NZ185539A - Cis-4a-aryl-2-substituted-2,3,4,4a,5,6,7,7a-octa hydro-1h-2-pyrindines and pharmaceutical compositions - Google Patents

Cis-4a-aryl-2-substituted-2,3,4,4a,5,6,7,7a-octa hydro-1h-2-pyrindines and pharmaceutical compositions

Info

Publication number
NZ185539A
NZ185539A NZ185539A NZ18553977A NZ185539A NZ 185539 A NZ185539 A NZ 185539A NZ 185539 A NZ185539 A NZ 185539A NZ 18553977 A NZ18553977 A NZ 18553977A NZ 185539 A NZ185539 A NZ 185539A
Authority
NZ
New Zealand
Prior art keywords
pyrindines
cis
aryl
substituted
pharmaceutical compositions
Prior art date
Application number
NZ185539A
Other languages
English (en)
Inventor
D Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NZ185539A publication Critical patent/NZ185539A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
NZ185539A 1976-11-02 1977-10-27 Cis-4a-aryl-2-substituted-2,3,4,4a,5,6,7,7a-octa hydro-1h-2-pyrindines and pharmaceutical compositions NZ185539A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
NZ185539A true NZ185539A (en) 1979-12-11

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ185539A NZ185539A (en) 1976-11-02 1977-10-27 Cis-4a-aryl-2-substituted-2,3,4,4a,5,6,7,7a-octa hydro-1h-2-pyrindines and pharmaceutical compositions

Country Status (26)

Country Link
JP (1) JPS5356669A (es)
AR (1) AR223454A1 (es)
AT (1) ATA782177A (es)
AU (1) AU513679B2 (es)
BE (1) BE860314A (es)
CA (1) CA1100136A (es)
CS (1) CS211380B2 (es)
DD (1) DD133795A5 (es)
DE (1) DE2748466A1 (es)
DK (1) DK485277A (es)
ES (3) ES463783A1 (es)
FR (1) FR2369267A1 (es)
GB (1) GB1590155A (es)
GR (1) GR70053B (es)
HU (1) HU176231B (es)
IE (1) IE45901B1 (es)
IL (1) IL53236A0 (es)
NL (1) NL7712053A (es)
NZ (1) NZ185539A (es)
PH (1) PH12590A (es)
PL (3) PL109690B1 (es)
PT (1) PT67194B (es)
RO (3) RO78300A (es)
SE (3) SE7712218L (es)
SU (3) SU812174A3 (es)
ZA (1) ZA776497B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL117572B1 (en) * 1977-12-27 1981-08-31 Lilly Co Eli Process for preparing novel derivatives of trans-4a-phenyl-2,3,4,4a,5,6,7,7a-octahydro-1h-2-pyrindine3,4,4a,5,6,7,7a-oktagidro-1h-2-piridina
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
CA2812526A1 (en) 2010-05-06 2011-11-10 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
DK2670752T3 (en) 2011-02-02 2016-07-04 Vertex Pharma PYRROLOPYRAZINE SPIROCYCLIC PIPERIDINAMIDE AS ION CHANNEL MODULATORS
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
MX347982B (es) 2011-03-14 2017-05-22 Vertex Pharma Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos.

Also Published As

Publication number Publication date
SU845777A3 (ru) 1981-07-07
SE8103107L (sv) 1981-05-18
CA1100136A (en) 1981-04-28
PL108610B1 (en) 1980-04-30
AU513679B2 (en) 1980-12-18
IE45901B1 (en) 1982-12-29
PL201885A1 (pl) 1978-12-04
IE45901L (en) 1978-05-02
IL53236A0 (en) 1977-12-30
AU3023577A (en) 1979-05-10
ES463783A1 (es) 1979-07-16
PT67194A (en) 1977-11-01
RO77935A (ro) 1981-12-25
ZA776497B (en) 1979-06-27
JPS5356669A (en) 1978-05-23
SU913941A3 (en) 1982-03-15
PT67194B (en) 1979-03-23
ES472276A1 (es) 1979-10-01
FR2369267A1 (fr) 1978-05-26
DD133795A5 (de) 1979-01-24
GB1590155A (en) 1981-05-28
ATA782177A (de) 1981-10-15
CS211380B2 (en) 1982-02-26
SE8103106L (sv) 1981-05-18
BE860314A (fr) 1978-04-28
SE7712218L (sv) 1978-05-03
DK485277A (da) 1978-05-03
PL108466B1 (en) 1980-04-30
GR70053B (es) 1982-07-26
HU176231B (en) 1981-01-28
DE2748466A1 (de) 1978-05-03
SU812174A3 (ru) 1981-03-07
AR223454A1 (es) 1981-08-31
ES463784A1 (es) 1978-06-16
PL109690B1 (en) 1980-06-30
FR2369267B1 (es) 1980-05-16
NL7712053A (nl) 1978-05-05
PH12590A (en) 1979-06-27
RO72900A (ro) 1981-11-04
RO78300A (ro) 1982-04-12

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