JPS6148369A - Medical sticking tape or sheet - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a medical adhesive tape or sheet with excellent water vapor permeability.

(Prior Art) Many medical tapes or sheets, such as adhesive plasters and adhesive sheets containing drugs in the adhesive, have been manufactured. When these tapes or sheets are attached to the skin for a long time (for example, more than half a day), the skin often becomes softened, rashes, redness, etc. due to stuffiness. This is because the adhesive constituting the tape or sheet and the base material such as the film supporting the adhesive have poor water vapor permeability.

Porous tapes and sheets are manufactured to increase the water vapor permeability of such medical tapes and sheets. Tapes and sheets have also been devised in which an adhesive is partially provided, for example, in a striped pattern, on a breathable base material such as cloth or nonwoven fabric. However, even if such tapes or sheets are used, localized dampness of the skin cannot be avoided, and therefore the occurrence of the skin disorders described above cannot be prevented. Japanese Patent Publication No. 39-4728 discloses a surgical adhesive tape in which a thin film of an acrylic acid ester porous adhesive is provided on the surface of a porous fiber base material such as a nonwoven fabric. Since the pore diameter of this porous adhesive thin film is large, ranging from several micrometers to several tens of micrometers, it can permeate not only water vapor but also liquids such as water. Therefore, when the tape is applied to the skin, dirt from the outside may penetrate and cause the wound to fester. There is also the drawback that the tape applied when taking a bath tends to peel off. If the adhesive contains a drug, the drug leaks out through the back surface of the tape.

Generally, acrylic ester-based adhesives have poor cohesive strength, so when a tape or sheet applied to the skin is peeled off, a so-called "adhesive residue phenomenon" occurs. Therefore, in the above publication, a polar monomer such as acrylic acid is added to form a polymer to increase the cohesive force of the adhesive. usually.

A crosslinking agent is further added to the prepared adhesive to perform post-crosslinking of the acrylic acid component. As the crosslinking agent, diamines, diols, and polyamines are used. If this crosslinking agent remains unreacted, it will cause wheat skin irritation. As the crosslinking reaction progresses, the water vapor permeability of the adhesive decreases.

Japanese Patent Publication No. 55-14108 discloses that polyvinylethyl ether having a hydrophilic group in one molecule or acrylic acid ester having a hydrophilic group in one molecule is coated on a film base material with high water vapor permeability such as acrylate or polyurethane. A water vapor permeable patch having a copolymer as an adhesive layer has been disclosed.

Polyvinyl alkyl ethers such as polyvinylethyl ether and acrylic acid ester polymers inherently have weak cohesive force and high water vapor permeability.However, when hydrophilic groups are introduced into these compounds.

The cohesive force is increased and water vapor permeability is achieved. However, because hydrophilic groups are present.

The affinity between the adhesive and the living tissue increases, and the adhesive force becomes too large. Therefore, when the sheet or tape is peeled off from a wound or the like, there is a risk of damaging the skin. In particular, it cannot be used to protect the affected area by applying it directly to the site of skin graft surgery. If the affinity of acrylic ester polymer with the skin increases.

If even a small amount of unreacted monomer remains, the irritation to the skin will be higher.

(Object of the Invention) An object of the present invention is to provide a medical adhesive tape or sheet with excellent water vapor permeability.

Another object of the present invention is to provide a medical adhesive tape or sheet that does not cause skin irritation because the adhesive used is inert and does not cause deterioration even if the adhesive contains a drug. be. Still another object of the present invention is to
An adhesive layer with appropriate cohesiveness and affinity for living tissue is provided, allowing it to be applied to the skin for a long time, and no adhesive remains on the skin even when the skin is removed.

Moreover, it is an object of the present invention to provide a medical adhesive tape or sheet that does not damage the skin. Still another object of the present invention is to
The object of the present invention is to provide a medical adhesive tape or sheet using an adhesive mainly composed of an acrylic alkyl ester polymer and having appropriate cohesive properties without the use of post-crosslinking. Still another object of the present invention is to provide a medical adhesive tape or sheet having an adhesive layer of a desired thickness.

(Structure of the Invention) The present invention provides alkyl/L[1,!
This was completed based on the inventors' knowledge that the average number of carbon atoms in the l chain has a large effect on the water vapor permeability of the (co)polymer. Therefore, in the medical adhesive tape or sheet of the present invention, the adhesive layer is formed on a water vapor permeable base material,
The adhesive is an acrylic acid alkyl ester containing an alkyl group having an average carbon number of 3.5 to 5.5 as an ester side chain; or an alkyl group having an average carbon number of 3.5 to 5.5 as an ester side chain. The main component is a polymer in which a straight chain portion is formed using as monomer components an acrylic acid alkyl ester and a methacrylic acid alkyl ester having an alkyl group having an average carbon number of 3.5 to 5.5 as an ester side chain. and has 2 or more polymerizable double bonds per 100 mole molecule of the monomer component of the polymer in 1 molecule.
, 001 to 061 mol molecules of a polyfunctional monomer, thereby achieving the above object.

Sufficient water vapor permeability can be obtained by using an acrylic acid alkyl ester polymer or a copolymer of acrylic acid alkyl ester and methacrylic acid alkyl ester as an adhesive, in which the average number of carbon atoms in the side chain alkyl group is 5.5 or less.

However, adhesives in which the average number of carbon atoms in the side chain alkyl group is less than 3.5 have poor adhesion to the skin. The (meth)acrylic acid alkyl ester that can be used alone as a raw material for the adhesive is an ester having a butyl group or a pentyl group. From the viewpoint of raw material cost, etc., esters containing a butyl group are preferred. The number of usable ester alkyl groups is 1
For example, 1-methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, t-butyl group, pentyl group, hexyl group.

Heptyl group, octyl group, 2-ethylhexyl group.

These are isooctyl group, decyl group, isodecyl group, and lauryl group. These are used by appropriately mixing them so that the average carbon number is 3.5 to 5.5.

In a copolymer of an acrylic acid alkyl ester and a methacrylic acid alkyl ester, the higher the content of the methacrylic acid alkyl ester as a constituent component, the lower the adhesiveness. Therefore, when using a methacrylic acid alkyl ester, it is preferable to increase the average carbon number of the alkyl group. The upper limit of the content of the methacrylic acid alkyl ester as a constituent component is the maximum average carbon number of the alkyl group, which is 5.
When it is set to 5, it is about 40%.

When preparing the adhesive, polyfunctional monomers are added at the same time. The polyfunctional monomer refers to a polyfunctional acrylic ester having two or more terminal acrylic ester groups in one molecule or a polyfunctional methacrylic ester having two or more terminal methacrylic ester groups in one molecule. Such polyfunctional monomers are added at a ratio of 0.001 to 0.1 mol molecules per 100 mol molecules of (meth)acrylic acid ester. By adding polyfunctional monomers.

The polymer formed becomes partially crosslinked. In the present invention, this is referred to as "slight crosslinking". Slight crosslinking is 0.001 to 0.1/) per 100 moles of monomer component of the polymer.
It is thought that this occurs at a ratio of molar molecules. In the present invention, a polyfunctional monomer (that is, a slight crosslinking agent) is added from the beginning of one reaction and the polymerization reaction is carried out without taking the conventional step of adding a crosslinking agent to an acrylic adhesive and performing post-crosslinking. Crosslinking can be achieved at the same time. Since the amount of the slight crosslinking agent is also much smaller than in the case of post-crosslinking, the water vapor permeability of the pressure-sensitive adhesive is not impaired by crosslinking. Unlike conventional products, crosslinking agents do not remain and cause skin irritation and drug deterioration.

Slight crosslinking imparts appropriate cohesive properties to the adhesive, so
Adhesion of the tape or sheet to the skin surface is improved. Furthermore, tapes and sheets 11. Even when cantering, a part of the adhesive does not remain on the skin surface or it sticks (so-called ``adhesive residue phenomenon'' or ``stringing phenomenon''). The stability of the adhesive solution obtained by slight crosslinking also increases. Therefore, it becomes possible to easily apply the adhesive solution onto the base material.

Polyfunctional monomers used for micro-crosslinking include (meth)acrylic esters at both ends such as polymethylene glycol (e.g. hexamethylene glycol), (meth)acrylic esters at both ends of polyethylene glycol, and both ends of polypropylene glycol. (meth)acrylic acid ester, glycerin di(meth)acrylic acid ester,
Glycerin tri(meth)acrylic ester, pentaerythritol di(meth)acrylic ester,
Examples include pentaerythritol-tri(meth)acrylic acid ester and trimethylolpropane-tri(meth)acrylic acid ester.

If the amount of the slight crosslinking agent added is less than the above range, sufficient cohesiveness of the adhesive cannot be obtained. If the amount added is too large, it becomes difficult to adjust the degree of polymerization during one reaction, and the reaction solution tends to gel. Even if a pressure-sensitive adhesive solution can be prepared without gelation, it is difficult to keep it stable in a solution state for a long period of time.

It is also possible to add monomers other than those mentioned above during the preparation of the adhesive to form a copolymer. Other monomers include, for example, vinyl acetate and vinylpyrrolidone.

Diacetone acrylamide, acrylonitrile.

Dimethylacrylamide, ethylene glycol mono (
Contains meth)acrylic acid ester and styrene.

These other monomers may be added to the extent that they do not adversely affect the water vapor permeability or cohesiveness of the adhesive.

The maximum amount of these other monomers added is usually 10 mol% of the total i-mer.

Polymerization of monomers is usually carried out in an organic solvent by a high concentration solution polymerization method using a radical polymerization catalyst such as an azobis-based or peroxide-based catalyst.

The adhesive thus obtained is inert.

In other words, a reactive group 1 such as a carboxyl group, an amino group, a glycidyl group, a hydroxyl group, etc.

Contains no. Therefore, it does not irritate the skin or alter the quality of the drug contained therein. Since it has good solubility in solvents, it can be easily coated on a substrate in a state dissolved in a solvent.

If necessary, a suitable drug is mixed into the adhesive solution obtained by polymerization to prepare a drug-containing adhesive tape or sheet. The drug must have the property of being absorbed transdermally and be compatible with the adhesive. The amount added is limited to a range that is compatible with the adhesive. - Medications that are or can be used mostly in ointment or cream form may be used. For example, anti-inflammatory drugs and anti-inflammatory analgesics.

These include coronary vasodilators, antiallergic agents, tranquilizers, and antihypertensive agents.

The water vapor permeability of an adhesive or an adhesive containing a drug is 1500 g per 24 hours at 40°C and in an atmosphere with a relative humidity difference of 80% when the film thickness is 20 μm.
/ m (1500g/%/24Hr/40'C
/80%R11) or more.

Examples of the water vapor permeable base material of the present invention include one example.

A plastic film or fibrous sheet is used. Materials for plastic films include2 For example, polyurethane, polyamino acids, urethane-amino acid copolymers9
Partially acetalized polyvinyl alcohol, methylcellulose, ethylcellulose, ethylene glycol or propylene glycol mono(meth)acrylate
There are (meth)acrylate copolymers containing 0% or more. In addition to plastic films made of such materials, water vapor permeability can also be obtained by punching holes in a film made of a plastic material with poor water vapor permeability and bonding the film to the above-mentioned water vapor permeable base material. Examples of plastic materials for films with poor water vapor permeability include polyethylene, polypropylene, ethylene/vinyl acetate copolymer, and polyamide.

These include polyester, polyvinyl chloride, and cellulose acetate. Examples of the fibrous sheet include paper, woven cloth, and nonwoven fabric. Furthermore, the fibrous sheet and the water vapor permeable plastic film may be used in combination. The water vapor permeability of the above water vapor permeable base material is 1500 g
/m/2411r/40℃/80%Il1 or more.

A pressure-sensitive adhesive layer is provided on the base material to obtain the medical tape or sheet of the present invention. To form the adhesive layer, an adhesive solution is applied onto the substrate and dried. In addition, after coating and drying an adhesive solution on release paper such as silicone,
A tape or sheet may be prepared by a transfer method in which this is bonded to a base material. When the release paper is removed, the adhesive is transferred from the release paper onto the substrate. The adhesive layer is preferably covered with release paper until just before use. Therefore, a preparation method using a transfer method is preferred.

Since the tape or sheet thus obtained uses an adhesive and a base material with high water vapor permeability, good water vapor permeability can be obtained as a whole. Its water vapor permeability is 700 g/I/24Hr/40°C/80%RH or more.

For example, when using a base material such as polyurethane film that is extremely flexible and easily stretched, or has a low surface hardness, it is necessary to prevent stretching and deformation due to tension during the processing process, and to prevent scratches caused by friction with other objects. Prevent it from occurring 1
In order to keep the surface clean, it is preferable that the surface of the base material be provided with some kind of appropriate protection. polyurethane film.

Usually, it is manufactured by being cast and coated on a type of removable backing paper called process paper, gelled and dried, and then adhered to the process paper. therefore.

When using polyurethane film as a base material,
It is preferable to process the paper while it is adhered to the process paper to produce a tape or sheet. Since the polyurethane film is reinforced by the processing paper, it will not be unnecessarily stretched during the processing process. Since the film surface is protected, no scratches will occur. If this process paper is peeled off at the time of use, the tape or sheet will not be stretched or deformed by the time of use. The same applies not only to polyurethane films but also to plastic films that are easily stretched or have low surface hardness.

(Example) The present invention will be described below with reference to Examples.

Spiked Blood Dish (A) Preparation of Adhesive Butyl Niacrylate 128. Og
(1,0 mol) and 0.0181 g (0,0000
8 mol) was added to 30 g of ethyl acetate, and 60
Stirring was performed at °C. Separately, a catalyst solution was prepared by dissolving 0.41 g of abbisisobutyronitrile in 100 g of ethyl acetate. 174 amounts of this catalyst solution were added dropwise to the above ethyl acetate solution over 15 hours. The temperature of this reaction solution was raised to 70° C., and the remaining amount of the catalyst solution was added dropwise over a further 15 hours. Further, stirring was continued while maintaining the temperature at 70°C for 8 hours to complete the polymerization. Note that when the viscosity of the reaction solution increased during one reaction, ethyl acetate was appropriately added. By doing this, it was possible to maintain the viscosity of the 9 reaction liquid at a level that allowed constant stirring.

The concentration of the adhesive component in the obtained solution was 24.7%.

The viscosity is 36', 000 cps (measured with a B a M type viscometer; rotor NCL3; 1.5 rpm;
21°C).

(B.) Preparation of adhesive sheet 2. A polyether polyurethane film with a thickness of 25 μm was used as the base material. This film was formed by casting, and was used with the processing paper still attached. The adhesive solution obtained in section (A) was applied onto a release paper whose surface had been treated with silicon so that the thickness after drying was 20 μm, and dried. The above-mentioned base material was superimposed on the surface of the obtained pressure-sensitive adhesive so that the film surface was in contact with the pressure-sensitive adhesive, and was pressure-bonded with a roller. By pressing, the adhesive layer is reliably transferred onto the base material. The sheet having the process paper and release paper obtained was cut into a desired size, the process paper and release paper were removed, and the sheet was used.

(C) Measurement of water vapor permeability The diameter of the two-opening part is 2 in the order of 48.
00mff glass wide-mouth bottle ($ equipped), add 3 ml of distilled water to it.
I put 0ml. The adhesive sheet obtained in section (B) was cut out in an area sufficiently wider than the opening of the wide-mouth bottle, and the adhesive surface of this adhesive sheet was placed inside to cover the opening of the wide-mouth bottle. The portion of the adhesive sheet that protruded from the opening was brought into close contact with the outer wall of the wide-mouthed bottle, and vinyl tape was further wrapped several times around the top. After accurately measuring the total weight of this wide-mouthed bottle, it was placed in a gear oven at 40° C. and 520% RH for 24 hours. After 24 hours, the total weight of the wide-mouth plate was measured, the amount of distilled water lost was determined, and 1m' of adhesive sheet was measured.
The amount of water vapor permeation per unit was calculated. Water vapor permeability is 14
80 g/m/2411r/40℃/80% (
(hereinafter expressed as 1480 g/m2). Note that the water vapor permeability of the base material alone was 2100 g/m.

LA) Preparation of adhesive sheet: As a natural rubber adhesive',
'An adhesive consisting of 10 parts by weight of natural natural rubber and 20 parts by weight of ester gum was used. Using this adhesive, an adhesive layer was formed on the same base material as in Example 1 to a thickness of 20 μm.

An adhesive sheet was obtained.

(B) Measurement of water vapor permeability: Example 1 Measurement was carried out according to the method in section (C). The water vapor permeability was 150 g/m2.

Izumi ■ Madaraji (A) Preparation of adhesive Butyl niacrylate 56.8g (
0.4 mol), butyl acrylate 76.8 g (0.4 mol), butyl acrylate 76.8 g (0.
6 mol) and polyethylene glycol-dimethacrylic acid ester 0.0168 g (0.00005 mol)
Add to 28g of ethyl acetate. Stirring was performed at 60'C under a nitrogen stream. Separately, a catalyst solution was prepared by dissolving 0.797 g of lauroyl peroxide in a mixed solution of 50 ml of ethyl acetate and 50 ml of n-hexane. Below, Example 1 (
The same operation as in section A) was carried out to obtain an adhesive solution. The concentration of the adhesive component in the obtained solution was 25.5%, and the viscosity was 470%.
It was 0 cps. The viscosity measurement conditions are as in Example 1 (A)
Same as section.

(B) Preparation of pressure-sensitive adhesive sheet: Using the pressure-sensitive adhesive obtained in Section (A) of this Example, a pressure-sensitive adhesive sheet was prepared according to the method of Section (B) of Example 1.

(C) Measurement of water vapor permeability: Using the pressure-sensitive adhesive sheet obtained in section (B) of this example, measurement was performed according to the method in section (C) of Example 1. Water vapor permeability is 1590 g/
It was m.

(D) Preparation of drug-containing adhesive sheet 2. Add 15 g of Salocol to the adhesive solution obtained in Example (A).

Methyl salicylate 3g, E-menthol 3g, d
- Camphor 2g and diphenhydramine hydrochloride 0,5
An anti-inflammatory analgesic agent consisting of g was added and dissolved.

The base material is 20% gamma-alkyl monoglutamate.
A film made by casting a copolymerized ether-based polyurethane resin to a thickness of 40 μm was used. Note that the base material was used with the processing paper removed. An adhesive solution containing the above-mentioned drug was applied onto a release paper whose surface had been treated with silicon so that the thickness after drying was 60 μm, and the solution was dried for 1 time. The above-mentioned base material was superimposed on the surface of the obtained pressure-sensitive adhesive and pressure-bonded with a roller. The resulting sheet with release paper is cut to the desired size. When used, the release paper is removed and the product has an anti-inflammatory and analgesic effect when applied to the back, lower back, etc. of the human body.

(E) Measurement of water vapor permeability of drug-containing adhesive sheet; Example 1 using the adhesive sheet obtained in section (D) of this example.
Measurements were made using the method in section (C). Water vapor permeability was 820 g/m. In addition.

The water vapor permeability of the substrate alone was 1930 g/tri.

Comparative Example 2 (A) Preparation of adhesive sheet: As a natural rubber adhesive, 100 parts by weight of natural rubber, 90 parts by weight of polyterpene and...
An adhesive consisting of 20 parts by weight of ester gum was used. Using this adhesive, a drug was mixed according to Example 2 (D) to prepare an adhesive sheet.

(B) Measurement of water vapor permeability Two comparative examples Using the adhesive sheet obtained in section (A). Example 1 Measurements were carried out in accordance with the method described in section (C). Water vapor permeability was 60 g/m.

Tenju soup 1 (A) Preparation of adhesive butyl acrylate 108.8g
(0.85 mol), ethyl acrylate 15.0 g
(0.15 mol) and trimethylolpropane-triacrylate 0.0118 g (0.000
04 mol) was added to 40 g of ethyl acetate, and the mixture was heated for 60 mol under a nitrogen stream.
Stirring was performed at 'C. Separately, benzoyl peroxide 0.48
A catalyst solution was prepared by dissolving 4 g in 100 mA of ethyl acetate. below.

Example 1 A pressure-sensitive adhesive solution was obtained by carrying out the same operation as in section (A). The concentration of the adhesive component in the resulting solution was 24.9%, and the viscosity was 31,000 cps. 8. The viscosity measurement conditions are the same as in Example 1 (A).

(B) Preparation of Adhesive Sheet 2 Using the adhesive obtained in Example (A), an adhesive sheet was prepared according to the method in Example 1 (B).

(C) Measurement of water vapor permeability 2 Using the pressure-sensitive adhesive sheet obtained in Example (B), measurements were carried out in accordance with the method in Example 1 (C). Water vapor permeability is 1620 g/
It was m.

(D> Preparation of drug-containing adhesive sheet yM: Thickness 2 as base material
A 5 μm polyether polyurethane film was used. This film was formed by casting, and was used with the processing paper still attached. The polymer component 100 was added to the adhesive solution obtained in Section (A) of this example.
Prednisolone, an anti-inflammatory agent, was added at a rate of 0.2 g/g. Using the obtained adhesive solution containing the drug and a base material, a sheet having Step 1 and release paper was prepared by a transfer method according to the method in Section (B) of Example 1.

The thickness of the adhesive layer was set to 40 μm.

(E) Measurement of water vapor permeability of drug-containing adhesive sheet (2) Example 1 Using the adhesive sheet obtained in Example (D),
Measurement was performed according to the method in section (C). Is the water vapor permeability 900g/rr? Met. This value is higher than the water vapor permeability of similar products generally on the market.
Indicates that it causes less wilting and irritation on the skin.

Preparation of adhesive (A): Example 1 Same as section (A).

(B) Preparation of adhesive sheet 2 The adhesive solution obtained in Example (A) was applied onto a silicone release layer so that the thickness after drying was 4.
It was applied to a thickness of 0 μm and dried. A rayon fiber nonwoven fabric with a thickness of 130 μm was layered as a base material on the adhesive layer and compressed through rolls.

The state was such that the nonwoven fabric bit into a part of the adhesive layer.

An equimolar addition reaction product of polyethyleneimine and octadecyl isocyanate was dissolved in toluene, and this was applied as a release treatment agent to the above nonwoven fabric at a solid content of 0.5 g per 1 m' and dried. While peeling off the release paper of the resulting pressure-sensitive adhesive sheet having a release paper, the pressure-sensitive adhesive sheet was wound onto a paper core. Cut this to an appropriate width,
A roll of adhesive tape was obtained.

(C) Measurement of water vapor permeability 2 Using the pressure-sensitive adhesive sheet obtained in Example (B), measurements were carried out according to the method in Example 1 (C). Water vapor permeability is 1840, /
It was rJ. In this example, since the base material is a porous nonwoven fabric, the water vapor permeability of the base material can be considered to be infinite. Therefore, the above value is considered to be the water vapor permeability of the adhesive layer.

Comparative Example 3 - Comparison was made with the example of the present invention using the acrylic adhesive used in jlQ.

(A) Preparation of adhesive 174.8 g (0.95 mol) of 2-ethylhexyl acrylate and 3 acrylic acid
．． 6 g (0.05 mol) to 50.0 g of ethyl acetate
In addition to.

Stirring was carried out at 560° C. under a nitrogen stream. Below, Example 1
A reaction was carried out using a catalyst in the same manner as in section (A) to obtain an adhesive solution. The concentration of the adhesive component in the obtained solution was 27.8
%, and the viscosity was 19,000 cps.

* (B) Preparation of adhesive sheet: Using the adhesive obtained in section (A) of this example, a pressure-sensitive adhesive sheet was prepared according to the method in section (B) of Example 1. When the resulting adhesive sheet was applied to the skin and then removed, the adhesive remained on the skin. This is because the internal cohesive force of the adhesive is insufficient.

(C) Measurement of water vapor permeability: Using the pressure-sensitive adhesive sheet obtained in section (B) of this example, measurement was performed according to the method in section (c) of Example 1. Water vapor permeability was 780 g/m2.

(D) Crosslinking treatment of adhesive: In order to resolve the lack of cohesive force of the adhesive obtained in this comparative example, crosslinking treatment was further performed. 1,4-Dioxytetramethylene dihexamethylene diisocyanate was added as a crosslinking agent to the adhesive solution obtained in Comparative Example (A) to carry out a crosslinking reaction of the acrylic acid moiety. The crosslinking agent was added at a rate of 0.2 mol per mol of monomer components.

(E) Preparation of sheet using cross-linked adhesive Two comparative examples Example 1 using the cross-linked adhesive solution obtained in section (D)
A pressure-sensitive adhesive sheet was prepared according to the method in section (B).

In addition, after applying and drying the adhesive, a curing treatment was performed at 90° C. for 30 minutes.

(F) Measurement of water vapor permeability of a sheet using a cross-linked adhesive: Using the sticky sheet obtained in section (E) of Wood Comparative Example,
Example 1 Measurement was carried out according to the method in section (C). Water vapor permeability was 650 g/m.

(Effects of the invention) The medical tape or sheet of the present invention thus has the following features:
Because it combines an adhesive with high water vapor permeability that is mainly composed of a (meth)acrylic acid (co)polymer containing an alkyl side chain with a specific number of carbon atoms and a base material with high water vapor permeability, it is extremely resistant to water vapor. Excellent transparency. Since the adhesive itself is inert and has no reactive groups, it does not emit any strange odor or irritate the skin when the tape or sheet is applied.

It does not alter the quality of the chemicals contained in the adhesive.

Since the adhesive is slightly cross-linked, it exhibits appropriate 'cE-collecting properties and affinity for living tissues. Therefore.

When the tape or sheet is peeled off from the skin, the adhesive will not remain on the skin or damage the skin wound.

Furthermore, since the adhesive is stable for a long time as a solution in an organic solvent, it is easy to form an adhesive layer, and a medical tape or sheet having an adhesive layer of a desired thickness can be provided.

that's all

Claims (1)

[Scope of Claims] 1. A medical adhesive tape or sheet in which an adhesive layer is formed on a water vapor permeable base material, the adhesive having an alkyl group having an average carbon number of 3.5 to 5.5. an acrylic acid alkyl ester containing as an ester side chain; or an acrylic acid alkyl ester containing an alkyl group having an average carbon number of 3.5 to 5.5 as an ester side chain and an average carbon number of 3.5 to 5.5 The main component is a polymer in which a straight chain portion is formed using a methacrylic acid alkyl ester having an alkyl group as an ester side chain as a monomer component. 0.001 to 0.1 having two or more double bonds in one molecule
A water vapor permeable medical tape or sheet that is slightly cross-linked by a molecular polyfunctional monomer. 2. When the film thickness of the adhesive is 20 μm, the water vapor permeability of the adhesive is 1500 g/m^2 or more per 24 hours in an atmosphere of 40°C with a relative humidity difference of 80%. The tape or sheet described in item 1. 3. The water vapor permeability of the base material is 1500g per 24 hours in an atmosphere of 40°C with a relative humidity difference of 80%.
/m^2 or more, the tape or sheet according to claim 1. 4. The water vapor permeability of the tape or sheet is 700 g/m^2 or more per 24 hours in an atmosphere of 40°C with a relative humidity difference of 80%, Claim 1
The tape or sheet according to item 2, item 3, or item 3. 5. The tape or sheet according to claim 1, wherein the base material is a plastic film or a fibrous sheet. 6. The tape or sheet according to claim 1, wherein the adhesive contains a drug. 7. The tape or sheet according to claim 1, wherein the adhesive is inert and has an appropriate affinity for living tissue.