LU91501I2 - Sugammadex et ses sels pharmaceutiquement acceptables-BRIDION - Google Patents

Sugammadex et ses sels pharmaceutiquement acceptables-BRIDION

Info

Publication number
LU91501I2
LU91501I2 LU91501C LU91501C LU91501I2 LU 91501 I2 LU91501 I2 LU 91501I2 LU 91501 C LU91501 C LU 91501C LU 91501 C LU91501 C LU 91501C LU 91501 I2 LU91501 I2 LU 91501I2
Authority
LU
Luxembourg
Prior art keywords
bridion
sugammadex
pharmaceutically acceptable
acceptable salts
salts
Prior art date
Application number
LU91501C
Other languages
English (en)
French (fr)
Other versions
LU91501I9 (ja
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8241767&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91501(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon Nv filed Critical Organon Nv
Publication of LU91501I2 publication Critical patent/LU91501I2/xx
Publication of LU91501I9 publication Critical patent/LU91501I9/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/724Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
LU91501C 1999-11-29 2008-11-26 Sugammadex et ses sels pharmaceutiquement acceptables-BRIDION LU91501I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99309558 1999-11-29
PCT/EP2000/011789 WO2001040316A1 (en) 1999-11-29 2000-11-23 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
EP00993261A EP1259550B1 (en) 1999-11-29 2000-11-23 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block

Publications (2)

Publication Number Publication Date
LU91501I2 true LU91501I2 (fr) 2009-01-26
LU91501I9 LU91501I9 (ja) 2019-01-02

Family

ID=8241767

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91501C LU91501I2 (fr) 1999-11-29 2008-11-26 Sugammadex et ses sels pharmaceutiquement acceptables-BRIDION

Country Status (34)

Country Link
US (3) USRE44733E1 (ja)
EP (1) EP1259550B1 (ja)
JP (2) JP3880041B2 (ja)
KR (1) KR100716524B1 (ja)
CN (1) CN1188428C (ja)
AR (1) AR026605A1 (ja)
AT (1) ATE288450T1 (ja)
AU (1) AU776536B2 (ja)
BE (1) BE2008C047I2 (ja)
BR (1) BRPI0015947B8 (ja)
CA (1) CA2390463C (ja)
CO (1) CO5251450A1 (ja)
CY (1) CY2008018I2 (ja)
CZ (1) CZ298206B6 (ja)
DE (2) DE122008000068I2 (ja)
DK (1) DK1259550T3 (ja)
ES (1) ES2237496T3 (ja)
FR (1) FR08C0052I2 (ja)
HK (1) HK1049489A1 (ja)
HU (1) HU227451B1 (ja)
IL (1) IL149423A0 (ja)
LU (1) LU91501I2 (ja)
MX (1) MXPA02004940A (ja)
NL (1) NL300356I2 (ja)
NO (2) NO328790B1 (ja)
NZ (1) NZ518752A (ja)
PE (1) PE20010902A1 (ja)
PL (1) PL203012B1 (ja)
PT (1) PT1259550E (ja)
RU (1) RU2260013C2 (ja)
SK (1) SK286282B6 (ja)
TW (1) TWI242015B (ja)
WO (1) WO2001040316A1 (ja)
ZA (1) ZA200203538B (ja)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6744471B1 (en) * 1997-12-05 2004-06-01 Olympus Optical Co., Ltd Electronic camera that synthesizes two images taken under different exposures
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
EP1333842B1 (en) * 2000-11-02 2006-08-30 Akzo Nobel N.V. Use of cortisol-sequestering agents for the treatment of hypercortisolaemia related disorders
AU2004285032A1 (en) 2003-10-31 2005-05-12 The University Of Kansas Sulfoalkyl ether-alkyl ether cyclodextrin derivatives
WO2006001844A2 (en) 2004-01-29 2006-01-05 Pinnacle Pharmaceuticals β-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST ANTHRAX LETHAL TOXIN
ES2717248T3 (es) 2004-04-23 2019-06-20 Cydex Pharmaceuticals Inc Formulación de DPI que contiene sulfoalquil éter ciclodextrina
KR20070101347A (ko) 2005-01-28 2007-10-16 핀나클 파마슈티컬스, 인코포레이티드 항균제로서의 β­시클로덱스트린 유도체
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
PL2581078T3 (pl) 2005-10-26 2015-07-31 Cydex Pharmaceuticals Inc Kompozycje eteru sulfoalkilowego cyklodekstryny i sposoby ich wytwarzania
US20090069412A1 (en) * 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched sugammadex
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
US7938283B2 (en) * 2008-06-20 2011-05-10 Grainpro, Inc. System and method for hermetic storage of agricultural commodities during shipping
US10463677B2 (en) 2008-11-07 2019-11-05 Cydex Pharmaceuticals, Inc. Composition containing sulfoalkyl ether cyclodextrin and latanoprost
CN101591402B (zh) * 2009-05-05 2011-11-30 杭州奥默医药技术有限公司 6-脱氧砜类环糊精衍生物及其制备方法
US8492538B1 (en) 2009-06-04 2013-07-23 Jose R. Matos Cyclodextrin derivative salts
DE102010012281A1 (de) * 2010-03-22 2011-09-22 Fresenius Medical Care Deutschland Gmbh Pharmazeutische Zusammensetzungen enthaltend substituiertes 6-Deoxy-6-sulfanylcyclodextrin
CN101864003B (zh) * 2010-06-11 2012-05-02 漆又毛 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法
EP2609120B1 (en) 2010-08-25 2015-07-29 Davuluri, Ramamohan Rao Improved process for preparation of sugammadex
CN102060941B (zh) * 2010-11-26 2012-12-26 漆又毛 6-脱氧α-氨基酸衍生物环糊精及制备和应用
DK3702374T3 (da) 2012-02-15 2022-06-27 Cydex Pharmaceuticals Inc Fremsgangsmåde til fremstilling for cyclodextrin-derivater
RU2747757C2 (ru) 2012-02-28 2021-05-13 Сидекс Фармасьютикалс, Инк. Композиции алкилированного циклодекстрина и способы их получения и применения
JP5892847B2 (ja) * 2012-04-27 2016-03-23 Dowaホールディングス株式会社 シクロデキストリンとシリカ含有物質との複合材料、及びその製造方法、並びにガス吸着剤
GB201211153D0 (en) * 2012-06-22 2012-08-08 Farmhispania Pharmaceutical compositions
NZ707323A (en) 2012-10-22 2018-11-30 Cydex Pharmaceuticals Inc Alkylated cyclodextrin compositions and processes for preparing and using the same
WO2014125501A1 (en) 2013-02-14 2014-08-21 Neuland Laboratories Limited An improved process for preparation of sugammadex sodium
EP3149052A4 (en) 2014-05-29 2018-01-03 UTI Limited Partnership Cyclodextrin-based polyanionic and non-ionic dendrimers
CN113350274A (zh) 2014-06-26 2021-09-07 丸石制药株式会社 具有改进的稳定性的罗库溴铵制剂
DK3183295T3 (da) 2014-08-22 2023-08-21 Cydex Pharmaceuticals Inc Fraktioneret alkyleret cyclodextrinsammensætning og fremgangsmåder til fremstilling og anvendelse af samme
CN105348412B (zh) * 2014-08-22 2018-06-05 江苏恩华药业股份有限公司 一种舒更葡糖钠的纯化方法
MX2017011966A (es) 2015-03-19 2018-06-06 Cydex Pharmaceuticals Inc Composiciones que contienen silimarina y sulfoalquil eter ciclodextrina y metodos de uso de las mismas.
CN104844732B (zh) * 2015-03-27 2017-05-03 山东滨州智源生物科技有限公司 一种舒更葡糖钠的制备方法
JP2018510912A (ja) * 2015-04-08 2018-04-19 リン,チャン−チュン ポリアニオン性および非イオン性のシクロデキストリン系デンドリマーの医薬組成物およびその使用
US10494450B2 (en) * 2015-05-29 2019-12-03 Lakshmi Prasad ALAPARTHI Processes for preparation of Sugammadex and intermediates thereof
CN104922693A (zh) * 2015-06-19 2015-09-23 南开大学 一种阴离子型环糊精与抗癌药物包合物及制备方法
JP2018530653A (ja) * 2015-10-07 2018-10-18 ユーティアイ リミテッド パートナーシップUti Limited Partnership 多官能性ポリアニオン性シクロデキストリンデンドリマー
CN108290964B (zh) 2015-11-25 2021-07-09 费森尤斯卡比依普莎姆有限责任公司 用于制备舒更葡糖及其中间体的改进的方法
ES2812226T5 (es) * 2015-11-25 2024-04-29 Fresenius Kabi Ipsum S R L Formas cristalinas de percloro-gamma-ciclodextrinas
SI3433285T1 (sl) * 2016-03-22 2020-10-30 Fresenius Kabi Ipsum S.R.L. Izboljšan postopek za pripravo sugamadeksa
WO2017188820A1 (en) * 2016-04-29 2017-11-02 Stichting Sanquin Bloedvoorziening Cyclodextrins as procoagulants
HRP20220705T1 (hr) * 2016-06-23 2022-07-22 Synthon B.V. Postupak dobivanja sugamadeksa
US10526422B2 (en) 2016-06-29 2020-01-07 Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. Process for preparation and purification of Sugammades sodium
JP6692941B2 (ja) * 2016-06-29 2020-05-27 北京叡創康泰医薬研究院有限公司Beijing Creatron Institute of Pharmaceutical Research Co., Ltd. スガマデックスの製造及び純化方法
CN107778383B (zh) * 2016-08-24 2020-03-10 王炳永 一种舒更葡糖钠的精制方法
US10385142B2 (en) 2017-01-23 2019-08-20 Scinopharm Taiwan, Ltd. Method for preparing sugammadex sodium
MX2019013053A (es) 2017-05-03 2020-02-07 Cydex Pharmaceuticals Inc Composicion que contiene ciclodextrina y busulfan.
CN109021148B (zh) * 2017-06-08 2020-11-10 天津科伦药物研究有限公司 一种制备舒更葡糖钠的方法
US10442871B2 (en) 2017-06-22 2019-10-15 Lawrence Livermore National Security, Llc Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof
EP3421504B1 (en) 2017-06-30 2019-09-18 Synthon B.V. Process for making sugammadex
US10233263B1 (en) * 2017-08-23 2019-03-19 Formosa Laboratories, Inc. Method for preparation of sugammadex sodium
TWI703163B (zh) * 2017-08-23 2020-09-01 台耀化學股份有限公司 舒更葡糖鈉之製備方法及其晶型
EP3717521B1 (en) 2017-11-27 2023-04-05 Medichem, S.A. Process for the synthesis of a cyclodextrin derivative
CN107892727B (zh) * 2017-11-27 2019-12-24 合肥博思科创医药科技有限公司 一种舒更葡糖钠的纯化方法
US11225565B2 (en) 2018-04-06 2022-01-18 Synthon B.V. Purification of sugammadex
KR102054228B1 (ko) * 2018-05-28 2019-12-10 연성정밀화학(주) 슈가마덱스 나트륨염의 제조방법
AU2019281969B2 (en) * 2018-06-07 2024-03-07 Merck Sharp & Dohme Llc Processes for the preparation of sugammadex
CN110615860A (zh) * 2018-06-20 2019-12-27 江苏恒瑞医药股份有限公司 一种舒更葡糖钠的纯化方法
WO2020028448A1 (en) 2018-08-02 2020-02-06 Pliva Hrvatska D.O.O. Solid state forms of sugammadex sodium
US11845811B2 (en) * 2018-09-20 2023-12-19 Natco Pharma Limited Process for the preparation of Sugammadex sodium and its novel polymorphic form
CA3112872A1 (en) 2018-09-27 2020-04-02 Werthenstein Biopharma Gmbh Novel crystalline forms of sugammadex
JP6950966B2 (ja) * 2018-11-01 2021-10-13 丸石製薬株式会社 スガマデクス又はその薬理学的に許容される塩含有液剤及びその製造方法
CN109438591B (zh) * 2018-12-29 2021-02-09 博瑞生物医药(苏州)股份有限公司 舒更葡糖钠的制备工艺
CN109824800A (zh) * 2018-12-29 2019-05-31 鼎元(天津)生物医药科技有限公司 一种选择性肌松拮抗药舒更葡萄糖钠的制备方法
WO2020201930A1 (en) 2019-03-29 2020-10-08 Hospira, Inc. An improved process for preparation of sugammadex acid and sugammadex sodium
CN111978435B (zh) 2019-05-22 2021-05-25 合肥博思科创医药科技有限公司 一种高纯度舒更葡糖钠的制备方法
US11324692B2 (en) 2019-07-03 2022-05-10 Galenicum Health S.L.U. Method to prepare pharmaceutical compositions of suggamadex
US20220273517A1 (en) 2019-08-30 2022-09-01 Terumo Kabushiki Kaisha Injection formulation
RU2724900C1 (ru) * 2019-10-24 2020-06-26 Маруиси Фармасьютикал Ко., Лтд. Препарат рокурония с улучшенной стабильностью
CN111019016B (zh) * 2019-12-27 2022-02-18 武汉嘉诺康医药技术有限公司 一种舒更葡糖钠杂质的合成方法
EP4110832A1 (en) 2020-02-28 2023-01-04 Medichem, S.A. Method for drying sugammadex
CN111714459B (zh) * 2020-06-18 2022-06-14 广州瑞尔医药科技有限公司 一种注射用舒更葡糖钠粉针剂及其制备方法
US11097023B1 (en) 2020-07-02 2021-08-24 Par Pharmaceutical, Inc. Pre-filled syringe containing sugammadex
ES2949710T1 (es) 2020-07-03 2023-10-02 Galenicum Health S L U Método para preparar composiciones farmacéuticas
US11446325B2 (en) * 2020-09-30 2022-09-20 Cyclolab Cyclodextrin Research And Development Laboratory Ltd. Cyclodextrin derivatives in the treatment or prevention of lysosomal neurodegenerative diseases
US11945788B2 (en) 2021-06-07 2024-04-02 Nuray Chemicals Private Limited Process for preparing pitolisant hydrochloride and solid-state forms thereof
CN113637097A (zh) * 2021-08-10 2021-11-12 北京恒创星远医药科技有限公司 6-全脱氧-6-全碘代-γ-环糊精晶体及其制备方法和应用
CN115708777A (zh) * 2021-08-19 2023-02-24 北京费森尤斯卡比医药有限公司 包含巯基环糊精衍生物或其可药用盐的包装药品和保存方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929813A (en) * 1973-12-26 1975-12-30 Interx Research Corp Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and process for preparing same
JPS52108027A (en) 1976-03-09 1977-09-10 Rikagaku Kenkyusho Anticarcinogen
US4816462A (en) 1982-05-18 1989-03-28 Nowicky Wassili Method for diagnosing and for the therapeutic treatment of tumors and/or infectious diseases of different types with alkaloid-compounds
HU194858B (en) 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
IT1196033B (it) 1984-02-22 1988-11-10 Chiesi Farma Spa Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
GB8506792D0 (en) 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
GB8613688D0 (en) 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (ja) 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
HU201783B (en) 1987-10-13 1990-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing partially methylized carboxy-acyl-beta-cyclodextrines and salts
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US5017566A (en) 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
US5173481A (en) 1989-04-03 1992-12-22 The United States Of America As Represented By The Department Of Health And Human Services Preparation of specifically substituted cyclodextrins
HUT58770A (en) 1989-04-03 1992-03-30 Janssen Pharmaceutica Nv Process for producing regioselective substituted cyclodextrines
DK0447171T3 (da) * 1990-03-15 1994-12-12 Tanabe Seiyaku Co Polysulfat af cyclodextrinderivat og fremgangsmåde til fremstilling deraf
US5180716A (en) 1990-08-01 1993-01-19 The Regents Of The University Of California Cyclodextrin complexes for neuraxial administration of drugs
JP2556236B2 (ja) 1991-08-29 1996-11-20 田辺製薬株式会社 β−シクロデキストリン誘導体のポリ硫酸エステル及びその製法
US5840881A (en) 1992-11-27 1998-11-24 Takeda Chemical Industries, Ltd. Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility
US5767112A (en) 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
AU708107B2 (en) 1994-11-04 1999-07-29 Commonwealth Scientific And Industrial Research Organisation Method for treating animals
GB2307176A (en) * 1995-11-15 1997-05-21 Todd Selwyn Everest Anti-inflammatory clathrating agents for topical use
US5935941A (en) 1997-10-24 1999-08-10 Pitha; Josef Alkylations of cyclodextrins leading to derivatives which have a ridgidly extended cavity
US5834446A (en) * 1996-06-21 1998-11-10 Queen's University At Kingston Nerve process growth modulators
JP4249282B2 (ja) 1998-02-27 2009-04-02 日本食品化工株式会社 新規シクロデキストリン誘導体及びその製造方法
DE69942317D1 (de) 1998-05-29 2010-06-10 Neurosciences Res Found Schmerzlinderung mit anandamide
CA2380920C (en) 1999-08-13 2011-07-19 Akzo Nobel N.V. Use of chemical chelators as reversal agents for drug-induced neuromuscular block
TWI242015B (en) 1999-11-29 2005-10-21 Akzo Nobel Nv 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
US20020111377A1 (en) 2000-12-22 2002-08-15 Albany College Of Pharmacy Transdermal delivery of cannabinoids
EP1368381B1 (en) 2001-02-14 2006-05-03 Akzo Nobel N.V. 2-alkylated-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block
TW200402417A (en) 2002-06-21 2004-02-16 Akzo Nobel Nv 1-[(Indol-3-yl)carbonyl]piperazine derivatives

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CA2390463C (en) 2009-02-03
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US6670340B1 (en) 2003-12-30
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US6949527B2 (en) 2005-09-27
HUP0203755A2 (hu) 2003-04-28
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EP1259550B1 (en) 2005-02-02
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LU91501I9 (ja) 2019-01-02
AU776536B2 (en) 2004-09-16
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BRPI0015947B8 (pt) 2021-07-06
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