RO70609B - Procedeu pentru prepararea unor peptide cu actiune acth - Google Patents
Procedeu pentru prepararea unor peptide cu actiune acthInfo
- Publication number
- RO70609B RO70609B RO75832A RO7583273A RO70609B RO 70609 B RO70609 B RO 70609B RO 75832 A RO75832 A RO 75832A RO 7583273 A RO7583273 A RO 7583273A RO 70609 B RO70609 B RO 70609B
- Authority
- RO
- Romania
- Prior art keywords
- group
- acth
- amino acid
- place
- instead
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
- C07K14/6955—Corticotropin [ACTH] with at least 1 amino acid in D-form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedeu pentru prepararea unor peptide cu actiune ACTH, constituite dintr-o secventa completa ACTH de la amino-acidul N-terminal pîna la cel putin al 16-lea aminoacid si care secventa ACTH contine, eventual si alti aminoacizi si anume în locul grupei Asn la puterea 25 grupa Asp, în locul grupei Gly26 grupa Ala si/sau în locul grupei Ala27 o grupa Gly si în locul primului aminoacid un acid alfa-aminoxi, caracterizat prin aceea ca, din peptidele sau peptidaminele constituite dintr-o secventa completa ACTH pîna la cel putin al 16-lea aminoacid N-terminal contin în locul primului aminoacid, un acid alfa aminooxi si eventual în locul grupei Ala la puterea 27 o grupa Gly în care grupa aminooxi si grupa amino sunt protejate prin grupe tert-butiloxicarbonil, iar grupele protectoare prin acidoliza în prezenta de apa si a unui solvent organic la temperatura camerei si eventual peptida obtinuta se transforma într-o sare de aditie cu acizi într-un complex.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HURI480A HU167655B (ro) | 1972-08-18 | 1972-08-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO70609A RO70609A (ro) | 1984-03-15 |
| RO70609B true RO70609B (ro) | 1984-03-31 |
Family
ID=11000901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO75832A RO70609B (ro) | 1972-08-18 | 1973-08-18 | Procedeu pentru prepararea unor peptide cu actiune acth |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3873510A (ro) |
| JP (1) | JPS532866B2 (ro) |
| AT (1) | AT340070B (ro) |
| AU (1) | AU472380B2 (ro) |
| BE (1) | BE803728A (ro) |
| CA (1) | CA1005051A (ro) |
| CH (1) | CH590212A5 (ro) |
| CS (1) | CS171183B2 (ro) |
| DD (1) | DD109969A5 (ro) |
| DE (1) | DE2341775C3 (ro) |
| ES (1) | ES417951A1 (ro) |
| FR (1) | FR2196174B1 (ro) |
| GB (1) | GB1416214A (ro) |
| HU (1) | HU167655B (ro) |
| IL (1) | IL42973A (ro) |
| NL (1) | NL7311407A (ro) |
| RO (1) | RO70609B (ro) |
| SE (1) | SE408299B (ro) |
| SU (1) | SU490284A3 (ro) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071510A (en) * | 1974-12-16 | 1978-01-31 | Lars Ake Ingemar Carlsson | Peptides having a high adrenocorticotropic effect and a method of producing the same |
| HU175151B (hu) * | 1976-12-24 | 1980-05-28 | Richter Gedeon Vegyeszet | Sposob poluchenija peptidov s aktivnost'ju tipa gastrina soderzhashchie fenilglicin |
| HU175152B (hu) * | 1976-12-30 | 1980-05-28 | Richter Gedeon Vegyeszet | Sposob poluchenija peptidov s gastrin-aktivnost'ju, soderzhahhikh amino-oksi-kisloty |
| JPS61186691U (ro) * | 1985-05-15 | 1986-11-20 | ||
| IT1204434B (it) * | 1986-01-15 | 1989-03-01 | Alfio Bertolini | Composizioni farmaceutiche comprendenti frammenti di acth per il trattamento terapeutico degli stati di shock e dell'insufficienza respiratoria e cardiocircolatoria |
-
1972
- 1972-08-18 HU HURI480A patent/HU167655B/hu unknown
-
1973
- 1973-08-10 CH CH1154673A patent/CH590212A5/xx not_active IP Right Cessation
- 1973-08-13 AT AT706273A patent/AT340070B/de not_active IP Right Cessation
- 1973-08-14 IL IL42973A patent/IL42973A/en unknown
- 1973-08-14 AU AU59204/73A patent/AU472380B2/en not_active Expired
- 1973-08-14 CA CA178,753A patent/CA1005051A/en not_active Expired
- 1973-08-15 GB GB3859973A patent/GB1416214A/en not_active Expired
- 1973-08-15 US US388546A patent/US3873510A/en not_active Expired - Lifetime
- 1973-08-16 CS CS5784A patent/CS171183B2/cs unknown
- 1973-08-16 SE SE7311207A patent/SE408299B/xx unknown
- 1973-08-17 SU SU731963873A patent/SU490284A3/ru active
- 1973-08-17 FR FR7330091A patent/FR2196174B1/fr not_active Expired
- 1973-08-17 JP JP9232473A patent/JPS532866B2/ja not_active Expired
- 1973-08-17 DE DE2341775A patent/DE2341775C3/de not_active Expired
- 1973-08-17 ES ES417951A patent/ES417951A1/es not_active Expired
- 1973-08-17 DD DD172966A patent/DD109969A5/xx unknown
- 1973-08-17 BE BE134685A patent/BE803728A/xx unknown
- 1973-08-17 NL NL7311407A patent/NL7311407A/xx not_active Application Discontinuation
- 1973-08-18 RO RO75832A patent/RO70609B/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2341775A1 (de) | 1974-02-28 |
| DD109969A5 (ro) | 1974-11-20 |
| SU490284A3 (ru) | 1975-10-30 |
| AU5920473A (en) | 1975-02-20 |
| AT340070B (de) | 1977-11-25 |
| CH590212A5 (ro) | 1977-07-29 |
| ATA706273A (de) | 1977-03-15 |
| FR2196174B1 (ro) | 1976-10-22 |
| ES417951A1 (es) | 1976-03-16 |
| SE408299B (sv) | 1979-06-05 |
| NL7311407A (ro) | 1974-02-20 |
| AU472380B2 (en) | 1976-05-20 |
| GB1416214A (en) | 1975-12-03 |
| CA1005051A (en) | 1977-02-08 |
| IL42973A0 (en) | 1973-11-28 |
| IL42973A (en) | 1977-06-30 |
| US3873510A (en) | 1975-03-25 |
| JPS49132074A (ro) | 1974-12-18 |
| JPS532866B2 (ro) | 1978-02-01 |
| DE2341775B2 (de) | 1980-04-24 |
| DE2341775C3 (de) | 1980-12-18 |
| BE803728A (fr) | 1973-12-17 |
| RO70609A (ro) | 1984-03-15 |
| HU167655B (ro) | 1975-11-28 |
| CS171183B2 (ro) | 1976-10-29 |
| FR2196174A1 (ro) | 1974-03-15 |
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