JP6088872B2 - Sophorolipid powder with suppressed decomposition of lactone type sophorolipid - Google Patents

Description

  The present invention relates to a stable sophorolipid powder in which decomposition of a lactone type sophorolipid is suppressed and a method for producing the same.

  Sophorolipid, which is known as one of biosurfactants that are biologically derived surfactants, is a fermentation product obtained from yeast fermentation (Non-patent Document 1). The sophorolipid is easily produced by, for example, inoculating yeast into a liquid medium containing a sugar such as glucose and a carbon source such as vegetable oil and fat, and aeration and stirring under mild temperature and pressure conditions. Sophorolipid has been tried to be applied in various fields such as detergents, pharmaceuticals, cosmetics and foods because of its high productivity and safety (Patent Document 1).

  Natural sophorolipid separated from yeast after fermentation is usually a viscous liquid at room temperature, and is obtained as a mixture of acid type and lactone type. When this natural sophorolipid is taken orally, for example, effects such as promoting protein absorption in the intestinal tract can be expected. However, when the natural sophorolipid is stored at room temperature, the lactone type sophorolipid in the liquid is decomposed and the composition and liquidity are not stable, and the protein absorption promoting effect may be reduced.

  Therefore, the present inventors tried to powder natural sophorolipid in order to obtain stable sophorolipid, but it was difficult to powder viscous sophorolipid. Even when lyophilization was attempted, the sophorolipid after lyophilization showed deliquescence, the decomposition of the lactone type was not suppressed, and a stable sophorolipid powder was not obtained.

JP 2009-62288 A

Gorin, Can. J Chem., 39, 846 (1961)

  An object of the present invention is to provide a sophorolipid powder containing a lactone type sophorolipid, the decomposition of the lactone type sophorolipid being suppressed, and having stability over time.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have surprisingly found that, when cyclodextrin is added to a natural sophorolipid-containing liquid and dried, a stable sophorolipid powder can be obtained. The present invention was completed through further studies.

That is, the present invention relates to the following inventions.
[1] A sophorolipid powder containing lactone type sophorolipid and cyclodextrin, wherein decomposition of the lactone type sophorolipid is suppressed.
[2] The sophorolipid powder according to [1], wherein the cyclodextrin is one or more selected from the group consisting of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin.
[3] The sophorolipid powder according to [1] or [2], wherein the content of cyclodextrin is 50% by mass to 99% by mass.
[4] The sophorolipid powder according to any one of [1] to [3], wherein the content of the lactone type sophorolipid is 1% by mass to 50% by mass.
[5] A method for producing a sophorolipid powder, comprising a step of pulverizing a mixed liquid containing a lactone type sophorolipid and cyclodextrin.
[6] The method for producing a sophorolipid powder according to [5], wherein the powdering step is freeze drying and spray drying.
[7] A tablet obtained by tableting the powder composition containing the powder according to any one of [1] to [6].

  In the sophorolipid powder of the present invention, decomposition of the contained lactone type sophorolipid is suppressed, and it has stability over time. Furthermore, the powder of the present invention is suitable for long-term storage because liquefaction during storage hardly occurs and caking hardly occurs.

Sophorolipid is a glycolipid composed of sophorose or sophorose partially hydroxylated with hydroxyl group and hydroxyl fatty acid. Sophorose is a sugar composed of two molecules of glucose linked by β1 → 2. A hydroxyl fatty acid is a fatty acid having a hydroxyl group. In addition, sophorolipid is roughly classified into an acid form (general formula (1)) in which a carboxyl group of a hydroxy fatty acid is liberated and a lactone type (general formula (2)) in which sophorose in the molecule is bound. The sophorolipid obtained by yeast fermentation is a mixture of the general formula (1) and the general formula (2), which has different fatty acid chain lengths (R ³ ), sophorose 6 ′ (R ² ) and 6 ″ positions ( There are those obtained as an aggregate of 30 or more structural homologues such as those in which R ¹ ) is acetylated or protonated.

In the general formula (1) or (2), R ⁰ is either hydrogen or a methyl group. R ¹ and R ² are each independently hydrogen or an acetyl group. R ³ is a saturated aliphatic hydrocarbon chain or an unsaturated aliphatic hydrocarbon chain having at least one double bond, and may have one or more substituents. The substituent is not particularly limited as long as it does not impair the effects of the present invention, for example, halogen, hydroxyl, lower _{(C 1 to 6)} alkyl group, a halo-lower _{(C 1 to 6)} alkyl group, hydroxy-lower _{(C 1 6)} alkyl group, a halo-lower _{(C 1 to 6)} alkoxy group, and the like. The number of carbon atoms of ^{R 3} is usually 11 to 20, preferably 13 to 17, more preferably 14 to 16.

  The sophorolipid powder of the present invention is characterized by containing the lactone type sophorolipid represented by the general formula (2) and cyclodextrin. The cyclodextrin is not particularly limited as long as the effects of the present invention are not hindered. For example, one or more selected from α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin and derivatives thereof are used. Examples of the derivatives include branched cyclodextrins and cyclodextrins having substituents such as a methyl group, a hydroxypropyl group, and an acetyl group. Among the cyclodextrins, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin and the like are particularly preferable from the viewpoint of storage stability.

  Although the content of cyclodextrin in the sophorolipid powder of the present invention is not particularly limited, it is about 50% by mass to 99% by mass from the viewpoint that decomposition of the lactone type sophorolipid is suppressed and the physiological activity of the sophorolipid can be effectively exhibited. It is preferable that it is about 80 mass%-95 mass%. In addition, the content of the sophorolipid in the sophorolipid powder of the present invention is preferably about 1 part by mass to 120 parts by mass with respect to 100 parts by mass of cyclodextrin from the viewpoint of storage stability such that deliquescence does not occur. It is more preferably 1 part by mass to 80 parts by mass, and further preferably about 20 parts by mass to 80 parts by mass.

  The content of the lactone type sophorolipid in the sophorolipid powder of the present invention is not particularly limited, but is preferably about 1% by mass to 50% by mass, and about 5% by mass to 20% by mass from the processing suitability and powder properties. More preferably. However, the content is measured immediately after the production of the sophorolipid powder (for example, within about 1 hour). In the sophorolipid powder of the present invention, the decomposition of the lactone type sophorolipid is suppressed, and the residual rate of the lactone type sophorolipid is high when a certain time has elapsed from the time of manufacture as compared with the conventional product.

  A method for producing a sophorolipid powder having a step of pulverizing a mixed liquid containing a lactone type sophorolipid and cyclodextrin is also included in the present invention. The liquid mixture is not particularly limited as long as it has a sophorolipid-containing liquid containing lactone type sophorolipid and cyclodextrin, and may contain other components as long as the effects of the present invention are not hindered.

  The sophorolipid-containing liquid is not particularly limited as long as it does not interfere with the effects of the present invention, but may be a natural sophorolipid-containing liquid, or may be a product obtained by separating only a lactone type from a natural sophorolipid, but costs and the like Is preferably a natural sophorolipid-containing liquid. Here, the natural sophorolipid refers to a product obtained by separating components containing sophorolipid from a culture solution obtained by culturing yeast, and is usually a mixture of acid sophorolipid, lactone sophorolipid, and the like.

  Examples of the yeast include Starmerella (Candida) bombicola, C.I. apicola, C.I. petrophilum, Rhodotorula (Candia), bogoriensis, C.I. batistae, C.I. , and so on. By culturing these yeasts by a known method, sophorolipid is produced. The yeast may be a strain distributed from a storage organization or a strain obtained by subculture thereof. Here, the sophorolipid produced by Rhodotorula (Candia) bogoriensis NRCC9862 is 13-[(2'-O-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy] docosanoic acid 6 ', 6' The hydroxyl group at the center of the alkyl group and the sophorose are glycosidically bonded. Although this sophorolipid is different from the general formulas (1) and (2), it is the same in that it is composed of sophorose and hydroxyl fatty acid, and such compounds are also included in the sophorolipid in the present invention.

  As a method for culturing yeast for sophorolipid production, for example, a method of culturing by simultaneously giving a high concentration of sugar and a hydrophobic oily substrate is preferable. Alternatively, not limited to this, a widely known method can be applied as long as the effect of the present invention is not hindered. The known method may be one described in JP-A-2002-045195. Specifically, a technique may be used in which Starmerella (Candida) bombicola is cultured as a production yeast using glucose as a sugar and a carbon source comprising a fatty acid and vegetable oil as a hydrophobic oily substrate.

  The medium composition is not particularly limited, but the fatty acid portion of sophorolipid is known to depend on the fatty acid chain length and the ratio of the hydrophobic substrate to be given, and can be controlled to some extent. As the hydrophobic substrate, for example, oleic acid or a lipid containing a high proportion of oleic acid is suitable. Examples of such lipids include vegetable oils such as palm oil, rice bran oil, rapeseed oil, olive oil and safflower oil, and animal oils such as pork fat and beef tallow. Furthermore, if a mixed substrate of triglyceride and oleic acid is used as the hydrophobic substrate, it is possible to obtain a sophorolipid containing oleic acid in a high ratio with a high yield and yield. From the viewpoint of industrial use, it is required to fermentatively produce sophorolipid with a stable and high yield / yield. In this case, a mixture of hydrophilic sugar and hydrophobic fat as a carbon source is preferable. Glucose is frequently used as the hydrophilic substrate.

  The natural sophorolipid-containing liquid is recovered from the obtained culture liquid by, for example, centrifugation, decantation, and the like, followed by washing with water. The method for recovering the natural sophorolipid-containing solution from the culture solution is not particularly limited as long as the effect of the present invention is not hindered, and a known method can be used. As such a method, for example, a method described in Japanese Patent Application Laid-Open No. 2003-9896 may be used. Specifically, in the purification process, by changing the pH of the sophorolipid that precipitates in the culture end solution, its solubility in water is controlled, so that about 50% water content can be obtained without using any organic solvent. A natural sophorolipid crude product can be obtained.

  The separation method when separating and using only the lactone type sophorolipid from the natural type sophorolipid is not particularly limited, and examples thereof include chromatographic separation and recrystallization methods.

  In the mixed liquid for pulverization, the concentration of sophorolipid (acid type and lactone type) is preferably about 0.5% by mass to 50% by mass from the viewpoint of easy powdering, etc. More preferably, it is about 5 mass%-35 mass%. The concentration of cyclodextrin is preferably about 25% by mass to 99% by mass, and more preferably about 30% by mass to 70% by mass. Further, the viscosity of the mixed solution is preferably about 5 to 50 mPa · S, more preferably about 5 to 20 mPa · S, from the viewpoint of easy powdering. In order to adjust the concentration range or the viscosity range, the mixed solution may be diluted with a solvent or dispersion medium such as water, ethanol, methanol, and glycerin, because adverse effects on the human body and the environment are reduced. It is particularly preferable to dilute with ethanol or purified water. The pH of the mixed solution is preferably adjusted to about pH 5 to 9, more preferably about pH 6 to 8, and most preferably about pH 6.5 to 7.5 from the viewpoint of suppressing decomposition of the lactone type sophorolipid. A pH adjuster is not specifically limited, Well-known pH adjusters, such as sodium hydrogencarbonate, can be used.

  The method for pulverizing the mixed solution is not particularly limited as long as the effect of the present invention is not hindered. For example, known methods such as a freeze-drying method, a recrystallization method, and a spray-drying method are used. From the viewpoint of efficiency, freeze-drying methods, spray-drying methods, and the like are preferably used, and most preferably, spray-drying methods and the like. The time from preparation of the mixed solution to pulverization is preferably within about 2 weeks, and more preferably within about 24 hours, in order to prevent decomposition of the lactone type sophorolipid.

  The average particle size of the sophorolipid powder of the present invention is not particularly limited, but is preferably about 300 μm or less, more preferably about 200 μm or less from the viewpoint of absorbability in the body. Here, the average particle size is defined as the particle size at which the cumulative weight of the particle size distribution measured by the sieving method reaches 50% by weight.

  The sophorolipid powder of the present invention may optionally have a coating layer in order to further increase the stability. Examples of the coating layer include yeast cell wall, hydroxypropyl methylcellulose, dolomite, calcium lactate and calcium citrate, a copolymer of methyl methacrylate and methacrylic acid, a copolymer of ethyl acrylate and methacrylic acid, hydroxypropyl methylcellulose phthalate, cellulose A layer having one or more coating materials selected from acetate phthalate and shellac is preferred, and hydroxypropylmethylcellulose phthalate, cellulose acetate phthalate and shellac are particularly preferred from the viewpoint of enteric properties. A plasticizer may be further added to the coating material. As the plasticizer, for example, triacetin, macrogol 400, triethyl citrate, Tween 80, castor oil, medium chain fatty acid and the like are used. The coating method is not particularly limited, but it is preferable to spray a solution or dispersion using a fine particle coating apparatus from the viewpoint of simplicity. The concentration of the solution or dispersion is not particularly limited as long as the effect of the present invention is not hindered, but is preferably about 0.5% to 30%, and more preferably about 1% to 10%. The solvent or dispersion medium is not particularly limited as long as the effect of the present invention is not hindered, and examples thereof include water, ethanol, glycerin, and the like, but ethanol is particularly preferable from the viewpoint of solubility.

  When orally administering the sophorolipid powder of the present invention, it may be a solid preparation such as powder, granule, pill, tablet and capsule, and may be a liquid such as syrup, but from the viewpoint of storage stability, Powders, tablets, and the like are particularly preferable, and tablets obtained by tableting the powder composition are most preferable from the viewpoints of convenience in oral intake and ease of handling. Tablets obtained by tableting a powder composition containing the sophorolipid powder of the present invention are also included in the present invention. When these preparations are produced, carriers or additives corresponding to the preparation form can be used. In addition to the sophorolipid-containing powder composition of the present invention, the formulation may contain other active ingredients.

  Examples of the carrier or additive include excipients (sodium polyacrylate, calcium polyacrylate, carboxymethylcellulose, lactose, dextrin, corn starch, crystalline cellulose, sucrose, sodium chloride, glucose, urea, starch, calcium carbonate, Kaolin, silicic acid and potassium phosphate, etc.), lubricant (magnesium stearate, calcium stearate, sucrose fatty acid ester, glycerin fatty acid ester, purified talc, polyethylene glycol, etc.), disintegrant (carboxymethylcellulose calcium, anhydrous hydrogen phosphate) Calcium, sodium carboxymethylcellulose, low-substituted hydroxypropylcellulose, dried starch, sodium alginate, agar powder, sodium bicarbonate and calcium carbonate) Compound (hydroxypropyl cellulose, gum arabic solution, water, ethanol, propanol, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cellulose, methyl cellulose, polyvinyl pyrrolidone, etc.), solubilizer (gum arabic and polysorbate 80, etc.) , Absorption enhancers (such as sodium lauryl sulfate), buffers (phosphate buffer, acetate buffer, borate buffer, carbonate buffer, citrate buffer, Tris buffer, etc.), preservatives (methyl parahydroxybenzoate) , Ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, chlorobutanol, benzyl alcohol, benzalkonium chloride, sodium dehydroacetate and sodium edetate), thickener (propylene glycol, glycerin, hydride) Xylethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, polyethylene glycol, etc.), stabilizers (sodium bisulfite, sodium thiosulfate, sodium edetate, sodium citrate, ascorbic acid, dibutylhydroxytoluene, etc.), pH adjusters (hydrochloric acid, Sodium hydroxide, phosphoric acid, acetic acid, etc.).

(Production Example 1)
As a culture medium, 10 g of glucose per liter (manufactured by Nippon Shokuhin Kako Co., Ltd., product name: eclipse-containing crystal glucose), 5 g of peptone (manufactured by Oriental Yeast Co., Ltd.), 3 g of yeast extract (manufactured by Asahi Food and Healthcare Co., Ltd., product name: Candida bombicola ATCC22214 was shaken and cultured at 30 ° C. for 2 days using a liquid medium containing Mist Powder N) and 3 g of malt extract (manufactured by Nippon Biocon Co., Ltd., product name: Maltax 10) to prepare a preculture solution. As a composition of the main culture medium, 100 g of glucose, 100 g of palm oil (manufactured by Yamagata Industrial Co., Ltd.), 3 g of ammonium chloride, 1 g of potassium hydrogen phosphate, 5 g of magnesium sulfate, 5 g of yeast extract, and 1 g of urea were used per 1 L. A 5 L fermenter was charged with 3 L of main culture medium, and the pH before sterilization was adjusted to 4-5. Inoculated 0.4% with respect to the charged amount, and fermented under conditions of 30 ° C. and 6 days aeration of 1 vvm. Fermentation was stopped 7 days after the start of the culture, and the culture solution taken out from the fermenter was left to stand, so that the settled sophorolipid was collected, and a natural sophorolipid-containing solution (approximately 50% water-containing product, production example product 1) Got.

Example 1
To 50 g of the natural sophorolipid-containing liquid obtained in Production Example 1, 25 g of water was added and stirred. Sodium bicarbonate was added to adjust the pH to 7.0, and water was added to 100 g to obtain a neutral natural sophorolipid-containing diluted solution. Neutral natural type sophorolipid-containing diluent 60g was added to 50g of β-cyclodextrin (CAVAMAX® W7 Food cyclochem). After mixing well, lyophilization was performed using a freeze dryer (VD-800R manufactured by Taitec Co., Ltd.). The obtained dried product was pulverized in a mortar, and sophorolipid powder was obtained through a mesh having an opening of 710 μm.
(Example 2)
To 50 g of the natural sophorolipid-containing liquid obtained in Production Example 1, 25 g of water was added and stirred. Sodium bicarbonate was added to adjust the pH to 7.0, and water was added to 100 g to obtain a neutral natural sophorolipid-containing diluted solution. To 100 g of β-cyclodextrin (CAVAMAX® W7 Food cyclochem) was added 120 g of a neutral natural sophorolipid-containing diluent, and 220 g of water was further added to dilute. After stirring well, spray drying was performed using a spray dryer (R-3K manufactured by Sakamoto Giken) to obtain a sophorolipid powder.

(Example 3)
To 50 g of the natural sophorolipid-containing liquid obtained in Production Example 1, 25 g of water was added and stirred. Sodium bicarbonate was added to adjust the pH to 7.0, and water was added to 100 g to obtain a neutral natural sophorolipid-containing diluted solution. Neutral natural type sophorolipid-containing diluent 60 g was added to 50 g of α-cyclodextrin (α-100 saltwater refined sugar). After mixing well, lyophilization was performed. The obtained dried product was pulverized in a mortar, and sophorolipid powder was obtained through a mesh having an opening of 710 μm.

Example 4
To 50 g of the natural sophorolipid-containing liquid obtained in Production Example 1, 25 g of water was added and stirred. Sodium bicarbonate was added to adjust the pH to 7.0, and water was added to 100 g to obtain a neutral natural sophorolipid-containing diluted solution. 60 g of a neutral natural sophorolipid-containing diluent was added to 50 g of γ-cyclodextrin (γ-100 saltwater port essential sugar). After mixing well, lyophilization was performed. The obtained dried product was pulverized in a mortar, and sophorolipid powder was obtained through a mesh having an opening of 710 μm.

(Example 5)
30 g of the natural sophorolipid-containing liquid obtained in Production Example 1 was added to 50 g of β-cyclodextrin. After mixing well, lyophilization was performed. The obtained dried product was pulverized in a mortar, and sophorolipid powder was obtained through a mesh having an opening of 710 μm.

(Example 6)
When 65 g of natural sophorolipid powder obtained in Example 1, 33 g of crystalline cellulose (Asahi Kasei Theuras FD101) and 2 g of calcium stearate (Nihon Oruralite CA-65) were mixed, tableting was performed automatically. A tablet without any was obtained. For tableting, a rotary tableting machine (Kikusui Seisakusho VIRGO 0512SS2AY-000-B00) was used.

(Example 7)
65 g of natural sophorolipid powder, 18 g of crystalline cellulose (Asahi Kasei Theuras FD101), 2 g of calcium stearate (Nihon Oruralite CA-65) and 15 g of lactoferrin (MLF-1 manufactured by Morinaga Milk Industry) are mixed. When tableting was performed by driving, tablets without defects were obtained.

(Comparative Example 1)
To 50 g of the natural sophorolipid-containing liquid obtained in Production Example 1, 25 g of water was added and stirred. Sodium bicarbonate was added to adjust the pH to 7.0, and water was added to 100 g to obtain a neutral natural sophorolipid-containing diluted solution. The neutral natural sophorolipid-containing diluted solution 60 g and porous starch 50 g were uniformly stirred and then freeze-dried. The dried product was pulverized in a mortar, and sophorolipid powder was obtained through a mesh having an opening of 710 μm.

(Comparative Example 2)
After 30 g of the natural sophorolipid-containing liquid obtained in Production Example 1 and 50 g of porous starch were uniformly stirred, lyophilization was performed. The dried product was pulverized in a mortar, and sophorolipid powder was obtained through a mesh having an opening of 710 μm.

(Comparative Example 3)
20 g of natural sophorolipid was lyophilized. The resulting foamy dried product was crushed with a mortar to obtain a brown sophorolipid powder.

(Comparative Example 4)
20 g of the neutral natural sophorolipid-containing diluent obtained in Example 1 was lyophilized. The resulting foamy dried product was crushed with a mortar to obtain a brown sophorolipid powder.

(Comparative Example 5)
Using a fluidized bed granulator, natural sophorolipid (diluted to 5% natural sophorolipid with ethanol) was sprayed on 200 g of porous starch (Ronfood OWP Nissho Chemical) to attempt granulation. The flowability of the porous starch itself was good, but a spherical lump was formed immediately after spraying, and the flowability was poor and granulation was difficult.

(Comparative Example 6)
Using a fine particle coating apparatus, 200 g of porous starch (Lonfood OWP Nissho Chemical) was sprayed with natural sophorolipid (diluted to 5% natural sophorolipid with ethanol) to attempt coating. The powder adhered to the fine particle coating unit and coating was difficult.

(Comparative Example 7)
Using a fluidized bed granulator, natural sophorolipid (diluted to 5% natural sophorolipid with ethanol) was sprayed on 200 g of β-cyclodextrin (CAVAMAX® W7 Food cyclochem). The flowability of the porous starch itself was good, but a spherical lump was formed immediately after spraying, and the flowability was poor and granulation was difficult.

(Comparative Example 8)
Using a fine particle coating apparatus, 200 g of β-cyclodextrin (CAVAMAX® W7 Food cyclochem) was sprayed with natural sophorolipid (diluted to 5% natural sophorolipid with ethanol). The powder adhered to the fine particle coating unit and coating was difficult.

(Test Example 1)
The natural sophorolipid powders obtained in Examples 1 to 4 and Comparative Examples 1 to 4 are allowed to stand for 24 hours at 50 ° C. and a humidity of 45% RH. Judged. Judgment criteria were ◯ (no deliquescence) when passing through a 710 μm mesh, and x (with deliquescence) when lumps remained on the mesh. When cyclodextrin was used, it was judged that fluidity was maintained and deliquescence did not occur. The results are shown in the table below.

(Test Example 2)
A comparative test was conducted on the stability of the lactone-type sophorolipid content using samples obtained by storing the powders of Example 1, Comparative Example 1 and Comparative Example 4 at 50 ° C. for 1 month. Using an anion exchange column (Nagel Nuc-eosil 100-5SB packed, φ4.6 × 250 mm) with 0.2 w / v% NaClO ₄ methanol solution as the mobile phase, the content of natural sophorolipid was compared using HPLC. . Detection was performed at 205 nm. The following table shows the ratio of the content of the lactone type sophorolipid under other conditions when the content of the lactone type sophorolipid in the powder of Example 1 stored for 1 month is 1.

  Lactone-type sophorolipid, which is the main component of natural sophorolipid powdered with cyclodextrin, is less decomposed at 50 ° C than when powdered with porous starch or natural sophorolipid alone is freeze-dried. it is conceivable that.

Claims (7)

  A sophorolipid powder containing lactone type sophorolipid and cyclodextrin, wherein decomposition of the lactone type sophorolipid is suppressed.   The sophorolipid powder according to claim 1, wherein the cyclodextrin is at least one selected from the group consisting of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin.   The sophorolipid powder according to claim 1 or 2, wherein the content of cyclodextrin is 50 mass% to 99 mass%.   The sophorolipid powder according to any one of claims 1 to 3, wherein the content of the lactone type sophorolipid is 1% by mass to 50% by mass.   A method for producing a sophorolipid powder, comprising a step of pulverizing a mixed liquid containing a lactone type sophorolipid and a cyclodextrin.   The method for producing a sophorolipid powder according to claim 5, wherein the powdering step is freeze drying and spray drying.   A tablet obtained by tableting the powder composition containing the powder according to any one of claims 1 to 6.