows a perspective view of an injection device 300 with a housing 302 removed to illustrate the interaction between the drive component 310 and the cap 315 when the cap is mounted on the injection device 300 to close and protect its distal portion. For clarity, the proximal end 344 of the cartridge holder 303 is not shown. When the cap 315 is fully inserted into the receiving part 309, the abutting annular surface 381 on the cap 315 abuts against the distal edge 385 of the housing, and the edge 382 of the cap abuts against the contact faces 374 of the drive component 310. This corresponds to the situation when the injection device 300 is cocked, i.e. . dose set. As long as the injection device 300 contains a sufficient amount of liquid preparation to dispense its full dose, the release button 305 will in such a situation protrude from the proximal opening 384 of the housing. However, in FIG. 19, the release button 305 is pressed against the spring base 360. This illustrates the situation when the user tried to activate the injection mechanism to withdraw the set dose from the cartridge 304 with the cap 315 installed on the injection device 300. In this case, pressing the shutter button 305 will also rotate the drive component 310 to overcome the force of the spring 311. However, since the edge 382 of the cap prevents the translational movement of the drive component 310 as a result of its abutment against the contact faces 374, these faces will simply slide along the edge 382 of the cap, and no output the drug is not followed. When the user releases the pressing force from the release button 305, the torque generated by the spring 311 will cause the drive component 310 to rotate in the opposite direction until the runners 373 come into contact with the respective stops 322 (not visible). During this movement, the contact faces 374 will slide along the edge 382 of the cap, returning to their original positions on this edge, so that the release button 305 will be forced to extend from the proximal opening 384 of the housing as a result of its corresponding pairing with the connecting ring 330. Holes 383 in the cap 315 are designed to receive corresponding protrusions (not shown) on the cartridge holder 303 to ensure that cap 315 can withstand a certain load on the side of contact faces 374 due to by means of a spring 311, when the drive component 310 is rotated to a position corresponding to the passage of the runners 373 beyond the edges 328 of the guide surface (not visible).

On Fig in longitudinal section presents a mechanism that works when the content in the injection device 300 is exhausted. In the position of Fig. 20, the tooth engaging member 376 extends beyond the extreme proximal tooth 390 on the piston rod 307 and forces the piston rod 307 to inject the last full the dose remaining in the cartridge 304. In this case, the drive component 310 reacted to reinstalling the cap 315 by moving it in the proximal direction relative to the piston rod 307. As long as doses of the drug remain in the cartridge 304, the introduction of the cap 315 into the receiving part 309 will result in both translational and rotational movement of the drive component 310, as will be described in more detail below. However, after the last full dose has been injected, this installation of the cap 315 will only translate the drive component 310 due to the corresponding design of the proximal end of the piston rod 307 and the distal portion of the runners 373. The locking face 393 at the proximal end of the piston rod 307 can abut the latch 375 to prevent rotation of the drive component 310 relative to the piston rod 307 counterclockwise. Furthermore, in order to prevent rotation of the drive component 310 with respect to the piston rod 307, the longitudinal track 394 (not visible) is adapted to receive the protrusion 379. The protrusion 379 enters the longitudinal track 394 at the same time as the latch 375 comes into contact with the stop face 393, so that the stop face 393 and longitudinal track 394 enhance the individual action of each of them in restricting the freedom of movement of the drive component 310.

Operation of the injection device of FIGS. 7-20. Next, the use of the injection device according to the fourth embodiment of the invention illustrated in FIGS. 7-20 will be described. 7, the injection device 300 is shown inoperative with a cap 315 mounted on it. When the user needs to inject, he removes the cap 315 from the injection device 300 and attaches the injection needle to the needle interface 343. The injection device 300 is already cocked and ready to inject the set dose, so the user simply selects the injection zone, inserts the injection needle into the skin and presses the trigger button 305, which protrudes from the hole 384 at the proximal end of the housing 302. Pressing the trigger button 305 in the distal direction toward the housing 302 causes a substantially purely translational displacement of the release button 305 relative to the housing 302, since the contact sides 365 of the release button 305 prevent its rotation, mating with Orons 354 segments. The translational displacement of the release button 305 causes the protrusions 334 to move along the spiral paths 351. The connecting ring 330 is axially fixed relative to the housing 302 (as a result of the tongues 333 entering the peripheral recesses 367 in the spring base 360, which is rigidly fixed relative to the housing 302). Therefore, when the protrusions 334 move along the spiral paths 351, the translational movement of the release button 305 translates into a rotational movement of the connecting ring 330 relative to the housing 302. The coupling between the tongues 333 and the longitudinal grooves 371 in the tubular body 370 causes the drive component 310 to rotate together with the connecting ring 330.

The rotation of the drive component 310, caused by pressing the shutter button 305, overcomes the torque of the spring 311. In a situation where the user has not yet pressed the shutter button 305, the runners 373 rest on the corresponding metering shelves 323, being pressed against the limiters 322 by the torque of the spring . When the drive component 310 is rotated by pressing the shutter release button 305, the runners 373 will slide down the dosing shelves 323 towards the edges 328. When the shutter release button 305 is almost completely inserted into the housing 302, the runners 373 reach the transition point at the edge 328, in wherein the spring 311 releases the stored translational energy stored therein and causes the runners 373, acting on them through jumpers 377 on the drive component 310, to lower down along the longitudinal guide surfaces 324 to end stopper 325 end dose. With this movement of the runners 373 along the indicated surfaces 324, the tooth engaging member 376 meshed with the tooth 319 of the piston rod 307 also moves and thereby forces the rod 307 to move along the axis forward along the central channel 380. Since the rod 307 the piston is connected to the piston 308, such a movement of the piston rod 307 will cause a corresponding movement of the piston 308 in the cartridge 304, leading to the removal of the set dose from the cartridge. Thus, as a result of substantially completely sinking the release button 305, the spring 311 will automatically withdraw the liquid preparation from the injection device 300, regardless of whether the user continues to press the pressure surface 352 or not.

When the piston rod 307 moves axially to bring out the set dose, the tip 327 of the dog 326 slips along the teeth 395 of the piston rod 307 located between two adjacent larger teeth 396, thereby providing an audible feedback mechanism indicating to the user by audible clicks, to continue the process of issuing a dose. When the piston rod 307 stops moving forward, the runners 373 will be at the end of the dose stopper 325, and the tip of the dog 32 will pass over the larger tooth 396, providing a distinctive audible signal (for example, a louder click) indicating that the movement of the piston 308 has stopped, those. dispensing is essentially complete. When the runners 373 are located at the end of the dose stopper 325, the drive component 310 occupies a position in the housing 302 in which it completely closes the window 399, thereby forming a visual signal that the dose has been dispensed. The user can then wait a few seconds before removing the injection needle from the skin. After that, all the user needs to do to prepare the injection device 300 for the next injection is to re-insert the cap 315 into the receiving part 309, i.e. re-install cap 315 on injection device 300.

Re-insertion of cap 315 into receiving part 309 after injection will result in the setting of the next dose, as will be described later. Due to the corresponding mating between the release button 305 and the connecting ring 330, the release button 305 will remain pressed inside the housing 302 when the user relieves pressure on the pressure surface 352 after activating the injection mechanism. This indicates to the user that the injection mechanism has been activated and that the dose from cartridge 304 is either being withdrawn or already withdrawn. When the cap 315 is inserted into the receiving part 309 after the injection, its edge 382 will abut against the contact faces 374 on the legs 372 of the drive component 310. When the edge 382 of the cap 315 is gradually moved, during its reinstallation, to the proximal end of the injection device 300 (and advance of the thrust annular surface 381 in the abutment position at the distal edge 385 of the housing) it will push the drive component 310 in the proximal direction. As a result, when the runners 373 move along the longitudinal guide surfaces 324 toward the edges 328, the drive component 310 is displaced along the axis, overcoming the corresponding force of the spring 311. When the edge 382 of the cap displaces the drive component 310 in the proximal direction so that the runners 373 reach the guide edge 328 surface, the torsion stress of the spring 311, increased during the injection, will cause the slide 373 to move up the dosing shelves 323 to the stops 322, thereby turning the drive component 310 relative to the piston rod 307 and housing 302. Due to the tilt of the metering shelves 323, this movement of the slider 373 will cause the drive component 310 to make a slight additional movement along the axis. Such a movement of the drive component 310 will cause an identical combined (translational and rotational) movement of the tooth engaging member 376, as a result of which it is disengaged from the tooth 391 on the piston rod 307 to advance to the next (in the proximal direction) tooth 392.

Since the axial displacement (equal to H + D) of the drive component 310 when the slider 373 moves from the end of the dose stopper 325 to the stops 322 exceeds the distance between two adjacent teeth 319 on the piston rod 307, the tooth engaging element 376 passes a short distance behind the tooth 392 as shown in FIG. Until the cap 315 enters the receiving part 309 so that its edge 382 has not yet moved the drive component 310 proximally to the position in which the skids 373 extend beyond the edges 328 of the guide surfaces, the tooth engaging member 376 does not extend beyond the next tooth 392 Therefore, if in this situation, the cap 315 is removed from the injection device 300, the axial force of the spring 311 will move the skids 373 back to the end of the stopper 325 of the end of the dose. As a result, the drive component 310 will return to the position it occupied when the injection was completed, and the tooth engaging member 376 will again engage with the tooth 391. In other words, the injection mechanism is not activated. However, if the cap 315 comes to a position in the receiving part 309 so that its edge 382 displaces the drive component 310 proximally so that the skids 373 pass the transition point at the edges 328 of the guide surfaces, the stored rotational energy of the spring 311 is released and moves the skids 373 along the dispensing shelves 323 to the position at the stops 322. Such rotational movement will be carried out with overcoming the axial force of the spring 311. For this, the inclination of the metering shelves 323 must be within certain limits to ensure The angular displacement of the drive component 310. In this embodiment, this slope is about 10 °, i.e. the angle θ is close to 260 °.

When the drive component 310 rotates as a result of the movement of the slides 373 along the metering shelves 323, the tooth engaging element 376 is moved, due to the combined, translational and rotational movement, from the position immediately below the tooth 392 (corresponding to the position of the slides 373 directly below the edges 328 of the guide surfaces ) to the position above the tooth 392. Such combined movement is provided by a spring 311, which releases its stored rotational energy when the runners 373 pass the edges 328 to the right yayuschih surfaces. Thus, upon reaching this transition point, the user no longer controls the process of setting the dose that will be set, even if the user removes the cap 315 from the injection device 300 or attempts to interrupt the installation by some other actions. In this case, the pre-torsion preload of the spring 311 ensures a stable position of the runners 373 on the metering shelves 323 at the stops 322, so that the injection device 300 is guaranteed to not operate until the user activates the injection mechanism to inject the set dose.

Since the drive component 310 and the connecting ring 330 are blocked from mutual rotation, the rotation of the drive component 310 when setting the dose also rotates the connecting ring 330, as a result of which the protrusions 334 will move along the spiral paths 351 in the release button 305, forcing it to move forward from the proximal opening 384 of the body. While the drive component 310 only rotates after the runners 373 extend beyond the edges 328 of the guide surfaces and the dose is actually set, the release button 305 will only protrude from the housing 302 after setting the dose. This allows the user to easily determine that the dose is not set or that the dose is set and the injection device is ready for injection. In other words, when the cap 315 is correctly installed on the injection device 300, the injection device 300 automatically sets the dose, and the shutter release button 305 automatically extends from the housing 302, thereby indicating that the device is ready for operation.

As will be explained later, when the cap 315 is mounted on the injection device 300, it is not possible to activate the injection mechanism to withdraw the dose from the cartridge 304. It has already been mentioned that when positioning the cap 315 in the receiving part 309, the edge 382 of the cap will abut against the contact faces 374 and move the drive component 310 in the housing 302 proximally. This will divert the drive component 310 from the window 399. Therefore, when the runners 373 are fixed on the metering shelves 323 and the dose is set, the user cannot see the drive component 310 through the window 399. As long as the cap 315 is on the injection device 300, the edge 382 of the cap abuts the contact faces 374. An attempt by the user is activated the injection mechanism, pressing the shutter release button 305 towards the housing 302, will be unsuccessful, since the edge 382 of the cap prevents any movement of the piston rod 307 in the housing 302. At the same time, the release button 305 can freely move towards the housing 302. When this button moves to its recessed position, the connecting ring 330 will rotate, driving the drive component 310 to overcome the force of the spring 311, as described above when considering the injection procedure. However, instead of the slide 373 moving down the dosing shelves 323, only their rotation will take place at a constant position along the axis. This is because the contact faces 374 will slide along the edge 382 of the cap and will not be able to move in the axial direction. By the time the shutter release button 305 is completely sunk into the housing 302, the drive component 310 will make an angular movement corresponding to the displacement of the runners 373 from the position on the metering shelves 323 of the stops 322 to the position beyond the edges of these shelves, at a height H + D above the end of the stopper 325 of the end doses.

If the user relieves pressure from the release button 305, the torsion stress of the spring 311 will immediately cause the drive component 310 to reverse. This will be possible because the runners 373 are located above the edges 328 of the guide surfaces, so that the drive component 310 will rotate together with the connecting ring 330. Reverse rotation of the connecting ring 330 will cause the release button 305 to extend from the housing opening 384 and return to the extreme proximal position indicating that the dose is set and the injection device 300 is ready for injection. In other words, when the cap 315 is mounted on the injection device 300, the user can press the release button 305 in the direction of the housing 302, but the preparation will not be output from the cartridge 304, and when the user relieves the pressure on the release button, the injection device 300 will automatically pull it out of the housing 302 due to the energy released by the spring 311 to reverse the drive component 310. When the runners 373 are above the end of the dose stopper 325, i.e. on the other side of the edges 328 of the guide surfaces, the force exerted by the spring 311 in the axial direction will tend to move the drive component 310 distally along the axis, acting against the contact force exerted by the edge 382 of the cap. However, the spring 311 is unable to withdraw the cap 315 from the receiving part 309 due to the mating between the cap 315 and this part. In addition, tabs (not shown) on the cartridge holder 303 are inserted into the holes 383 in the cap 315 to enhance this coupling. Thus, an injection device has been developed that is unable to withdraw the drug from the cartridge, being closed by a cap, but allowing the trigger to move freely inside and out of the housing.

After the injection device 300 has been reused for injection, as soon as the last full dose is withdrawn from the cartridge 304, the tooth engaging member 376 is engaged with the extreme proximal tooth 390 on the piston rod 307. If the user returns the cap 315 to the injection device 300, the edge 382 of the cap, as described above, will move the drive component 310 proximally inside the housing 302, so that the tooth engaging member 376 will be disengaged from the tooth 390. However, when the skids 373 come closer to the transition point at the edges 328 of the guide surfaces, the latch 375 will engage with the locking face 393, and the protrusion 379 will slide into the longitudinal groove 394. This will make it impossible to rotate the drive component 310 relative to the stem 307 EDSS. Since the piston rod 307 is blocked from rotation in the central channel 380, it cannot rotate relative to the housing 302. In this situation, the drive component 310 is unable to rotate relative to the housing 302. The connecting ring 330, fixed from rotation relative to the drive component 310, will also not be able to rotate, so that the release button 305 does not extend from the opening 384 of the housing. Thus, the user will be given a clear signal that the last dose has been injected and that the injection device 300 is empty.

From the above description, it is clear that the transition point at the edges 328 of the guiding surfaces forms the boundary between manual and automatic operations when setting the dose: everything that happens before the runners 373 approach the edges 328 of the guiding surfaces is in the hands of the user, whereas after passing the runners 373 of these edges 328 control passes to the injection device 300, which automatically sets the dose and blocks the injection mechanism. Similarly, during injection, everything that happens while the runners 373 are on the dispensing shelves is in the hands of the user, but after the runners 373 pass the edges 328 of the guide surfaces, the injection device 300 will automatically inject, which cannot be interrupted.

21-30 show an injection device 400 according to a fifth embodiment of the invention. It is functionally identical to the injection device 300 and essentially contains the same features. However, there are certain differences between the two options, which will become clear from the following description.

21, the injection device 400 is shown in longitudinal section. It contains a housing 402, a cartridge 404, in which a liquid preparation is located, a cartridge holder 403, a receiving part 409 and a cap 415. The liquid preparation is located between the piston 408, capable of axially moving inside the cartridge 404, the cartridge tube wall 440 and the self-sealing wall 442, blocking the outlet channel 441. An injection needle 406 is attached to the injection device 400 via a needle interface 443. The piston rod 407, movable in the axial direction, is attached to the piston 408 through the stem leg 447. The piston rod 407 can be moved along the axis by the drive component 410. The movement of the drive component 410 and the piston rod 407 is guided by the guide component 420. Energy for the operation of the injection device 400 is provided by a spring 411, which is supplied with a preliminary rotational voltage. This spring is attached to the housing 402 at its proximal end through the spring base 460 and is connected to the drive component 410 at its distal end. At the base 460 of the spring, the distal end of the button spring 450 is also fixed, pressing the shutter button 405 to the position in which it protrudes from the proximal end of the housing 402.

22 and 23, the guide component 420 is shown in more detail. It comprises a metering shelf 423 configured to support and guide the drive component 410 during the second part of the dose setting process and the first part of the injection process. A longitudinal guide surface 424 extends from the dispensing shelf 423 to the end of the dose end stopper 425. The dispensing shelf 423 is in the form of a spiral segment that extends along the lateral surface from the point of connection with the longitudinal guide surface 424 to the longitudinal movement limiter 422. It should be understood that a similar set of the same surfaces (which is not visible in the drawings) is radially opposite to this set of guide surfaces. On the guide component 420 there is a dog 426 for interacting with the piston rod 407. Between the outer wall 429 of the inner tubular part of the guide component 420 and the wall of this component there is a tubular gap 489. Two radially opposite guide elements 436 are configured to interact with the piston rod 407 (not shown) passing through this component, directing its axial movements and preventing its rotation relative to the housing 402. The distal edge 485 of the guide component 420 can abut against the cap 415 when this cap is inserted into the receiving part 409.

On Fig shows a drive component 410 having a tubular body 470, a pair of pressure faces 469, two runners 473, made with the ability to move along the guide surfaces of the guide component 420, two contact faces 474 and the element 476 for engagement with teeth, able to engage with teeth on the piston rod 407 to force the piston rod 407 forward to the distal end of the injection device 400. There is also a latch 475 to interface with the proximal end of the piston rod 407 after the cartridge 404 has the last dose is withdrawn.

25 shows a release button 405 having a pressure surface 452 for acting on it by the operator of the injection device 400. The release button 405 also contains two groups of segments 453, 455, each of which is provided with pressure faces 416 that can slide into contact with with pressure faces 469 on the drive component 410. Each of the segments 455 is equipped with a hook 456, which, when the injection mechanism is activated to inject the set dose, can interact with latches (not shown) in the housing 402 for holding the release button 405 recessed into the housing 402, with overcoming the resistance of the button spring 450. Each segment 453 is provided with a longitudinal slot 457, which can mate with a corresponding protrusion (not shown) made in the housing 402 to block the shutter button 405 from rotation relative to the housing 402. These protrusions (not shown) can axially move inside the slots 457, so that the release button 405 is able to move along the axis relative to the housing 402 by a distance determined by the axial size of the longitudinal slots 457.

26 illustrates the functional relationship between the release button 405 and the drive component 410. For clarity, the assembly of these components is separated from the rest of the injection device. When the user acts on the release button 405 by pressing on its pressing surface 452, the pressure faces 416 interlock with the pressure faces 469 on the drive component 410. The sheer forward movement of the release button 405 causes the pressure edges 469 to slide along the pressure edges 416, resulting in a drive component 410 rotates (rotates) clockwise relative to the release button 405 (and the housing 402). In an injection situation, this will cause the tooth engaging member 476 to engage with the tooth on the piston rod 407 and, when the runners 473 pass the transition point at the edges 428 of the guide surfaces, the spring 411 will force the drive component 410 and, therefore, the member 476 for engagement with the teeth and the piston rod 407 to axial displacement in the distal direction to inject the set dose. The interface between the shutter release button 405 and the drive component 410 operates in both directions. So, if the drive component 410 rotates counterclockwise (for example, when setting the dose), the pressure faces 469 will slide along the pressure faces 416 on the segments 453, 455, so that the release button 405 will be pulled out of the position in which it was held and extended in the axial direction from the housing 402 under the action of the spring 450.

On Fig presents the situation when the element 476 for engagement with the teeth was transferred in the process of setting the dose from the tooth 491 to the next tooth in the proximal direction 492. For clarity, the presented assembly is separated from the rest of the injection device. Therefore, the proximal end 497 of the spring is visible, which is actually fixed to the base 460 of the spring.

On Fig presents the situation when the runners 473 are on the metering shelves 423 at the stops 422 (not visible), and the injection device is ready for injection. For clarity, the assembly shown is separated from the rest of the injection device. Pressing the shutter button 405 (not shown) will cause the drive component 410 to rotate clockwise (when viewed from the shutter button), overcoming the force caused by the rotational stress of the spring 411. After passing beyond the edges 428 of the guide surfaces, the slide 473 will be forced to move along the longitudinal guide surfaces 424 to the end of the stopper 425 of the end of the dose.

On Fig illustrates the situation of exhaustion of content. After the last complete dose has been withdrawn from the injection device 400, and the user has again inserted the cap 415 into the receiving part 409 to move the drive component 410 in the proximal direction in the same way as was described with the injection device 300, the tooth engaging member 476 will be disengaged from the proximal tooth 490 and will shift along the piston rod 407 up. This movement will occur in synchronization with the movement of the slides 473 upward along the longitudinal guide surfaces 424. In this case, when the runners 473 approach the transition point at the edges 428 of the guide surfaces, the latch 475 will interact with the locking face 493, making it impossible to rotate the drive component 410 relative to the rod 407 piston. Since the piston rod 407 is blocked from rotation in the housing 402, the drive component 410 in this situation is unable to rotate relative to the housing 402. In all previous cases, when the user re-inserted the cap 415 into the receiving part 409 after injection and, therefore, the drive component 410 was displaced proximally so so that the runners 473 passed the edges 428 of the guiding surfaces, providing a dose setting, the final part of the dose setting was carried out automatically by a spring 411, which released the energy stored in it for the rotation of the drive component 410. This rotation of the drive component 410 caused the simultaneous translational movement of the release button 405, since the interaction between the pressure faces 469, 416 brought the hooks 456 out of contact with the latches (not shown) in the housing 402. As a result, the button spring 450 was released. pulling the release button 405 from the housing 402. This indicated to the user that the dose was set and that the device was ready for the next injection.

Since the drive component 410 will be unable to rotate if the cap 415 is mounted on the injection device 400 after the injection of the last full dose, the button spring 450 will not be released and therefore the release button 405 will not extend from the housing 402. This will signal to the user that the injection device 400 devastated.

FIG. 30 shows a perspective view of an injection device 400 with the housing 402 removed to illustrate the interaction between the drive component 410 and cap 415. A situation is presented where a user attempts to dispense a dose from cartridge 404 (not visible) with cap 415 installed on injection device 400. The order of the main movements is similar to that described with reference to Fig. 19, and the only significant difference is in the action of the button spring 450, which provides the movement of the release button 405 in Simal direction. The edge 482 of the cap abuts against the contact faces 474 and prevents the drive component 410 from moving along the axis toward the distal end of the injection device 400. The depressing of the release button 405 causes the contact edges 474 to slide along the edge 482 of the cap, so that the tooth engaging member 476 cannot move and enter in contact with the tooth 419 on the piston rod 407. The rotational voltage of the spring 411 creates a torque applied to the drive component 410, which unlocks the button spring 450 due to the interaction between the pressure faces 469 and segments 453, 455. When the cap 415 is correctly positioned in the receiving part 409, the abutting annular surface 481 abuts against the distal edge 485 of the guide component 420 (see FIG. 23). A pair of protrusions 488 on the cap 415 is designed to be inserted into the receiving track on the inner wall of the guide component 420 to guide the cap 415 when mounted on the injection device 400.

On Fig in longitudinal section shows an injection device 500 according to the sixth embodiment of the invention, in the cocked state, when the dose is already set. The injection device 500 includes a housing 502, a cartridge 504 with a piston 508, a cap 515, a piston rod 507, and a drive component 510 comprising a tooth engaging member 576. This element is engaged with the tooth 519 on the piston rod 507, which provides for the forced movement of the piston rod 507 to the end of the injection device 500 carrying the needle. The drive component 510 also includes latches 512 that can radially deflect and are designed to interact with protrusions 587 on the housing 502. The latches 512 are elastically pressed against the inner wall of the housing 502. There is also a main spring 511 for transmitting energy to the drive component 510 during injection and an auxiliary a spring 550 for depressing the release button 505 to a position in which it protrudes from the proximal end of the housing 502. The release button 505 has longitudinally oriented tabs 558 ending in hooks 556, which can interact with the radially projecting latches 546 to hold the shutter release button 505 in the recessed position in the housing 502, counteracting the force exerted by the auxiliary spring 550. An injection needle 506 is attached to the injection device 500.

Figures 32a-32c illustrate in detail the release mechanism of the release button of the injection device 500. In Figure 32a, the release button 505 is recessed into the housing 502, i.e. The situation is presented when the user injected. The release button 505 is held in this position (despite the opposing force from the side of the auxiliary spring 550) as a result of pairing between the hooks 556 and the latches 546.

32b, the drive component 510 is displaced proximally into the housing 502 since the user mounted a cap 515 on the injection device 500. This forced the inclined pressing surfaces 548 of the latches 512 to slide along their corresponding inclined surfaces 549 of the protrusions 587 with the hooks coming into contact with the corresponding pressing surfaces 559 556. Further movement in the proximal direction of the drive component 510 and therefore of the latches 512 will force the inclined pressing surfaces 548 of the latches 512 to slide along the inclined surfaces 559 ryuchkov 556, causing hooks 556 are withdrawn from mating with the latches 546. When the hooks 556 are fully withdrawn from said interface, three steps occur simultaneously. The auxiliary spring 550 releases the energy stored therein and pulls the release button 505 from the housing 502 in the proximal direction, and the latches 512 deviate inside the housing 502 and engage with the proximal faces of the protrusions 587, thereby cocking the main spring 511, as shown in FIG. 32s In addition, the tooth engaging member 576 extends beyond the proximal tooth 519 on the piston rod 507, completing the dose setting.

When the user presses the shutter release button 505 to inject the set dose, the tabs 558 are displaced distally in the housing 502, while simultaneously deflecting radially outward due to the sliding interface with the latches 546. As a result, the inclined pressing surfaces 559 of the hooks 556 engage with the inclined pressing surfaces 548 of the latches 512. When the release button 505 is fully recessed into the housing 502, the tabs 558 will force the inclined pressure surfaces 548 of the latches 512 to slide along the inclined pressure surfaces 559 of the hooks 556 to the position where the latches 512 are disengaged from the protrusions 587. This will cause the main spring 511 to release the energy stored in it and move the drive component 510 distally inside the housing 502 to withdraw the dose of the drug through the injection needle 506. At the same time, the elasticity the tabs 558 will cause the hooks 556 to mate with the latches 546, thereby cocking the auxiliary spring 550 and holding the release button 505 inside the housing 502.

Examples

The following are various examples of the invention in accordance with its second aspect.

1. An injection device containing:

- a variable volume tank having an output channel,

- means for setting the dose,

- injection means for conducting an injection of a prescribed dose and containing a rod with teeth, at least on one of its parts, configured to reduce the volume of the tank,

- a drive component configured to move relative to the specified rod during dose setting and transmitting the drive force to the specified rod during injection and containing a mating element designed to interface with the specified rod,

- guide means, configured to direct the movement of the drive component and / or the specified rod, and

- means of supplying energy, functionally associated with the means for setting the dose and with the injection means and designed to store and release energy to ensure translational and rotational motion,

however, when activating the means for setting the dose in order to set the dose, the mating element extends beyond the tooth on the specified rod through a combined translational / rotational movement.

2. An injection device, as in example 1, in which when the means for setting the dose to set the dose is activated, the energy supply means releases energy for rotational movement.

3. An injection device, as in example 1 or 2, in which, when actuating the means for setting the dose to set the dose, the means of supplying energy stores energy for translational motion.

4. An injection device, as in any of the previous examples, in which when the injection means is activated to inject a set dose, the energy supply means stores energy for rotational movement.

5. An injection device, as in any of the previous examples, in which when the injection means is activated to inject a set dose, the energy supply means releases energy for translational movement.

6. An injection device, as in any of the previous examples, in which the guide means comprises an inclined guide surface.

7. Injection device, as in example 6, in which the guiding means further comprises a substantially flat longitudinal guiding surface connected to an inclined guiding surface at its edge, forming a transition point between the purely translational motion and the combined translational / rotational motion.

8. An injection device, as in example 7, in which the angle between the essentially flat longitudinal guide surface and the inclined guide surface is from 180 ° to 270 °, preferably from 225 ° to 270 °, particularly preferably from 240 ° to 270 ° .

9. An injection device, as in Example 7, in which the drive component is guided by a substantially flat longitudinal guide surface during the first part of the dose setting and an inclined guide surface during the second part of the dose setting.

10. An injection device, as in example 9, in which the second part of the dose setting is performed automatically by the injection device.

11. An injection device, as in any of the previous examples, in which the guide means comprises a latch for holding the energy supply means in a stable state.

12. An injection device, as in any of the previous examples, in which the energy supply means comprises a compressible spring configured to pre-create a rotational voltage therein.

13. An injection device, as in any of the previous examples, in which the energy supply means comprises a compressible spring and a torsion spring.

14. An injection device, as in any of the previous examples, further comprising a removable cap and a receiving part configured to abut or pair with the cap when mounted on the injection device, the receiving part being operatively connected to the dose setting means in this way that the installation of the cap on the injection device activates the means for setting the dose, forcing the mating element to pass the tooth on the specified rod through a combined translator o / rotary motion.

15. An injection device containing:

- a variable volume tank having an output channel,

- means for setting the dose,

- injection means for conducting an injection of a prescribed dose and containing a rod with teeth, at least on one of its parts, configured to reduce the volume of the tank,

- a drive component configured to move relative to the specified rod during dose setting and transmitting the drive force to the specified rod during injection and containing a mating element designed to interface with the specified rod,

- guide means, configured to direct the movement of the drive component and / or the specified rod,

- a push button operatively associated with the means for setting the dose and with the injection means and configured to axially move between the first position corresponding to the set dose and the second position corresponding to actuating the injection means for injecting the set dose, and

- means of supplying energy, functionally associated with the means for setting the dose and with the injection means and designed to store and release energy to ensure translational and rotational motion,

the actuation of the means for setting the dose to set the dose causes the following actions:

- the mating element extends beyond the tooth on the specified rod through a combined translational / rotational movement,

- the means of supplying energy stores energy for translational motion, released only when the injection means, and

- the push button moves from the second to the first position.

16. An injection device, as in example 15, additionally containing a removable cap and a receiving part made with the possibility of abutment in the cap or pair with it when it is installed on the injection device, and the receiving part is functionally connected with the means for setting the dose so that the installation the cap on the injection device drives a dose setting means to set the dose.

The following are various examples of the invention in accordance with its third aspect.

1. An injection device containing:

- a variable volume tank having an output channel,

- means for setting the dose,

- injection means for conducting an injection of a prescribed dose and containing a rod with teeth, at least on one of its parts, configured to reduce the volume of the tank,

- a drive component configured to move relative to the specified rod during dose setting and transmitting the drive force to the specified rod during injection and containing a mating element designed to interface with the specified rod, and

- guide means, configured to direct the movement of the drive component and / or the specified rod,

wherein the guiding means comprises a first substantially flat longitudinal guiding surface and a second substantially flat longitudinal guiding surface with a smaller longitudinal dimension than that of said first longitudinal guiding surface.

2. An injection device, as in example 1, in which the guide means further comprises an angular surface connecting the first and second, essentially flat longitudinal guide surfaces.

3. An injection device, as in example 2, in which the angular surface comprises an inclined guide surface.

4. An injection device, as in example 2, in which the angular surface is connected to the first essentially flat longitudinal guide surface and to the second, essentially flat longitudinal guide surface at right angles.

5. Injection device, as in any of the previous examples, in which the drive component is guided, during the injection, the first essentially flat longitudinal guide surface.

6. An injection device, as in any of the previous examples, in which the guiding means further comprises a support shelf configured to support the drive component until the injection means is actuated for the first time.

7. Injection device, as in example 6, in which the support shelf is connected at its edge with a second, essentially flat longitudinal guide surface.

8. An injection device, as in example 7, in which, when the injection means is actuated for the first time, the drive component moves from its initial position, in which it is supported by the support shelf, along the second substantially flat longitudinal guide surface to the position in which he relies on the angular surface, thereby shifting the specified rod along the axis by a distance shorter than the distance corresponding to the injection of the prescribed dose.

9. An injection device, as in example 8, additionally containing means for supplying energy, functionally associated with means for setting the dose and with the injection means and designed to store and release energy to ensure translational and rotational motion.

10. An injection device, as in example 9, in which the very first actuation of the injection means forces the energy supply means to move the drive component from its initial position, in which it is supported by the support shelf, along a second substantially flat longitudinal guide surface to the position in which it rests on a corner surface.

The following are various examples of the invention in accordance with its fourth aspect.

1. An injection device for injecting a prescribed dose of a liquid preparation, comprising:

- housing

- a reservoir for the drug,

- a piston made with the possibility of axial movement in the tank,

- means for setting the dose,

- injection means that provides an injection of a prescribed dose and containing a piston rod for discontinuous delivery of the piston in the reservoir forward in order to infer a predetermined volume of liquid preparation, each discrete supply corresponding to a predetermined dose,

- a push button operatively associated with the means for setting the dose and with the injection means and configured to axially move between the first position corresponding to the set dose and the second position corresponding to actuating the injection means for injecting the set dose, and

- holding means for holding the push button in the second position when the injection means is actuated in order to inject the set dose,

however, the retaining means is operatively connected with the means for setting the dose so that when the means for setting the dose is activated to set the dose, the holding means is automatically deactivated.

2. An injection device, as in example 1, in which when the means for setting the dose to set the dose is activated, the push button automatically moves from the second to the first position.

3. An injection device, as in example 2, in which the push button is moved from the second to the first position by a force transmitting component that activates the push button by translational and / or rotational movements.

4. An injection device, as in any of the previous examples, additionally containing means for supplying energy, acting on the push button, trying to shift it to the first position.

5. An injection device, as in example 4, in which the means of supplying energy contains a spring.

6. An injection device, as in any of the previous examples, in which the movement of the push button from the second to the first position is purely translational.

7. An injection device, as in any of the previous examples, in which the movement of the push button from the first to the second position is purely translational.

8. Injection device, as in any of the previous examples, in which the holding means ensures the fixation of the push button by matching its dimensions with the dimensions of the housing.

9. An injection device, as in example 8, in which the push button contains a latch designed to interface with a protrusion on the housing.

10. Injection device, as in example 9, in which the specified fixation of the push button is deactivated by a force transmitting component having a thrust surface configured to mate when moving with sliding, with a thrust surface on the latch to release the latch from the interface with the specified protrusion.

11. An injection device, as in example 3, in which the holding means provides frictional coupling between the push button and the housing.

12. An injection device, as in any of the previous examples, further comprising a drive component configured to move relative to the piston rod during dose setting and transmitting the drive force to the piston rod during injection, wherein the drive component comprises means for transmitting force.

13. An injection device, as in example 12, in which the push button and the drive component are functionally connected in such a way that the rotational or spiral movement of the drive component causes axial movement of the push button and vice versa.

14. Injection device, as in example 12 or 13, additionally containing a mating element designed to interface with the drive component and the push button.

15. Injection device, as in example 14, in which the push button and the mating element are connected by connecting with a screw guide.

16. An injection device, as in example 15, in which the push button contains a segment with a spiral path, and the mating element contains a protrusion made with the possibility of pairing with the specified segment and move along it.

17. Injection device, as in example 16, in which the holding means provides coupling between the push button and the mating element.

18. Injection device, as in example 13, in which the piston rod contains a structural element designed to interface with the drive component, to prevent rotation of the drive component when the amount of drug remaining in the tank is insufficient to ensure a full dose, and thereby prevent installation dose means for setting the dose.

19. An injection device, as in example 13, in which the piston rod contains a structural element designed to interface with the drive component to prevent the drive component from rotating when the amount of drug remaining in the tank is insufficient to ensure a full dose, and thereby prevent movement push button from second to first position.

20. An injection device, as in any of the previous examples, further comprising:

- removable cap and

- the receiving part, made with the possibility of emphasis in the cap or pair with it when it is installed on the injection device,

however, the receiving part is functionally connected with the means for setting the dose so that the installation of the cap on the injection device automatically deactivates the holding means and ensures the movement of the push button from the second to the first position.

The following are various examples of the invention in accordance with its fifth aspect.

1. An injection device for injecting a prescribed dose of a liquid preparation, comprising:

- a reservoir capable of holding the drug,

- a piston made with the possibility of movement along the axis in the tank,

- means for setting the dose,

- injection means that provides an injection of a prescribed dose and containing a piston rod for discontinuous delivery of the piston in the reservoir forward in order to infer a predetermined volume of liquid preparation, each discrete supply corresponding to a predetermined dose,

- removable cap and

- the receiving part, made with the possibility of emphasis in the cap or pair with it when it is installed on the injection device,

however, the injection agent is functionally connected with the receiving part in such a way that it is deactivated by installing the cap on the injection device, thereby preventing the drug from being removed from the reservoir.

2. Injection device, as in example 1, in which the removal of the cap from the injection device activates the injection agent, thereby providing the possibility of removing the drug from the tank.

3. An injection device, as in example 1 or 2, in which the cap is mounted on and / or removed from the injection device by means of essentially linear motion.

4. An injection device, as in any of the previous examples, in which the cap is mounted on and / or removed from the injection device by a rotational or spiral movement.

5. An injection device, as in any of the previous examples, in which, when the cap is installed on the injection device, the piston rod is blocked from axial movement.

6. An injection device, as in any of the previous examples, further comprising a drive component configured to transmit a driving force to the piston rod during injection, and when the cap is mounted on the injection device, the piston rod is capable of rotational movement, but is blocked from translational movement relative to cap.

7. Injection device, as in example 6, in which, when the cap is mounted on the injection device, the drive component abuts against the cap.

8. An injection device, as in example 6 or 7, further comprising means for holding the cap on the injection device with overcoming linear force from the drive component.

9. An injection device, as in example 6, further comprising a release button operably connected to the dose setting means and the injection means and configured to axially move between the first position corresponding to the set dose and the second position corresponding to actuating the injection means for injection of a set dose, while with the cap installed on the injection device, the release button is able to move between the first and second positions niyami.

10. Injection device, as in example 9, additionally containing means for supplying energy, functionally associated with means for setting the dose and with injection means and designed to store and release energy to ensure translational and rotational motion.

11. Injection device, as in example 10, in which the force applied to move the release button from the first to the second position with the cap installed on the injection device causes the drive component to rotate, while the energy supply means stores energy to provide rotational movement.

12. An injection device, as in example 11, in which the release of the force exerted on the release button with the cap mounted on the injection device causes the drive component to rotate, while the energy supply means releases energy to provide rotational movement.

13. An injection device, as in example 12, in which, when the indicated force is removed, the release button automatically moves from the second to the first position.

14. Injection device, as in any of the previous examples, in which the means for setting the dose is functionally connected to the receiving part so that the installation of the cap on the injection device leads to the setting of the dose of the means for setting the dose.

Claims (16)

1. An injection device containing:
- a variable volume tank having an output channel,
- means for setting the dose,
- injection means for conducting an injection of a prescribed dose and containing a rod with teeth, at least on one of its parts, configured to reduce the volume of the tank,
- a drive component configured to move relative to the specified rod during dose setting and transmitting the drive force to the specified rod during injection and containing a mating element designed to interface with the specified rod,
- guide means, configured to direct the movement of the drive component and / or the specified rod, and
- means of supplying energy, functionally associated with the means for setting the dose and with the injection means and designed to store and release energy to ensure translational and rotational motion,
however, when activating the means for setting the dose in order to set the dose, the mating element extends beyond the tooth on the specified rod through a combined translational / rotational movement. 2. The injection device according to claim 1, characterized in that when the means for setting the dose is set in order to set the dose, the energy supply means releases energy for the rotational movement. 3. The injection device according to claim 1 or 2, characterized in that when the means for setting the dose is set in order to set the dose, the energy supply means stores energy for translational movement. 4. The injection device according to claim 1 or 2, characterized in that when the injection means is activated to inject a set dose, the energy supply means stores energy for rotational movement. 5. The injection device according to claim 1 or 2, characterized in that when the injection means is activated to inject a set dose, the energy supply means releases energy for translational movement. 6. The injection device according to claim 1 or 2, characterized in that the guide means comprises an inclined guide surface. 7. The injection device according to claim 6, characterized in that the guide means further comprises a substantially flat longitudinal guide surface connected to an inclined guide surface at its edge, forming a transition point between the purely translational motion and the combined translational / rotational motion. 8. The injection device according to claim 7, characterized in that the angle between the essentially flat longitudinal guide surface and the inclined guide surface is from 180 ° to 270 °, preferably from 225 ° to 270 °, particularly preferably from 240 ° to 270 °. 9. The injection device according to claim 7, characterized in that the drive component is guided by a substantially flat longitudinal guide surface during the first part of the dose setting and an inclined guide surface during the second part of the dose setting. 10. The injection device according to claim 9, characterized in that the second part of the dose setting is performed automatically by the injection device. 11. The injection device according to claim 1 or 2, characterized in that the guide means comprises a latch for holding the means of supplying energy in a stable state. 12. The injection device according to claim 1 or 2, characterized in that the means of supplying energy contains a compressible spring configured to pre-create a rotational voltage in it. 13. The injection device according to claim 1 or 2, characterized in that the means of supplying energy contains a compressible spring and a torsion spring. 14. The injection device according to claim 1 or 2, characterized in that it further comprises a removable cap and a receiving part, made with the possibility of emphasis on the cap or pair with it when it is installed on the injection device, and the receiving part is functionally connected with the means for setting the dose so that the installation of the cap on the injection device actuates the means for setting the dose, forcing the mating element to pass the tooth on the specified rod through a combined translational / rotational sensible movement. 15. An injection device containing:
- a variable volume tank having an output channel,
- means for setting the dose,
- injection means for conducting an injection of a prescribed dose and containing a rod with teeth, at least on one of its parts, configured to reduce the volume of the tank,
- a drive component configured to move relative to the specified rod during dose setting and transmitting the drive force to the specified rod during injection and containing a mating element designed to interface with the specified rod,
- guide means, configured to direct the movement of the drive component and / or the specified rod,
- a push button operatively associated with the means for setting the dose and the injection means and configured to axially move between the first position corresponding to the set dose and the second position corresponding to actuating the injection means for injecting the set dose, and
- means of supplying energy, functionally associated with the means for setting the dose and with the injection means and designed to store and release energy to ensure translational and rotational motion,
the actuation of the means for setting the dose to set the dose causes the following actions:
- the mating element extends beyond the tooth on the specified rod through a combined translational / rotational movement,
- the means of supplying energy stores energy for translational motion, released only when the injection means, and
- the push button moves from the second to the first position. 16. The injection device according to clause 15, characterized in that it further comprises a removable cap and a receiving part, made with the possibility of emphasis on the cap or pair with it when it is installed on the injection device, and the receiving part is functionally connected with the means for setting the dose in this way that the installation of the cap on the injection device drives the means for setting the dose to set the dose.

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