MX350962B - Metodo para fabricar moleculas heterodimericas de fragmentos cristalizables de anticuerpo, utilizando efectos electrostaticos de direccion. - Google Patents

Metodo para fabricar moleculas heterodimericas de fragmentos cristalizables de anticuerpo, utilizando efectos electrostaticos de direccion.

Info

Publication number
MX350962B
MX350962B MX2013006814A MX2013006814A MX350962B MX 350962 B MX350962 B MX 350962B MX 2013006814 A MX2013006814 A MX 2013006814A MX 2013006814 A MX2013006814 A MX 2013006814A MX 350962 B MX350962 B MX 350962B
Authority
MX
Mexico
Prior art keywords
polypeptides
making antibody
electrostatic steering
steering effects
heterodimeric molecules
Prior art date
Application number
MX2013006814A
Other languages
English (en)
Inventor
Wittekind Michael
Kannan Gunasekaran
Yan Wei
Pentony Martin
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX350962B publication Critical patent/MX350962B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invención se refiere a métodos de fabricación de proteínas Fc-heterodiméricas o polipéptidos. La invención también se refiere a las proteínas Fc-heterodiméricas o a los propios polipéptidos, incluyendo los componentes de los polipéptidos individuales que comprenden el heterodímero. Los ácidos nucleicos codifican tales polipéptidos, vectores de expresión, y células hospederas. Además, la invención se refiere a composiciones farmacéuticas que contienen una o más proteínas Fc-heterodiméricas o polipéptidos.
MX2013006814A 2008-01-07 2009-01-06 Metodo para fabricar moleculas heterodimericas de fragmentos cristalizables de anticuerpo, utilizando efectos electrostaticos de direccion. MX350962B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1956908P 2008-01-07 2008-01-07
US12030508P 2008-12-05 2008-12-05
PCT/US2009/000071 WO2009089004A1 (en) 2008-01-07 2009-01-06 Method for making antibody fc-heterodimeric molecules using electrostatic steering effects

Publications (1)

Publication Number Publication Date
MX350962B true MX350962B (es) 2017-09-27

Family

ID=40578139

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013006814A MX350962B (es) 2008-01-07 2009-01-06 Metodo para fabricar moleculas heterodimericas de fragmentos cristalizables de anticuerpo, utilizando efectos electrostaticos de direccion.

Country Status (14)

Country Link
US (2) US8592562B2 (es)
EP (3) EP2235064B1 (es)
JP (3) JP6157046B2 (es)
AU (1) AU2009204501B2 (es)
CA (1) CA2709847C (es)
CY (1) CY1117162T1 (es)
DK (1) DK2235064T3 (es)
ES (2) ES2774337T3 (es)
HU (1) HUE028536T2 (es)
MX (1) MX350962B (es)
PL (1) PL2235064T3 (es)
PT (1) PT2235064E (es)
SI (1) SI2235064T1 (es)
WO (1) WO2009089004A1 (es)

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