MX2020008680A - Terapia de combinacion con apilimod y agentes glutamatergicos. - Google Patents
Terapia de combinacion con apilimod y agentes glutamatergicos.Info
- Publication number
- MX2020008680A MX2020008680A MX2020008680A MX2020008680A MX2020008680A MX 2020008680 A MX2020008680 A MX 2020008680A MX 2020008680 A MX2020008680 A MX 2020008680A MX 2020008680 A MX2020008680 A MX 2020008680A MX 2020008680 A MX2020008680 A MX 2020008680A
- Authority
- MX
- Mexico
- Prior art keywords
- apilimod
- combination therapy
- glutamatergic agents
- glutamatergic
- agents
- Prior art date
Links
- 229950002889 apilimod Drugs 0.000 title abstract 2
- 239000003971 excitatory amino acid agent Substances 0.000 title abstract 2
- HSKAZIJJKRAJAV-KOEQRZSOSA-N n-[(e)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine Chemical compound CC1=CC=CC(\C=N\NC=2N=C(OCCC=3N=CC=CC=3)N=C(C=2)N2CCOCC2)=C1 HSKAZIJJKRAJAV-KOEQRZSOSA-N 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se proporcionan composiciones y métodos relacionados con el uso de apilimod en combinación con agentes glutamatérgicos para el tratamiento de enfermedades y trastornos neurológicos y para el tratamiento de cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862633335P | 2018-02-21 | 2018-02-21 | |
PCT/US2019/018662 WO2019164861A1 (en) | 2018-02-21 | 2019-02-20 | Combination therapy with apilimod and glutamatergic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020008680A true MX2020008680A (es) | 2020-09-25 |
Family
ID=65729429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020008680A MX2020008680A (es) | 2018-02-21 | 2019-02-20 | Terapia de combinacion con apilimod y agentes glutamatergicos. |
Country Status (13)
Country | Link |
---|---|
US (3) | US10751345B2 (es) |
EP (1) | EP3755332A1 (es) |
JP (2) | JP7354123B2 (es) |
KR (1) | KR20200138714A (es) |
CN (1) | CN111801098A (es) |
AU (1) | AU2019223014B2 (es) |
BR (1) | BR112020016256A2 (es) |
CA (1) | CA3090807A1 (es) |
IL (1) | IL276609A (es) |
MX (1) | MX2020008680A (es) |
RU (1) | RU2020130837A (es) |
TW (1) | TW202000205A (es) |
WO (1) | WO2019164861A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10751345B2 (en) | 2018-02-21 | 2020-08-25 | AI Therapeutics, Inc. | Combination therapy with apilimod and glutamatergic agents |
IL280177B1 (en) * | 2018-07-22 | 2024-09-01 | Biohaven Therapeutics Ltd | Use of riluzole prodrugs to treat Alzheimer's disease |
US20240016810A1 (en) * | 2020-06-11 | 2024-01-18 | Kineta, Inc. | Compositions and methods for the treatment and prevention of neurological disorders |
KR20230027189A (ko) * | 2020-06-24 | 2023-02-27 | 바이오하벤 테라퓨틱스 리미티드 | 강박 장애를 치료하기 위한 조성물 및 방법 |
WO2022197767A1 (en) * | 2021-03-17 | 2022-09-22 | Memorial Sloan-Kettering Cancer Center | Methods for improving survival in lung cancer patients via ketamine oncoprotection |
IL309143A (en) * | 2021-06-11 | 2024-02-01 | Orphai Therapeutics Inc | Stabilized Epilimod compositions and their uses |
WO2024015281A1 (en) * | 2022-07-11 | 2024-01-18 | AI Therapeutics, Inc. | Apilimod combination therapy |
WO2024015286A1 (en) * | 2022-07-11 | 2024-01-18 | AI Therapeutics, Inc. | Apilimod combination therapy |
WO2024107448A1 (en) * | 2022-11-15 | 2024-05-23 | Orphai Therapeutics Inc. | Apilimod combination therapy |
WO2024118515A1 (en) * | 2022-11-28 | 2024-06-06 | Orphai Therapeutics Inc. | Pikfyve inhibitor combination therapy |
WO2024191947A1 (en) * | 2023-03-15 | 2024-09-19 | Orphai Therapeutics Inc. | Pikfyve inhibitor combination therapy |
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WO2016112072A1 (en) | 2015-01-07 | 2016-07-14 | President And Fellows Of Harvard College | Methods for treating or preventing ebolavirus or marburgvirus infections |
WO2016118709A1 (en) | 2015-01-23 | 2016-07-28 | Lam Therapeutics, Inc. | Anti-viral compositions containing pikfyve inhibitors and use thereof |
US20180015098A1 (en) * | 2015-02-03 | 2018-01-18 | Lam Therapeutics, Inc. | Apilimod compositions and methods for using same |
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-
2019
- 2019-02-20 US US16/280,106 patent/US10751345B2/en active Active
- 2019-02-20 EP EP19710520.8A patent/EP3755332A1/en active Pending
- 2019-02-20 AU AU2019223014A patent/AU2019223014B2/en active Active
- 2019-02-20 CN CN201980014793.3A patent/CN111801098A/zh active Pending
- 2019-02-20 MX MX2020008680A patent/MX2020008680A/es unknown
- 2019-02-20 RU RU2020130837A patent/RU2020130837A/ru unknown
- 2019-02-20 CA CA3090807A patent/CA3090807A1/en active Pending
- 2019-02-20 JP JP2020543481A patent/JP7354123B2/ja active Active
- 2019-02-20 KR KR1020207024498A patent/KR20200138714A/ko not_active Application Discontinuation
- 2019-02-20 BR BR112020016256-6A patent/BR112020016256A2/pt not_active Application Discontinuation
- 2019-02-20 WO PCT/US2019/018662 patent/WO2019164861A1/en unknown
- 2019-02-20 TW TW108105639A patent/TW202000205A/zh unknown
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2020
- 2020-08-07 US US16/987,542 patent/US11439649B2/en active Active
- 2020-08-10 IL IL276609A patent/IL276609A/en unknown
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2022
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2023
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US11439649B2 (en) | 2022-09-13 |
US11957688B2 (en) | 2024-04-16 |
JP2021514358A (ja) | 2021-06-10 |
EP3755332A1 (en) | 2020-12-30 |
CA3090807A1 (en) | 2019-08-29 |
AU2019223014B2 (en) | 2024-10-17 |
WO2019164861A1 (en) | 2019-08-29 |
CN111801098A (zh) | 2020-10-20 |
TW202000205A (zh) | 2020-01-01 |
US20190255061A1 (en) | 2019-08-22 |
IL276609A (en) | 2020-09-30 |
US10751345B2 (en) | 2020-08-25 |
JP2023179515A (ja) | 2023-12-19 |
JP7354123B2 (ja) | 2023-10-02 |
US20230069069A1 (en) | 2023-03-02 |
RU2020130837A (ru) | 2022-03-21 |
AU2019223014A1 (en) | 2020-08-20 |
RU2020130837A3 (es) | 2022-03-21 |
BR112020016256A2 (pt) | 2020-12-15 |
US20210077502A1 (en) | 2021-03-18 |
KR20200138714A (ko) | 2020-12-10 |
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