NO180308C - Fremgangsmåte for fremstilling av en tilnærmet ikke-racemisk form av furo (3,4-c) pyridin-derivater - Google Patents

Fremgangsmåte for fremstilling av en tilnærmet ikke-racemisk form av furo (3,4-c) pyridin-derivater

Info

Publication number
NO180308C
NO180308C NO911852A NO911852A NO180308C NO 180308 C NO180308 C NO 180308C NO 911852 A NO911852 A NO 911852A NO 911852 A NO911852 A NO 911852A NO 180308 C NO180308 C NO 180308C
Authority
NO
Norway
Prior art keywords
furo
preparation
pyridine derivatives
racemic form
approximate non
Prior art date
Application number
NO911852A
Other languages
English (en)
Other versions
NO180308B (no
NO911852L (no
NO911852D0 (no
Inventor
Charles R Eck
Paul C Ahrens
Rae Marie Saltzstein
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of NO911852D0 publication Critical patent/NO911852D0/no
Publication of NO911852L publication Critical patent/NO911852L/no
Publication of NO180308B publication Critical patent/NO180308B/no
Publication of NO180308C publication Critical patent/NO180308C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO911852A 1990-05-14 1991-05-13 Fremgangsmåte for fremstilling av en tilnærmet ikke-racemisk form av furo (3,4-c) pyridin-derivater NO180308C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/523,238 US5130252A (en) 1990-05-14 1990-05-14 Resolution of furopyridine enantiomers and synthetic precursors thereof

Publications (4)

Publication Number Publication Date
NO911852D0 NO911852D0 (no) 1991-05-13
NO911852L NO911852L (no) 1991-11-15
NO180308B NO180308B (no) 1996-12-16
NO180308C true NO180308C (no) 1997-03-26

Family

ID=24084213

Family Applications (1)

Application Number Title Priority Date Filing Date
NO911852A NO180308C (no) 1990-05-14 1991-05-13 Fremgangsmåte for fremstilling av en tilnærmet ikke-racemisk form av furo (3,4-c) pyridin-derivater

Country Status (32)

Country Link
US (1) US5130252A (no)
JP (1) JPH05117277A (no)
KR (1) KR910020015A (no)
AR (1) AR247762A1 (no)
AT (1) AT400445B (no)
AU (1) AU642368B2 (no)
BE (1) BE1007016A3 (no)
CA (1) CA2042421C (no)
CH (1) CH682488A5 (no)
DE (1) DE4115681C2 (no)
DK (1) DK88991A (no)
DZ (1) DZ1499A1 (no)
ES (1) ES2033574B1 (no)
FI (1) FI97807C (no)
FR (1) FR2661919B1 (no)
GB (1) GB2244056B (no)
GR (1) GR1001593B (no)
HK (1) HK131993A (no)
IE (1) IE65891B1 (no)
IT (1) IT1248743B (no)
LU (1) LU87935A1 (no)
MA (1) MA22154A1 (no)
MY (1) MY107567A (no)
NL (1) NL194615C (no)
NO (1) NO180308C (no)
NZ (1) NZ238009A (no)
OA (1) OA09352A (no)
PT (1) PT97657B (no)
SE (1) SE510808C2 (no)
TN (1) TNSN91035A1 (no)
TW (1) TW226998B (no)
ZA (1) ZA913461B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0221494D0 (en) * 2002-09-16 2002-10-23 Generics Uk Ltd Novel processes for the preparation of 1.3-dihydro-6-methylfuro (3,4-c) pyndin derivatives
WO2005009446A1 (en) * 2003-07-17 2005-02-03 Cotherix, Inc. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
US20110251396A1 (en) * 2003-07-17 2011-10-13 Gilead Sciences, Inc. Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
US20050113314A1 (en) * 2003-08-29 2005-05-26 Fong Benson M. Cicletanine in combination with oral antidiabetic and/or blood lipid-lowering agents as a combination therapy for diabetes and metabolic syndrome
US20060089374A1 (en) * 2003-07-17 2006-04-27 Glenn Cornett Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
US20060154959A1 (en) * 2005-01-13 2006-07-13 Navitas Pharma Combination therapies of cicletanine and carvedilol
WO2006072172A1 (en) * 2005-01-05 2006-07-13 Medicure International Inc. Compounds and methods for regulating triglyceride levels
US20080096915A1 (en) * 2005-01-13 2008-04-24 Greenberg Traurig LLP Compositions for the treatment of metabolic disorders
US20070141174A1 (en) * 2005-01-13 2007-06-21 Navitas Pharma, Inc. Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension
US20070105817A1 (en) * 2005-11-09 2007-05-10 Jim Page Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension
JP2010514841A (ja) * 2007-01-03 2010-05-06 グレン ブイ． コルネット， 肺疾患および心疾患の処置におけるシクレタニンおよびｐｋｃ阻害剤
US8354394B2 (en) 2009-10-29 2013-01-15 Merck Sharp & Dohme Corp. Diuretics

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN156817B (no) * 1981-02-10 1985-11-09 Scras
US4985365A (en) * 1981-11-28 1991-01-15 Sumitomo Chemical Company, Ltd. Process for producing optically active benzyl alcohol compound
EP0101076B1 (en) * 1982-08-13 1989-01-04 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for production of optically active oxazolidinone derivative
IN160104B (no) * 1983-04-05 1987-06-27 Scras
JPS59216590A (ja) * 1983-05-24 1984-12-06 Ube Ind Ltd 光学活性フエニルプロパルギルアルコ−ル誘導体の製法
GB8327817D0 (en) * 1983-10-18 1983-11-16 Scras 4-halo-furo-(3 4-c)-pyridine derivatives
GB8330517D0 (en) * 1983-11-16 1983-12-21 Scras 6-vinyl-furo-(3,4-c)pyridine derivatives
GB8330658D0 (en) * 1983-11-17 1983-12-29 Scras 7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives
GB8402740D0 (en) * 1984-02-02 1984-03-07 Scras Furo-(3 4-c)-pyridine derivatives
JPS60224494A (ja) * 1984-04-24 1985-11-08 Nissan Chem Ind Ltd α−メチルベンジルアルコ−ル類の光学分割法
GB8414559D0 (en) * 1984-06-07 1984-07-11 Scras Pyridine derivatives
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
JPS61289899A (ja) * 1985-06-18 1986-12-19 Kanegafuchi Chem Ind Co Ltd 光学活性２−ハロ−１−フエニルエタノ−ルおよびそのエステルの製造法
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
DE3737335A1 (de) * 1987-11-04 1989-05-18 Basf Ag Verfahren zur herstellung eines biokatalysators und dessen verwendung zur razematspaltung
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
DE3990349T1 (de) * 1988-04-06 1990-04-26 Scras Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
GB8907480D0 (en) * 1989-04-03 1989-05-17 Scaras Societe De Conseils De Separation of insomers of furo(3,4-c)pyridine derivatives
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives

Also Published As

Publication number Publication date
GR910100180A (en) 1992-07-30
AU7620091A (en) 1991-11-14
FI912315A (fi) 1991-11-15
OA09352A (fr) 1992-09-15
DK88991A (da) 1991-11-15
LU87935A1 (fr) 1992-03-03
ATA98291A (de) 1995-05-15
FI97807C (fi) 1997-02-25
GB2244056B (en) 1993-08-11
IT1248743B (it) 1995-01-26
DZ1499A1 (fr) 2004-09-13
FI912315A0 (fi) 1991-05-13
BE1007016A3 (fr) 1995-02-21
SE9101431L (sv) 1991-11-15
AU642368B2 (en) 1993-10-14
PT97657A (pt) 1992-02-28
MY107567A (en) 1996-04-30
NO180308B (no) 1996-12-16
KR910020015A (ko) 1991-12-19
TW226998B (no) 1994-07-21
NL194615B (nl) 2002-05-01
GR1001593B (el) 1993-03-31
CA2042421C (en) 2000-08-22
MA22154A1 (fr) 1991-12-31
NO911852L (no) 1991-11-15
NZ238009A (en) 1992-11-25
IE911628A1 (en) 1991-11-20
FI97807B (fi) 1996-11-15
AR247762A1 (es) 1995-03-31
AT400445B (de) 1995-12-27
TNSN91035A1 (fr) 1992-10-25
US5130252A (en) 1992-07-14
ES2033574B1 (es) 1994-02-01
NO911852D0 (no) 1991-05-13
GB9109810D0 (en) 1991-06-26
IE65891B1 (en) 1995-11-29
ZA913461B (en) 1992-02-26
GB2244056A (en) 1991-11-20
NL9100749A (nl) 1991-12-02
ITMI911255A1 (it) 1992-11-08
CH682488A5 (fr) 1993-09-30
SE510808C2 (sv) 1999-06-28
NL194615C (nl) 2002-09-03
HK131993A (en) 1993-12-10
PT97657B (pt) 1998-09-30
CA2042421A1 (en) 1991-11-15
JPH05117277A (ja) 1993-05-14
SE9101431D0 (sv) 1991-05-13
DE4115681C2 (de) 2003-10-30
FR2661919A1 (fr) 1991-11-15
DK88991D0 (da) 1991-05-13
ITMI911255A0 (it) 1991-05-08
FR2661919B1 (fr) 1994-12-30
ES2033574A1 (es) 1993-03-16
DE4115681A1 (de) 1991-11-21

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