NO20062249L - 1H-imidazolderivater som cannabionidreseptor modulatorer - Google Patents

1H-imidazolderivater som cannabionidreseptor modulatorer

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Publication number
NO20062249L
NO20062249L NO20062249A NO20062249A NO20062249L NO 20062249 L NO20062249 L NO 20062249L NO 20062249 A NO20062249 A NO 20062249A NO 20062249 A NO20062249 A NO 20062249A NO 20062249 L NO20062249 L NO 20062249L
Authority
NO
Norway
Prior art keywords
imidazole derivatives
cannabionide
receptor modulators
compounds
preparation
Prior art date
Application number
NO20062249A
Other languages
English (en)
Inventor
Cornelis Gerrit Kruse
Josephus H M Lange
Herman H Van Stuivenberg
Hiskias G Keizer
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20062249L publication Critical patent/NO20062249L/no

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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

Oppfinnelsen vedrører en gruppe lH-imidazolderivater som er modulatorer av cannabinoid-reseptorer, fremgangsmåter for fremstilling av disse forbindelser, nye mellomprodukter som er nyttige ved syntese av de nevnte imidazolderivatene, fremgangsmåter for fremstilling av disse mellomproduktene, farmasøytiske sammensetninger som inneholder en eller flere av disse lH-imidazolderivatene som aktive ingredienser, så vel som anvendelsen av disse farmasøytiske sammensetningene for behandling av psykiatriske og neurologiske forstyrrelser hvori cannabinoid-reseptorer er involvert. Forbindelsene har den generelle formel (I) der R, R1-R4 og X har betydningene som er gitt i beskrivelsen.
NO20062249A 2003-10-20 2006-05-18 1H-imidazolderivater som cannabionidreseptor modulatorer NO20062249L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51210503P 2003-10-20 2003-10-20
EP03103867 2003-10-20
PCT/EP2004/052575 WO2005040130A1 (en) 2003-10-20 2004-10-19 1h-imidazole derivatives as cannabinoid receptor modulators

Publications (1)

Publication Number Publication Date
NO20062249L true NO20062249L (no) 2006-07-11

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ID=34524747

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Application Number Title Priority Date Filing Date
NO20062249A NO20062249L (no) 2003-10-20 2006-05-18 1H-imidazolderivater som cannabionidreseptor modulatorer

Country Status (13)

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EP (1) EP1675833B1 (no)
JP (1) JP2007509048A (no)
KR (1) KR20060117952A (no)
AT (1) ATE496896T1 (no)
AU (1) AU2004283903B2 (no)
BR (1) BRPI0414511A (no)
CA (1) CA2534824A1 (no)
DE (1) DE602004031245D1 (no)
IL (1) IL173436A (no)
MX (1) MXPA06002064A (no)
NO (1) NO20062249L (no)
RU (1) RU2337907C2 (no)
WO (1) WO2005040130A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200528102A (en) * 2003-10-24 2005-09-01 Solvay Pharm Gmbh Novel medical combination treatment of obesity involving 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
EP1845972A4 (en) * 2005-01-10 2010-12-22 Univ Connecticut CANNAPINOID RECEPTORS APPLYING NOVEL HETEROPYRROL ANALOGS
US7759352B2 (en) 2006-04-14 2010-07-20 Merck Sharp & Dohme Corp. Substituted imidazole-4-carboxamides as cholecystokinin-1 receptor modulators
CA2649403C (en) 2006-04-14 2011-06-21 Merck & Co., Inc. Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators
JP2009533445A (ja) 2006-04-14 2009-09-17 メルク エンド カムパニー インコーポレーテッド コレシストキニン−１受容体モジュレータとしての置換イミダゾール４−カルボキサミド
EP2114408B1 (en) 2007-01-26 2011-10-12 Merck Sharp & Dohme Corp. Substituted aminopyrimidines as cholecystokinin-1 receptor modulators
WO2010079241A1 (es) 2009-01-12 2010-07-15 Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion Uso de antagonistas y/o agonistas inversos de los receptores cb1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI231757B (en) * 2001-09-21 2005-05-01 Solvay Pharm Bv 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
WO2003063781A2 (en) * 2002-01-29 2003-08-07 Merck & Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
US7145012B2 (en) * 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof

Also Published As

Publication number Publication date
EP1675833A1 (en) 2006-07-05
IL173436A0 (en) 2006-06-11
JP2007509048A (ja) 2007-04-12
DE602004031245D1 (de) 2011-03-10
IL173436A (en) 2011-01-31
AU2004283903B2 (en) 2010-12-02
WO2005040130A1 (en) 2005-05-06
ATE496896T1 (de) 2011-02-15
RU2006113197A (ru) 2006-09-10
KR20060117952A (ko) 2006-11-17
EP1675833B1 (en) 2011-01-26
RU2337907C2 (ru) 2008-11-10
MXPA06002064A (es) 2006-05-19
CA2534824A1 (en) 2005-05-06
AU2004283903A1 (en) 2005-05-06
BRPI0414511A (pt) 2006-11-07

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