KR101391834B1 - Whitening cosmetic compounds and method for fabricating the same - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin whitening, and more particularly, to a cosmetic composition for skin whitening which is prepared by using nano-sized titanium dioxide and arbutin, which have a skin whitening effect, as an effective ingredient having a skin whitening effect.
The cosmetic composition according to the present invention has the effect of suppressing excessive melanin production in the skin cells, which is one of the active ingredients contained in the facial skin when applied, and gives skin whitening effect while improving spots and freckles Titanium dioxide, which gives whitening effect when exposed to light, is contained as an active ingredient, which is advantageous in that whitening and skin whitening can be given outdoors.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition for skin whitening,

The present invention relates to a cosmetic composition for skin whitening and a method for producing the same, and more particularly to a cosmetic composition for skin whitening, which comprises titanium dioxide and arbutin, which have skin whitening effect, as a whitening active ingredient and contains Keratone horny moisturizing component, The present invention relates to a cosmetic composition for whitening skin and a process for producing the same.

The skin color of a person is determined by the concentration and distribution of melanin in the skin. In addition to hereditary factors, it is also affected by environmental or physiological conditions such as sunlight, fatigue, and stress. Melanin is produced by a nonenzymatic oxidation reaction after an enzyme called tyrosinase acts on tyrosine, a kind of amino acid, and is converted into dopa (DOPA) and dopaquinone (Dopaquinone). However, the pathway through which melanin is made is known, but the mechanism by which melanin synthesis, a previous step in which tyrosinase acts, is not yet elucidated. If such a synthesis of melanin occurs excessively in the skin, it may darken skin tone, and may cause spots and freckles. Therefore, inhibiting the synthesis of melanin pigment in the skin can brighten the skin tone to realize whitening of the skin, and can improve skin hypercholesterolemia caused by ultraviolet rays, hormones and hereditary causes, such as spots and freckles have. Therefore, conventionally, a substance having an inhibitory activity against tyrosinase such as hydroquinone, ascorbic acid, kojic acid, glutathione, etc. is added to a cosmetic such as ointment or essence, Whitening, and improvement of skin hypercholesterolemia such as spots and freckles. However, although hydroquinone exerts a predetermined whitening effect, there is a problem that the skin irritation is so severe that the compounding amount must be limited to a very small amount. Ascorbic acid is easily oxidized and the cosmetic composition containing the hydroquinone is discolored or deteriorated. . Furthermore, thiol compounds such as glutathione and cysteine have not only unpleasant odors but also problems with transdermal absorption, and their glycosides and derivatives are also highly polar, making them difficult to use as a blending ingredient for cosmetics. On the other hand, the placenta extract and the like have no irritation to the skin, but the whitening effect is insufficient.

On the other hand, studies on percutaneous absorption preparations that effectively penetrate the skin into the skin have been continuing in skin-related research, as confirmed by the In Vitro Test. The main techniques are sufficient moisturization of the skin, micro capsule preparation (such as Liposome preparation), hydrogel, and microparticulation of the active ingredient (such as nano treatment).

In addition, in the whitening of the skin, it is possible to prevent the melanin from turning black due to the UV protection function, or to reduce the melanin pigment that has been converted to black to attain the whitening effect. However, this is because the sunlight, specifically, . The addition of ultraviolet light at the same time as whitening constantly cancels the artificial whitening function, because it keeps melanin blackening phenomenon. Therefore, when a whitening component acts and immediately after it and when a certain ultraviolet blocking effect is concurrently performed, a whitening effect is visually confirmed and can be stably maintained for a certain period of time. This is because unlike the case where a separate ultraviolet screening agent or ingredient is applied simultaneously or sequentially with the whitening agent to make the whitening-blackening process on the skin, the whitening phenomenon caused by the function of the initially applied whitening agent is maintained, So that the state of the skin becomes a color reference.

There have been many proposals concerning skin whitening cosmetic compositions. Korean Patent Laid-Open Publication No. 2008-78371 has proposed a raw material for creams for whitening skin of a silkworm mushroom mycelium culture using mulberry leaf extract, Korean Patent Publication No. 2010-7061 , There has been proposed a skin whitening cosmetic composition containing an extract of Capsicum annuum as an active ingredient. However, there is a question about the skin whitening effect using natural extracts, and the production process is difficult and mass production is difficult, It is still difficult to produce such a product.

SUMMARY OF THE INVENTION The present invention has been made to solve the above problems,

It is an object of the present invention to provide a pharmaceutical composition containing albutin, which has a high effect of inhibiting melanin formation, and titanium dioxide, which gives a whitening effect when exposed to light, as an effective ingredient for skin whitening such as spots and freckles improvement by inhibiting excessive melanin production in skin cells. Cream or lotion type, and a process for producing the same.

In addition, the present invention relates to a composition for improving the percutaneous absorption rate of arbutin and preventing the whitening effect from being canceled by blocking the irradiation of additional ultraviolet rays while the whitening effect is proceeding, and also to provide a cream having a whitening effect of titanium dioxide nanoparticles Or lotion type cosmetic composition and a process for producing the same.

The skin whitening cosmetic composition provided by the production method of the present invention is characterized by containing arbutin and nano-sized titanium dioxide as an effective ingredient for skin whitening.

In addition, the cosmetic composition for skin whitening according to the present invention is a composition for keratin horny moisturizing ingredient which is prepared by mixing at least one of butylene glycol, sodium hyaluronate, glycerin, sodium chondroitin sulfate, betaine, mannan, and ceramide 3; A softening agent obtained by mixing at least one of wheat germ oil, camellia oil, cetyl hexyl hexanoate, ceresin, lecithin, olive oil, squalane, phytosterol and shea butter; Skin whitening ingredient which is formed by mixing at least one of titanium dioxide, arbutin, magnesium ascorbyl bosphate, mulberry root extract, bark extract, and dipotassium glycyrrhizinate; A skin regeneration component composed of a mixture of at least one of hydrolyzed pea protein and human oligopeptide 1; Fine lines and anti-aging ingredients composed of adenosine; A plant extract component comprising at least one of Aloe Vera leaf juice, Ginkgo biloba extract, and centipede centrum extract; A vitamin component comprising a mixture of tocopheryl acetate or panthenol; A complexing agent component comprising disodium edithioate; And a fragrance component composed of a combination of natural aroma essence.

The skin-whitening cosmetic composition according to the present invention may further comprise a skin-forming component comprising a copolymer of sodium acrylate and sodium acryloyldimethyltaurate or a copolymer of dimethicone and vinyl dimethicone; A suspension combustion component in which polysorbate 80, taxol-10,1-dimethicone are mixed together; And a surface treatment component composed of dimethicone, cetyl dimethicone, cyclopentasiloxane, cyclohexasiloxane, stearyl dimethicone, and the like.

Among the skin whitening cosmetic compositions according to the present invention, the components for promoting transdermal absorption of arbutin are largely moisturizing and moisturizing the skin to hydrate the epidermal keratin horny layer, thereby increasing the pore size between the keratin layers and increasing the hydrophilic component arbutin to effectively absorb melanin Keratin skin moisturizing ingredients that can be absorbed and reached the basal layer where existing epidermis and blood vessels are present and a composition similar to the intercellular lipid of the stratum corneum to effectively prevent keratin horny moisturizing component from being lost, Or a flexible component having a composition similar to that of the cell membrane.

Therefore, in addition to sodium hyaluronate, glycerin, and butylene glycol, betaine, mannan, and ceramide 3 have been used as keratonic horny moisturizing agents. Examples of the softeners having a component similar to sebum or cell membrane include lecithin, squalane, , Phytosterol, and shea butter.

In addition, titanium dioxide, which is one of the key elements of the present invention, was pre-processed in the form of fine nano (nanotubes) and allowed to be stably dispersed in a cream or lotion type liquid composition.

On the other hand, the nanoparticle-type titanium dioxide is mixed with the suspension component so as not to be exclusively mixed with the surface of the skin constituted by sweat, sebum and interstitial lipid, so that the cosmetic composition according to the present invention is adhered well to the skin A surface treatment component composed of a silicone oil component such as dimethicone, setting dimethicone, stearyl dimethicone and the like was added and formed.

In addition, when titanium dioxide is surface-treated with a skin-attaching component such as sodium acrylate / sodium acryloyldimethyltaurate copolymer and dimethicone / bithydimethicone crosspolymer, the dispersion stability in formulation is excellent, and the surface lipid (Sebaceous, intercellular lipid - derived components) as well as adhesion stability to skin was relatively excellent.

According to the present invention, arbutin, which is one of the active ingredients contained in the application to the facial skin, inhibits excessive melanin production in the skin cells, thereby giving effects such as stain and freckle improvement, Titanium dioxide, which gives whitening effect when exposed, is contained as an active ingredient, and it has an advantage that skin whitening and whitening effect can be given especially in the outdoors.

In addition, the cosmetic composition according to the present invention provides a moist and moisturizing effect even when only a small amount of water is supplied immediately with a soft and light creamy texture, thereby improving black, grayish skin, fine wrinkles and thick wrinkles, There are other benefits that protect and make you lively and beautiful skin.

In addition, the present invention provides a cosmetic composition which can increase the transdermal absorption rate of arbutin, prevent the addition of ultraviolet rays while preventing the whitening effect from being canceled while the whitening effect is progressing, and provide a whitening effect of the titanium dioxide nanoparticles There are also other advantages.

FIG. 1 shows dispersion stability of titanium dioxide according to the size of the skin of Asian people.

(1) Preparation of a Composition Containing Titanium Dioxide Nanoparticles
In order to improve the skin stability and adhesion of titanium dioxide of 10 to 20 nm in size, sodium acrylate / sodium acryloyldimethyltaurate copolymer and dimethicone / vinyl dimethicone crosspolymer And mixed with polysorbate 80 as a suspension component and cephem / piperidine-10/1-dimethicone. The titanium dioxide nanoparticle-containing composition was prepared by mixing dimethicone, cetyl dimethicone, cyclopentasiloxane / cyclohexasiloxane, and stearyl dimethicone, which are silicone oils, for surface treatment of titanium dioxide.

(2) Production of cream
Next, for the production of the cream, a mixture of butyleneglycol, sodium hyaluronate, glycerin, sodium chondroitin sulfate, betaine, mannan, and ceramide 3 was used as a keratin horny moisturizing ingredient.
Flexible powders were prepared by mixing wheat germ oil, camellia oil, cetyl hexyl hexanoate, ceresin, lecithin, olive oil, squalane, phytosterol and shea butter.
As a skin whitening ingredient, the composition containing the titanium dioxide nanoparticles prepared in (1) was mixed with arbutin, magnesium ascorbyl bosphate, mulberry root extract, mulberry bark extract, and dipotassium glycyrrhizate.
Adenosine was used as a fine wrinkle and anti-aging ingredient.
As a skin regeneration component, a mixture of hydrolyzed pea protein (plant stem cell extract) and Human Oligopeptide 1 was used.
Aloe Vera leaf extract, Ginkgo biloba extract, and Kunchuk extract were used as plant extracts.
As a vitamin component, tocopheryl acetate and panthenol were mixed.
Disodium edetate was used as a complexing agent, and a combination of natural aroma essences was used as a fragrance component.
Ingredients for the preparation of water and common cream in the above mixtures were further added to prepare a white creamy cosmetic composition.

Comparative Example 1 was prepared by excluding arbutin and nano-sized titanium dioxide in the cream form cosmetic composition of Example 1 above.

A method of using the cream prepared in Example 1

First, apply an appropriate amount to face, hands, feet, legs (whitening part), then roll lightly with a feeling of massage.

Afterwards, after about 1 to 2 minutes massage with a feeling of being absorbed into the skin, wash it lightly with lukewarm water after 3 minutes.

Lastly, dry the skin with a towel so that it dries well, then wipe it with toner or mist.

<Sensory Test>

The whitening effect of Example 1 and Comparative Example 1 was evaluated by human sensory test.

Twenty persons were selected for each of 10 healthy women and men aged 40 to 50 years suffering from melanin on the skin, and the face was divided into two halves. On the left ball, the cosmetic composition according to the present invention of Example 1 was applied to the right The control group of Comparative Example 1 was applied to the ball for 2 months, twice a day in the morning and evening. The evaluation of the whitening effect was made by evaluating the degree of the whitening effect using the following evaluation scores by subjective evaluation of the subject after using the composition of the present invention. The results are shown in Table 1 below.

Evaluation table for skin whitening effect division male female score 0 point 1 point 2 points 3 points 0 point 1 point 2 points 3 points Example 1 3 5 3 3 4 3 Comparative Example 1 10 10

 (Score)

 3: Whitening effect is over 75% better than the control group

 2: Whitening effect is 50 ~ 75% better than the control

 1: Whitening effect is 25 ~ 50% better than the control group

0: Whitening effect is less than 25% as compared with the control.

When the composition of the present invention was used as a cream cosmetic composition, the cosmetic composition of Example 1 containing arbutin and titanium dioxide showed a whitening effect compared to the cosmetic composition of Comparative Example 1, The effect was excellent.

FIG. 1 shows the dispersion stability of titanium dioxide according to the size of the skin of Asian people.

Nano-sized titanium dioxa, which is used as a skin whitening ingredient, has a certain nano size, and when a mixture of dimethicone, cetyl dimethicone, cyclopentasiloxane / cyclohexasiloxane, and stearyl dimethicone is not added, , Agglomeration, solidification, and the like, thereby resulting in phase separation due to changes in color, viscosity, compositional ratio, and the like, so that the whitening effect and the ultraviolet blocking effect can not be properly observed. Therefore, in order to be able to see whitening effect and ultraviolet ray blocking effect while showing no signs when the skin is applied to the skin, it is necessary to limit the particle size to 10 to 20 nm, to maintain the electrical repulsive force between titanium dioxide particles, It was confirmed that it is preferable to add a silicone oil-based surface treatment component in order to cause the resin on the surface to cause steric hindrance of the absorption amount.

Claims (4)

(1) Titanium dioxide having a size of 10 to 20 nm, a mixture of dimethicone, cetyl dimethicone, cyclopentasiloxane, cyclohexasiloxane, and stearyl dimethicone, which are silicone oils, as a surface treatment component and sodium acrylate A copolymer of dimethicone and vinyl dimethicone, and a titanium dioxide nano-mixture of polysorbate 80, meteorite, piperidine-10,1-dimethicone as suspension components, Preparing a particle-containing composition; And
(2) mixing the following components; &Lt; RTI ID = 0.0 &gt; 1, &lt; / RTI &gt;
Herein, the following components are &quot;
A keratoene horny moisturizing ingredient comprising at least one of butylene glycol, sodium hyaluronate, glycerin, sodium chondroitin sulfate, betaine, mannan, and ceramide 3;
A softening agent obtained by mixing at least one of wheat germ oil, camellia oil, cetyl hexyl hexanoate, ceresin, lecithin, olive oil, squalane, phytosterol and shea butter;
A skin whitening component which is formed by mixing the titanium dioxide-containing composition obtained in the step (1) with arbutin, magnesium ascorbyl bospate, mulberry root extract, mulberry bark extract, and dipotassium glycyrrhizate;
A skin regeneration component composed of a mixture of at least one of hydrolyzed pea protein and human oligopeptide 1;
Fine lines and anti-aging ingredients composed of adenosine;
A plant extract component comprising a mixture of at least one of Aloe Vera leaf juice, Ginkgo biloba extract, and Centella asiatica;
A vitamin component comprising a mixture of tocopheryl acetate or panthenol;
A complexing agent component comprising disodium edithioate; And
A fragrance component comprising a combination of natural aroma essences; . delete delete delete

Images