MXPA03004884A - Ciclohexil (alquil)-propanolaminas, metodo de preparacion y composiciones farmaceuticas que contienen las mismas. - Google Patents

Ciclohexil (alquil)-propanolaminas, metodo de preparacion y composiciones farmaceuticas que contienen las mismas.

Info

Publication number
MXPA03004884A
MXPA03004884A MXPA03004884A MXPA03004884A MXPA03004884A MX PA03004884 A MXPA03004884 A MX PA03004884A MX PA03004884 A MXPA03004884 A MX PA03004884A MX PA03004884 A MXPA03004884 A MX PA03004884A MX PA03004884 A MXPA03004884 A MX PA03004884A
Authority
MX
Mexico
Prior art keywords
agents
formula
compounds
pharmaceutical compositions
compositions containing
Prior art date
Application number
MXPA03004884A
Other languages
English (en)
Inventor
Philippe R Bovy
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of MXPA03004884A publication Critical patent/MXPA03004884A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/16Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invencion se refiere a compuestos de la formula (l), en donde: A es un grupo de la formula (a) o (b), sus sales o solvatos, composiciones farmaceuticas que los contienen, un metodo para prepararlos y compuestos intermedios utilizados en dicho metodo. Los compuestos de la formula (I) pueden prescribirse para tratar enfermedades gastro-intestinales tales como enfermedades inflamatorias del Intestino tal como sindrome de colon irritable (IBD), como moduladores de motricidad intestinal, como Iipoliticos, agentes anti-obesidad, agentes anti-diabeticos, psicotropicos, agentes anti-glaucoma, cicatrizadores, anti-depresores, como inhibidor de contracciones uterinas, como tocoliticos para prevenir o retardar los partos prematuros, para el tratamiento y/o profilaxis de la dismenorrea. Por otro lado, los compuestos de la formula (I) pueden utilizarse en el tratamiento de ciertas enfermedades del sistema nervioso central, tal como, por ejemplo la depresion, asi como ciertos problemas del sistema urinario tal como incontinencia urinaria.
MXPA03004884A 2000-11-30 2001-11-30 Ciclohexil (alquil)-propanolaminas, metodo de preparacion y composiciones farmaceuticas que contienen las mismas. MXPA03004884A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0015477A FR2817257B1 (fr) 2000-11-30 2000-11-30 Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
PCT/FR2001/003784 WO2002044139A1 (fr) 2000-11-30 2001-11-30 Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant

Publications (1)

Publication Number Publication Date
MXPA03004884A true MXPA03004884A (es) 2004-05-04

Family

ID=8857054

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03004884A MXPA03004884A (es) 2000-11-30 2001-11-30 Ciclohexil (alquil)-propanolaminas, metodo de preparacion y composiciones farmaceuticas que contienen las mismas.

Country Status (25)

Country Link
US (3) US7388031B2 (es)
EP (1) EP1341753B1 (es)
JP (1) JP4024149B2 (es)
CN (2) CN1935787A (es)
AR (1) AR031438A1 (es)
AT (1) ATE374177T1 (es)
AU (2) AU2207902A (es)
BR (1) BR0115768A (es)
CA (1) CA2429267C (es)
CY (1) CY1106997T1 (es)
CZ (1) CZ305140B6 (es)
DE (1) DE60130676T2 (es)
DK (1) DK1341753T3 (es)
ES (1) ES2290201T3 (es)
FR (1) FR2817257B1 (es)
HK (1) HK1055945A1 (es)
HU (1) HU229583B1 (es)
ME (1) MEP23308A (es)
MX (1) MXPA03004884A (es)
PL (1) PL206695B1 (es)
PT (1) PT1341753E (es)
RS (1) RS51571B (es)
SI (1) SI1341753T1 (es)
SK (1) SK287551B6 (es)
WO (1) WO2002044139A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2817257B1 (fr) * 2000-11-30 2009-03-20 Sanofi Synthelabo Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant
FR2840304B1 (fr) * 2002-05-29 2007-05-18 Sanofi Synthelabo Derives d'oxophenyl-cyclohexyl-propanolamine, leur preparation et leur application en therapeutique
FR2840301B1 (fr) * 2002-05-29 2007-03-23 Sanofi Synthelabo Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique
EP2011490A1 (en) * 2007-07-05 2009-01-07 Sanofi-Aventis Beta adrenergic receptor ligand derivatives for modulating apoptosis
FR2935141B1 (fr) * 2008-08-21 2010-10-08 Sanofi Aventis Procede de preparation de l'ester ethylique de l'acide 4-[trans-4-[(phenylmethyl)-amino]cyclohexyl]benzoique et de son sel hemifumarate
AU2009308708B2 (en) * 2008-10-31 2015-11-19 Medivation Technologies, Inc. Azepino [4, 5-b] indoles and methods of use
CN116143575B (zh) * 2023-04-21 2023-06-30 研峰(天津)科学技术应用研究有限公司 昆虫信息素原料3-环己基-1-丙炔合成方法

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CA1336911C (en) * 1988-06-03 1995-09-05 David Taiwai Wong Serotonin antagonists
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Also Published As

Publication number Publication date
WO2002044139A1 (fr) 2002-06-06
US7419974B2 (en) 2008-09-02
YU41703A (sh) 2006-05-25
CN1478074A (zh) 2004-02-25
US7388031B2 (en) 2008-06-17
CA2429267C (fr) 2010-09-28
SI1341753T1 (sl) 2007-12-31
ES2290201T3 (es) 2008-02-16
CN1283622C (zh) 2006-11-08
US20040053916A1 (en) 2004-03-18
AU2207902A (en) 2002-06-11
HU229583B1 (en) 2014-02-28
HUP0400565A2 (hu) 2004-06-28
AU2002222079B2 (en) 2006-12-14
HUP0400565A3 (en) 2004-08-30
CY1106997T1 (el) 2012-01-25
FR2817257B1 (fr) 2009-03-20
JP4024149B2 (ja) 2007-12-19
AR031438A1 (es) 2003-09-24
FR2817257A1 (fr) 2002-05-31
JP2004514708A (ja) 2004-05-20
DK1341753T3 (da) 2008-01-14
BR0115768A (pt) 2003-12-30
US20070015745A1 (en) 2007-01-18
EP1341753B1 (fr) 2007-09-26
PL364746A1 (en) 2004-12-13
PT1341753E (pt) 2007-11-13
ATE374177T1 (de) 2007-10-15
DE60130676D1 (de) 2007-11-08
CN1935787A (zh) 2007-03-28
US7718646B2 (en) 2010-05-18
RS51571B (en) 2011-08-31
US20080261949A1 (en) 2008-10-23
SK6522003A3 (en) 2003-11-04
CA2429267A1 (fr) 2002-06-06
PL206695B1 (pl) 2010-09-30
SK287551B6 (sk) 2011-01-04
DE60130676T2 (de) 2008-07-17
MEP23308A (en) 2010-06-10
EP1341753A1 (fr) 2003-09-10
CZ20031499A3 (cs) 2003-08-13
CZ305140B6 (cs) 2015-05-20
HK1055945A1 (en) 2004-01-30

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