JPS6072542A - Light ray ct apparatus - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (a) Industrial Application Field The present invention relates to a computer 117i layer imaging device (hereinafter referred to as cT device) for obtaining a 1lffi layer image of an object, particularly a living body. .

(LJ) Prior art Conventional C] - Devices include x m cr device, emission CT device (positive 1 to long CT equipment, sink/L
/7:4 t-ton C1-M@), NMR-C-1-device J3J, and ultra-n-wave CT device are known.

Behind these devices, the metabolism of living organisms (fF,
Emission CT equipment and NMR are used to observe
・CT! It is a place.

However, the emission C1 device is a device that observes radiation, and has the disadvantage that radiation exposure cannot be measured by MI since it injects Uzioin 1--B (R1) into the raw water.
MR・c-"The device is for observing electromagnetic waves, and requires equipment that generates a strong magnetic field and magnetic shielding equipment, which has the disadvantage that the device itself and its ancillary equipment are large.

On the other hand, it has recently been proposed to use light to spectroscopically investigate cell tissues of living organisms. [1-Oxygen properties of myocardial tissue 1111 Village and others ゛Heart” VOl, 14N0
．． 2 '82], [l"Physiological significance of myoglobin J
Ill 4'tOthers ``Biophysics'' VOl, IG
No.

1-7611, [l' Optical Meas
ureme++t of1+1traCOIIular
oxygen conccntration orR
at Heart in VitroJ-1-amu
ra et al” A RC+-11V E SO
F[310CI-1[EMIsTRY AND1310
PI-IYS I C3″Vol, 191 No.

IN ovcmber, -78J.

(c) Purpose of the Invention The present invention provides a device that combines light and a CT device, that is, it uses light to analyze the abicularis function of a living body in a spectroscopic manner. The purpose of this invention is to provide a device that can perform two-dimensional analysis.

With the device of this invention, for example, it is possible to quantitatively observe the two-dimensional distribution of the binding state of oxygen in proteins such as hemoglobin and myoglobin that can bind to oxygen molecules in the living body, and also to quantitatively observe the binding state of oxygen in proteins such as hemoglobin and myoglobin in the living body. The oxidation and reduction states of 1 hechromes, etc. are functions of the acid M fA degree J3 and 1 energy state, and from these oxidation and reduction states, the mitochondrial oxygen concentration can be observed in two dimensions with I1j, and J and R For example, myoglobin in an oxygen-deficient state is tl
Measuring blood damage can be helpful in discovering the extent of organic damage, its extent, and its exact location.

(d) Structure of the Invention The C-1-H arrangement of the present invention transmits a light beam of a wavelength that is absorbed by the object to be measured, and uses the data of the intensity of the light beam to detect the inside of the object to be measured. It is characterized by obtaining a two-dimensional distribution image of a measurement target, and can be called a light beam CT system.

1. That is, the light beam CT apparatus i, 1, ijl of the present invention and/or light source means for applying a near-infrared light beam to an object to be measured; A light detection means for receiving a light beam and outputting a signal according to the light intensity; a beam scanning means for transmitting the light beam at different positions with respect to an object to be measured; Based on the light beam position signal and the output signal of the light detecting means, two of the objects to be measured are located inside the object to be measured.
The apparatus is configured to include a data processing means for calculating the dimensional distribution and an image display means for displaying the two-dimensional distribution obtained by the data processing means as an image.

The wavelength of the light beam applied to the light source means is preferably 500 nm to 150011 m when the object to be measured is a living body, but this is because at a wavelength shorter than 500 nm, scattering of C in the living body becomes large. This is because wavelengths longer than 150011111 are absorbed by water in the living body, and the transmittance of the light beam decreases by seventy.

The light beam received by the light detection means is either a monochromatic light beam with a wavelength that has a selectively high absorbance with respect to the object to be measured, or a monochromatic light beam with a wavelength that selectively has a high absorbance with respect to the object to be measured. - two or three different wavelengths of a monochromatic light beam whose absorbances differ from that of the monochromatic light beam and whose absorbances with respect to other absorbing substances are substantially the same;
It is preferable that the light beam has a wavelength greater than or equal to the wavelength. world 2
The main purpose of using a light beam with an iU length or a wavelength of 3 or more is to avoid the effects of fouling, scattering, and changes in the thickness of the object.3.C is a specific example of two different wavelengths. teeth,
When the object to be measured is moisture, examples include a light beam with a wavelength of about 145011 m, more preferably a light beam with a wavelength of about 145011111 nm, and a light beam with a wavelength of about 1200 nm. When the object to be measured is hemoglobin, a light beam with a wavelength of about 650 nm or a light beam with a wavelength of about a 5 o n 111 is used.
A light beam with a wavelength of about 750 nm can be emitted. By using a light beam with two wavelengths of approximately G50nn+ and approximately 750 II..., only He-E globin can be measured. This also means that the observation of oxygen metabolism is i+JO. Hemoglobin has an absorption peak near 11,000 nm, and measurement using this wavelength is also possible. Furthermore, when the measurement target is chromium, about 850
One may mention a light beam with a wavelength of nrn, or a light beam with a wavelength of about 85011 m and a light beam with a wavelength of about 90011 m.

By using a light beam with two wavelengths of about 850 If m and about 900 r+m, only oxidized ditochrome can be measured, and this is bootchrome! ? Targeted in vivo 1
Observation of the concentration of %(J3Jζ) and observation of oxygen metabolism are effective.

In order to select the wavelength of the light beam, a monochromatic light source such as a semiconductor laser is used as the light source means, or a white light source such as a tungsten lamp or a hagen lamp is used as the light source means, and the light source means or light detector is used as the light source means. The means may be provided with a filter or a spectrometer such as a Gray-J ink. As the light detecting means, an A to D, a foot transistor, or a PbS cell can be used.

As the beam scanning means, an X-ray scanning means proposed in a known X-ray CT apparatus can be used. For example, the translation/rotation method in JP-A No. 50-156387, the rotation method in JP-A-50-28894,
Unexamined Japanese Patent Application No. 11i, l 52-10 G 1398 Detector all around installation/beam source rotation method in J3, Unexamined Japanese Patent Application No. 11fl
It is possible to use the beam source J3 J: and detector all-around installation system described in BL-126088. In particular, this invention
The light source means J3 and the light detection means in 3 are smaller and safer than the X-ray source Jj and the X-ray detector, so both fronts are placed around the entire circumference of the object to be measured and C1 is electrically scanned at high speed. Easy to use.

The data processing means mentioned above may utilize the data processing means proposed in J3 for a known device. For example, special 17i1 Showa 50-2838! J34 in i month
:J data processing means can be used.

The video display means displays an image on CI'<T.
It is possible to use any known video display means.

(Small) Embodiment (1), not shown in FIG. 1, is an embodiment of this light beam CTI device.

As shown in FIG. 2, the light source means (2) consists of a tungsten lamp (3) and an interference filter (5), f□). C approximately 6 due to switching rotation of (6)
A light beam with a wavelength of 5011111 nm and a light beam with a wavelength of about 750 nm are alternately emitted.

The light detection means (8) is approximately GO
Optical filter 00 that cuts out light with a wavelength of Onm or more
). The optical filter (10) is used to prevent the effects of illumination within the measurement field. That is, if the illumination in the measurement chamber is provided by a low-pressure light source such as a light source such as a light source such as a light source such as a light source such as a light source, the illumination light is filtered by the optical filter 001, so that it cannot affect the measurement in any way.

The light source means (2) and the light detection means (8) are arranged to face each other, and the transmitted light is detected by placing the object to be measured (0) between them.

The beam scanning means (11) is a known translation/rotation system.
It is. It translates and one ta(1z rotates and bell 1~(13
a) If (131+) rotates, the light source means (2)
The light detection means (8) is translated, and the light beam scans the object to be measured (0) while maintaining the same angle. Furthermore, if the rotary motor system (rotary motor system) rotates and the gantry (I5) rotates, the angle of the light beam that strikes the object to be measured (0) changes.

The position signal related to translational scanning is output from the position sensor (J (+6+), and the signal related to the angle is output from the position sensor 1 (J).
17).

08) is an operator system that performs interactions such as A operator, electromechanical control of the entire device, and data processing, that is, a profile in translational scanning. Repeat this process with different angles to create as many profiles as possible 4!7
'U, From these, derive the two-dimensional component Ii of the light-absorbing substance.

Since a light beam with a wavelength of about G50nm is absorbed by the Hesigling l-1 bin, a wave of about G50nm [(corresponding to J
From the output signal of the optical detector 81 means (8), it is possible to determine the two-dimensional distribution of hesiglobin. Also about 750
A beam of light with a wavelength of nanometers is used to detect oxygenated hemoglobin.
The deoxygenated vemog I" for a bottle (which receives a similar absorption as a light beam with a wavelength of about 050 nm), and the Therefore, the two-dimensional distribution of the oxygen-concentrated melon can be observed from the difference between the output signals of the photodetector (8) for both wavelengths.The correspondence between the two wavelengths and the output signal H of the photodetector (8) is determined by the switching synchronization signal of the interference filters f5) and (61.Roughly speaking, if the timing of data collection is synchronized with the heartbeat of the living body or the signal of the respiration detector, the heartbeat or
+It is possible to observe the state of metabolism in synchronization with inhalation.

The two-dimensional distribution of the light-absorbing substance, that is, the object to be measured, obtained by the computer system f181 is displayed as a C image on the CRT display 09).

FIG. 3 shows another example of the structure of the light source means (2).
The two wavelengths of light beams are mutually radiated onto the object to be measured (0) by the rotation of the left mirror (7).

(A) is Rayleigh die A-de (20+, [21)
(LJ) is the case when a dye Rayleigh device is used. I like the latter (22a) (23a)
is a YAG relay device.

(22a) (23b) are pigments;
a ) (231) ), the wavelength can be selected relatively freely.

Figure 4 shows the main parts of another embodiment of this light beam CT device, which has a unique beam scanning means that takes advantage of the property that the light beam can be guided to an optical fiber. There is.

In other words, small lenses (24a) (24b) - (24q) (
24r)... is arranged. Optical fibers (2
5a) (25b) -(25q) (25r)
− is derived, and each optical fiber (25a) (25b
) 7.-(25Q) (251'')... are connected to two optical fibers (27a) (27a = ), (27
1+ ) (27b i, -, (27q ) (27q
'-),<27r)(27rl,...).

Split into two (back of one optical fiber, one optical fiber (
27a) (27b)...(27q) <27
The ends of the optical fibers (27ai (27b'),
The ends of (27(1') (27r')... are also arranged in a circumferential manner 1 on the fixing plate (29) and fixed and covered.Fixing plate (28)
A rotating light shielding plate (30) with a transparent hole (31) is placed opposite to the rotating light shielding plate (30), and a light source means (2) is placed behind the rotating light shielding plate (30).
). Further, a rotating light shielding plate (32) with a through hole (33) formed therein is opposed to the fixed plate (29), and a light detection means (8) is placed behind the rotating light shielding plate (32).

The light beam emitted from the light source means (2) enters one optical fiber (271) whose position corresponds to the through hole (31), passes through the optical fiber (25b) coupled to it, and passes through the small optical fiber (25b). h' as a fan beam from the lens (2411)
l IJ'l will be done. Light is incident on the optical fibers within the irradiation area of the fan beam, but the light is incident on the single optical fiber (27(1-)) whose position corresponds to the through hole (33). ) is received by the photodetector (8).

If you fix the C rotating light shielding plate (30) at about 1d and rotate the rotating light shielding plate (32), you can obtain multiple pieces of data corresponding to the angle at one position.
Changing the position of the rotating light-shielding plate (30) and repeating the same process, U can obtain enough data to sieve two dimensions (1j).

Figure 5 (The state of blood circulation in a person's palm is observed by the absorption of light rays and shows the situation.a The thickness of the palm is approximately 25
+nm 't', light source means (2) and light detection means (8
) and tightened or loosened the upper arm band (B) to change the blood circulation state. Figure 6 shows the observation results, and (a) shows that the light source means (2) is 50W.
Tungsden lamp J3 and optical filter [transmission wavelength 1
In the case of 10C1On, half (111 width 20++ m), (b) is the case where the light source means is a 3111W sea 1F diode (wavelength 78 (Lnm)).The light detection means (8) are both silicon photodiodes A- The voltage obtained by amplifying the output signal YJ is used as data (shown in Figure 6).Tighten the band (B) at the time indicated by the white arrow and loosen the band (B) at the time indicated by the black arrow. However, the band
8) When tightened, the valve becomes tooth-like, resulting in enzyme deficiency and increased light absorption.

Incidentally, for example, myA globin may be selected as the 1ltlll constant 1st element. In addition, a substance (chemical solution, gas, etc.) that absorbs light at a specific wavelength may be injected into a single object to be measured to improve contrast.

(f) Effects of the invention At the position of the light ray C-1-u of this invention, the following effects can be obtained: J, Rebo, and next J, U.

(2) A two-dimensional distribution of light absorbing matter Y'-th 111 degrees within the object to be measured can be obtained non-invasively.

■ The function of KO+ in C1 organisms can be observed based on the change between u and 5 in the two-dimensional distribution of light-absorbing substance concentration, and can be used for sectional diagnosis...1.

■ It is safe because there is no IM exposed to the radiation line (Il is high, and it is easy to handle and maintain).

(4) Light) J3J and the detector are X-ray sources J3 and
Since it is cheaper and smaller than a radiation detector, the cost of the device itself is lower and it is also more compact. In addition, there is no need for X-ray protection IIJJ equipment or magnetic shielding facilities, and the cost of the equipment is low.

(2) Selection of the wavelength of the light beam Since this is easier, observation can be made at a wavelength suitable for the desired object to be measured.

■ By using two wavelengths or three or more wavelengths in a single manner, it is possible to eliminate the influence of C1 reflection, scattering, measurement error, and absorption by light-absorbing substances other than the measurement target.

■ A substance that absorbs light at a specific wavelength is injected into a living body or object and used as a contrast method or laser method.
This means that even things that cannot be observed in their natural state can be observed.
Becomes Noh.

A Pa side (I) U 111 f:? '>Is l1t
1. Fig. 1 is an explanatory diagram of the configuration of an embodiment of the light beam CT apparatus of the present invention.)) Fig. 2 is an explanatory diagram of the configuration of the light source means and photodetection means 4 (4 components) shown in Fig. 1. , FIG. 3 is a diagram corresponding to FIG. 2 with another example of the light source means, and FIG. 4 is a diagram showing the light ray Ci of the present invention.
The center part of the other embodiments of the device is also an explanatory diagram of the ``6'' structure. Figure 6 is an explanatory diagram of an experiment in which the state of blood circulation is observed using a light beam. It is a graph.

(1)...Light ray C1-device, (2)...
・Light it<i means, (3)...Tungsden lamp, (51(Gl...Interference filter, (7)
...Lefter mirror, (lack 3) ...Photodetection means, (9) ...F 1st to die A-D, +
IO)...Optical filter, (11)...
・Beam scanning device, (12)...translation motor,
(14)...Rotating motor, (16) (17)
...Location sensor, (18)...Data processing Jj [device, (19)...CRT display.

Figure 3 Figure 4 50th Figure 6 (stomach) Sanskrit - [] e&’′ (B) 'lfJ! iDFF

Claims (1)

[Claims] 1. Light source means for emitting a light beam of t+J light congratulations/or near-infrared light to an object to be measured, and receiving the light beam transmitted through the object to be measured and emitting the light. A light detection means for outputting a signal according to the intensity, a beam scanning means for transmitting the light beam at different positions with respect to the object to be measured, and a light beam position signal related to the beam scanning means, etc. data processing means for eliminating the two-dimensional distribution of the measurement target inside the object to be measured based on the output signal of the device; and displaying the two-dimensional distribution obtained by the data processing means as an image
A light ray C1 apparatus comprising an image displaying means.
- Equipment. 3. Claim 1 or 2, wherein the light source means is capable of emitting light beams of two or more different wavelengths.
0 beam device as described in section. 4. The light beam CT apparatus according to claim 3, wherein the photodetecting means outputs output signals corresponding to optical frames of two or more different wavelengths with discrimination ability. 5. The data processing means corresponds to each wavelength of the light detection means corresponding to the light beam of two or more than three different wavelengths.
5. The optical CT apparatus according to claim 4, wherein the optical beam CT apparatus calculates the two-dimensional component ij of the object to be measured based on the resultant optical beam position signal. 6. The light beam C1-device according to any one of claims 1 to 5, wherein the light source means comprises a tungsten lamp. 7. The light beam CT apparatus according to any one of claims 1 to 5, wherein the light source means includes a halogen lamp. 8. A light beam CT apparatus according to any one of claims 1 to 15, wherein the light source means includes a xenon lamp. 9. Claim 1 in which the light source means includes a laser device
The optical CT apparatus according to any one of Items 1 to 5. 10. The optical CT apparatus according to claim 9, wherein the Rayleigh device comprises a dye sheath 11 device. 11. The optical CT apparatus according to claim 9, wherein the laser device is a semiconductor laser device. 12. The light beam C'1 device according to any one of claims 1 to 11, wherein the photodetecting means includes a photomultiplier tube. 13. The optical FA according to any one of claims 1 to 11, wherein the photodetecting means is a hood A (including a die A).
cr-r device. 14. The zero-beam device according to any one of claims 1 to 11, wherein the light detection means comprises an A1-1 transistor. 15. The optical CT system according to any one of claims 1 to 11, wherein the photodetecting means comprises a photoconductive cell.