JPWO2021183540A5 - - Google Patents
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- Publication number
- JPWO2021183540A5 JPWO2021183540A5 JP2022554573A JP2022554573A JPWO2021183540A5 JP WO2021183540 A5 JPWO2021183540 A5 JP WO2021183540A5 JP 2022554573 A JP2022554573 A JP 2022554573A JP 2022554573 A JP2022554573 A JP 2022554573A JP WO2021183540 A5 JPWO2021183540 A5 JP WO2021183540A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- oligonucleotide
- composition according
- antigen
- immunogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 45
- 230000002163 immunogen Effects 0.000 claims 40
- 108091034117 Oligonucleotide Proteins 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 4
- 101900123149 Varicella-zoster virus Envelope glycoprotein E Proteins 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- PFCLMNDDPTZJHQ-XLPZGREQSA-N 2-amino-7-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidin-4-one Chemical group C1=CC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PFCLMNDDPTZJHQ-XLPZGREQSA-N 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 claims 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- 238000010255 intramuscular injection Methods 0.000 claims 2
- 239000007927 intramuscular injection Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 2
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 229940047712 aluminum hydroxyphosphate Drugs 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940029575 guanosine Drugs 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062987243P | 2020-03-09 | 2020-03-09 | |
| US62/987,243 | 2020-03-09 | ||
| PCT/US2021/021544 WO2021183540A1 (en) | 2020-03-09 | 2021-03-09 | Shingles vaccines comprising a tlr9 agonist |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023517597A JP2023517597A (ja) | 2023-04-26 |
| JPWO2021183540A5 true JPWO2021183540A5 (zh) | 2024-03-15 |
Family
ID=77672121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022554573A Pending JP2023517597A (ja) | 2020-03-09 | 2021-03-09 | Ｔｌｒ９アゴニストを含む帯状疱疹ワクチン |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230061403A1 (zh) |
| EP (1) | EP4117726A4 (zh) |
| JP (1) | JP2023517597A (zh) |
| KR (1) | KR20230013237A (zh) |
| CN (1) | CN115768892A (zh) |
| AU (1) | AU2021236059A1 (zh) |
| BR (1) | BR112022017852A2 (zh) |
| CA (1) | CA3174927A1 (zh) |
| IL (1) | IL296283A (zh) |
| MX (1) | MX2022011159A (zh) |
| WO (1) | WO2021183540A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL313715A (en) * | 2021-12-23 | 2024-08-01 | Dynavax Tech Corp | Immunogenicity of CPG-assisted shingles vaccine |
| CN116655748B (zh) * | 2023-02-28 | 2024-07-26 | 易慧生物技术(上海)有限公司 | 一种截短型水痘-带状疱疹病毒gE蛋白及其应用 |
| CN118085111B (zh) * | 2024-04-28 | 2024-08-09 | 天津中逸安健生物科技有限公司 | 一种融合蛋白gE-Fc及其在制备重组带状疱疹疫苗中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0109297D0 (en) * | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
| HUE036894T2 (hu) * | 2004-06-15 | 2018-08-28 | Idera Pharmaceuticals Inc | Immunstimuláló oligonukleotid multimerek |
| EP1979488A4 (en) * | 2006-01-09 | 2009-05-27 | Univ California | IMMUNOSTIMULATORY COMBINATIONS OF TNFRSF, TLR, NLR, RHR, PURINERGIC RECEPTOR AND CYTOKINE RECEPTOR AGONISTS USED FOR VACCINES AND ANTI-TUMOR IMMUNOTHERAPY |
| CN102517302A (zh) * | 2011-12-28 | 2012-06-27 | 中国人民解放军军事医学科学院野战输血研究所 | 一种重组表达水痘-带状疱疹病毒截短型糖蛋白e的方法及其应用 |
| EP3041505A4 (en) * | 2013-09-05 | 2017-04-19 | Merck Sharp & Dohme Corp. | Methods of immunization with varicella zoster virus antigen |
| EP3079717A1 (en) * | 2013-12-09 | 2016-10-19 | Bullet Biotechnology, Inc. | Specific virus-like particle-cpg oligonucleotide vaccines and uses thereof |
| WO2017192874A1 (en) * | 2016-05-04 | 2017-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Albumin-binding immunomodulatory compositions and methods of use thereof |
| IL267643B2 (en) * | 2016-12-26 | 2023-12-01 | Mogam Inst Biomedical Res | Herpes zoster vaccine |
| CN109602901B (zh) * | 2019-01-08 | 2022-05-27 | 成都迈科康生物科技有限公司 | 一种带状疱疹病毒疫苗及其制备方法和应用 |
-
2021
- 2021-03-09 KR KR1020227034628A patent/KR20230013237A/ko unknown
- 2021-03-09 EP EP21767529.7A patent/EP4117726A4/en active Pending
- 2021-03-09 CN CN202180032671.4A patent/CN115768892A/zh active Pending
- 2021-03-09 MX MX2022011159A patent/MX2022011159A/es unknown
- 2021-03-09 IL IL296283A patent/IL296283A/en unknown
- 2021-03-09 CA CA3174927A patent/CA3174927A1/en active Pending
- 2021-03-09 WO PCT/US2021/021544 patent/WO2021183540A1/en active Application Filing
- 2021-03-09 BR BR112022017852A patent/BR112022017852A2/pt unknown
- 2021-03-09 US US17/910,334 patent/US20230061403A1/en active Pending
- 2021-03-09 JP JP2022554573A patent/JP2023517597A/ja active Pending
- 2021-03-09 AU AU2021236059A patent/AU2021236059A1/en active Pending
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