PT2565191E - Derivados do ácido 4-(indol-7- ilcarbonilaminometil)ciclo-hexanocarboxílico como antagonistas de receptores ep4, úteis no tratamento de insuficiência renal crónica ou de nefropatia diabética - Google Patents
Derivados do ácido 4-(indol-7- ilcarbonilaminometil)ciclo-hexanocarboxílico como antagonistas de receptores ep4, úteis no tratamento de insuficiência renal crónica ou de nefropatia diabética Download PDFInfo
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- PT2565191E PT2565191E PT121947899T PT12194789T PT2565191E PT 2565191 E PT2565191 E PT 2565191E PT 121947899 T PT121947899 T PT 121947899T PT 12194789 T PT12194789 T PT 12194789T PT 2565191 E PT2565191 E PT 2565191E
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- ylcarbonylaminomethyl
- indol
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Organic Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
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JP2008127424 | 2008-05-14 |
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PT2565191E true PT2565191E (pt) | 2014-12-04 |
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PT121947899T PT2565191E (pt) | 2008-05-14 | 2009-05-12 | Derivados do ácido 4-(indol-7- ilcarbonilaminometil)ciclo-hexanocarboxílico como antagonistas de receptores ep4, úteis no tratamento de insuficiência renal crónica ou de nefropatia diabética |
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US (1) | US8598355B2 (pt) |
EP (2) | EP2565191B1 (pt) |
JP (1) | JP5375824B2 (pt) |
KR (1) | KR101612971B1 (pt) |
CN (1) | CN102026961B (pt) |
AU (1) | AU2009247262B2 (pt) |
BR (1) | BRPI0912778B1 (pt) |
CA (1) | CA2724077C (pt) |
CY (1) | CY1115944T1 (pt) |
DK (1) | DK2565191T3 (pt) |
ES (1) | ES2518919T3 (pt) |
HR (1) | HRP20141248T1 (pt) |
IL (1) | IL208955A0 (pt) |
MX (1) | MX2010012357A (pt) |
PL (1) | PL2565191T3 (pt) |
PT (1) | PT2565191E (pt) |
RU (1) | RU2479576C9 (pt) |
SI (1) | SI2565191T1 (pt) |
TW (1) | TW201000460A (pt) |
WO (1) | WO2009139373A1 (pt) |
ZA (1) | ZA201007686B (pt) |
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TW201326154A (zh) * | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ep2受體拮抗劑之新穎2h-吲唑 |
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CN106478606B (zh) * | 2016-09-21 | 2019-05-10 | 沈阳药科大学 | N-取代吲哚类衍生物及其应用 |
US11066405B2 (en) | 2017-04-18 | 2021-07-20 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
AU2018255300B2 (en) * | 2017-04-18 | 2021-10-28 | Tempest Therapeutics, Inc. | Bicyclic compounds and their use in the treatment of cancer |
US11168080B2 (en) | 2017-04-26 | 2021-11-09 | Mitobridge, Inc. | Dynamin-1-like protein inhibitors |
HRP20211532T1 (hr) | 2017-05-18 | 2022-01-07 | Idorsia Pharmaceuticals Ltd | N-supstituirani derivati indola |
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CN109836434B (zh) * | 2017-11-27 | 2020-09-25 | 上海宇耀生物科技有限公司 | 噻吩并环类化合物及其合成方法和应用 |
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CN110386941A (zh) * | 2019-08-15 | 2019-10-29 | 上海邦耀生物科技有限公司 | Ep4受体拮抗剂和pd-1抑制剂联合用于癌症的治疗 |
CN113087719B (zh) * | 2020-02-05 | 2024-01-26 | 上海宇耀生物科技有限公司 | 一种ep4受体拮抗剂的多晶型物及其制备方法与用途 |
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CA2660133C (en) * | 2006-08-11 | 2015-10-27 | Merck Frosst Canada Ltd. | Thiophenecarboxamide derivatives as ep4 receptor ligands |
EA015931B1 (ru) | 2006-12-15 | 2011-12-30 | Глэксо Груп Лимитед | Бензамидные производные как агонисты ер-рецепторов |
ES2400293T3 (es) | 2007-02-26 | 2013-04-08 | Merck Canada Inc. | Derivados de indol e indolina ciclopropilamida como antagonistas de receptores EP4 |
CA2681861A1 (en) | 2007-03-26 | 2008-10-16 | Astellas Pharma Inc. | Ornithine derivative |
WO2009005076A1 (ja) * | 2007-07-03 | 2009-01-08 | Astellas Pharma Inc. | アミド化合物 |
GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
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2009
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- 2009-05-12 PL PL12194789T patent/PL2565191T3/pl unknown
- 2009-05-12 WO PCT/JP2009/058821 patent/WO2009139373A1/ja active Application Filing
- 2009-05-12 JP JP2010511978A patent/JP5375824B2/ja not_active Expired - Fee Related
- 2009-05-12 CN CN200980117392.7A patent/CN102026961B/zh not_active Expired - Fee Related
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- 2009-05-12 EP EP09746580A patent/EP2277858A4/en active Pending
- 2009-05-12 US US12/992,388 patent/US8598355B2/en active Active
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- 2009-05-12 SI SI200931064T patent/SI2565191T1/sl unknown
- 2009-05-12 BR BRPI0912778-0A patent/BRPI0912778B1/pt not_active IP Right Cessation
- 2009-05-12 DK DK12194789.9T patent/DK2565191T3/da active
- 2009-05-12 AU AU2009247262A patent/AU2009247262B2/en not_active Ceased
- 2009-05-12 RU RU2010150911/04A patent/RU2479576C9/ru active
- 2009-05-12 ES ES12194789.9T patent/ES2518919T3/es active Active
- 2009-05-12 KR KR1020107021529A patent/KR101612971B1/ko active IP Right Grant
- 2009-05-14 TW TW098115967A patent/TW201000460A/zh unknown
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2010
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- 2010-10-27 ZA ZA2010/07686A patent/ZA201007686B/en unknown
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2014
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- 2014-12-22 HR HRP20141248AT patent/HRP20141248T1/hr unknown
Also Published As
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AU2009247262B2 (en) | 2013-01-31 |
BRPI0912778B1 (pt) | 2019-04-30 |
TW201000460A (en) | 2010-01-01 |
JP5375824B2 (ja) | 2013-12-25 |
CA2724077C (en) | 2016-04-26 |
CY1115944T1 (el) | 2017-01-25 |
IL208955A0 (en) | 2011-01-31 |
ES2518919T3 (es) | 2014-11-05 |
JPWO2009139373A1 (ja) | 2011-09-22 |
EP2565191A1 (en) | 2013-03-06 |
EP2565191B1 (en) | 2014-10-08 |
EP2277858A1 (en) | 2011-01-26 |
CN102026961B (zh) | 2014-04-09 |
HRP20141248T1 (en) | 2015-03-13 |
DK2565191T3 (da) | 2014-11-10 |
RU2479576C9 (ru) | 2014-03-10 |
WO2009139373A1 (ja) | 2009-11-19 |
SI2565191T1 (sl) | 2014-12-31 |
KR101612971B1 (ko) | 2016-04-15 |
US20110144153A1 (en) | 2011-06-16 |
CA2724077A1 (en) | 2009-11-19 |
RU2010150911A (ru) | 2012-06-20 |
BRPI0912778A2 (pt) | 2015-10-13 |
PL2565191T3 (pl) | 2015-03-31 |
AU2009247262A1 (en) | 2009-11-19 |
EP2277858A4 (en) | 2012-06-13 |
US8598355B2 (en) | 2013-12-03 |
RU2479576C2 (ru) | 2013-04-20 |
ZA201007686B (en) | 2012-02-29 |
KR20110006654A (ko) | 2011-01-20 |
MX2010012357A (es) | 2010-12-07 |
CN102026961A (zh) | 2011-04-20 |
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