JPH03178922A - Dandruff-suppressing agent composition - Google Patents
Dandruff-suppressing agent compositionInfo
- Publication number
- JPH03178922A JPH03178922A JP1316748A JP31674889A JPH03178922A JP H03178922 A JPH03178922 A JP H03178922A JP 1316748 A JP1316748 A JP 1316748A JP 31674889 A JP31674889 A JP 31674889A JP H03178922 A JPH03178922 A JP H03178922A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- dandruff
- scalp
- arginine
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000001840 Dandruff Diseases 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- 239000004475 Arginine Substances 0.000 claims abstract description 9
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 9
- 210000004761 scalp Anatomy 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 8
- -1 perfumery Substances 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 6
- 239000002453 shampoo Substances 0.000 abstract description 6
- 235000015961 tonic Nutrition 0.000 abstract description 6
- 230000001256 tonic effect Effects 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 4
- 239000003676 hair preparation Substances 0.000 abstract description 4
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 229960000716 tonics Drugs 0.000 abstract description 3
- 238000011282 treatment Methods 0.000 abstract description 3
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 239000003086 colorant Substances 0.000 abstract description 2
- 239000002537 cosmetic Substances 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract description 2
- 239000008266 hair spray Substances 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 239000002562 thickening agent Substances 0.000 abstract description 2
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 230000005722 itchiness Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 7
- 150000001483 arginine derivatives Chemical class 0.000 description 7
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 6
- 239000003205 fragrance Substances 0.000 description 6
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 5
- 230000007803 itching Effects 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 229940055577 oleyl alcohol Drugs 0.000 description 2
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- 206010000349 Acanthosis Diseases 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- LSPKYLAFTPBWIL-BYPYZUCNSA-N Glu-Gly Chemical compound OC(=O)CC[C@H](N)C(=O)NCC(O)=O LSPKYLAFTPBWIL-BYPYZUCNSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- WEQJQNWXCSUVMA-RYUDHWBXSA-N Phe-Pro Chemical compound C([C@H]([NH3+])C(=O)N1[C@@H](CCC1)C([O-])=O)C1=CC=CC=C1 WEQJQNWXCSUVMA-RYUDHWBXSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- WBLIXGSTEMXDSM-UHFFFAOYSA-N chloromethane Chemical compound Cl[CH2] WBLIXGSTEMXDSM-UHFFFAOYSA-N 0.000 description 1
- 229940075285 dandruff control Drugs 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229940074096 monoolein Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明はフケ抑制剤組成物に関する。さらに詳しくは
リジン及びその誘導体から選ばれる一種またＬよ二種
以−４−を含有することを特徴とし、有効性及び安全性
に優れたフケ抑制剤組成物に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to anti-dandruff compositions. For more details
The present invention relates to a dandruff suppressant composition which is characterized by containing one or more L selected from lysine and its derivatives, and which is excellent in effectiveness and safety.
［従来の技術］
一般にフケは皮脂腺の分泌物、汗腺の分泌物、表皮層の
剥離物又は脱離物から成り、通常は皮脂腺等の分泌昂進
により発生する。特に細菌や酵母が皮膚に感染すると
、フケの発生が病的に助長されると言われている。この
ため従来から抗菌剤又は殺菌剤を添加した頭髪化粧料が
フケ防止用頭髪化粧料として使用されてきた。[Prior Art] Dandruff generally consists of secretions from sebaceous glands, secretions from sweat glands, and peeled or detached substances from the epidermal layer, and is usually caused by increased secretion of sebaceous glands, etc. Especially when bacteria or yeast infect the skin.
It is said that the occurrence of dandruff is pathologically promoted. For this reason, hair cosmetics to which antibacterial agents or bactericidal agents have been added have traditionally been used as hair cosmetics for preventing dandruff.
［発明が解決しようとする課題］
炎来狡負Ａ胴遣漁−
しかしながら、殺菌剤や抗菌剤の中には、皮膚刺激性の
点で人体に対する安全性等に問題があるものがあり、又
殺菌剤や抗菌剤を含む頭皮改善剤は連続的な使用により
、皮膚常在菌の微妙なバランスをくずしてしまうと言う
、いわゆるエコロジーの観点から、時には望ましくない
事態を引き起こすことが指摘されている。例えば、従来
からフケ防止用薬剤として最も効果があると認められて
いるジンクビリデオン（ＺＰＴ）も抗菌剤の組部に含ま
れるが、これを多量に用いることはできるだけ避けるこ
とが望ましいと言われている。[Problems to be Solved by the Invention] Enraikusei A Bokageryo - However, some disinfectants and antibacterial agents have problems with their safety for the human body in terms of skin irritation, and It has been pointed out that continuous use of scalp improvement agents containing bactericides and antibacterial agents can sometimes cause undesirable situations from an ecological perspective, as they disrupt the delicate balance of resident bacteria on the skin. . For example, zinc virideon (ZPT), which has traditionally been recognized as the most effective anti-dandruff agent, is included in the group of antibacterial agents, but it is said that it is desirable to avoid using large amounts of this as much as possible. .
発明の目的
本発明は前記従来技術の問題点に鑑みなされたものであ
り、その目的は有効なフケ抑制作用を持ち、しかも頭皮
に対し安全性良好な物質を提供するところにある。OBJECTS OF THE INVENTION The present invention has been made in view of the problems of the prior art, and its purpose is to provide a substance that has an effective dandruff suppressing effect and is also safe for the scalp.
前記目的を達成するために、本発明者らは安全性に優れ
た物質の中から、特に頭皮に使用してフケを有効に予防
することができる化合物を得るべく、鋭意研究を重ねた
結果、 アルギニン及びその誘導体が増殖性の表皮肥厚
、紅斑を伴う乾燥、落屑性の変化に対して極めて有効で
あること見出し ノこ 。In order to achieve the above object, the present inventors conducted intensive research to obtain a compound that can be used particularly on the scalp to effectively prevent dandruff from among substances with excellent safety. It was found that arginine and its derivatives are extremely effective against proliferative acanthosis, dryness with erythema, and scaling changes.
上記化合物がプロテアーゼ阻害作用を有することば公知
であるが、フケ抑制に対する作用は報告されておらず、
またフケ抑制剤への応用も知られていない。It is known that the above compound has a protease inhibitory effect, but no effect on dandruff control has been reported.
Furthermore, its application as a dandruff suppressant is also unknown.
」二記知見に基いて本発明を完成するに至った。The present invention was completed based on the second finding.
１課題を解決するための手段１
すなわち本発明はアルギニン及びその誘導体から選ばれ
る一種またしょ二種以−ヒを含有することを特徴とする
フケ抑制剤組成物を提供するものである。Means for Solving the Problem 1 That is, the present invention provides an anti-dandruff composition containing one or more selected from arginine and its derivatives.
以下、本発明の構成について詳述する。Hereinafter, the configuration of the present invention will be explained in detail.
本発明にはアルギニン及びその誘導体が使用されるが、
それは下記一般式で表される。Although arginine and its derivatives are used in the present invention,
It is expressed by the following general formula.
ＲＩ−ＮＨ−ＣＨ １ （ＣＨ２）３−Ｃ１ｔ ＣＯ〜Ｒ２ ” Ｎ Ｈ２ Ｎｌ＋ ３ Ｒ＋”Ｈ，Ｄ Ｐｈｅ Ｐｒｏ、Ｇｌｕ−Ｇｌｙ、 Ｉｌｅ １ｕ ＧＩｙ。RI-NH-CH 1 (CH2)3-C1t CO~R2 ” N H2 Nl+ 3 R+”H,D Phe Pro, Glu-Gly, Ile 1u GIy.
Ｐｒ。Pr.
Ｐｈｅ、Ａｌａ
Ｐｈｅ
Ｒ２”Ｏｔｌ、ＣＨ２Ｃｌ
Ｊｌｅ：イソロイシン
Ａｈａ：アラニン）
本発明でしょ、これらの中から一種または二種以上を任
意に選択できる。Phe, Ala Phe R2"Otl, CH2Cl Jle: Isoleucine Aha: Alanine) According to the present invention, one or more of these can be arbitrarily selected.
本発明のフケ抑制剤組成物中へのアルギニン及びその誘
導体の配合量は組成物全量中０．００１〜１０重量％、
好ましくは０．１〜５重量％である。０．００１重景重
量満では本発明の効果が充分得られず、１０重量％を越
えると、製剤上あるいはコスト的に好ましくない。The amount of arginine and its derivatives incorporated into the dandruff suppressant composition of the present invention is 0.001 to 10% by weight based on the total amount of the composition.
Preferably it is 0.1 to 5% by weight. If the amount is less than 0.001% by weight, the effect of the present invention cannot be sufficiently obtained, and if it exceeds 10% by weight, it is unfavorable in terms of formulation or cost.
本発明のフケ抑制剤組成物は前記の必須成分に加えて、
必要に応じ、本発明の効果を損なわない範囲内で、化粧
品、医薬部外品、医薬品等に一般に用いられる各種成分
、水性成分、保湿剤、増粘剤、防腐剤、酸化防止剤、香
料、色剤、薬剤、生薬などを配合することができる。In addition to the above-mentioned essential ingredients, the dandruff suppressant composition of the present invention includes:
If necessary, various ingredients commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., aqueous ingredients, humectants, thickeners, preservatives, antioxidants, fragrances, Colorants, drugs, herbal medicines, etc. can be added.
また、本発明のフケ抑制剤組成物は任意の剤型、例えば
、シャンプー、リンス等の頭髪化粧料、ヘアトニック、
ヘアコンデショナー、スカルプトリートメント等の養毛
料、ヘアリキッド、ヘアースプレィ、ヘアクリーム等の
整髪料、等の剤型をとることができる。Moreover, the dandruff suppressant composition of the present invention can be used in any dosage form, for example, hair cosmetics such as shampoos and conditioners, hair tonics,
It can take the form of hair nourishing agents such as hair conditioners and scalp treatments, hair styling agents such as hair liquids, hair sprays, and hair creams.
［発明の効果］
本発明のフケ抑制剤組成物は、安全でフケを有効に防止
することができる。また、本発明のツク゛抑制剤組成物
は特にシャンプー、リンス等の界面活性剤に起因する頭
皮刺激により発生ずるフケの予防及び治療に有効性が高
い。さらに頭皮のかゆみ防止にも高い効果を有する。[Effects of the Invention] The dandruff suppressant composition of the present invention is safe and can effectively prevent dandruff. Furthermore, the anti-dandruff composition of the present invention is particularly effective in preventing and treating dandruff caused by scalp irritation caused by surfactants in shampoos, conditioners, and the like. It is also highly effective in preventing itchy scalp.
［実施例］
次に実施例をあげて本発明をさらに詳細に説明する。本
発明はこれらにより限定されるものではない。配合量は
重量％である。[Example] Next, the present invention will be explained in more detail by giving examples. The present invention is not limited to these. The blending amount is in weight%.
実施例に先立ち、本発明で用いた評価法、試験法を説明
する。Prior to Examples, evaluation methods and test methods used in the present invention will be explained.
実使用試験
フケ症で悩む、年齢１８〜４０歳の男子６０名、女子４
０名を対象に、表〜１の実施例１〜３、比較例１のヘア
トニックを毎日洗髪後に使用してもらい、２週間後に症
状を評価した。また表−２の実施例４〜６、比較例２の
シャンプーについては毎日ジャンプ
してもらい、
同様に２週間後に症状を
評価した。Practical test: 60 boys and 4 girls aged 18 to 40 suffering from dandruff.
No subjects were asked to use the hair tonics of Examples 1 to 3 and Comparative Example 1 in Table 1 after washing their hair every day, and their symptoms were evaluated two weeks later. In addition, the shampoos of Examples 4 to 6 and Comparative Example 2 in Table 2 were asked to jump every day, and the symptoms were similarly evaluated 2 weeks later.
その結果を表−４に示す。The results are shown in Table-4.
表
表
尚、上記のアルギニン及びその誘導体１〜４は表−４に
示すとおりである。Table 4 The above arginine and its derivatives 1 to 4 are as shown in Table 4.
Ｒ＋−ＮＨ−ＣＨ−ＮＨ−（ＣＩ（２）３−ＣＨ−ＣＯ
−Ｒ２１
＋Ｎｉｌ。 ＮＨ
３
０
（評価）
実使用によるフケの予防、治療の効果を次の４段階で評
価した。R+-NH-CH-NH-(CI(2)3-CH-CO
-R21 +Nil. NH30 (Evaluation) The effectiveness of prevention and treatment of dandruff through actual use was evaluated in the following four stages.
著効：＠シいフケの減少とかゆみの消失有効：フケの減
少とかゆみの軽減
やや有効：フケの減少かかゆみの軽減かのどちらかを認
める
悪化：使用ににリフケが増加、かゆみの増悪表−４から
明らかなように本発明のフケ抑制剤組成物はフケの発生
予防、治療およびかゆみの改善に優れた効果を示した。Excellent effect: @Reduction of dandruff and disappearance of itching Effective: Reduction of dandruff and reduction of itching Slightly effective: Reduction of dandruff or reduction of itching Deterioration: Increased dandruff and exacerbation of itching due to use As is clear from Table 4, the dandruff suppressant composition of the present invention showed excellent effects in preventing and treating dandruff and improving itching.
実施例７ ヘアトニック
（１）アルギニン誘導体１
（２）ラウリルジメチルアミンオキシド（３）ラウリル
硫酸ナトリウム
（４）プロピレングリコール
（５〉 ヒアルロン酸ナトリウム
（６）香料
（７） ７５％エタノール
重量％
１．０
０．５
０．０５
５．０
０．０１
適量
残余
実施例８ リンス
（１）アルギニン誘導体２
（２）アルギニン誘導体４
（３）ステアリルトリメチル
アンモニウムクロライド
（４）セチルアルコール
（５）シリコン油
（６）ポリオキシエチレン
（１０モル）オレイル
アルコールエーテル
（７）グリセリン
重量％
０．３
０．０５
２．０
２．０
３．０
１．０
５．０
３
（８）防腐剤
（９）香料
（１０）精製水
実施例９ 頭皮用乳液
（１）アルギニン誘導体１
（２）アルギニン誘導体３
（３）アルギニン
（４）ステアリン酸
（５）セチルアルコール
（６）ミツロウ
（７）ポリオキシエチレン
（１０モル）モノ
オレイン酸エステル
（８）プロピレングリコール
（９）エタノール
（１０）防腐剤
（１１）香料
（１２）精製水
４
適量
適量
残余
重量％
１．０
１．０
１．０
１．５
０．５
２．０
１．０
５．０
３．０
適量
適量
残余
実施例ＩＯヘアトニック
（１）アルギニン誘導体３
重量％
０．００１
（２）ポリオキシエチレン（８モル）
オレイルアルコールエーテル
（３）１・３−ブヂレングリコール
（４）香料
（５） ６０％エタノール
０．０５
０．２
適量
残余
実施例１］ シャンプー
（１）アルギニン誘導体２
（２）ココイルメチル
タウリンナトリウム
（３）ラウリン酸
ジェタノールアミド
（４）エチレングリコール
脂肪酸エステル
（５）プロピレングリコール
（６）エデト酸２ナトリウム
（７）ラウリルジメチル
重量％
５．０
１．０
４．５
２．０
３．５
０．１
５．０
５
アミノ酢酸ベタイン
（８）
香料
適量
（９）
精製水
残余Example 7 Hair tonic (1) Arginine derivative 1 (2) Lauryl dimethylamine oxide (3) Sodium lauryl sulfate (4) Propylene glycol (5> Sodium hyaluronate (6) Fragrance (7) 75% Ethanol weight% 1.0 0.5 0.05 5.0 0.01 Appropriate amount remaining Example 8 Rinse (1) Arginine derivative 2 (2) Arginine derivative 4 (3) Stearyltrimethylammonium chloride (4) Cetyl alcohol (5) Silicone oil (6) Polyoxyethylene (10 mol) Oleyl Alcohol Ether (7) Glycerin Weight % 0.3 0.05 2.0 2.0 3.0 1.0 5.0 3 (8) Preservative (9) Fragrance (10) Purified water Example 9 Emulsion for scalp (1) Arginine derivative 1 (2) Arginine derivative 3 (3) Arginine (4) Stearic acid (5) Cetyl alcohol (6) Beeswax (7) Polyoxyethylene (10 mol) Monoolein Acid ester (8) Propylene glycol (9) Ethanol (10) Preservative (11) Fragrance (12) Purified water 4 Appropriate amount Appropriate amount Remaining weight% 1.0 1.0 1.0 1.5 0.5 2.0 1 .0 5.0 3.0 Appropriate amount Appropriate amount Remaining Example IO Hair tonic (1) Arginine derivative 3 Weight % 0.001 (2) Polyoxyethylene (8 mol) Oleyl alcohol ether (3) 1,3-butylene Glycol (4) Fragrance (5) 60% ethanol 0.05 0.2 Appropriate amount remaining Example 1] Shampoo (1) Arginine derivative 2 (2) Sodium cocoyl methyl taurate (3) Jetanolamide lauric acid (4) Ethylene glycol Fatty acid ester (5) Propylene glycol (6) Disodium edetate (7) Lauryl dimethyl weight% 5.0 1.0 4.5 2.0 3.5 0.1 5.0 5 Betaine aminoacetate (8) Fragrance Appropriate amount (9) Remaining purified water
Claims (1)
は二種以上を含有することを特徴とするフケ抑制剤組成
物。(1) A dandruff suppressant composition containing one or more selected from arginine and its derivatives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1316748A JP2826142B2 (en) | 1989-12-06 | 1989-12-06 | Dandruff inhibitor composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1316748A JP2826142B2 (en) | 1989-12-06 | 1989-12-06 | Dandruff inhibitor composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03178922A true JPH03178922A (en) | 1991-08-02 |
| JP2826142B2 JP2826142B2 (en) | 1998-11-18 |
Family
ID=18080475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1316748A Expired - Fee Related JP2826142B2 (en) | 1989-12-06 | 1989-12-06 | Dandruff inhibitor composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2826142B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0747035A3 (en) * | 1995-06-07 | 1998-03-04 | Beiersdorf Aktiengesellschaft | Composition for the treatment of dandruff and the treatment of hair |
| US6432394B2 (en) * | 1999-04-19 | 2002-08-13 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc | Hair conditioning compositions comprising one or more dibasic amino acids |
| CN110859766A (en) * | 2019-10-14 | 2020-03-06 | 澳宝化妆品（惠州）有限公司 | Scalp multi-directional nursing composition and application thereof |
| CN110934762A (en) * | 2019-10-14 | 2020-03-31 | 澳宝化妆品（惠州）有限公司 | Scalp multi-aspect nursing composition containing arginine derivative and application thereof |
-
1989
- 1989-12-06 JP JP1316748A patent/JP2826142B2/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0747035A3 (en) * | 1995-06-07 | 1998-03-04 | Beiersdorf Aktiengesellschaft | Composition for the treatment of dandruff and the treatment of hair |
| US6432394B2 (en) * | 1999-04-19 | 2002-08-13 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc | Hair conditioning compositions comprising one or more dibasic amino acids |
| CN110859766A (en) * | 2019-10-14 | 2020-03-06 | 澳宝化妆品（惠州）有限公司 | Scalp multi-directional nursing composition and application thereof |
| CN110934762A (en) * | 2019-10-14 | 2020-03-31 | 澳宝化妆品（惠州）有限公司 | Scalp multi-aspect nursing composition containing arginine derivative and application thereof |
| CN110934762B (en) * | 2019-10-14 | 2022-08-09 | 澳宝化妆品（惠州）有限公司 | Scalp multi-aspect nursing composition containing arginine derivative and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2826142B2 (en) | 1998-11-18 |
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