LT3983B - Novel vitamin d analogues, process for their preparation, intermediate chemical compounds and pharmaceutical compositions - Google Patents

Novel vitamin d analogues, process for their preparation, intermediate chemical compounds and pharmaceutical compositions Download PDF

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Publication number
LT3983B
LT3983B LTIP1536A LTIP1536A LT3983B LT 3983 B LT3983 B LT 3983B LT IP1536 A LTIP1536 A LT IP1536A LT IP1536 A LTIP1536 A LT IP1536A LT 3983 B LT3983 B LT 3983B
Authority
LT
Lithuania
Prior art keywords
compound
pregna
formula
sec
dihydroxy
Prior art date
Application number
LTIP1536A
Other languages
English (en)
Lithuanian (lt)
Inventor
Martin John Calverley
Kai Hansen
Lise Binderup
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of LTIP1536A publication Critical patent/LTIP1536A/xx
Publication of LT3983B publication Critical patent/LT3983B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LTIP1536A 1989-02-23 1993-12-06 Novel vitamin d analogues, process for their preparation, intermediate chemical compounds and pharmaceutical compositions LT3983B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898904154A GB8904154D0 (en) 1989-02-23 1989-02-23 Chemical compounds
SG131794A SG131794G (en) 1989-02-23 1994-09-12 Novel vitamin D analogues

Publications (2)

Publication Number Publication Date
LTIP1536A LTIP1536A (en) 1995-09-25
LT3983B true LT3983B (en) 1996-06-25

Family

ID=26295003

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1536A LT3983B (en) 1989-02-23 1993-12-06 Novel vitamin d analogues, process for their preparation, intermediate chemical compounds and pharmaceutical compositions

Country Status (22)

Country Link
EP (1) EP0460032B1 (hu)
JP (1) JP2807083B2 (hu)
KR (1) KR0163194B1 (hu)
AT (1) ATE104957T1 (hu)
AU (1) AU627001B2 (hu)
CA (1) CA2044280C (hu)
DE (1) DE69008517T2 (hu)
DK (1) DK0460032T3 (hu)
ES (1) ES2055905T3 (hu)
FI (1) FI92929C (hu)
GB (1) GB8904154D0 (hu)
HK (1) HK128894A (hu)
HU (1) HU211025B (hu)
IE (1) IE63123B1 (hu)
LT (1) LT3983B (hu)
LV (1) LV10428B (hu)
NO (1) NO178065C (hu)
PT (1) PT93232B (hu)
RO (1) RO109939B1 (hu)
RU (1) RU2037484C1 (hu)
SG (1) SG131794G (hu)
WO (1) WO1990009991A1 (hu)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904153D0 (en) * 1989-02-23 1989-04-05 Leo Pharm Prod Ltd Chemical compounds
DE4011682A1 (de) * 1990-04-06 1991-10-10 Schering Ag 24-oxa-derivate in der vitamin d-reihe
GB9015774D0 (en) * 1990-07-18 1990-09-05 Leo Pharm Prod Ltd Novel treatment
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
GB9220272D0 (en) * 1992-09-25 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
GB9220439D0 (en) * 1992-09-28 1992-11-11 Leo Pharm Prod Ltd Chemical compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
US5945410A (en) * 1997-03-17 1999-08-31 Wisconsin Alumni Research Foundation 2-alkyl-19-nor-vitamin D compounds
US6306844B1 (en) 1997-03-17 2001-10-23 Wisconsin Alumni Research Foundation Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength
US6392071B1 (en) 1997-03-17 2002-05-21 Wisconsin Alumni: Research Foundation 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds
US6316642B1 (en) 1997-03-17 2001-11-13 Wisconsin Alumni Research Foundation 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds
US6359152B2 (en) 1997-07-21 2002-03-19 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US5939406A (en) * 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US5962707A (en) * 1998-08-18 1999-10-05 Wisconsin Alumni Research Foundation 19-nor-vitamin D3 compounds with calcemic activity
JP4803939B2 (ja) * 2000-04-19 2011-10-26 中外製薬株式会社 ビタミンｄ誘導体
US20030018017A1 (en) * 2001-01-25 2003-01-23 Deluca Hector F. Method of treatment of type I diabetes
KR20050120787A (ko) 2003-04-10 2005-12-23 위스콘신 얼럼나이 리서어치 화운데이션 2-프로필리덴-19-노르-비타민 ｄ 화합물
US6894037B2 (en) 2003-07-03 2005-05-17 Wisconsin Alumni Research Foundation 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
US7713951B2 (en) 2004-04-09 2010-05-11 Wisconsin Alumni Research Foundation 2-alkylidene-18,19-dinor-vitamin D compounds
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
NZ571896A (en) 2006-04-05 2011-09-30 Wisconsin Alumni Res Found 1-Alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin D compounds and methods of making and use thereof
US8377913B2 (en) * 2007-11-20 2013-02-19 Abbvie Inc. Vitamin D receptor activators and methods of making
JP5563324B2 (ja) * 2010-02-03 2014-07-30 フォーモサ・ラボラトリーズ・インコーポレーテッド マキサカルシトール中間体およびその製造方法
WO2012122451A2 (en) 2011-03-09 2012-09-13 Teva Pharmaceutical Industries Ltd. Polymorphs of maxacalcitol and process for the preparation of maxacalcitol
CN102796134B (zh) * 2012-08-31 2015-07-01 甘肃皓天化学科技有限公司 一种马沙骨化醇中间体的制备方法
CN103910666A (zh) * 2014-04-15 2014-07-09 湖南华腾制药有限公司 一种制备马沙骨化醇的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0078704A1 (en) 1981-11-02 1983-05-11 Research Institute For Medicine And Chemistry Inc. Intermediates in the synthesis of vitamin D derivatives
EP0184112A2 (en) 1984-11-27 1986-06-11 Chugai Seiyaku Kabushiki Kaisha Novel vitamin D derivatives and process for producing the same
EP0227826A1 (en) 1985-08-02 1987-07-08 Leo Pharm Prod Ltd NEW VITAMIN-D-ANALOGA.
WO1989010351A1 (en) 1988-04-21 1989-11-02 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis Novel vitamin d analogues

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904153D0 (en) * 1989-02-23 1989-04-05 Leo Pharm Prod Ltd Chemical compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0078704A1 (en) 1981-11-02 1983-05-11 Research Institute For Medicine And Chemistry Inc. Intermediates in the synthesis of vitamin D derivatives
EP0184112A2 (en) 1984-11-27 1986-06-11 Chugai Seiyaku Kabushiki Kaisha Novel vitamin D derivatives and process for producing the same
EP0227826A1 (en) 1985-08-02 1987-07-08 Leo Pharm Prod Ltd NEW VITAMIN-D-ANALOGA.
WO1989010351A1 (en) 1988-04-21 1989-11-02 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis Novel vitamin d analogues

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ABE J. ET AL.: "Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton", FEBS LETTERS, 1987, pages 58, XP025606586, DOI: doi:10.1016/0014-5793(87)80550-1
MARTIN J. CALVERLEY: "Synthesis of mc 903, a biologically active vitamin D metabolite analogue", TETRAHEDRON, 1987, pages 4609 - 4619, XP002336467, DOI: doi:10.1016/S0040-4020(01)86903-9
MURAYAMA E, MIYAMOTO K, KUBODERA N, MORI T, M: "Synthetic studies of vitamin D3 analogues. VIII. 1) Synthesis of 22-oxavitamin D3 analogues", CHEM PHARM BULL, 1987, pages 4410
MURAYAMA. E ET AL.: "Synthetic studies of vitamin Dj analogs: syntheses of 22-oxa-vitamin D, analog", CHEM. PHARM. BULL., 1986, pages 2286
RED. T. W. GREENE: "Protecting Groups in Organic Synthesis"

Also Published As

Publication number Publication date
NO912902D0 (no) 1991-07-25
RO109939B1 (ro) 1995-07-28
FI92929C (fi) 1995-01-25
JPH04503669A (ja) 1992-07-02
KR920701145A (ko) 1992-08-11
NO912902L (no) 1991-07-25
WO1990009991A1 (en) 1990-09-07
LV10428B (en) 1995-10-20
HK128894A (en) 1994-11-25
JP2807083B2 (ja) 1998-09-30
KR0163194B1 (ko) 1999-01-15
NO178065B (no) 1995-10-09
DE69008517D1 (de) 1994-06-01
EP0460032A1 (en) 1991-12-11
FI913812A0 (fi) 1991-08-12
HU211025B (en) 1995-09-28
HUT59664A (en) 1992-06-29
LTIP1536A (en) 1995-09-25
EP0460032B1 (en) 1994-04-27
RU2037484C1 (ru) 1995-06-19
DE69008517T2 (de) 1994-08-18
PT93232A (pt) 1990-08-31
CA2044280A1 (en) 1990-08-24
DK0460032T3 (da) 1994-06-06
IE900421L (en) 1990-08-23
FI92929B (fi) 1994-10-14
GB8904154D0 (en) 1989-04-05
AU5198390A (en) 1990-09-26
NO178065C (no) 1996-01-17
AU627001B2 (en) 1992-08-13
LV10428A (lv) 1995-02-20
ES2055905T3 (es) 1994-09-01
SG131794G (en) 1995-01-13
IE63123B1 (en) 1995-03-22
PT93232B (pt) 1995-12-29
CA2044280C (en) 1999-12-21
ATE104957T1 (de) 1994-05-15

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