JP2599415B2 - Chitosan gel composition and method for producing the same - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a chitosan gel composition, and more particularly to a chitosan gel composition comprising chitosan and wood vinegar and a method for producing the same.

(Prior Art) Chitin (β-1,4-poly-N-acetylglucosamine) is present in the cell walls of crustaceans such as crabs and shrimps, insects, mushrooms and microorganisms, and has an estimated 100 billion tons per year.
Is a natural macromolecule that is also produced biologically and exists in nature next to cellulose.

Chitosan is a deacetylated product of chitin obtained by treating this chitin with a concentrated alkali, and glucosamine (2-amino-D-glucose).
Which is a basic polysaccharide having the following general formula:

In recent years, as research on the effective use of unused resources has become active, studies have been made on chitin and chitosan, and many reports have been made. For example, the effect of chitosan on the growth of phytopathogenic fungi [Stoessel et al., Stoessel et al., “Phytopathologische Zeitsch
rift "), Vol. 111, pp. 82-89 (1984)], that chitosan is effective for the growth and growth of bacteria (Japanese Patent Application Laid-Open No. Sho 62-62).
No. 83877).

Some reports have also been made on the gelation of chitosan. Among them, the use of chitosan gel is described in Hirano, "Supplied Food Chemicals", 1, 1 (1987), as a functional low-food material. It is reported to be useful as an immobilized carrier for nutrients, enzymes, effective microorganisms and the like, or as a food-forming material.

Further, regarding the method for producing chitosan gel, a method for preparing chitin gel [Hirano et al., “Biopolymer (Biopolyme
r), Vol. 15, p. 1685 (1976)], and a method for preparing N-propionyl, N-hexanoyl, N-octanoyl, N-decanoyl, N-lauroyl, N-benzoyl chitosan gel according to the method. [Hirano et al., "Carbohyd. Res.", 47,315 (1976); Hirano et al., "Agric. Biol. Chem.", 39, 1335 (1975); Hirano et al.
"Agric. Biol. Chem.", 41, 1547 (1977); Hirano et al., "8th.
International Symposium on Carbohydrate Chemistr
y ", Kyoto, August 16-20 (1976) Abst. p. 766].

Also, a method of gelling by dissolving chitosan in acetic acid, adding formalin and allowing to stand (Hirano et al., “Agric.
Biol. Chem. ", 41, 1547 (1977)] or a method for producing a glutaraldehyde gel by a similar method. (Problems to be Solved by the Invention) As described above, chitosan is a natural product. Since it is a basic polysaccharide obtained by deacetylating chitin that is present in a large amount in water, if the gelled chitosan gel can be used as a food, cosmetic, or drug material, it is advantageous in terms of production costs and the like.

However, according to the chitosan gel preparation method of the conventional method described above, in the manufacturing process, food, cosmetics, or undesired as a drug material, for example, because formalin is used, the above-mentioned food, cosmetics, or drug material as There was a problem in terms of security when using it.

Therefore, it is convenient to be able to gel chitosan, which is approved as a food additive, approved as cosmetics, or approved as a drug material.

(Means for Solving the Problems) The present invention has been made in view of the above-mentioned problems, and the present inventors have made chitosan a wood vinegar solution, particularly a food additive, a cosmetic, or a chemical material. It has been found that chitosan can be easily gelled by dissolving it in a wood vinegar solution that has been approved as the present invention, thereby completing the present invention.

That is, the chitosan gel composition of the present invention is obtained by dissolving chitosan in a wood vinegar solution, leaving it at a predetermined temperature for a predetermined time, and gelling the dissolved substance,
It is a chitosan gel composition comprising chitosan and wood vinegar.

The chitosan used in the present invention preferably has a degree of deacetylation of 60% or more, and when the degree of deacetylation is less than 60% and is dissolved in wood vinegar, This is because it is not preferable because insolubles are generated.

Any of the wood vinegar liquids used can be used, but preferably, those approved as food additives, cosmetics, or drug materials (preferably, about 3 to about 3 to about 3% when organic acids are quantified as acetic acid). Contains 10%, pH is about 1.0 ~
3.0), and is advantageously used as an aqueous solution containing 20 to 100% wood vinegar (see Reference Example below).

The chitosan prepared as described above is added to the wood vinegar solution, and the mixture is stirred and dissolved at room temperature, preferably for 2 hours or longer, and then left at room temperature for a predetermined time to obtain a brown chitosan gel composition. .

Reference Example (Ratio of chitosan and wood vinegar effect on chitosan gelation) 0.5 g, 1 g, 2 g, 3 g, 4 g, 5 g, and 6 g of chitosan (degree of deacetylation 90%) were each added to wood vinegar solution ("Flavour Smoke SF 2 "; manufactured by Tokai Chemical Co., Ltd.) 99.5 g, 99 g, 98 g, 97 g, 96 g, 95 g,
In addition to 94 g (stock solution to 10-fold dilution), the mixture was stirred and dissolved at room temperature for about 2 hours, and then allowed to stand at room temperature for 22 hours to conduct a gelation experiment of chitosan. The results are shown in the table below. However, gelation was judged visually.

Example 1 3 g of chitosan (manufactured by Yaegaki Fermentation Giken Co., Ltd .; degree of deacetylation: 90%) was added to 97 g of a stock solution of wood vinegar ("Flavored Smoke SF2", manufactured by Tokai Kasei Co., Ltd.) in a 200 ml beaker. Thereafter, the mixture was stirred and dissolved at room temperature, and then allowed to stand at room temperature for 5 hours to obtain 98.2 g of a brown chitosan gel.

Example 2 A 2-fold dilution of wood vinegar ("Flavour Smoke SF2", manufactured by Tokai Kasei Co., Ltd.) in which 2 g of chitosan (manufactured by Yaegaki Fermentation Giken Co., Ltd .; deacetylation degree: 70%) was placed in a 200 ml beaker.
After addition to 98 g, the mixture was stirred and dissolved at room temperature, and then allowed to stand at room temperature for 20 hours to obtain 98.4 g of brown chitosan gel.

(Effect) The chitosan gel composition according to the present invention comprises chitosan and wood vinegar, especially wood vinegar which has been approved as a food additive, cosmetic or chemical material, and chitosan is a naturally occurring substance present in a large amount. Since it is obtained from a certain chitin, it is extremely excellent in terms of safety, production cost, and the like when considered as a food, cosmetic, or drug material.

Further, the chitosan gel composition of the present invention, the food,
It is an excellent composition with a wide range of applications, such as being considered not only as a cosmetic or pharmaceutical material, but also as a culture medium for microorganisms, for example.

In addition, according to the method for producing a chitosan gel composition of the present invention, chitosan obtained from chitin, which is a naturally occurring substance, is a wood vinegar solution, particularly a food additive, cosmetics, or wood vinegar that has been approved as a drug material. Since a chitosan gel composition composed of chitosan and wood acetic acid can be obtained simply by dissolving in a liquid and allowing it to stand, this is an excellent production method that is simple, has low production cost, and can be used for industrial production.

Claims (2)

(57) [Claims] 1. A chitosan gel composition comprising chitosan and wood vinegar. 2. A chitosan gel composition comprising chitosan and wood vinegar is obtained by adding chitosan to a wood vinegar solution and dissolving it, and then leaving the mixture to stand for a predetermined time at a predetermined temperature to gel the dissolved substance. A method for producing a chitosan gel composition, comprising: