JPS54119441A - Novel bicyclooctane derivative - Google Patents

Novel bicyclooctane derivative

Info

Publication number
JPS54119441A
JPS54119441A JP2733278A JP2733278A JPS54119441A JP S54119441 A JPS54119441 A JP S54119441A JP 2733278 A JP2733278 A JP 2733278A JP 2733278 A JP2733278 A JP 2733278A JP S54119441 A JPS54119441 A JP S54119441A
Authority
JP
Japan
Prior art keywords
formula
endo
group
hydroxymethyl
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2733278A
Other languages
English (en)
Japanese (ja)
Inventor
Hiromi Shimomura
Akihiko Sugie
Sumimoto Katsube
Hisao Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP2733278A priority Critical patent/JPS54119441A/ja
Priority to ES478384A priority patent/ES478384A1/es
Priority to NL7901818A priority patent/NL7901818A/xx
Priority to FR7905846A priority patent/FR2419271A1/fr
Priority to AT0172179A priority patent/AT364097B/de
Priority to IT7948266A priority patent/IT7948266A0/it
Priority to BE0/193893A priority patent/BE874683A/fr
Priority to GB7908169A priority patent/GB2019847B/en
Priority to AU44930/79A priority patent/AU4493079A/en
Priority to SE7902083A priority patent/SE7902083L/xx
Priority to GB7935144A priority patent/GB2030144B/en
Priority to DE19792909088 priority patent/DE2909088A1/de
Priority to DK97179A priority patent/DK97179A/da
Publication of JPS54119441A publication Critical patent/JPS54119441A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2733278A 1978-03-09 1978-03-09 Novel bicyclooctane derivative Pending JPS54119441A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP2733278A JPS54119441A (en) 1978-03-09 1978-03-09 Novel bicyclooctane derivative
ES478384A ES478384A1 (es) 1978-03-09 1979-03-07 Un procedimiento para la obtencion de un compuesto de bici- clooctano.
NL7901818A NL7901818A (nl) 1978-03-09 1979-03-07 Nieuwe bicyclo-octaanderivaten, werkwijze ter bereiding van deze verbindingen, alsmede farmaceutische prepara- ten die zo'n verbinding bevatten.
FR7905846A FR2419271A1 (fr) 1978-03-09 1979-03-07 Nouveaux derives bicyclo-octaniques, leur preparation et leur utilisation comme medicaments
AT0172179A AT364097B (de) 1978-03-09 1979-03-07 Verfahren zur herstellung von neuen bicyclooctanderivaten
IT7948266A IT7948266A0 (it) 1978-03-09 1979-03-08 Procedimento per la preparazione di derivati di bicicloottano e di composizioni farmaceutiche che li con tengono e prodotto ottenuto
BE0/193893A BE874683A (fr) 1978-03-09 1979-03-08 Nouveaux derives bicyclo-octaniques leur preparation et leur utilisation comme medicaments
GB7908169A GB2019847B (en) 1978-03-09 1979-03-08 Bicyclooctanes processes for producing them and pharmaceutical compositions containing them
AU44930/79A AU4493079A (en) 1978-03-09 1979-03-08 Bicyclooctane derivatives
SE7902083A SE7902083L (sv) 1978-03-09 1979-03-08 Bicyklooktanderivat till anvendning som medel mot trombos
GB7935144A GB2030144B (en) 1978-03-09 1979-03-08 Keto-bicyclooctanes
DE19792909088 DE2909088A1 (de) 1978-03-09 1979-03-08 Bicyclooctanderivate, verfahren zu ihrer herstellung und ihre verwendung bei der thrombosebekaempfung
DK97179A DK97179A (da) 1978-03-09 1979-03-08 Bicyclooctanderivater samt deres fremstilling og anvendelse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2733278A JPS54119441A (en) 1978-03-09 1978-03-09 Novel bicyclooctane derivative

Publications (1)

Publication Number Publication Date
JPS54119441A true JPS54119441A (en) 1979-09-17

Family

ID=12218104

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2733278A Pending JPS54119441A (en) 1978-03-09 1978-03-09 Novel bicyclooctane derivative

Country Status (12)

Country Link
JP (1) JPS54119441A (fr)
AT (1) AT364097B (fr)
AU (1) AU4493079A (fr)
BE (1) BE874683A (fr)
DE (1) DE2909088A1 (fr)
DK (1) DK97179A (fr)
ES (1) ES478384A1 (fr)
FR (1) FR2419271A1 (fr)
GB (2) GB2030144B (fr)
IT (1) IT7948266A0 (fr)
NL (1) NL7901818A (fr)
SE (1) SE7902083L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5557559A (en) * 1978-10-19 1980-04-28 Schering Ag Prostane derivative*its manufacture and antihypertensive drug containing it

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2013661B (en) * 1978-01-26 1982-11-10 Erba Farmitalia 9-deoxy-9 -methylene isosteres of pgi2
CA1201712A (fr) * 1980-02-28 1986-03-11 Paul A. Aristoff Analogues de la carbacycline
DE3021895A1 (de) * 1980-06-06 1981-12-24 Schering Ag Berlin Und Bergkamen, 1000 Berlin Neues verfahren zur herstellung von carbacyclin-zwischenprodukten
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
AU546158B2 (en) * 1982-05-06 1985-08-15 Cbd Corp. Cycloaliphatic pharmaceutical compounds
US4689345A (en) * 1982-05-06 1987-08-25 Cbd Corporation Oxygenated alkyl substituted bicyclo alkanes
US4689349A (en) * 1982-05-06 1987-08-25 Cbd Corporation Anti-tumor halo bicyclo alkanones
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5495552A (en) * 1978-01-06 1979-07-28 Sankyo Co Ltd Prostacyline derivative and its preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5557559A (en) * 1978-10-19 1980-04-28 Schering Ag Prostane derivative*its manufacture and antihypertensive drug containing it
JPS6312051B2 (fr) * 1978-10-19 1988-03-17 Schering Ag

Also Published As

Publication number Publication date
GB2030144A (en) 1980-04-02
AT364097B (de) 1981-09-25
GB2030144B (en) 1982-10-20
NL7901818A (nl) 1979-09-11
ES478384A1 (es) 1979-08-01
AU4493079A (en) 1979-09-13
FR2419271B1 (fr) 1983-07-29
SE7902083L (sv) 1979-09-10
FR2419271A1 (fr) 1979-10-05
DK97179A (da) 1979-09-10
BE874683A (fr) 1979-09-10
GB2019847B (en) 1982-10-13
DE2909088A1 (de) 1979-09-20
IT7948266A0 (it) 1979-03-08
GB2019847A (en) 1979-11-07
ATA172179A (de) 1981-02-15

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