MA55097A - Oxystérols et leurs procédés d'utilisation - Google Patents

Oxystérols et leurs procédés d'utilisation

Info

Publication number
MA55097A
MA55097A MA055097A MA55097A MA55097A MA 55097 A MA55097 A MA 55097A MA 055097 A MA055097 A MA 055097A MA 55097 A MA55097 A MA 55097A MA 55097 A MA55097 A MA 55097A
Authority
MA
Morocco
Prior art keywords
oxysterols
methods
Prior art date
Application number
MA055097A
Other languages
English (en)
Inventor
Botella Gabriel Martinez
Albert Jean Robichaud
Francesco G Salituro
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of MA55097A publication Critical patent/MA55097A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA055097A 2015-07-06 2016-07-06 Oxystérols et leurs procédés d'utilisation MA55097A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562189048P 2015-07-06 2015-07-06
US201662280394P 2016-01-19 2016-01-19

Publications (1)

Publication Number Publication Date
MA55097A true MA55097A (fr) 2022-01-05

Family

ID=57686105

Family Applications (2)

Application Number Title Priority Date Filing Date
MA055097A MA55097A (fr) 2015-07-06 2016-07-06 Oxystérols et leurs procédés d'utilisation
MA42410A MA42410B1 (fr) 2015-07-06 2016-07-06 Oxystérols et leurs méthodes d'utilisation

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA42410A MA42410B1 (fr) 2015-07-06 2016-07-06 Oxystérols et leurs méthodes d'utilisation

Country Status (28)

Country Link
US (4) US10201550B2 (fr)
EP (2) EP3828194A1 (fr)
JP (3) JP2018519351A (fr)
KR (2) KR102703602B1 (fr)
CN (2) CN113292623A (fr)
AU (3) AU2016289967B2 (fr)
BR (3) BR122023021450A2 (fr)
CA (1) CA2991214C (fr)
CO (1) CO2018000660A2 (fr)
CY (1) CY1124496T1 (fr)
DK (1) DK3319611T3 (fr)
ES (1) ES2865258T3 (fr)
HR (1) HRP20210526T8 (fr)
HU (1) HUE053778T2 (fr)
IL (2) IL256710B2 (fr)
LT (1) LT3319611T (fr)
MA (2) MA55097A (fr)
MD (1) MD3319611T2 (fr)
MX (2) MX2018000282A (fr)
PE (1) PE20180483A1 (fr)
PH (1) PH12018500065A1 (fr)
PL (1) PL3319611T3 (fr)
PT (1) PT3319611T (fr)
RS (1) RS61718B1 (fr)
RU (2) RU2021100620A (fr)
SG (1) SG10202010553XA (fr)
SI (1) SI3319611T1 (fr)
WO (1) WO2017007836A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20230747T1 (hr) 2011-09-08 2024-01-05 Sage Therapeutics, Inc. Neuroaktivni steroidi, pripravci i njihova uporaba
HUE055668T2 (hu) 2013-03-13 2021-12-28 Sage Therapeutics Inc Neuroaktív szteroidok
WO2015195967A1 (fr) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxystérols et leurs procédés d'utilisation
EP3166613A4 (fr) 2014-07-09 2018-02-21 Duke University Compositions et méthodes pour la réparation de la myéline
MX2018000280A (es) 2015-07-06 2018-03-08 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos.
SI3319611T1 (sl) 2015-07-06 2021-08-31 Sage Therapeutics, Inc. Oksisteroli in postopki za uporabo le-teh
MA42409A (fr) 2015-07-06 2018-05-16 Sage Therapeutics Inc Oxystérols et leurs procédés d'utilisation
WO2017173358A1 (fr) * 2016-04-01 2017-10-05 Sage Therapeutics, Inc. Oxystérols et leurs méthodes d'utilisation
WO2017193046A1 (fr) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxystérols et méthodes d'utilisation associées
ES2884071T3 (es) 2016-07-07 2021-12-10 Sage Therapeutics Inc 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA
CN115850361A (zh) * 2016-09-30 2023-03-28 萨奇治疗股份有限公司 C7取代的氧固醇及其作为nmda调节剂的方法
EP3529256B1 (fr) 2016-10-18 2023-08-09 Sage Therapeutics, Inc. Oxystérols et leurs procédés d'utilisation
CN110267966B (zh) 2016-10-18 2022-07-08 萨奇治疗股份有限公司 氧甾醇及其使用方法
CA3050001A1 (fr) 2017-01-13 2018-07-19 Duke University Compositions et methodes pour le traitement de maladies ou de troubles associes a la myeline et a une inflammation
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
KR20240035444A (ko) 2021-06-11 2024-03-15 세이지 테라퓨틱스, 인크. 알츠하이머병 치료를 위한 신경활성 스테로이드
CN113667734B (zh) * 2021-07-16 2022-05-24 四川大学华西医院 Shank3片段序列甲基化检测试剂在制备精神分裂症诊断试剂盒中的用途
WO2023028278A2 (fr) * 2021-08-25 2023-03-02 Sage Therapeutics, Inc. Composés modulateurs de nmda positifs et leurs procédés d'utilisation
WO2023083979A1 (fr) * 2021-11-10 2023-05-19 Umecrine Ab STÉROÏDES 3β-HYDROXY, 3α-ÉTHYLE POUR LA MODULATION DU SOUS-TYPE α3 DU RÉCEPTEUR GABA-A
EP4447953A1 (fr) 2021-12-13 2024-10-23 Sage Therapeutics, Inc. Combinaison de modulateurs positifs du récepteur muscarinique et de modulateurs allostériques positifs de nmda

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2594323A (en) 1948-07-22 1952-04-29 Upjohn Co 24-substituted delta 5-cholene-3, 24-diols
US3079385A (en) 1961-01-24 1963-02-26 Roussel Uclaf Novel process of preparation of polyhydroxylated pregnanes
US3206459A (en) 1962-10-19 1965-09-14 Syntex Corp 10alpha-pregnan-19-ol derivatives
US4071625A (en) 1974-05-13 1978-01-31 Richardson-Merrell Inc. 19-Oxygenated-5α-androstanes for the enhancement of libido
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
AU698834B2 (en) 1993-05-24 1998-11-12 Purdue Pharma Ltd. Methods and compositions for inducing sleep
IL110309A0 (en) 1993-07-15 1994-10-21 Univ Kentucky Res Found A method of protecting against neuron loss
WO1995021617A1 (fr) 1994-02-14 1995-08-17 Cocensys, Inc. Androstanes et pregnanes de modulation allosterique du recepteur du gaba
US5595996A (en) 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
JPH08268917A (ja) 1995-03-31 1996-10-15 D D S Kenkyusho:Kk 癌組織への移行性の高い制癌剤
CZ394197A3 (cs) 1995-06-06 1998-06-17 Cocensys, Inc. Neuroaktivní steroidy androstanové a pregnanové řady
US6645953B2 (en) 1995-06-23 2003-11-11 Novo Nordisk A/S Meiosis regulating compounds
US5888996A (en) 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
US5841272A (en) 1995-12-20 1998-11-24 Sundstrand Corporation Frequency-insensitive current sensor
US6122371A (en) 1997-07-22 2000-09-19 Atwell; Ronald C. Apparatus for protecting coin-operated telephones from vandalism and larceny
KR20010043558A (ko) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US8541600B2 (en) * 1998-11-24 2013-09-24 Harbor Therapeutics, Inc. 11-aza, 11-thia and 11-oxa sterol compounds and compositions
US6376530B1 (en) * 1999-05-10 2002-04-23 Merck & Co., Inc. Cyclic amidines useful as NMDA NR2B antagonists
GB9910934D0 (en) 1999-05-11 1999-07-14 Res Inst Medicine Chem Chemical compounds
GB0000228D0 (en) 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0019290D0 (en) 2000-08-04 2000-09-27 Symphar Sa Methods for inducing apolipoprotein E secretion
GR1003861B (el) 2000-12-29 2002-04-11 Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa.
GB0107822D0 (en) 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US20070197484A1 (en) 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
EP1450816A4 (fr) 2001-11-08 2008-02-13 Univ Chicago Methode de traitement de troubles lies a un taux de cholesterol eleve
CA2468989A1 (fr) 2001-12-07 2003-06-19 Daniel M. Schwartz Traitement de la degenerescence maculaire liee au vieillissement
NZ547344A (en) 2002-03-27 2007-11-30 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
KR101130212B1 (ko) 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법
GB0216621D0 (en) * 2002-07-17 2002-08-28 Imaging Res Solutions Ltd Imaging compounds
AU2003291074A1 (en) * 2002-11-22 2004-06-18 Merck & Co., Inc. 2-[(4-benzyl)-1-piperidinyl)methyl]benzimidazole-5-ol derivatives as NR2B receptor antagonists
AU2003288231A1 (en) 2002-12-13 2004-07-09 Bayer Healthcare Ag Cholesterol 24-hydroxylase (cyp46) as therapeutic target for the treatment of alzheimer's disease
FR2850023B1 (fr) 2003-01-17 2007-04-06 Mapreg Medicaments pour le systeme nerveux
GB0403889D0 (en) 2004-02-21 2004-03-24 Univ Edinburgh Uses of er-beta modulators
US8604011B2 (en) 2004-09-27 2013-12-10 The Regents Of The University Of California Therapy for treatment of chronic degenerative brain diseases and nervous system injury
JP2009528291A (ja) 2006-02-27 2009-08-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア オキシステロール化合物及びヘッジホッグ経路
US8273747B2 (en) 2006-11-02 2012-09-25 Curis, Inc. Small organic molecule regulators of cell proliferation
AU2008265595B2 (en) 2007-06-20 2014-12-04 PureTech LYT 100 Inc. Substituted N-Aryl pyridinones as fibrotic inhibitors
GB0712494D0 (en) 2007-06-27 2007-08-08 Isis Innovation Substrate reduction therapy
MX2010004682A (es) 2007-11-06 2010-05-19 Organon Nv Metodo de supresion de hormonas en humanos.
WO2009090063A1 (fr) 2008-01-16 2009-07-23 Jado Technologies Gmbh Dérivés de sapogénine stéroïde, androstane et sapogénine triterpénoïde pour le traitement et la prévention de maladies infectieuses
BRPI0912362A2 (pt) 2008-05-09 2015-10-06 Univ Emory antagonista do receptor nmda para o tratamento de transtornos neuropsiquiátricos
WO2010065709A2 (fr) 2008-12-03 2010-06-10 Amin Khan Dérivés d'acide hydroxamique, préparation et utilisations thérapeutiques de ceux-ci
US20120040916A1 (en) 2008-12-22 2012-02-16 Massachusetts Institute Of Technology Molecular inhibitors of the wnt/beta-catenin pathway
WO2010088414A2 (fr) 2009-01-28 2010-08-05 Emory University Potentialisateurs du récepteur nmda, sélectifs pour des sous-unités, et destinés au traitement d'états neurologiques
US8829213B2 (en) 2009-07-29 2014-09-09 The University Of Chicago Liver X receptor agonists
WO2011028794A2 (fr) 2009-09-01 2011-03-10 Lazarus Therapeutics, Inc. Traitement de la chorée de huntington avec de la cyclosérine et un agoniste des récepteurs nmda
FR2953138B1 (fr) 2009-12-02 2015-10-16 Assist Publ Hopitaux Marseille Composes aminosteroidiens pour une application topique locale pour la decolonisation cutaneo-muqueuse de staphylococcus aureus
KR101692275B1 (ko) 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
GB201008047D0 (en) * 2010-05-14 2010-06-30 Ge Healthcare Ltd Method of synthesis
US20120035156A1 (en) 2010-08-09 2012-02-09 Daniela Alberati Combination of glyt1 compound with antipsychotics
US8969525B2 (en) 2010-11-09 2015-03-03 Enzo Life Sciences, Inc. Hydroxycholesterol immunoassay
WO2012142039A1 (fr) 2011-04-15 2012-10-18 University Of North Dakota Combinaison d'un modulateur du récepteur hépatique x (lxr) et d'un modulateur du récepteur des œstrogènes (er) pour le traitement de maladies liées à l'âge
EP2714081A4 (fr) 2011-05-27 2015-09-09 Cytocure Llc Méthodes, compositions et trousses pour le traitement du cancer
JP2014521662A (ja) 2011-07-29 2014-08-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア GABAA受容体のモジュレーターとしての新規な17β−ヘテロアリール置換ステロイド
HRP20230747T1 (hr) 2011-09-08 2024-01-05 Sage Therapeutics, Inc. Neuroaktivni steroidi, pripravci i njihova uporaba
CA3152410A1 (en) 2011-10-14 2013-04-18 Sage Therapeutics, Inc. 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders
EP2841067A4 (fr) 2012-04-25 2016-04-13 Univ California Plate-forme de criblage de médicaments pour le syndrome de rett
US20140149272A1 (en) 2012-08-17 2014-05-29 Trueex Group Llc Interoffice bank offered rate financial product and implementation
KR101993899B1 (ko) 2012-12-18 2019-09-24 워싱톤 유니버시티 신경활성 19-알콕시-17-치환된 스테로이드, 그의 전구약물, 및 그를 사용한 치료 방법
CN105073119A (zh) 2013-01-23 2015-11-18 司菲埃拉制药私人有限公司 用于线粒体生物发生和与线粒体功能障碍或耗竭相关的疾病的新颖11β-羟基类固醇化合物
EA031905B1 (ru) 2013-01-29 2019-03-29 Аптиникс Инк. Спиролактамные модуляторы рецептора nmda и их применение
WO2014160441A1 (fr) 2013-03-13 2014-10-02 Sage Therapeutics, Inc. Stéroïdes neuroactifs, leurs compositions et utilisations
HUE055668T2 (hu) * 2013-03-13 2021-12-28 Sage Therapeutics Inc Neuroaktív szteroidok
WO2015195967A1 (fr) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxystérols et leurs procédés d'utilisation
EP3166613A4 (fr) 2014-07-09 2018-02-21 Duke University Compositions et méthodes pour la réparation de la myéline
US10016095B2 (en) * 2014-10-03 2018-07-10 Progressive International Corporation Salad spinner
AU2015330906A1 (en) 2014-10-07 2017-04-27 Sage Therapeutics, Inc. Neuroactive compounds and methods of use thereof
MX2018000280A (es) 2015-07-06 2018-03-08 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos.
MA42409A (fr) 2015-07-06 2018-05-16 Sage Therapeutics Inc Oxystérols et leurs procédés d'utilisation
SI3319611T1 (sl) 2015-07-06 2021-08-31 Sage Therapeutics, Inc. Oksisteroli in postopki za uporabo le-teh
GB2557875A (en) 2015-09-02 2018-07-04 Univ Swansea Diagnostic methods and kits
WO2018170336A1 (fr) 2017-03-15 2018-09-20 Modernatx, Inc. Formulation de nanoparticules lipidiques
IL271343B2 (en) 2017-06-23 2023-12-01 Intercept Pharmaceuticals Inc Methods and intermediates for the preparation of bile acid derivatives
CN111565724A (zh) 2017-11-10 2020-08-21 马瑞纳斯制药公司 加奈索酮用于治疗遗传性癫痫病

Also Published As

Publication number Publication date
NZ738847A (en) 2024-05-31
CN108135912A (zh) 2018-06-08
BR112018000129B1 (pt) 2024-01-09
EP3319611B1 (fr) 2021-01-20
BR112018000129A2 (pt) 2018-09-04
DK3319611T3 (da) 2021-04-12
US10201550B2 (en) 2019-02-12
PT3319611T (pt) 2021-04-22
IL256710A (en) 2018-03-29
KR20240137111A (ko) 2024-09-19
AU2021218228B2 (en) 2023-11-16
US20180200267A1 (en) 2018-07-19
MX2020011449A (es) 2022-02-28
RU2021100620A (ru) 2021-01-29
JP2021054864A (ja) 2021-04-08
EP3319611A4 (fr) 2019-03-06
IL305404A (en) 2023-10-01
IL256710B2 (en) 2024-01-01
WO2017007836A1 (fr) 2017-01-12
KR102703602B1 (ko) 2024-09-06
MA42410A (fr) 2018-05-16
EP3828194A1 (fr) 2021-06-02
CY1124496T1 (el) 2022-07-22
CN108135912B (zh) 2021-07-02
LT3319611T (lt) 2021-05-10
HRP20210526T1 (hr) 2021-05-28
AU2021218228A1 (en) 2021-09-09
HUE053778T2 (hu) 2021-07-28
JP2022120062A (ja) 2022-08-17
CO2018000660A2 (es) 2018-07-10
RS61718B1 (sr) 2021-05-31
ES2865258T3 (es) 2021-10-15
PL3319611T3 (pl) 2021-07-12
PH12018500065A1 (en) 2018-07-09
US20240277733A1 (en) 2024-08-22
CA2991214C (fr) 2024-04-30
HRP20210526T8 (hr) 2021-08-20
BR122023021450A2 (pt) 2023-12-26
AU2024200268A1 (en) 2024-02-01
EP3319611A1 (fr) 2018-05-16
US10765685B2 (en) 2020-09-08
US20210145848A1 (en) 2021-05-20
IL256710B1 (en) 2023-09-01
JP2018519351A (ja) 2018-07-19
AU2016289967A1 (en) 2018-02-01
AU2016289967B2 (en) 2021-09-09
RU2018104278A (ru) 2019-08-06
CA2991214A1 (fr) 2017-01-12
BR122021005552B1 (pt) 2024-01-02
MX2018000282A (es) 2018-03-08
SI3319611T1 (sl) 2021-08-31
PE20180483A1 (es) 2018-03-07
US20190125764A1 (en) 2019-05-02
NZ777726A (en) 2024-05-31
RU2018104278A3 (fr) 2019-10-31
MA42410B1 (fr) 2021-04-30
RU2744267C2 (ru) 2021-03-04
MD3319611T2 (ro) 2021-06-30
KR20180026743A (ko) 2018-03-13
CN113292623A (zh) 2021-08-24
SG10202010553XA (en) 2020-12-30

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