PE20001355A1 - 1,3-diamino-cetonas como inhibidores de proteasas - Google Patents

1,3-diamino-cetonas como inhibidores de proteasas

Info

Publication number
PE20001355A1
PE20001355A1 PE1999001311A PE00131199A PE20001355A1 PE 20001355 A1 PE20001355 A1 PE 20001355A1 PE 1999001311 A PE1999001311 A PE 1999001311A PE 00131199 A PE00131199 A PE 00131199A PE 20001355 A1 PE20001355 A1 PE 20001355A1
Authority
PE
Peru
Prior art keywords
alkyl
diamine
het
aralkyl
cycloalkyl
Prior art date
Application number
PE1999001311A
Other languages
English (en)
Spanish (es)
Inventor
Wells Marquis Robert
Frank Veber Daniel
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20001355A1 publication Critical patent/PE20001355A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PE1999001311A 1998-12-23 1999-12-23 1,3-diamino-cetonas como inhibidores de proteasas PE20001355A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11414398P 1998-12-23 1998-12-23

Publications (1)

Publication Number Publication Date
PE20001355A1 true PE20001355A1 (es) 2001-01-28

Family

ID=22353596

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999001311A PE20001355A1 (es) 1998-12-23 1999-12-23 1,3-diamino-cetonas como inhibidores de proteasas

Country Status (9)

Country Link
EP (1) EP1140897A4 (ja)
JP (1) JP2002533452A (ja)
AR (1) AR021970A1 (ja)
AU (1) AU2713100A (ja)
CO (1) CO5180541A1 (ja)
DZ (1) DZ2976A1 (ja)
HK (1) HK1041690A1 (ja)
PE (1) PE20001355A1 (ja)
WO (1) WO2000039115A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
WO2001034599A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
EP1232154A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp PROTEASE INHIBITORS
AU1474801A (en) 1999-11-10 2001-06-06 Smithkline Beecham Corporation Protease inhibitors
CN1416346A (zh) 2000-03-21 2003-05-07 史密丝克莱恩比彻姆公司 蛋白酶抑制剂
US6982263B2 (en) 2001-06-08 2006-01-03 Boehringer Ingelheim Pharmaceuticals, Inc. Nitriles useful as reversible inhibitors of cysteine proteases
US7087604B2 (en) 2002-03-08 2006-08-08 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
WO2006029154A2 (en) * 2004-09-07 2006-03-16 Smithkline Beecham Corporation Novel compounds
CN101137412B (zh) 2005-01-13 2012-11-07 布里斯托尔-迈尔斯·斯奎布公司 用作凝血因子XIa抑制剂的取代的二芳基化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ2285A1 (fr) * 1996-08-08 2002-12-25 Smithkline Beecham Corp Inhibiteurs de protéase de la cystéine.
TR199902752T2 (xx) * 1997-05-08 2000-06-21 Smithkline Beecham Corporation Proteaz inhibit�rleri.

Also Published As

Publication number Publication date
EP1140897A1 (en) 2001-10-10
AU2713100A (en) 2000-07-31
JP2002533452A (ja) 2002-10-08
AR021970A1 (es) 2002-09-04
DZ2976A1 (fr) 2004-03-15
EP1140897A4 (en) 2002-04-03
HK1041690A1 (zh) 2002-07-19
WO2000039115A1 (en) 2000-07-06
CO5180541A1 (es) 2002-07-30

Similar Documents

Publication Publication Date Title
PE20001340A1 (es) 4-amino-azepan-3-ona como inhibidores de proteasas
PE20011233A1 (es) Compuestos alquil aminoazepan-3-ona como inhibidores de proteasas
DK0734381T3 (da) Morpholin- og thiomorpholintachykininreceptorantagonister
PE99198A1 (es) Inhibidores de proteasas
PE110899A1 (es) Derivados de acidos ariloxiarilsulfonilamino hidroxamicos
DE69133299D1 (de) Aminosulfonylcarbamate
HRP20000445B1 (en) Aryl fused azapolycyclic compounds
DK1409467T3 (da) N-acylsphingosinglucosyltransferase-inhibitor
PT788356E (pt) Metodo e composicoes para a inibicao de proteina-quinases.
PE20060215A1 (es) 4-fenilamino-quinazolin-6-il-amidas
YU34896A (sh) Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
PE20021004A1 (es) Derivados de piperidina como inhibidores de la ccr5
PE20001355A1 (es) 1,3-diamino-cetonas como inhibidores de proteasas
PE71599A1 (es) Inhibidores de proteasas
PE106099A1 (es) Uso de derivados hidroxicumaranonas sustituidos como agentes antitumorales y antimetastasicos
PE68599A1 (es) Inhibidores de proteasas
PE20000435A1 (es) Compuestos azapoliciclicos condensados con arilo
RS49965B (sr) Supstituisani bisindolmaleimidi za inhibiciju ćelijske proliferacije
DE69919436D1 (de) N-Acyl und N-Aroyl Aralkylamide
PE20001486A1 (es) Compuestos etereos anular de 7 a 14 miembros como inhibidores de proteasas
PE20000725A1 (es) Compuestos de alcoxipirrolidinona como inhibidores de proteasas
PE20001607A1 (es) 4-AMINO-4,5-DIHIDRO-BENZO[b][1,4]DIOXOCIN-3-ONA COMO INHIBIDORES DE PROTEASAS
PE20001564A1 (es) 1,3-dioxepin-5-ona con un anillo de 7 miembros como inhibidores de proteasas
ATE42747T1 (de) N-(2-(tetrahydro-3,5-dioxo-1h-pyrrolizin-7a(5h) yl)ethyl>aminderivate.
ATE34173T1 (de) Thiazolderivate als h2-rezeptor-antagonisten.

Legal Events

Date Code Title Description
FC Refusal