RS60921B1 - Postupak za dobijanje (4s)-4-(4-cijano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro-1-6-naftiridin-3-karboksamida i njegovo prečišćavanje za upotrebu kao aktivnog farmaceutskog sastojka - Google Patents

Postupak za dobijanje (4s)-4-(4-cijano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro-1-6-naftiridin-3-karboksamida i njegovo prečišćavanje za upotrebu kao aktivnog farmaceutskog sastojka

Info

Publication number: RS60921B1
Authority: RS; Serbia
Prior art keywords: carbox; naphthyridine; methoxyphenyl; dihydro; ethoxy
Prior art date: 2014-08-01

Application number

RS20201213A

Other languages

English (en)

Inventor

Johannes Platzek

Gunnar Garke

Alfons Grunenberg

Original Assignee

Bayer Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-08-01

Filing date

2015-07-29

Publication date

2020-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51260727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS60921(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-07-29 Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG

2020-11-30 Publication of RS60921B1 publication Critical patent/RS60921B1/sr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

RS20201213A 2014-08-01 2015-07-29 Postupak za dobijanje (4s)-4-(4-cijano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro-1-6-naftiridin-3-karboksamida i njegovo prečišćavanje za upotrebu kao aktivnog farmaceutskog sastojka RS60921B1 (sr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP14179544		2014-08-01
EP15742306.2A EP3174875B1 (de)	2014-08-01	2015-07-29	Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff
PCT/EP2015/067340 WO2016016287A1 (de)	2014-08-01	2015-07-29	Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff

Publications (1)

Publication Number	Publication Date
RS60921B1 true RS60921B1 (sr)	2020-11-30

Family

ID=51260727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RS20201213A RS60921B1 (sr)	2014-08-01	2015-07-29	Postupak za dobijanje (4s)-4-(4-cijano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro-1-6-naftiridin-3-karboksamida i njegovo prečišćavanje za upotrebu kao aktivnog farmaceutskog sastojka

Country Status (31)

Country	Link
US (4)	USRE49575E1 (sr)
EP (2)	EP3660015A1 (sr)
JP (1)	JP6818674B2 (sr)
KR (2)	KR20230066477A (sr)
CN (4)	CN116655629A (sr)
AR (1)	AR101403A1 (sr)
AU (1)	AU2015295376C1 (sr)
BR (1)	BR112017001678B1 (sr)
CA (2)	CA3146285C (sr)
CL (1)	CL2017000263A1 (sr)
CO (1)	CO2017000886A2 (sr)
DK (1)	DK3174875T3 (sr)
ES (1)	ES2828704T3 (sr)
HR (1)	HRP20201800T1 (sr)
HU (1)	HUE051350T2 (sr)
IL (1)	IL250239B (sr)
JO (1)	JO3648B1 (sr)
LT (1)	LT3174875T (sr)
MX (1)	MX369467B (sr)
MY (1)	MY198066A (sr)
PE (1)	PE20170141A1 (sr)
PL (1)	PL3174875T3 (sr)
PT (1)	PT3174875T (sr)
RS (1)	RS60921B1 (sr)
RU (1)	RU2729998C9 (sr)
SG (1)	SG11201700785UA (sr)
SI (1)	SI3174875T1 (sr)
TW (1)	TWI684593B (sr)
UA (1)	UA122773C2 (sr)
UY (1)	UY36251A (sr)
WO (1)	WO2016016287A1 (sr)

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Publication number	Priority date	Publication date	Assignee	Title
RS60921B1 (sr) *	2014-08-01	2020-11-30	Bayer Pharma AG	Postupak za dobijanje (4s)-4-(4-cijano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro-1-6-naftiridin-3-karboksamida i njegovo prečišćavanje za upotrebu kao aktivnog farmaceutskog sastojka
PE20180554A1 (es)	2015-08-21	2018-04-02	Bayer Pharma AG	Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificacion para su uso como principio activo farmaceutico
EP3560922A1 (de)	2018-04-24	2019-10-30	Bayer Aktiengesellschaft	Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester
WO2020178177A1 (de)	2019-03-05	2020-09-10	Bayer Aktiengesellschaft	Verfahren zur herstellung von 4-amino-5-methylpyridon
AU2020230965A1 (en)	2019-03-05	2021-09-23	Bayer Aktiengesellschaft	Synthesis of 4-amino-5-methyl-1H-pyridin-2(1H)-on (intermediate compound for the synthesis of the MR antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine
EP4045502A1 (de) *	2019-10-17	2022-08-24	Bayer Aktiengesellschaft	Photochemisches verfahren zur herstellung von (4r, 4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid
KR20220084102A (ko) *	2019-10-17	2022-06-21	바이엘 악티엔게젤샤프트	(4s)-(4-시아노-2-메톡시페닐)-5-에톡시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복실산의 아실옥시메틸 에스테르의 제조 방법
KR20220084101A (ko) *	2019-10-17	2022-06-21	바이엘 악티엔게젤샤프트	부분입체이성질체 타르타르산 에스테르를 사용한 라세미체 분리에 의한 2-시아노에틸 (4s)-4-(4-시아노-2-메톡시페닐)-5-히드록시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복실레이트의 제조 방법
MX2022004467A (es) *	2019-10-17	2022-05-03	Bayer Ag	Procedimiento para preparar (4s)-4-(4-ciano-2-metoxi-fenil)-5-etox i-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxilato de 2-cianoetilo mediante separacion de racematos utilizando esteres diastereomericos de acido tartarico.
EP3900722A1 (en)	2020-04-22	2021-10-27	Bayer AG	Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases
US20230201174A1 (en)	2020-04-22	2023-06-29	Bayer Aktiengesellschaft	Combination of finerenone and a sglt2 inhibitor for the treatment and/or prevention of cardiovascular and/or renal diseases
TW202214624A (zh)	2020-06-16	2022-04-16	德商拜耳廠股份有限公司	藉由催化不對稱漢斯（ｈａｎｔｚｓｃｈ）酯還原法進行之製備（４ｓ）－４－（４－氰基－２－甲氧基苯基）－５－乙氧基－２，８－二甲基－１，４－二氫－１，６－㖠啶－３－羧醯胺的方法
CN112237573B (zh) *	2020-10-29	2023-12-22	瑞阳制药股份有限公司	含finerenone的片剂及其制备方法
WO2022214206A1 (en)	2021-04-08	2022-10-13	Bayer Aktiengesellschaft	Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases
CN114149427A (zh) *	2021-12-18	2022-03-08	上海鼎雅药物化学科技有限公司	非奈利酮及其中间体的合成方法
CN115340539B (zh)	2022-01-19	2024-02-27	奥锐特药业股份有限公司	制备非奈利酮及其中间体的方法
CN115340540A (zh) *	2022-01-20	2022-11-15	奥锐特药业股份有限公司	制备非奈利酮及其中间体的方法
CN114524812A (zh) *	2022-03-18	2022-05-24	湖南凯铂生物药业有限公司	1,4-二氢-1,6-萘啶化合物的晶型制备以及合成方法
WO2023205164A1 (en)	2022-04-18	2023-10-26	Teva Pharmaceuticals International Gmbh	Processes for the preparation of finerenone
EP4286368A1 (de)	2022-05-31	2023-12-06	Bayer Aktiengesellschaft	Verfahren zur herstellung von 4-formyl-3-methoxybenzonitril
WO2024075139A1 (en) *	2022-10-06	2024-04-11	Maithri Drugs Private Limited	A process for preparation of finerenone and intermediates thereof
WO2024110523A1 (en) *	2022-11-23	2024-05-30	Bayer Aktiengesellschaft	Treatment of chronic kidney disease in type i diabetes mellitus
WO2024126694A1 (en)	2022-12-16	2024-06-20	Bayer Aktiengesellschaft	Sequential one-pot synthesis for preparing 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
WO2024147053A1 (en) *	2023-01-03	2024-07-11	Optimus Drugs Pvt Ltd	Improved process for the preparation of finerenone
WO2024193455A1 (zh) *	2023-03-17	2024-09-26	江苏恒瑞医药股份有限公司	一种1,4-二氢-1,6-萘啶酰胺化合物的可药用盐、晶型及其制备方法

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RS60921B1 (sr) *	2014-08-01	2020-11-30	Bayer Pharma AG	Postupak za dobijanje (4s)-4-(4-cijano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro-1-6-naftiridin-3-karboksamida i njegovo prečišćavanje za upotrebu kao aktivnog farmaceutskog sastojka

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Also Published As

Publication number	Publication date
KR20230066477A (ko)	2023-05-15
JP6818674B2 (ja)	2021-01-20
CA2956529A1 (en)	2016-02-04
PL3174875T3 (pl)	2021-01-25
MX2017001507A (es)	2017-05-23
PT3174875T (pt)	2020-11-05
US10399977B2 (en)	2019-09-03
BR112017001678A2 (pt)	2018-07-17
EP3174875A1 (de)	2017-06-07
DK3174875T3 (da)	2020-11-16
EP3660015A1 (de)	2020-06-03
US20190127369A1 (en)	2019-05-02
US10059707B2 (en)	2018-08-28
SI3174875T1 (sl)	2020-12-31
RU2729998C9 (ru)	2020-10-20
LT3174875T (lt)	2020-11-25
KR102527893B1 (ko)	2023-05-02
TW201619155A (zh)	2016-06-01
WO2016016287A1 (de)	2016-02-04
CN106795155A (zh)	2017-05-31
ES2828704T3 (es)	2021-05-27
CN116655630A (zh)	2023-08-29
CA3146285C (en)	2024-01-02
HUE051350T2 (hu)	2021-03-01
USRE49575E1 (en)	2023-07-11
RU2017106602A3 (sr)	2019-02-21
KR20170040278A (ko)	2017-04-12
UA122773C2 (uk)	2021-01-06
CO2017000886A2 (es)	2017-05-10
AR101403A1 (es)	2016-12-14
AU2015295376C1 (en)	2020-07-16
SG11201700785UA (en)	2017-02-27
CN116655629A (zh)	2023-08-29
CL2017000263A1 (es)	2017-09-29
USRE49860E1 (en)	2024-03-05
NZ728558A (en)	2023-08-25
RU2017106602A (ru)	2018-09-05
PE20170141A1 (es)	2017-04-02
CN106795155B (zh)	2023-06-16
JO3648B1 (ar)	2020-08-27
HRP20201800T1 (hr)	2020-12-25
UY36251A (es)	2016-01-29
IL250239A0 (en)	2017-03-30
IL250239B (en)	2019-09-26
BR112017001678B1 (pt)	2024-01-16
CN116655627A (zh)	2023-08-29
MY198066A (en)	2023-07-31
TWI684593B (zh)	2020-02-11
AU2015295376A1 (en)	2017-02-16
AU2015295376B2 (en)	2019-10-03
RU2729998C2 (ru)	2020-08-13
EP3174875B1 (de)	2020-08-19
CA3146285A1 (en)	2016-02-04
JP2017522357A (ja)	2017-08-10
MX369467B (es)	2019-11-08
US20170217957A1 (en)	2017-08-03

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