JP3439809B2 - Artificial cornea - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an artificial cornea used to replace a cornea having a reduced visual function due to a corneal disease and to restore the visual function. 2. Description of the Related Art Conventionally, compared with an artificial cornea made of a synthetic resin material such as PMMA or silicon, the affinity with surrounding corneal tissue is better, and no gap is formed between the artificial cornea and the natural cornea. An artificial cornea having a supporting member made of a biocompatible metal material such as a titanium-based metal has been proposed. As an example, an artificial cornea (KlineOczna 8) proposed by Aradna Kurkova et al.
4: 379-380 [1982]), the optical member is formed of a synthetic resin material such as PMMA or silicon, and the support member is formed of a biocompatible metal material such as pure titanium, titanium alloy or tantalum. Artificial cornea was used. In such an artificial cornea, a cylindrical optical member A as shown in FIG. 5, a ring C having a central hole C1 for fitting the optical member A, and a ring C integrally formed on the left and right sides of the ring C are formed. However, an artificial cornea 20 composed of a supporting member B composed of flaps D and D, and a cylindrical optical member A in a central hole E1 of a shield-shaped supporting member E as shown in FIG.
There was such a thing as an artificial cornea 30 fitted with. These artificial corneas 20, 30 have good compatibility with the corneal tissue because the support members B and E are made of the above-mentioned metal material, and furthermore have excellent workability, so that the thickness of the support members can be made extremely small, and surgical invasion can be performed. There was an effect that there was almost no. [0004] However, since all of the above-mentioned biocompatible metallic materials have a silver-white metallic luster, there is a large difference from the color tone of the iris. There was a noticeable discomfort. [0005] In order to solve the above-mentioned problems, the present invention provides a support member for an artificial cornea which is made of pure titanium or a titanium alloy and has a thickness of 45 mm on its surface.
By applying a coating layer mainly composed of titanium oxide of 0 to 1400 °, good bonding with the natural cornea is realized, and the color tone of the support member is changed to the color tone of the natural iris seen in various races. In addition, it is intended to provide an artificial cornea with excellent aesthetics. An embodiment of the present invention will be described below in detail with reference to the drawings. FIG. 1 is an exploded perspective view of the artificial cornea 1 and FIG.
The main body 2c is a supporting member for supporting the optical member 3 fitted in the central hole 2a inserted between the front layer F and the rear layer N of the cornea K, as shown in FIG. The surface is coated with a titanium oxide-based coating layer having a thickness of 450 to 1400 ° to give a natural iris or a desired color tone, and the shape is cut as a whole as shown in FIG. It has a head dome shape, and has a plurality of through holes 2b in the main body 2c. The optical member 3 is made of a single-crystal alumina (sapphire) or a light-transmitting material such as PMMA or silicon which is not harmful to living organisms. As shown in FIGS. As shown in FIG. 3, the center hole 2 of the support member 2 has a suitable curvature.
a to form a stepped portion 3d having a tapered rearward opening along the circumference of the side surface 3c, or a groove 3 for fitting and inserting a part of the support member 2 as shown in FIG.
e was formed. In the artificial cornea 1 thus constructed, the support member 2 is made of biocompatible titanium or a titanium alloy, so that it is well-adapted to corneal tissue and has excellent bonding with the natural cornea. Between the cornea K and the shape of the cornea K.
Furthermore, by coating a coating layer mainly composed of titanium oxide with a thickness of 450 to 1400 ° on the surface, and appropriately controlling the thickness, the iris which is seen in various races such as gold, brown and blue can be obtained. It can be adjusted to the color tone and is aesthetically excellent. Hereinafter, a method of manufacturing the support member 2 will be described. First, a plurality of support members 2 on a disk having a central hole 2a and a through hole 2b formed therein are formed at a time by a known photo-etching method on a sheet-like thin plate made of pure titanium or a titanium alloy. The support member 2 is further press-molded to form a truncated dome-shaped support member 2 having a curvature R of the cornea K. Subsequently, the support member 2 thus molded was subjected to ultrasonic cleaning with an organic solvent, immersion in a mixed solution containing hydrofluoric acid, water washing, and ethanol immersion, and then sufficiently dried. The operation using an acid mixed solution containing hydrofluoric acid was performed in a draft chamber, and these solutions used were stored in a draft chamber in an adjusted state. Following this pretreatment, anodization was carried out in a beaker containing a 1% aqueous solution of HPO3 stored and cooled in a refrigerator, under the conditions of a voltage of 13.00-37.0 V and a liquid temperature similar to room temperature, according to a conventional method. And a thickness of 45 is applied to the surface of the support member 2.
A coating layer composed mainly of titanium oxide of 0 to 1400 ° was applied. Experimental Example According to the method described above, the support member 2 was formed and molded, and subjected to Auger electron optical analysis using the following apparatus and measuring conditions: [Apparatus] JAMP7100E JEOL Ltd. Acceleration voltage 5 KV Etching Rate 1.87Å / sec. Etching cycle converted by calibration value using standard SiO2 film 5sec / cycle Analysis area φ100μm Intermediate of sputtering time at two points interpolated by 16% each from the median of the maximum and minimum fluctuation bands of the peak in this result The time was regarded as the etching time required for removing the film containing oxygen atoms, and this was multiplied by the etching rate to calculate the film thickness. Table 1 shows the results. [Table 1] As is apparent from Table 1, when the thickness of the coat layer is 450 to 1400 °, the color tone of the support member 2 is changed to any color tone of the iris whose appearance is seen in various races such as gold, brown, and blue. It conforms to In contrast,
When the thickness is less than 450 °, for example, when the thickness is 360 °, the color tone is gray yellow, and the difference from the color tone of the iris is large.
When the color was larger than 1400 °, the color tone was gray-blue, and the difference from the color tone of the iris was also large, which was inappropriate. According to the artificial cornea of the present invention, the supporting member is composed of pure titanium or a titanium alloy, and a coating layer mainly composed of titanium oxide having a thickness of 450 to 1400.degree. Therefore, while having better bonding properties with the natural cornea, a color tone of the support member can be obtained that conforms to all required color tones of the iris found in various races, and is also excellent in aesthetics. .

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an exploded perspective view showing an artificial cornea according to an embodiment of the present invention. FIG. 2 is a cross-sectional view showing a state where the artificial cornea of FIG. 1 is implanted in the cornea. FIG. 3 is a central sectional view of the artificial cornea of FIG. 1; FIG. 4 is a sectional view of an optical member constituting the artificial cornea of FIG. 1; FIG. 5 is a perspective view of a conventional artificial cornea. FIG. 6 is a perspective view of a conventional artificial cornea. [Explanation of symbols] K · · · cornea, F · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·
Central hole, 2b ... Through hole, 2c

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-5-329200 (JP, A) JP-A-2-134612 (JP, A) JP-A-58-46319 (JP, A) JP-A-61- 166501 (JP, A) JP-A-3-17280 (JP, A) Japanese Patent Publication No. 49-24429 (JP, B1) A) (58) Field surveyed (Int. Cl. ⁷ , DB name) A61L 27/00 A61F 2/14 WPI (DIALOG)

Claims (1)

(57) [Claims 1] An optical member made of a translucent material having no harm to the living body to be used as a substitute cornea at the time of corneal transplantation or to replace a cornea, and is made of pure titanium or titanium. An artificial cornea which is fitted into a central hole formed in a support member made of an alloy, and has a thickness of 450 to
An artificial cornea having a coating layer of titanium oxide of 1400 ° as a main component applied thereon, and a color tone of the support member is adjusted to a color tone of a natural iris found in various races.