JP2012024111A - Guide wire for insertion in living body vessel part - Google Patents

Abstract

PROBLEM TO BE SOLVED: To capture an occlusive substance such as a thrombus in a thinner living body vessel part, in a guide wire used for medical treatment of the thrombus or the like.SOLUTION: This guide wire 20 includes: a root part connected with a rotating mechanism; a body part 24 which is inserted into an axial-direction through-hole of a catheter 10, and is movable in the axial direction and rotatable around the axis; and a tip part 28 wherein a portion of a predetermined axial-direction length is slenderly divided into a plurality of portions by slits or the like along the axial direction in an end part of the body part 24. The guide wire 20 is made of a shape-memory alloy material imparted with hyperelasticity. When the tip part 28 projects from the tip of the catheter 10, the plurality of slender division portions respectively expand in a direction perpendicular to the axial direction, and forms an expansion tip part 30 forming a predetermined envelope outline shape.

Description

  The present invention relates to a guide tube for inserting a living body tube portion, and more particularly, to a guide wire for inserting a living body tube portion that is inserted into an axial through hole of a catheter and is movable and rotatable in the axial direction.

  When a thrombus, plaque, or the like is present in a blood vessel of a living body, blood vessel stenosis occurs. Therefore, in order to dilate the blood vessel, placement of a balloon or a stent is performed via a catheter.

  Further, Patent Document 1 discloses a filter element that is mounted on a filter carrier for feeding through a patient's vasculature and has an inlet end and an outlet end and is foldable as an embolism prevention device. The filter element has one or more inlet openings whose inlet end is sized to allow blood and embolic material to enter the filter body, the outlet end of which allows blood to pass, but preferably within the filter body. It has a plurality of outlet openings that are sized to trap any material. And it is stated that a drawer device, which is a catheter or pod, engages the filament, slides on the filter to fold the filter element, and the filter element is rotatably mounted on the filter carrier.

Special table 2001-52239 gazette

  According to the conventionally known balloon method and stent method, a blood vessel that becomes narrowed by a thrombus or the like can be expanded. For example, in a thin blood vessel of 1 mm or less such as a cerebral blood vessel, these can be treated using a catheter. It is almost impossible to insert. Further, according to the method of Patent Document 1, it is possible to capture an embolic substance in a blood vessel and, depending on the case, to draw it out and discharge it, but in order to add a complicated filter structure, it can be applied to a thin blood vessel. There are limitations.

  An object of the present invention is to provide a guide wire for inserting a living body tube that can be applied to a thinner living body tube in the treatment of a thrombus and the like. Another object of the present invention is to provide a guide tube for inserting a living body tube portion that can capture an occluding substance such as a thrombus in a thinner living body tube portion.

  A guide wire for inserting a biological tube according to the present invention includes a root portion to which a rotation mechanism is connected, a main body portion that is inserted into an axial through hole of a catheter, is movable in the axial direction, and can be rotated around an axis. A portion having a predetermined axial length at an end portion of the main body portion, and a distal end portion that is divided into a plurality of elongated portions along the axial direction. When the distal end portion protrudes from the distal end of the catheter, the plurality of elongated divisions Each of the portions is expanded in a direction perpendicular to the axial direction to form a predetermined envelope contour shape.

  Moreover, it is preferable that the guide tube for inserting a living body tube according to the present invention is made of a shape memory alloy material imparted with superelasticity.

  In the living body tube insertion guide wire according to the present invention, the distal end portion is preferably divided into a plurality of elongated portions at the end portion of the main body portion by a plurality of slits having end portions on both sides.

  Moreover, in the living body tube insertion guide wire according to the present invention, the distal end portion is divided into a plurality of elongated portions at the end portion of the main body portion by a plurality of cuts having end portions on the root side and opened on the distal end side. It is preferable.

  In the living body tube insertion guide wire according to the present invention, it is preferable that the distal end portion is provided with uneven portions at a plurality of cut portions.

  In the guide tube for inserting a living body tube according to the present invention, it is preferable that the distal end portion has coupling means for integrally coupling the divided portions on the distal end side of the plurality of divided portions divided by the cuts.

  With the above configuration, the guide tube for inserting a living body tube portion is divided into a plurality of elongated portions along the axial direction at a predetermined axial length portion at the end of the body portion inserted into the axial through hole of the catheter. The And when a front-end | tip part protrudes from the front-end | tip of a catheter, several elongate division | segmentation parts each expand in the direction perpendicular | vertical to an axial direction, and form a predetermined envelope outline shape. For example, if the tip is plastically deformed into a predetermined envelope contour shape so that it does not exceed the elastic limit even if it is inserted into the catheter and deformed, it can be used as a free shape when protruding from the tip of the catheter. It can return to the envelope outline shape. Accordingly, the thickness passing through the axial through hole of the catheter is the same for the main body portion and the distal end portion. The outer diameter of the catheter depends on the outer shape of the catheter that passes through the catheter. However, if only one guide wire is passed, the outer diameter of the catheter itself can be 1 mm or less.

  Further, the guide tube for inserting a living body tube portion is made of a shape memory alloy material to which superelasticity is imparted. Since shape memory alloys with superelasticity still remain at the elastic limit even when subjected to large deformations, they do not exceed the elastic limit even if they are inserted into the catheter and greatly deformed. The contour shape can be formed by fairly large plastic deformation. Therefore, since the envelope contour shape for entwining the thrombus can be increased, the ability to remove the thrombus can be enhanced.

  In this way, when only one guide wire is passed through the catheter without using a balloon, a stent, a filter element, etc., and the tip portion protrudes from the tip of the catheter, a plurality of elongated divided portions are perpendicular to the axial direction. Since the envelope contour shape is formed in a predetermined direction to form a predetermined envelope contour shape, it can be applied to a thinner living body tube portion as compared with the prior art. Further, since the envelope contour shape of the tip portion can be rotated around the axis, an occlusive substance such as a thrombus can be entangled and captured in this envelope contour shape.

  Further, in the guide tube for inserting a living body tube portion, the distal end portion is divided into a plurality of elongated portions at the end portion of the main body portion by a plurality of slits having end portions on both sides. That is, a living body tube insertion guide wire can be obtained only by performing a process of making a slit in the distal end portion of the guide wire.

  In the guide tube for inserting a living body tube portion, the distal end portion is divided into a plurality of elongated portions at the end portion of the main body portion by a plurality of cuts having end portions on the root side and open on the distal end side. A guide wire for inserting a living body tube can be obtained more easily than the process of inserting a slit.

  Further, in the guide tube for inserting a living body tube portion, the tip portion is provided with uneven portions at a plurality of cut portions. This makes it easier to entangle and capture occlusive substances such as thrombus.

  Moreover, in the guide tube for inserting a living body tube portion, the distal end portion has coupling means for integrally coupling the divided portions on the distal end side of the plurality of divided portions divided by the cuts. As a result, a guide wire for inserting a living body tube having the same external function as a slit having end portions at both ends can be obtained.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. The materials, shapes, dimensions, the number of divisions at the tip, and the like described below are examples, and these contents can be changed as appropriate according to the purpose of use.

  In the following, a nickel-titanium alloy will be described as a shape memory material to which a superelastic metal is applied. However, this is merely an example, and even if it is other than this, it is 5 to 10 times that of a normal metal by heat treatment. Any metal can be used as long as it has the elastic range and has superelastic characteristics that can return to its original shape even when a large deformation is applied. For example, an alloy to which copper, cobalt, chromium, iron or the like is added as necessary based on a nickel-titanium alloy may be used, and further, a nickel-aluminum alloy or the like may be used.

  Below, the same code | symbol is attached | subjected to the same element in all the drawings, and the overlapping description is abbreviate | omitted. In the description in the text, the symbols described before are used as necessary.

  FIG. 1 is a view for explaining the configuration and action of a guide tube 20 for inserting a living body tube. Here, although not a component of the guide tube 20 for inserting a living body tube portion, a catheter 10 and a blood vessel 4 as a living tube portion into which these are inserted are shown. The blood vessel 4 is shown to have a blocking substance 8 attached to the tube wall of the tube portion 6 through which blood passes, and that portion being narrowed. A representative example of the occlusive substance is an athenome segment formed in the carotid artery. Since the blood vessel 4 is constricted by these occluding substances and the blood flow is stopped in some cases is called a thrombus, the occluding substance is also a thrombotic substance.

  When a thrombotic substance adheres to the blood vessel 4 and becomes narrowed, the flow of blood flow is inhibited, so that the blood vessel 4 is expanded. For this purpose, the catheter 10 is passed from the outside into the blood vessel 4 and inserted to the affected area, where the balloon is expanded using the inner catheter or guide wire, or the stent is expanded. When the balloon or stent cannot be carried to the affected area by the catheter 10 in a thin blood vessel, the thrombus substance is dissolved with a drug or the like.

  A biological tube insertion guide wire 20 shown in FIG. 1 is a thin wire that is inserted into an axial through hole of the catheter 10 and is movable in the axial direction and rotatable around the axis. Hereinafter, the guide tube 20 for inserting a living body tube portion is simply referred to as a guide wire 20. In this way, the entire instrument that encloses an elongate wire or the like in an elongate tube and passes the inside of the blood vessel 4 as a unit is sometimes called a catheter. The elongate wires stored in the through holes are distinguished from each other as inner catheters. Therefore, the catheter 10 of FIG. 1 can also be called an outer catheter and the guide wire 20 can be called an inner catheter.

  Here, the catheter 10 is a tube having a function of passing the guide wire 20. As such a catheter 10, a general one selected for medical use and having a thin outer diameter can be used. The outer diameter is preferably about 2 mm or less, preferably about 1 mm or less, and about 0.80 mm which is a standard inch type. It is desirable that the inner diameter has such a dimension that the guide wire 20 can be smoothly introduced while having a sufficient tube thickness and a gap that can be moved in the axial direction can be secured. For example, when the outer diameter is 0.80 mm, the inner diameter is preferably 0.46 mm. As the catheter 10, a nylon tube in which a stainless mesh is embedded can be used.

  The guide wire 20 includes a root portion 22, a main body portion 24, and an expanded distal end portion 30 shown as an expanded state in FIG. 1. The expanded distal end portion 30 is in an expanded state when protruding from the distal end of the catheter 10, but is originally a material having the same thickness as the main body portion 24. In other words, the guide wire 20 is an elongated bar that is originally composed of a single material having the same thickness.

  As the guide wire 20, a metal rod made of a shape memory alloy material suitable for medical use can be used. The outer diameter is preferably about 1 mm or less, preferably 0.5 mm or less, for example, about 0.43 mm to 0.25 mm, which is a standard numerical value for an inch system.

  As a shape memory alloy material, it has superelasticity by performing heat treatment in a deformed state, and has an elastic range 5 to 10 times that of ordinary metals when returned to room temperature. However, a material that can return to its original shape when the deformation force is removed is used. As such a metal material, a nickel-titanium alloy can be used. The nickel-titanium alloy can have a shape recovery temperature of room temperature or lower, and can be, for example, about 500 ° C. for about 30 minutes as a heat treatment for imparting superelasticity.

  The rotation mechanism 12 is connected to the root portion 22 of the guide wire 20. The rotation mechanism 12 is a mechanism that rotates the guide wire 20 around an axis, and can be configured with a small motor, a drive circuit, and the like. In some cases, a handle mechanism can be provided so that an operator who performs an operation of inserting the catheter 10 and the guide wire 20 into the living body can easily rotate manually. The total length of the guide wire 20 is set to be sufficiently longer than the total length of the catheter 10 so that the root portion 22 of the guide wire 20 does not enter the inside of the catheter 10.

  FIG. 2 is a diagram for explaining a state in which the distal end portion of the guide wire 20 is housed in the catheter 10 and a change state when protruding from the distal end of the catheter 10. As the dimensions of the catheter 10 and the guide wire 20, for example, when the inner diameter of the catheter 10 is 0.46 mm and the outer diameter of the guide wire 20 is 0.43 mm, the catheter 10 is located at the body portion 24 of the guide wire 20. The gap between the inner diameter of the guide wire 20 and the outer diameter of the guide wire 20 is 0.03 mm. Thereby, the guide wire 20 can move in the axial direction relative to the inside of the catheter 10, and can be rotated around the axis by the rotation mechanism 12.

  2 is a view showing a state in which the distal end portion of the guide wire 20 is accommodated in the catheter 10, and here, the distal end portion in which the outer diameter is regulated by the inner wall of the catheter 10 and folded. 28 is shown. The folded distal end portion 28 is the shape of the expanded distal end portion 30 described with reference to FIG. 1 when superelasticity is applied, but the shape of the superelasticity is applied by the inner wall of the catheter 10. A large deformation is applied so that the outer diameter is regulated. Therefore, the folded distal end portion 28 applies a force to be expanded to the inner wall of the catheter 10.

  The lower view of FIG. 2 is compared with the upper view, and the distal end portion of the guide wire 20 protrudes from the distal end portion of the catheter 10 by moving the catheter 10 in the direction of the white arrow, and is superelastic. It is a figure which shows a mode that it returns to the shape at the time of becoming and becomes the expansion front-end | tip part 30. FIG. The time when this state occurs inside the blood vessel 4 is the state described in FIG. It is to be noted that the guide wire 20 is left as it is, so that only the catheter 10 is easily moved in the direction of the white arrow, and the catheter 10 is moved toward the front side, that is, on the side where the rotation mechanism 12 of the guide wire 20 is provided. A handle is preferably provided.

  The shape of the expanded distal end portion 30 shown in the lower diagram of FIG. 2 is the state in which the deformation is applied when heat treatment is applied to the distal end portion of the guide wire 20 to apply superelasticity. Shape. That is, in the step of applying superelasticity, an appropriate deformation jig is used so that the distal end portion of the guide wire 20 has a predetermined envelope contour shape. The heat treatment is performed. As the deformation jig for forming the envelope contour shape, a metal sphere having an appropriate outer diameter can be used.

  The outer diameter of the envelope contour shape can be appropriately determined according to the inner diameter of the blood vessel 4 when the guide wire 20 is inserted and expanded. In the above example, when the outer diameter of the catheter 10 is 0.8 mm, the inner diameter of the blood vessel 4 is about 1 mm, so the outer diameter of the envelope contour shape can also be about 1 mm. As described with reference to FIG. 1, the function of the widening tip portion 30 having the envelope contour shape is to entangle the occluding substance 8, and at this time, it is preferable to rotate the guide wire 20 around the axis. Compared to the inner diameter of the blood vessel 4, the outer diameter of the envelope contour shape does not have to be so large.

  FIG. 3 is a view showing a state of the guide wire 20 prepared before the step of superelasticity. As described above, the guide wire 20 is an elongated rod originally composed of a single material having the same thickness. For example, in the above example, the guide wire 20 is a nickel-titanium alloy thin wire having an outer diameter of 0.43 mm. is there. As shown in FIG. 3, the distal end portion of the guide wire 20 is a distal end portion 26 with a slit provided with a plurality of slits 32. That is, in the above example, a plurality of slits having end portions on both sides are carved by processing at the distal end portion of a thin wire having an outer diameter of 0.43 mm and are divided into a plurality of elongated portions.

  In FIG. 3, two elongated slits 32 are cut along the axial direction at the distal end portion of the guide wire 20 so as to be orthogonal to each other in a plane perpendicular to the axis. The process of cutting the slit 32 can be performed by laser processing or the like. This processing is performed in an atmosphere at room temperature or the like on the nickel-titanium alloy fine wire as the raw material. In this way, a process of giving superelasticity is performed on the guide wire 20 having the slit-attached tip portion 26 provided with the plurality of slits 32.

  Therefore, the manufacturing method of the guide wire 20 is performed through the following steps. First, a thin line of shape memory material having an outer diameter corresponding to the inner diameter of the target catheter 10 is prepared (thin line preparation step). In the above example, a nickel-titanium alloy fine wire having an outer diameter of 0.43 mm is prepared. The length is sufficiently longer than the entire length of the catheter 10. Next, a plurality of slits are processed at a predetermined slit length at the tip of the thin wire (slit processing step). Thereby, the guide wire 20 which has the front-end | tip part 26 with a slit is obtained.

  In the example of FIG. 3, two slits 32 perpendicular to each other in a plane perpendicular to the axial direction are formed by laser processing or the like. As a guide, the slit length is half of the circumferential length of the sphere in contact with the inner diameter of the target blood vessel 4. Since the tip portion with slit 26 is divided into four elongated portions whose both ends are connected to each other, the flexibility of the four elongated portions is used to make the tip portion with slit 26 have an arbitrary shape. be able to.

  Next, the process which gives superelasticity is performed with respect to the guide wire 20 which has the front-end | tip part 26 with a slit (superelasticity provision process). In the above example, the four divided portions of the tip portion 26 with slit are opened, and a metal sphere is disposed therein as a jig, and is held in an envelope contour shape. And the heat processing for super-elastically providing the front-end | tip part of the guide wire 20 is performed in the state hold | maintained in the outer shape of the envelope outline shape in this way. In the above example, heating is performed at about 500 ° C. for 30 minutes. After heating, return to room temperature and remove the metal bulb.

  As a result, the guide wire 20 having the expanded distal end portion 30 whose distal end portion has an envelope contour shape is obtained. Since the envelope contour portion has superelasticity, it has an elastic range 5 to 10 times that of a state where superelasticity is not applied. Therefore, when an external force is applied to the outer shape of the envelope contour shape and plastic deformation does not occur even in a flat state and the external force is removed, the outer shape of the original envelope contour shape is restored.

  In this way, when the widening tip 30 with superelasticity is formed on the guide wire 20, the rotation mechanism 12 is connected to the root thereof. This completes the preparation of the guide wire 20. The prepared guide wire 20 is inserted into and stored in the axial through hole of the catheter 10 separately prepared (accommodating step in the catheter). At this time, the distal end portion of the guide wire 20 becomes the folded distal end portion 28 as described with reference to the upper side of FIG. The folded tip 28 is inserted to the vicinity of the tip of the catheter 10.

  Then, the catheter 10 in which the guide wire 20 is accommodated is inserted into the blood vessel 4 of the target living body (insertion step). A marker (not shown) is attached to the distal end portion of the catheter 10, and the position of the distal end of the catheter 10 in the blood vessel 4 of the living body can be observed on a monitor or the like using, for example, X-rays. And the base part of the catheter 10 is operated, the front-end | tip of the catheter 10 is made to reach | attain the site | part which should remove the obstruction | occlusion substance 8 through the blood vessel 4 of a biological body (part setting process).

  When the distal end portion of the catheter 10 reaches a desired site, the catheter 10 is moved to the near side while the position of the guide wire 20 is left as it is, as described in the lower diagram of FIG. As a result, the folded distal end portion 28 of the guide wire 20 protrudes from the distal end of the catheter 10, and a plurality of elongated divided portions are expanded by the slits 32 in the direction perpendicular to the axial direction. A shape is formed to become the expanded tip 30 (expanding step).

  Therefore, the guide wire 20 is rotated around the axis by the rotating mechanism 12 or moved back and forth in the axial direction by the operation on the hand side, and the occluding substance 8 is entangled in the envelope contour shape and removed from the vessel wall or inside of the blood vessel 4. Yes (occlusion substance capture step). At an appropriate time, the distal end portion entangled with the occlusive substance 8 is stored in the catheter 10 again by returning the catheter 10 to the original position or pulling the guide wire 20 further forward. In this state, the catheter 10 containing the guide wire 20 passes through the blood vessel 4 again, is pulled out, and is returned to the outside of the living body, whereby the occluding substance 8 can be carried out of the living body (discharge process).

  In the above description, the plurality of slits 32 are formed at the distal end portion of the guide wire 20. However, the shape may be effective for entanglement of the occluding substance 8 by other methods. 4 to 6 are views showing examples of guide wires having different tip end shapes.

  The guide wire 40 shown in FIG. 4 is provided with a plurality of cuts having an end portion on the base side and an open end side at the end portion of the main body portion 24, thereby forming a tip portion 42 that is divided into a plurality of elongated portions. The tip end sides of the plurality of divided parts are integrally coupled. As a result, the distal end portion 42 of the guide wire 40 can be formed into a plurality of elongated divided portions by a simple cutting process without using slit processing, and the distal end side thereof is integrated by, for example, a thin wire binding member 44, thereby It can be made into the same shape as what gave the slit process. Giving super-elasticity to the envelope contour shape can be realized by a process similar to that described with reference to FIGS.

  According to this method, management of the length of the slit 32 becomes unnecessary. In other words, the distal end portion of the main body portion 24 of the guide wire 40 is provided with a cut over an appropriate length, and the length of the cut at the distal end portion is adjusted later so as to correspond to the size of the desired envelope contour shape. Just cut it.

  As shown in FIG. 4, the guide wire 50 shown in FIG. 5 is provided with a cut 54 at the end of the main body 24 to form a plurality of elongated tip portions 52, and the tip side is integrated. They are not tied together and remain separated from each other. FIG. 5 shows the outer shape after imparting superelasticity. In order to impart superelasticity to the envelope contour shape that opens at the tip side in this way, for example, a spherical or elliptical sphere jig is used, as in the case described in relation to FIG. 2 and FIG. Since the tip portions of the plurality of divided parts are separated from each other, it is preferable to use another jig that presses each of the divided parts against the outer surface of the jig.

  According to this method, the shape of the distal end portion to which superelasticity is imparted is an envelope contour shape that opens at the distal end side, so that it is expected that the occlusive substance 8 can be easily taken from the opening.

  The guide wire 60 shown in FIG. 6 is a diagram illustrating an example in which a process for attaching a locking shape is added to the tip portion 62 divided into a plurality of parts when the process described in FIGS. 4 and 5 is performed. FIG. 6 shows a state before applying superelasticity, that is, a state in which a cut 66 is made in the material thin line and a process of applying the locking portion 64 is performed. The step of imparting superelasticity is performed thereafter. In this case, the tip side may be bound as shown in FIG. 4, or the tip side may be left open as shown in FIG.

  The locking portion 64 is for preventing the occluding substance 8 entangled in the elongated end portion from peeling again and keeping it tangled. Therefore, it is preferable to have a concavo-convex shape such as a bowl-shaped one or a surface roughened like a bowl surface.

  In the above description, the biological tube portion insertion guide wire has been described as being made of a shape memory alloy material to which superelasticity is imparted, but it may be a normal thin metal wire that cannot impart superelasticity. Even in this case, if the tip portion is plastically deformed to a predetermined envelope contour shape so that it does not exceed the elastic limit even if it is inserted into the catheter and deformed, the free shape can be obtained when protruding from the tip of the catheter. It is possible to return to the original envelope contour shape.

  For example, if a general steel fine wire is preliminarily processed into an envelope contour shape so as to have an outer shape larger than the inner diameter of the catheter, if it is within the inner diameter of the catheter, the inner diameter is within the elastic limit range. Although it is deformed, when it protrudes from the distal end of the catheter, it returns to the original enveloped contour shape. Thus, even if it is a normal thin metal wire, although it is a small external shape compared with the case where super elasticity is given, it can be expanded to an envelope outline shape when it protrudes from the tip of a catheter.

It is a figure explaining the structure of the guide wire for biological tube insertion in embodiment which concerns on this invention, and its effect | action. In embodiment which concerns on this invention, it is a figure explaining the mode of the state when the front-end | tip part of a guide wire is accommodated in the inside of a catheter, and the case where it protrudes from the front-end | tip of a catheter. In embodiment which concerns on this invention, it is a figure which shows the mode of the guide wire prepared before the process of attaching | subjecting superelasticity. In embodiment which concerns on this invention, it is a figure which shows one example of the guide wire from which the shape of a front-end | tip part differs. In embodiment which concerns on this invention, it is a figure which shows the other example of the guide wire from which the shape of a front-end | tip part differs. In embodiment which concerns on this invention, it is a figure which shows another example of the guide wire from which the shape of a front-end | tip part differs.

Explanation of symbols

  4 Blood vessel, 6 Tube part, 8 Occlusion substance, 10 Catheter, 12 Rotating mechanism, 20, 40, 50, 60 (For insertion of living body part) Guide wire, 22 Root part, 24 Body part, 26 Tip part with slit, 28 Folded tip, 30 widened tip, 32 slit, 42, 52, 62 tip, 44 binding member, 54, 66 break, 64 locking part.

Claims (6)

A root part to which the rotation mechanism is connected;
A body portion that is inserted into the axial through hole of the catheter, is movable in the axial direction, and is rotatable about the axis;
A tip portion having a predetermined axial length at the end of the main body is elongated into a plurality of portions along the axial direction; and
Have
A guide for inserting a living body tube section, wherein when the distal end portion protrudes from the distal end of the catheter, a plurality of elongated divided portions are respectively expanded in a direction perpendicular to the axial direction to form a predetermined envelope contour shape. Wire. The guide tube for inserting a biological tube according to claim 1,
A guide tube for inserting a living body tube, comprising a shape memory alloy material provided with superelasticity. The guide tube for inserting a living body tube according to claim 1 or 2,
The tip is
A guide tube for inserting a living body tube portion, characterized in that, at the end portion of the main body portion, it is divided into a plurality of elongated portions by a plurality of slits having end portions on both sides. The guide tube for inserting a living body tube according to claim 1 or 2,
The tip is
A living-tube-part-inserting guide wire characterized by being divided into a plurality of elongated portions by a plurality of cuts having an end portion on the base side and an open end side at an end portion of the main body portion. The guide tube for inserting a biological tube according to claim 4,
The tip is
A guide tube for inserting a living body tube portion, wherein uneven portions are provided in a plurality of cut portions. The guide tube for inserting a biological tube according to claim 4,
The tip is
A guide tube for inserting a living body tube section, characterized by having coupling means for integrally coupling each divided portion at the distal end side of a plurality of divided portions divided by a cut.

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