NO981522L - Aminosyrederivater, deres fremstilling og anvendelse som endotelinantagonister - Google Patents

Aminosyrederivater, deres fremstilling og anvendelse som endotelinantagonister

Info

Publication number: NO981522L
Authority: NO; Norway
Prior art keywords: preparation; amino acid; acid derivatives; endothelin antagonists; endothelin
Prior art date: 1995-10-04

Application number

NO981522A

Other languages

English (en)

Other versions

NO981522D0 (no

NO311025B1 (no

Inventor

Dagmar Klinge

Wilhelm Amberg

Andreas Kling

Hartmut Riechers

Liliane Unger

Manfred Raschack

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-04

Filing date

1998-04-03

Publication date

1998-04-03

1998-04-03 Application filed by Basf Ag filed Critical Basf Ag

1998-04-03 Publication of NO981522D0 publication Critical patent/NO981522D0/no

1998-04-03 Publication of NO981522L publication Critical patent/NO981522L/no

2001-10-01 Publication of NO311025B1 publication Critical patent/NO311025B1/no

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
150000003862 amino acid derivatives Chemical class 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/58—Two sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO19981522A 1995-10-04 1998-04-03 Aminosyrederivater, legemiddel inneholdende dem og anvendelse som endotelinantagonister NO311025B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19536891A DE19536891A1 (de)	1995-10-04	1995-10-04	Neue Aminosäurederivate, ihre Herstellung und Verwendung
PCT/EP1996/004205 WO1997012878A1 (de)	1995-10-04	1996-09-26	Aminosäurederivate, ihre herstellung und verwendung als endothelinantagonisten

Publications (3)

Publication Number	Publication Date
NO981522D0 NO981522D0 (no)	1998-04-03
NO981522L true NO981522L (no)	1998-04-03
NO311025B1 NO311025B1 (no)	2001-10-01

Family

ID=7773950

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19981522A NO311025B1 (no)	1995-10-04	1998-04-03	Aminosyrederivater, legemiddel inneholdende dem og anvendelse som endotelinantagonister

Country Status (24)

Country	Link
US (1)	US6440975B1 (no)
EP (1)	EP0874829A1 (no)
JP (1)	JP2000500738A (no)
KR (1)	KR19990063998A (no)
CN (1)	CN1202890A (no)
AU (1)	AU713763B2 (no)
BG (1)	BG63389B1 (no)
BR (1)	BR9610821A (no)
CA (1)	CA2231500A1 (no)
CO (1)	CO4770961A1 (no)
CZ (1)	CZ104598A3 (no)
DE (1)	DE19536891A1 (no)
HR (1)	HRP960437A2 (no)
HU (1)	HUP9900085A3 (no)
IL (1)	IL123611A (no)
MX (1)	MX9801987A (no)
MY (1)	MY115211A (no)
NO (1)	NO311025B1 (no)
NZ (1)	NZ319595A (no)
PL (1)	PL326081A1 (no)
SK (1)	SK43098A3 (no)
TR (1)	TR199800623T2 (no)
WO (1)	WO1997012878A1 (no)
ZA (1)	ZA968304B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19636046A1 (de)	1996-09-05	1998-03-12	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten
AU746706B2 (en) *	1997-07-03	2002-05-02	Du Pont Pharmaceuticals Company	Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6365589B1 (en)	1998-07-02	2002-04-02	Bristol-Myers Squibb Pharma Company	Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US6124463A (en) *	1998-07-02	2000-09-26	Dupont Pharmaceuticals	Benzimidazoles as corticotropin release factor antagonists
MXPA01007335A (es) *	1999-01-22	2004-06-07	Wyeth Corp	Derivados de acilo los cuales tratan trastornos relacionados con alfa4 beta1 integrina y cd49d/cd29 (vla-4).
US6900232B2 (en)	2000-06-15	2005-05-31	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists
US6531494B1 (en)	2001-08-29	2003-03-11	Pharmacia Corporation	Gem-substituted αvβ3 antagonists
EP1341773A2 (en)	2000-12-07	2003-09-10	Cv Therapeutics, Inc.	Substituted 1,3,5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis
TWI281470B (en)	2002-05-24	2007-05-21	Elan Pharm Inc	Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en)	2002-05-24	2003-12-16	Elan Pharm Inc	Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
WO2005076854A2 (en) *	2004-02-04	2005-08-25	Smithkline Beecham Corporation	Pyrimidinone compounds useful as kinase inhibitors
WO2007041270A1 (en)	2005-09-29	2007-04-12	Elan Pharmaceuticals, Inc.	Pyrimidinyl amide compounds which inhibit leukocyte adhesion mediated by vla-4
CN101273035A (zh)	2005-09-29	2008-09-24	伊兰制药公司	抑制由vla-4介导的白细胞粘附的氨基甲酸酯化合物
EA017110B1 (ru)	2006-02-27	2012-09-28	Элан Фамэсьютикэлс, Инк.	ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА
CN1908183B (zh) *	2006-08-16	2010-09-29	上海奥利实业有限公司	具内皮素拮抗作用的天然蛋白的酶解混合肽
US8497276B2 (en)	2009-03-31	2013-07-30	Arqule, Inc.	Substituted indolo-piperidine compounds
SG175355A1 (en)	2009-04-27	2011-12-29	Elan Pharm Inc	Pyridinone antagonists of alpha-4 integrins
WO2016020288A1 (en)	2014-08-04	2016-02-11	Nuevolution A/S	Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
US11447479B2 (en)	2019-12-20	2022-09-20	Nuevolution A/S	Compounds active towards nuclear receptors
CA3174176A1 (en)	2020-03-31	2021-10-07	Sanne Schroder Glad	Compounds active towards nuclear receptors
CA3174252A1 (en)	2020-03-31	2021-10-07	Nuevolution A/S	Compounds active towards nuclear receptors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4092150A (en) *	1976-08-27	1978-05-30	Fmc Corporation	Herbicidal 5-pyrimidinecarbonitriles
DE68914197T2 (de)	1988-06-20	1994-11-10	Ihara Chemical Ind Co	Alkansäurederivate und herbizide Mittel.
CA2053603A1 (en) *	1990-10-19	1992-04-20	Katsumasa Harada	3-alkoxyalkanoic acid derivative, process for preparing the same and herbicide using the same
DE4105518A1 (de)	1991-02-22	1992-08-27	Basf Ag	Sulfonylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung
DE69226813T2 (de) *	1991-06-07	1999-02-18	Ube Industries, Ltd., Ube, Yamaguchi	Pyrimidin- oder Triazin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Herbizide
DE4411225A1 (de) *	1994-03-31	1995-10-05	Basf Ag	Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) *	1994-10-14	2007-05-16	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung
US5958934A (en) *	1996-05-23	1999-09-28	Syntex (U.S.A.) Inc.	Aryl pyrimidine derivatives and uses thereof

1995
- 1995-10-04 DE DE19536891A patent/DE19536891A1/de not_active Withdrawn
1996
- 1996-09-26 PL PL96326081A patent/PL326081A1/xx unknown
- 1996-09-26 HR HR19536891.6A patent/HRP960437A2/hr not_active Application Discontinuation
- 1996-09-26 SK SK430-98A patent/SK43098A3/sk unknown
- 1996-09-26 EP EP96933398A patent/EP0874829A1/de not_active Withdrawn
- 1996-09-26 TR TR1998/00623T patent/TR199800623T2/xx unknown
- 1996-09-26 IL IL12361196A patent/IL123611A/xx not_active IP Right Cessation
- 1996-09-26 WO PCT/EP1996/004205 patent/WO1997012878A1/de not_active Application Discontinuation
- 1996-09-26 BR BR9610821A patent/BR9610821A/pt not_active Application Discontinuation
- 1996-09-26 US US09/051,020 patent/US6440975B1/en not_active Expired - Lifetime
- 1996-09-26 KR KR1019980702475A patent/KR19990063998A/ko not_active Application Discontinuation
- 1996-09-26 HU HU9900085A patent/HUP9900085A3/hu unknown
- 1996-09-26 NZ NZ319595A patent/NZ319595A/en unknown
- 1996-09-26 CN CN96198556A patent/CN1202890A/zh active Pending
- 1996-09-26 CZ CZ981045A patent/CZ104598A3/cs unknown
- 1996-09-26 AU AU72147/96A patent/AU713763B2/en not_active Ceased
- 1996-09-26 CA CA002231500A patent/CA2231500A1/en not_active Abandoned
- 1996-09-26 JP JP9513946A patent/JP2000500738A/ja not_active Abandoned
- 1996-09-27 MY MYPI96004014A patent/MY115211A/en unknown
- 1996-10-03 CO CO96052652A patent/CO4770961A1/es unknown
- 1996-10-03 ZA ZA9608304A patent/ZA968304B/xx unknown
1998
- 1998-03-13 MX MX9801987A patent/MX9801987A/es not_active IP Right Cessation
- 1998-04-01 BG BG102362A patent/BG63389B1/bg unknown
- 1998-04-03 NO NO19981522A patent/NO311025B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ104598A3 (cs)	1998-09-16
IL123611A (en)	2001-08-26
HUP9900085A3 (en)	2001-11-28
NO981522D0 (no)	1998-04-03
NZ319595A (en)	2001-03-30
BG63389B1 (bg)	2001-12-29
AU713763B2 (en)	1999-12-09
WO1997012878A1 (de)	1997-04-10
PL326081A1 (en)	1998-08-17
CN1202890A (zh)	1998-12-23
DE19536891A1 (de)	1997-04-10
AU7214796A (en)	1997-04-28
MY115211A (en)	2003-04-30
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