JPS5569580A - Preparation of nitrogen-containing polycyclic compound - Google Patents

Preparation of nitrogen-containing polycyclic compound

Info

Publication number
JPS5569580A
JPS5569580A JP14384178A JP14384178A JPS5569580A JP S5569580 A JPS5569580 A JP S5569580A JP 14384178 A JP14384178 A JP 14384178A JP 14384178 A JP14384178 A JP 14384178A JP S5569580 A JPS5569580 A JP S5569580A
Authority
JP
Japan
Prior art keywords
formula
compound
room temperature
reducing agent
reaction product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14384178A
Other languages
Japanese (ja)
Other versions
JPS6141514B2 (en
Inventor
Sumimoto Katsube
Keiichi Ono
Hajime Kawakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP14384178A priority Critical patent/JPS5569580A/en
Priority to US06/093,606 priority patent/US4316028A/en
Priority to AU52864/79A priority patent/AU532001B2/en
Priority to EP81104366A priority patent/EP0042526B1/en
Priority to EP79104535A priority patent/EP0013315B1/en
Priority to DE7979104535T priority patent/DE2966204D1/en
Priority to ES486028A priority patent/ES486028A0/en
Priority to DE8181104366T priority patent/DE2967412D1/en
Priority to AT81104366T priority patent/ATE12071T1/en
Priority to AT79104535T priority patent/ATE4666T1/en
Priority to CA000340171A priority patent/CA1136139A/en
Publication of JPS5569580A publication Critical patent/JPS5569580A/en
Priority to US06/259,179 priority patent/US4382936A/en
Publication of JPS6141514B2 publication Critical patent/JPS6141514B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To obtain the title compound having a cerebral vasodilator action in high yield and purity in simple procedures, by dehydrating the reaction product between a keto ester derivative and a reducing agent.
CONSTITUTION: A keto ester of formula I: (R is lower alkyl group) is reacted with a reducing agent, e.g. BNaH4 or Raney-nickel, in a mixed solvent of water and methanol at room temperature to 70°C to give an alcohol derivative of formula II, which is then dehydrated in the presence of a base, e.g. NaH or triethylamine, or an acid, e.g. sulfuric or p-toluenesulfonic acid, at room temperature to the boiliing point of the solvent to form a compound of formula III. The starting compound of formula I can be obtained by hydrolyzing the reaction product between a compound of the formula XCH2CO2R (X is halogen) and a base in the presence of an acid catalyst.
COPYRIGHT: (C)1980,JPO&Japio
JP14384178A 1978-11-20 1978-11-20 Preparation of nitrogen-containing polycyclic compound Granted JPS5569580A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP14384178A JPS5569580A (en) 1978-11-20 1978-11-20 Preparation of nitrogen-containing polycyclic compound
US06/093,606 US4316028A (en) 1978-11-20 1979-11-13 Process for producing eburnane derivatives
AU52864/79A AU532001B2 (en) 1978-11-20 1979-11-15 Polycyclic indole derivatives
DE8181104366T DE2967412D1 (en) 1978-11-20 1979-11-16 Process for producing apovincaminic acid esters and their salts
EP79104535A EP0013315B1 (en) 1978-11-20 1979-11-16 Eburnane derivatives, their synthesis and pharmaceutical compositions containing them
DE7979104535T DE2966204D1 (en) 1978-11-20 1979-11-16 Eburnane derivatives, their synthesis and pharmaceutical compositions containing them
ES486028A ES486028A0 (en) 1978-11-20 1979-11-16 A PROCEDURE FOR PREPARING DERIVATIVES OF INDOL POLICICLICOS
EP81104366A EP0042526B1 (en) 1978-11-20 1979-11-16 Process for producing apovincaminic acid esters and their salts
AT81104366T ATE12071T1 (en) 1978-11-20 1979-11-16 PROCESS FOR THE PREPARATION OF ESTERS OF APOVINCAMIC ACID AND ITS SALTS.
AT79104535T ATE4666T1 (en) 1978-11-20 1979-11-16 EBURNAN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
CA000340171A CA1136139A (en) 1978-11-20 1979-11-20 Polycyclic indole derivatives
US06/259,179 US4382936A (en) 1978-11-20 1981-04-30 Cerebral vasodilator eburnane derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14384178A JPS5569580A (en) 1978-11-20 1978-11-20 Preparation of nitrogen-containing polycyclic compound

Publications (2)

Publication Number Publication Date
JPS5569580A true JPS5569580A (en) 1980-05-26
JPS6141514B2 JPS6141514B2 (en) 1986-09-16

Family

ID=15348185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14384178A Granted JPS5569580A (en) 1978-11-20 1978-11-20 Preparation of nitrogen-containing polycyclic compound

Country Status (1)

Country Link
JP (1) JPS5569580A (en)

Also Published As

Publication number Publication date
JPS6141514B2 (en) 1986-09-16

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