JP2009125486A - Biosensor set and needle integrated measuring instrument - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biosensor set and a needle integrated measuring instrument having a simple structure and easily executing measurement in a simple structure. <P>SOLUTION: This biosensor set 3 includes a biosensor cartridge 9 integrally having a puncture device and a biosensor chip, a tubular storage case 7 storing and retaining the biosensor cartridge 9 and being inserted into a measurement opening 11 of a puncture/measuring instrument 5 along with the biosensor cartridge 9, and an engagement means 13 provided between the tubular storage case 7 and the biosensor cartridge 9 and capable of releasing the retention with respect to the biosensor cartridge 9. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a biosensor set and a needle-integrated measurement apparatus that measure and analyze a chemical substance using a reagent contained in a biosensor chip, for example.

Conventionally, a biosensor in which a biosensor chip and a lancet are integrated has been disclosed (see, for example, Patent Document 1).
FIG. 10A is a perspective view of the biosensor described in Patent Document 1, and FIG. 10B is an exploded perspective view of the biosensor.

  As shown in FIG. 10, the lancet-integrated sensor 100 includes a chip body 101, a lancet 103, and a protective cover 105. The chip body 101 has a cover 101a and a substrate 101b that can be opened and closed, and an internal space 102 is formed on the inner surface of the cover 101a. The internal space 102 has a shape that can accommodate the lancet 103 in a movable manner.

The needle 104 provided at the tip of the lancet 103 can be moved in and out from an opening 102 a formed at the front end of the internal space 102 of the chip body 101 as the lancet 103 moves.
The shape of the internal space 101a is curved so that the width of the inner space 101a is slightly narrower than that of the lancet 103 at the end where the protrusion 103a is located. It is like that.

The protective cover 105 has a tube part 105 a into which the needle 104 is inserted, and the tube part 105 a can be accommodated inside the chip body 101 as the needle 104 moves.
Therefore, in a state before use, the protective cover 105 is put on the needle 104 to protect the needle 104 and prevent the user from being accidentally injured. Note that the substrate 101b is provided with a pair of electrode terminals 106 so that it can be electrically connected to a measuring apparatus (not shown).

  In use, the protective cover 105 is removed and the lancet 103 is pushed to cause the needle 104 to protrude from the chip body 101. After puncturing the subject in this state, the needle 104 is housed inside the chip body 101, and the opening 102a provided at the front end of the chip body 101 is brought close to the puncture port to collect the outflowed blood.

WO02-056769

  However, the lancet-integrated sensor 100 described in Patent Document 1 is integrated by incorporating the lancet 103 inside the chip body 101, but strictly speaking, the chip body 101 and the lancet 103 have a separate structure. The lancet 103 can move with respect to the chip body 101. For this reason, the structure is complicated, the manufacturing is troublesome, and there is an inconvenience that the size of the sensor 100 is increased and the manufacturing cost is increased.

  In the lancet-integrated sensor 100, after the lancet 103 is pushed and the object is punctured by the protruding needle 104, the needle 104 is housed inside the chip body 101, and the opening 102a at the front end of the chip is brought close to the puncture port. In order to collect the spilled blood, puncture, needle storage, and collection operations must be performed separately. For this reason, when the measurement is performed several times a day, the work is complicated and is not appropriate, and a biosensor system capable of sampling with a simpler operation has been demanded.

  Furthermore, in order to improve the measurement success probability in the conventional lancet-integrated sensor, it is desirable to use a decompression type blood collection assist mechanism. However, if the measuring device is provided with a loading opening for the lancet-integrated sensor, this loading is possible. The opening must have an airtight opening / closing structure, which also complicates the structure and increases manufacturing costs.

  Accordingly, the present invention has been made in view of the above situation, and it is an object of the present invention to provide a biosensor set and a needle-integrated measuring apparatus that can perform simple measurement with a simple structure.

The object of the present invention is to provide a biosensor cartridge integrally including a puncture device and a biosensor chip,
A cylindrical storage case that holds and holds the biosensor cartridge, and is inserted into a measurement opening of a puncture measurement device together with the biosensor cartridge;
Engagement means provided between the cylindrical housing case and the biosensor cartridge, and capable of releasing the holding of the biosensor cartridge;
It is achieved by a biosensor set characterized by comprising:

  According to the biosensor set having the above-described configuration, when the biosensor cartridge is mounted on the puncture measuring device, the biosensor cartridge can be mounted without direct contact, and the user may be injured by accidentally touching the needle of the puncture tool, or the sensor chip terminal. It is possible to prevent inadequate conduction by touching.

In the biosensor set configured as described above, the engagement means includes an engagement groove formed along a circumferential direction in a part of the outer peripheral part of the biosensor cartridge, and a part of the inner peripheral part of the cylindrical housing case. A locking projection formed along the circumferential direction and engaged with the engaging groove,
It is desirable that the engagement between the engagement groove and the locking projection can be released by rotating the biosensor cartridge and the cylindrical housing case relative to each other about the axis.

  According to the biosensor set having such a configuration, when the cylindrical storage case that stores and holds the biosensor cartridge is inserted in the axial direction of the measurement opening, the cylindrical groove is formed in the engagement groove formed in the outer peripheral portion of the biosensor cartridge. By engaging a locking projection formed on the inner peripheral portion of the storage case, the movement of the biosensor cartridge in the axial direction can be restricted and the state held in the storage case can be maintained. Then, when the biosensor cartridge and the cylindrical storage case are rotated relative to each other about the axis, the locking protrusion is released from the engagement groove, and the movement restriction in the axial direction is released. Therefore, the biosensor cartridge in the cylindrical storage case Can be punctured.

Further, in the biosensor set having the above-described configuration, a pair of the engagement grooves are formed on both sides of the biosensor cartridge,
It is desirable that a pair of the locking projections be formed on the opposing inner wall surface of the cylindrical housing case.

  According to the biosensor set having such a configuration, the pair of locking protrusions formed on the opposed inner wall surfaces of the cylindrical housing case engage with the engaging grooves formed on both sides of the biosensor cartridge, The sensor cartridge and the cylindrical storage case can be stored and held on the same axis. This makes it difficult for the biosensor cartridge to tilt during relative rotation, and makes it possible to improve the holding release property and the detachability.

  In the biosensor set having the above-described configuration, it is desirable that both end openings of the cylindrical housing case are sealed with a peelable sealing material.

  According to the biosensor set having such a configuration, the inside of the cylindrical housing case that houses the biosensor cartridge can be maintained in a sterile state. During use, the sealing seal material is peeled and removed to insert the device insertion side opening into the measurement opening of the puncture measuring device and connect the terminal of the sensor chip to the connector portion of the puncture measuring device. A needle or the like, which is a puncture device for a puncture device, can be protruded from a tip opening that is in contact with the needle. Further, when the distal end opening is pressed against a subject, for example, a finger, it can function as a positioning means when puncturing with an inner puncture device.

Further, the above-mentioned object according to the present invention is a needle-integrated measuring device having a puncture measuring device that loads a biosensor cartridge integrally provided with a puncture device and a biosensor chip and performs puncture and measurement,
A cylindrical storage case that holds and holds the biosensor cartridge, and that is inserted into the opening of the puncture measurement device together with the biosensor cartridge so that one of the opening portions at both ends protrudes outside the device,
Engagement means provided between the cylindrical housing case and the biosensor cartridge, and capable of releasing the biosensor cartridge after the biosensor cartridge is attached to the puncture measurement device;
This is achieved by a needle-integrated measuring apparatus characterized by comprising:

  According to the needle-integrated measurement device having the above-described configuration, the biosensor cartridge can be attached to the puncture measurement device by simply inserting the cylindrical storage case that stores and holds the biosensor cartridge into the measurement opening of the puncture measurement device. A single operation of the switch can perform puncture, sampling, and measurement.

Further, after the cylindrical storage case is attached to the puncture measurement device, the biosensor cartridge can be punctured and measured by releasing the holding of the cylindrical storage case with respect to the biosensor cartridge. That is, the biosensor cartridge can be attached to the puncture measuring device without direct contact.
Further, since the biosensor cartridge can be mounted using the measurement opening of the puncture measurement apparatus, a puncture measurement apparatus has a dedicated airtight loading opening for mounting the biosensor cartridge integrally provided with the puncture tool and the biosensor chip. There is no need to provide a separate device.

  According to the biosensor set and the needle integrated measurement device according to the present invention, the biosensor cartridge can be attached to the puncture measurement device simply by inserting the cylindrical housing case that contains and holds the biosensor cartridge into the measurement opening of the puncture measurement device. For example, puncturing, sampling, and measurement can be performed with a single operation of the puncture switch.

  In addition, after the cylindrical storage case is attached to the puncture measurement device, the holding of the cylindrical storage case with respect to the biosensor cartridge is released, and puncture and measurement using the biosensor cartridge are possible. Therefore, the biosensor cartridge can be mounted on the puncture measuring device without direct contact, and can be mounted hygienically simply and safely.

Further, since the biosensor cartridge can be mounted using the measurement opening of the puncture measurement apparatus, a puncture measurement apparatus has a dedicated airtight loading opening for mounting the biosensor cartridge integrally provided with the puncture tool and the biosensor chip. There is no need to provide a separate device.
Therefore, it is possible to provide a biosensor set and a needle-integrated measurement apparatus that can be easily measured with a simple structure.

DESCRIPTION OF EXEMPLARY EMBODIMENTS Hereinafter, preferred embodiments of a needle integrated measuring apparatus and a biosensor set according to the invention will be described with reference to the drawings.
It should be understood that the embodiments disclosed herein are illustrative and non-restrictive in every respect. The scope of the present invention is defined by the terms of the claims, rather than the meanings described below, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.

FIG. 1 is a configuration diagram of a needle integrated measuring apparatus and a biosensor set according to an embodiment of the present invention, and FIG. 2 is an exploded perspective view of the biosensor set shown in FIG.
The needle-integrated measurement apparatus 1 according to the present embodiment includes a puncture measurement apparatus 5 that loads a biosensor cartridge 9 that is integrally provided with a puncture tool 25 and a biosensor chip 23, which will be described later, and performs puncture and measurement.

  Furthermore, the needle-integrated measurement device 1 accommodates and holds the biosensor cartridge 9 and is inserted into the measurement opening 11 of the puncture measurement device 5 together with the biosensor cartridge 9 so that one of the opening portions at both ends protrudes outside the device. The cylindrical storage case 7 to be worn, and provided between the cylindrical storage case 7 and the biosensor cartridge 9, after the biosensor cartridge 9 is attached to the puncture measuring device 5, the holding to the biosensor cartridge 9 is released. Possible engagement means 13.

As shown in FIGS. 1 and 2, the cylindrical housing case 7 is formed in a cylindrical shape (cylindrical in this embodiment) made of a transparent resin material (polystyrene, polycarbonate, acrylic resin, etc.) opened at both ends. The biosensor cartridge 9 is accommodated and held on the same axis.
A pair of locking projections 39, 39 constituting the engaging means 13 together with a pair of engaging grooves 37, 37 to be described later project from a substantially intermediate inner circumferential surface in the longitudinal direction of the cylindrical housing case 7. ing. Further, on the outer peripheral surface of the device insertion side opening 7 a of the cylindrical housing case 7, an engaging projection 38 that functions as an insertion guide and a retaining stopper when inserted into the measurement opening 11 of the puncture measurement device 5 is projected. ing.

  The cylindrical housing case 7 that houses and holds the biosensor cartridge 9 is inserted into the measurement opening 11 of the puncture measuring device 5 together with the biosensor cartridge 9 so that the tip opening 7b that is one of the opening portions at both ends protrudes outside the device. Inserted (see FIG. 5).

  As will be described in detail later, the engaging means 13 provided between the cylindrical storage case 7 and the biosensor cartridge 9 causes the cylindrical storage case 7 and the biosensor cartridge 9 to rotate relative to each other about the axis line. The holding of the cylindrical housing case 7 with respect to the biosensor cartridge 9 can be released.

  In the cylindrical housing case 7, the device insertion side opening 7a for removing the biosensor cartridge 9 is sealed with a peelable sealing material 15a. In use, the cylindrical housing case 7 peels and removes the hermetic seal material 15a so that the terminal insertion portion 17 (see FIG. 5), which is the connector portion of the puncture measuring device 5, is provided via the device insertion side opening 7a. The biosensor cartridge 9 is attached to the puncture measuring device 5 side.

  The cylindrical housing case 7 is sealed with a peelable sealing material 15b at the tip opening 7b opposite to the device insertion side opening 7a. When the sealing material 15b attached to the tip opening 7b is peeled off, the tip of the biosensor cartridge 9 can protrude from the tip opening 7b. That is, the cylindrical housing case 7 itself inserted into the puncture measuring device 5 can be used as the contact portion of the subject. In addition, it is desirable that the cylindrical housing case 7 is disposable and used only once.

That is, the biosensor set 3 is composed of the cylindrical housing case 7, the biosensor cartridge 9, and the sealing materials 15a and 15b.
In the biosensor set 3, the inside of the biosensor cartridge 9 is aseptically obtained by sealing the device insertion side opening 7a and the tip opening 7b at both ends of the cylindrical housing case 7 with the sealing materials 15a and 15b. Can be kept in a state. Further, by being accommodated in the cylindrical accommodation case 7, the user does not touch the elastic body 19 of the biosensor cartridge 9 or the puncture device N (see FIG. 3), and safety is ensured.

  In this biosensor set 3, the cylindrical housing case 7 has a storage case for the biosensor cartridge 9 and an insertion assisting means, a contact portion with respect to the subject, and a protective cap for the puncture measuring device 5 with the biosensor cartridge 9 inserted. Will function as well. The biosensor set 3 can also be used as a disposal case after use of the biosensor cartridge 9. The biosensor set 3 is provided for a user who uses the puncture measuring device 5 by being hermetically packaged, for example, in a plurality of units. The biosensor set 3 is preferably disposable from the viewpoint of hygiene.

FIG. 3 is an exploded perspective view of the biosensor cartridge shown in FIG.
As shown in FIG. 3, the biosensor cartridge 9 has an exterior cover 21. Inside the outer cover 21, a biosensor chip 23 with an elastic body 19 attached to the tip and a puncture device 25 are sandwiched and fixed.

The exterior cover 21 of the present embodiment is formed in an integral structure in which the upper lid portion 21a and the lower lid portion 21b are connected by the hinge portion 21c, but the upper lid portion 21a and the lower lid portion 21b are separated by the hinge portion 21c. It is good also as another body structure.
An aeration / surplus blood discharge path 27 is formed on the inner surface of the upper lid portion 21a across the front and rear ends, and the aeration / surplus blood discharge path 27 communicates with a decompression-type blood collection assist mechanism (not shown) to apply a negative pressure. That is, an airtight chamber (not shown) communicating with the reduced pressure blood collection assist mechanism is formed inside the puncture measuring device 5, and the negative pressure in the airtight chamber is aerated / surplus blood of the biosensor cartridge 9 inserted into the measurement opening 11. The blood flowing out from the puncture port of the subject through the discharge path 27 is sucked and effectively introduced into the sample collection port 29 of the biosensor cartridge 9.

Chip pressing ribs 31, 31 project from the inner surfaces of the top lid portion 21 a and the lower lid portion 21 b, and the tip pressing rib 31 of the elastic body 19 is in a state where the upper lid portion 21 a and the lower lid portion 21 b are joined. The biosensor chip 23 is directly clamped from the front and back surfaces by entering the notch 19a.
Further, retaining pins 33 and 33 project from the inner surfaces of the top ends of the upper lid portion 21a and the lower lid portion 21b. The retaining pins 33 are elastic in a state where the upper lid portion 21a and the lower lid portion 21b are joined. The elastic body 19 is prevented from coming off from the outer cover 21 when pressed by the body 19. Thereby, the biosensor chip 23 and the elastic body 19 are firmly and integrally fixed by the exterior cover 21 without using an adhesive.

The upper lid portion 21a and the lower lid portion 21b are formed with a joint convex portion 35a and a joint concave portion 35b, and the joint convex portion 35a and the joint concave portion 35b are fitted in a state where the upper lid portion 21a and the lower lid portion 21b are joined. Heat-sealed to each other.
In view of this, the biosensor cartridge 9 can heat-bond the joint convex portions 35a and the joint concave portions 35b while applying a force from above and below the upper lid portion 21a and the lower lid portion 21b, whereby a plurality of (this embodiment) is shown in FIG. In this case, the elastic body 19 and the biosensor chip 23 are firmly sandwiched between the joint portions 35 at four locations.

  A pair of engagement grooves 37 and 37 constituting the engagement means 13 are formed on both side portions which are a part of a substantially intermediate outer peripheral portion in the longitudinal direction of the biosensor cartridge 9, and each engagement groove 37 is a cylinder. It engages with a locking projection 39 provided on the shape containing case 7.

As shown in FIG. 3, the biosensor chip 23 is accommodated on the upper surface of a puncture device 25 formed in a plate shape from a resin material. The elastic body 19 is inserted into the tip of the puncture device 25 that houses the biosensor chip 23.
The puncture device 25 is formed in a rectangular plate shape, and the puncture device N projects from one end in the longitudinal direction. Examples of the puncture device N include a hollow injection needle, a lancet needle, a cannula, and the like. These needles may be fixed to resin, or may be integrated with resin (the needle itself is also molded with resin). In the present embodiment, an example in which a lancet needle is fixed to a resin is illustrated as an example of a puncture device N.

On the upper surface of the puncture device main body 41, an accommodating portion 41a for placing the biosensor chip 23 is formed by the peripheral wall 41b. The biosensor chip 23 is accommodated in the accommodating portion 41a in a state surrounded by the peripheral wall 41b, and can be easily assembled without using an adhesive.
The peripheral wall 41 b is opened as a notch opening 41 c at the tip of the puncture device main body 41. In the notch opening 41c, an inclined introduction surface 41d that is inclined downward is formed immediately above the puncture device N.

In the inclined introduction surface 41d, the lower end of the downward inclination is close to the root of the puncture device N, and the upper end is close to the tip of the biosensor chip 23. That is, the sampling port 29 is disposed near the upper end of the inclined introduction surface 41d. In addition, a ventilation / surplus blood discharge path 27 provided in the upper lid portion 21a of the exterior cover 21 is disposed on the opposite side of the inclined introduction surface 41d across the sample collection port 29.
As a result, when a negative pressure is applied to the ventilation / surplus blood discharge path 27 located on the opposite side of the inclined introduction surface 41d, a main flow path reaching the sample collection port 25 is formed, and the root of the puncture device N is formed. The reached blood is efficiently introduced into the sampling port 29.

  Further, locking projections 43, 43 are provided on the inner side of the substantially central portions of the peripheral walls 41b, 41b, and the locking projections 43, 43 engage locking recesses 45, 45 formed in the biosensor chip 23. The movement in the axial direction when the biosensor chip 23 is punctured is restricted.

The biosensor chip 23 has two substrates 23a and 23b facing each other, and a spacer layer 47 sandwiched between the two substrates 23a and 23b. Detection electrodes 49a and 49b are provided on the surface of the substrate 23a on the side of the spacer layer 47, and the tip portions (the lower left end portion in FIG. 3) are bent in an L shape in a direction facing each other, so that a predetermined interval is provided. Holding.
At the rear end 23c of the biosensor chip 23, the substrate 23a extends from the substrate 23b and the spacer layer 47, and the detection electrodes 49a and 49b are exposed on the substrate 23a.

A hollow reaction portion 51 is formed by the two substrates 23 a and 23 b and the spacer layer 47 from the tip of the biosensor chip 23 to the portion where the two detection electrodes 49 a and 49 b are opposed to each other.
At the tip of the hollow reaction part 51, a sample collection port 29 for introducing blood into the hollow reaction part 51 as a sample collected by puncturing the subject with a puncture device N is provided. The sample collection port 29 is disposed in the vicinity of the puncture device N so that even a small amount of sample can be collected reliably, and the burden on the user can be reduced.

  In the hollow reaction part 51, the detection electrodes 49a and 49b are exposed, and for example, an enzyme and a mediator are immobilized and reacted with glucose in blood immediately above or in the vicinity of the detection electrodes 49a and 49b in the hollow reaction part 51. A reagent 53 that generates current is provided. Therefore, the hollow reaction part 51 is a part where a sample such as blood collected from the sample collection port 29 undergoes a biochemical reaction with the reagent 53.

  Examples of the reagent 53 include enzymes such as glucose oxidase (GOD), glycolose dehydrogenase (GDH), cholesterol oxidase and urigase, and electron acceptors such as potassium ferricyanide, ferrocene and benzoquinone. In consideration of the blood sampling burden of the specimen, the volume of the hollow reaction part 51 is preferably 1 μL (microliter) or less, particularly preferably 300 nL (nanoliter) or less. With such a minute hollow reaction part 51, it is possible to collect a sufficient blood volume of the specimen even if the diameter of the chip body is small. The puncture needle preferably has a diameter of 1000 μm or less.

  As the material of the substrates 23a and 23b and the spacer layer 47, an insulating material film is selected. As the insulating material, ceramics, glass, paper, biodegradable material (for example, polylactic acid microorganism-producing polyester), poly Examples thereof include thermoplastic resins such as vinyl chloride, polypropylene, polystyrene, polycarbonate, acrylic resin, polybutylene terephthalate and polyethylene terephthalate (PET), thermosetting resins such as epoxy resins, and plastic materials such as UV curable resins. A plastic material such as polyethylene terephthalate is preferable because of its mechanical strength, flexibility, and ease of chip fabrication and processing. Representative PET resins include Melinex and Tetron (trade names, manufactured by Teijin DuPont Films, Inc.), Lumirror (trade names, manufactured by Toray Industries, Inc.), and the like.

As shown in FIG. 3, an annular recess 59 is formed on the front end surface 19 b of the elastic body 19 attached to the tip of the biosensor cartridge 9. The annular recess 59 has a cylindrical protrusion 61 at the center bottom. Forming.
A through hole 63 that penetrates the elastic body 19 is formed in the center of the protrusion 61, and a puncture device N is inserted through the through hole 63. The through hole 63 is formed larger than the outer diameter of the puncture device N. The dimension of the elastic body 19 in the axial direction is a length that covers the tip of the puncture device N. That is, the puncture device N is accommodated in the through hole 63.

  The elastic body 19 is compressed and deformed by pressing the front end surface 19b in the axial direction. Further, when the same pressing force is applied, the projecting portion 61 is also deformed so as to be crushed to the vicinity of the bottom surface of the annular recess 59. Due to this compressive deformation, the puncture device N is relatively projected from the front end surface 19 b of the elastic body 19. This pressing force is applied by the drive unit 65 (see FIG. 5) of the puncture measuring device 5.

As described above, when the elastic body 19 attached to the tip of the biosensor cartridge 9 is pressed against the subject, the elastic body 19 is compressed and deformed, and the puncture instrument N inserted therein is relatively protruded to cause the subject. Puncture. When the pressing force is weakened, the puncture device N is pulled out of the subject by the restoring force of the elastic body 19, the sample flows out from the puncture port, and the outflow sample can be collected by only one pressing operation. Yes.
In the present embodiment, the elastic body 19 has an elliptical cross-sectional shape in the direction orthogonal to the axis. Since the elastic body 19 has an elliptical cross section, the cushion volume is smaller than that of the circular cross section (the force of compressive deformation is reduced), and puncture with a small driving force is possible.

  The elastic body 19 contains at least one of natural rubber, synthetic rubber, and sponge as an essential material. By using at least one of natural rubber, synthetic rubber, and sponge as the main material of the elastic body 19, it becomes easy to obtain raw materials, and the elastic body 19 having a desired hardness can be produced at a low cost with good moldability. . Further, the surface of the elastic body 19 may be covered with a coating material that prevents the bleeding substance due to bleeding from adhering to the subject. As a result, it is possible to suppress a decrease in the measurement success rate due to mixing of the exuding substance into the collected sample, and it is possible to prevent the influence on the subject.

  Further, a surfactant (not shown) is applied to the inner wall surface of the through hole 63 of the elastic body 19, and the surfactant facilitates the introduction of the sample into the sample collection port 29. This surfactant is also applied to the sample collection port 29 and the inner wall of the hollow reaction part 51.

FIG. 4 is a front view of the biosensor set showing the engaged state and the disengaged state of the engaging means.
As shown in FIG. 4, the engaging means 13 described above is provided between the cylindrical housing case 7 and the biosensor cartridge 9 constituting the biosensor set 3.

  The engaging means 13 includes a pair of engaging grooves 37 and 37 formed on both side portions which are a part of a substantially intermediate outer peripheral portion in the longitudinal direction of the biosensor cartridge 9 and a substantially intermediate portion in the longitudinal direction of the cylindrical housing case 7. And a pair of locking projections 39, 39 respectively engaged with the pair of engaging grooves 37, 37.

  Therefore, in the biosensor cartridge 9, as shown in FIG. 4 (a), the engagement protrusion 37 formed on the inner periphery of the cylindrical housing case 7 is engaged with the engagement groove 37 formed on the outer periphery of the biosensor cartridge 9. As a result, the movement in the axial direction is restricted and held in the cylindrical housing case 7.

When the biosensor cartridge 9 and the cylindrical housing case 7 are rotated relative to each other about the axis, the engagement groove 37 is detached from the locking projection 39 as shown in FIG. Is released.
That is, the biosensor cartridge 9 is inserted into the measurement opening 11 of the puncture measuring device 5 together with the cylindrical housing case 7, and only the inserted cylindrical housing case 7 is rotated, so that the holding by the engaging means 13 is released. Is done. That is, the biosensor cartridge 9 can be inserted without direct contact.

  In this state, since the rear end portion 23c of the biosensor cartridge 9 is inserted into the terminal insertion portion 17 of the drive unit 65, the engagement with the cylindrical housing case 7 is released, so that The sensor cartridge 9 moves relative to the axial direction of the cylindrical storage case 7 so that the puncture device N protruding from the cylindrical storage case 7 can be punctured.

As shown in FIGS. 2 and 4, a pair of engaging grooves 37 are preferably formed on both sides of the biosensor cartridge 9, and a pair of locking protrusions 39 are formed on the opposing inner wall surface of the cylindrical housing case 7. .
In this case, the locking protrusion 39 is formed in a crescent shape, so that locking / unlocking with the engaging groove 37 by relative rotation can be realized. Thus, by engaging the pair of engaging protrusions 39, 39 with the pair of engaging grooves 37, 37, the biosensor cartridge 9 and the cylindrical housing case 7 can be accommodated and held coaxially. This makes it difficult for the biosensor cartridge 9 to tilt at the time of relative rotation, thereby improving the holding release property.

In the above embodiment, an example in which a pair of engaging grooves are formed on the outer peripheral portion of the biosensor cartridge and the locking projection is formed on the inner wall portion of the cylindrical housing case is illustrated. It is good also as a structure which provides a latching protrusion in a part of this, and forms an engaging groove in a part of inner wall part of a cylindrical storage case.
That is, a biosensor cartridge integrally including a puncture device and a biosensor chip, and a cylindrical storage case that holds and holds the biosensor cartridge and is inserted into a measurement opening of the puncture measurement device together with the biosensor cartridge And a biosensor set provided between the cylindrical housing case and the biosensor cartridge and capable of releasing the holding of the biosensor cartridge, wherein the engagement means includes the biosensor A locking projection formed along a circumferential direction on a part of the outer peripheral portion of the cartridge, and an engagement formed along a circumferential direction on a portion of the inner circumferential portion of the cylindrical housing case and engaging with the locking projection. A groove, and by rotating the biosensor cartridge and the cylindrical storage case relative to each other about the axis, It is also possible to allow disengagement of the engagement groove and retaining projection.

Next, the puncture measurement device 5 will be described.
FIG. 5 shows a state before the drive unit of the puncture measuring device is retracted, (a) is a partial sectional front view, (b) is a longitudinal sectional view, and FIG. 6 is a longitudinal sectional view after the drive unit of the puncture measuring device is retracted. It is.

In the apparatus main body 6 of the puncture measuring apparatus 5, a power source 69, a control device 71, and a display unit 73 are provided together with a drive unit 65 described later, and these are electrically connected to each other.
The drive unit 65 for driving the biosensor cartridge 9 in the puncture direction is between the puncture block 79 movable in the puncture direction along the guide shaft 81, and between the inner wall of the apparatus main body 6 and the rear end of the puncture block 79. And an intervening compression coil spring 75.

The puncture block 79 is provided with an elastically deformable elastic locking piece 67 having a locking projection 67a at the tip, and a terminal insertion portion 17 to which the detection electrodes 49a and 49b of the biosensor cartridge 9 are mounted. .
In a state before the biosensor cartridge 9 is attached to the terminal insertion portion 17, the locking projection 67 a is urged to the left in FIG. It is in contact with the wall.

  On the other hand, the biosensor cartridge 9 is inserted into the measurement opening 11, and the compression coil spring 75 is compressed by retracting the puncture block 79 while inserting the rear end portion 23c of the biosensor chip 23 into the terminal insertion portion 17 ( In FIG. 6), the locking projection 67 a is inserted into the opening 70 formed so as to penetrate the inside and the outside of the apparatus main body 6, and is locked to the edge thereof. Thereby, the puncture block 79 is restricted from moving in the puncture direction.

In a state where the locking projection 67a is locked to the opening 70, the compression coil spring 75 is in a compressed state, and biases the puncture block 79 in the puncture direction. In this state, by rotating the cylindrical housing case 7 of the biosensor set 3 about the axis, the holding of the biosensor cartridge 9 by the engaging means 13 is released, and only the biosensor cartridge 9 can be driven out by the puncture block 79. become.
Therefore, when the puncture switch 68 attached to the opening 70 is pressed to release the locking state of the locking projection 67a, the compression coil spring 75 expands and moves the puncturing block 79 in the puncturing direction.

  Accordingly, the puncture block 79 of the drive unit 65 is driven in the puncture direction (downward in FIG. 5) by pressing the puncture switch 68 with the biosensor cartridge 9 attached. As a drive source for the drive unit 65, an electromagnetic solenoid, a motor, or the like can be used in addition to the compression coil spring 75 shown in the figure.

  The terminal insertion portion 17 is connected to the control device 71 and the like by an electric wire 80 which is a conduction mechanism, and reaction information between the sample and the reagent 53 detected by the detection electrodes 49a and 49b of the biosensor chip 23 is obtained from the electric wire 80. Via the control device 71. Further, a switch 77 is provided on the surface of the puncture measuring device 5, and the history of the accumulated measurement results is displayed on the display unit 73 sequentially from the past or sequentially close to the present by operation of the switch 77. It is like that.

Next, the operation of the above-described needle integrated type measuring apparatus 1 will be described.
The needle-integrated measuring apparatus 1 according to the present embodiment is small as shown in FIGS. 1 and 5 and is a handy type that a user can hold with one hand.
In order to use this needle-integrated measuring apparatus 1, first, one biosensor set 3 is prepared, and the sealing materials 15 a and 15 b of the cylindrical housing case 7 are peeled off.

  Next, the side of the cylindrical housing case 7 is picked with fingers, and the device insertion side opening 7a side of the cylindrical housing case 7 is inserted into the measurement opening 11 of the puncture measuring device 5 as shown in FIG. At this time, the engagement protrusion 38 of the cylindrical housing case 7 is fitted into the guide groove 83 formed on the inner wall of the measurement opening 11 to be inserted and guided. Therefore, the detection electrodes 49a and 49b of the biosensor cartridge 9 inserted integrally are non-rotatably attached to the terminal insertion portion 17 of the puncture block 79 in an appropriate direction, and the biosensor chip 23 is controlled by the control device. 71 is in an electrically connected state.

Further, by pushing the biosensor set 3 into the measurement opening 11, the compression coil spring 75 of the drive unit 65 is compressed and the puncture block 79 is held in a puncturable state by the elastic locking piece 67 as shown in FIG. The
Next, the locking projection 39 is removed from the engaging groove 37 of the biosensor cartridge 9 by rotating the cylindrical housing case 7 protruding from the puncture measuring device 5 by 90 degrees. As a result, the biosensor cartridge 9 can move relative to the cylindrical housing case 7 in the axial direction, and can be punctured. Further, since the engaging projection 38 of the cylindrical storage case 7 is introduced into the circumferential groove 84 communicating with the back side of the guide groove 83 by the rotation of the cylindrical storage case 7, the cylindrical storage case 7 is prevented from coming off. It will be in the state.

  In this state, as shown in FIG. 7, the subject M is applied to the tip of the cylindrical housing case 7 to close the tip opening 7 b of the cylindrical housing case 7. When the cylindrical housing case 7 inserted into the measurement opening 11 is protruded and the tip opening 7b is pressed against, for example, a finger of the subject M, the inner biosensor cartridge 9 is used for puncturing. Used as positioning means.

When the puncture switch 68 is pressed in this state and the locking state of the locking projection 67a is released, the puncture block 79 is moved in the puncture direction by the urging force of the compression coil spring 75, and the biosensor cartridge 9 is pressed by the puncture block 79. Is done.
Therefore, in the biosensor cartridge 9, as shown in FIG. 8, the elastic body 19 slightly protrudes from the distal end opening 7 b of the cylindrical housing case 7, and the elastic body 19 protruding from the distal end opening 7 b is attached to the subject M. Since it is pressed and compressed and deformed, puncturing is performed with the relatively projecting puncture device N.

As shown in FIG. 9, the elastic body 19 deformed by the pressing force returns to its original shape by the restoring force. Along with this, the biosensor cartridge 9 is slightly retracted, and the puncture instrument N is removed from the subject M.
When the puncture device N is removed from the subject M, blood (sample) B flowing out from the puncture hole is guided to the sample collection port 29 opened at the tip of the biosensor chip 23, and a hollow reaction is performed from the sample collection port 29. It flows into the part 51.

  Note that the needle-integrated measurement device 1 according to the present embodiment applies a negative pressure to the puncture measurement device 5 from a decompression-type blood collection assisting mechanism (not shown) immediately before pressing the puncture switch 68, and passes through the measurement opening 11. To act on the biosensor cartridge 9. Thereby, the blood B flowing out from the puncture hole is efficiently sucked into the sample collection port 29 of the biosensor chip 23.

  When the blood B flowing into the hollow reaction portion 51 reacts with the reagent 53, a current is generated, and this current is input to the control device 71 via the detection electrodes 49a and 49b and the terminal insertion portion 17 of the substrate 23a. . Thereby, components in blood are measured, and the measurement result is displayed on the display unit 73 by the control device 71.

  As described above, according to the needle-integrated measurement device 1 according to the present embodiment, the biometric cartridge 9 can be simply inserted into the measurement opening 11 of the puncture measurement device 5 by inserting the cylindrical storage case 7 storing and holding the biosensor cartridge 9. The sensor cartridge 9 can be attached to the puncture measuring device 5 and puncture, sampling and measurement can be performed by a single operation of the puncture switch 68.

  In addition, after the cylindrical housing case 7 is attached to the puncture measuring device 5, the biosensor cartridge 9 can be punctured and measured by releasing the holding of the cylindrical housing case 7 from the biosensor cartridge 9. That is, the biosensor cartridge 9 can be mounted on the puncture measuring device 5 without direct contact, and can be mounted hygienically simply and safely.

In addition, in the needle-integrated measuring apparatus 1, it is desirable to include a reduced-pressure blood collection assist mechanism in order to improve the measurement success probability. The decompression-type blood collection assisting mechanism applies a negative pressure to the inside of the main body 6 of the puncture measuring device 5 to suck blood B flowing out from the puncture hole of the subject M through the measurement opening 11, and thereby biosensor cartridge 9. Can be effectively introduced into the sampling port 29. According to the needle-integrated measurement device 1 of the present embodiment, when this reduced-pressure blood collection assist mechanism is provided, the puncture measurement device 5 is not provided with a dedicated sensor loading opening in the puncture measurement device 5. Since the biosensor cartridge 9 can be inserted using the essential measurement opening 11, the airtight opening and closing structure for sensor loading is omitted, the device structure is simplified, and the measurement success probability is improved while the manufacturing cost is reduced. Can be made.
Therefore, it is possible to provide the needle-integrated measuring apparatus 1 and the biosensor set 3 that can be easily measured with a simple structure.

The engaging means 13 according to the needle-integrated measuring apparatus 1 of the present embodiment includes an engaging groove 37 formed in a part of the outer peripheral portion of the biosensor cartridge 9 along the circumferential direction, and the cylindrical housing case 7. A locking projection 39 that is formed along a circumferential direction on a part of the inner peripheral portion and engages with the engaging groove 37 is provided.
Therefore, when the cylindrical storage case 7 that stores and holds the biosensor cartridge 9 is inserted in the axial direction of the measurement opening 11, the movement of the biosensor cartridge 9 is restricted in the cylindrical storage case 7. The held state is maintained. Then, by merely rotating the biosensor cartridge 9 and the cylindrical housing case 7 relative to each other about the axis, the locking projection 39 is released from the engaging groove 37, the axial movement restriction is released, and the cylindrical housing case 7 is released. The inner biosensor cartridge 9 can be punctured.

Furthermore, in the engaging means 13 of this embodiment, a pair of engaging grooves 37 are formed on both sides of the biosensor cartridge 9, and a pair of locking protrusions 39 are formed on the opposing inner wall surface of the cylindrical housing case 7.
Therefore, a pair of locking protrusions 39, 39 formed on the opposing inner wall surface of the cylindrical housing case 7 engages with the engaging grooves 39, 39 formed on both sides of the biosensor cartridge 9, and the biosensor cartridge 9 and the cylindrical storage case 7 can be stored and held on the same axis. This makes it difficult for the biosensor cartridge 9 to tilt during relative rotation, and makes it possible to improve the holding and releasing properties.

  FIG. 10 is a schematic configuration diagram of a needle-integrated measuring apparatus and a biosensor set according to another embodiment of the present invention, and FIGS. 11 and 12 are explanatory diagrams showing a sample collection procedure of the puncture measuring apparatus shown in FIG. is there. In addition, about the structural member substantially the same as the needle | hook integrated measuring apparatus 1 of the said embodiment, the same code | symbol is attached | subjected and detailed description is abbreviate | omitted.

  A needle integrated measurement apparatus 201 according to the present embodiment includes a biosensor cartridge 209 integrally provided with a puncture tool 25 and a biosensor chip 23, and a puncture measurement apparatus 205 that loads the biosensor cartridge 209 and performs puncture and measurement. Have.

  Furthermore, as shown in FIGS. 10 to 12, the needle-integrated measuring apparatus 201 according to the present embodiment accommodates and holds at least the elastic body 19 and the puncture device N of the biosensor cartridge 209, and one of the opening portions at both ends thereof. A cylindrical housing case 207 that is inserted into the measurement opening 211 of the puncture measuring device 205 together with the biosensor cartridge 209 so as to protrude outside the device, and is provided between the cylindrical housing case 207 and the biosensor cartridge 209. And an engaging means 213 capable of releasing the holding of the biosensor cartridge 209 after the biosensor cartridge 209 is attached to the puncture measuring device 205.

  The biosensor cartridge 209 has substantially the same configuration as that of the biosensor cartridge 9 of the above embodiment except that a locking projection 237 that constitutes the engaging means 213 is provided instead of the engaging groove 37.

  As shown in FIGS. 10 to 12, the cylindrical housing case 207 is formed in a cylindrical shape made of a resin material having transparency opened at both ends, and holds the biosensor cartridge 209 on the same axis. However, the cylindrical storage case 207 of this embodiment does not completely store and hold the entire biosensor cartridge as the cylindrical storage case 7 of the above embodiment, and covers at least the elastic body 19 and the puncture device N. Is to hold.

  On the inner peripheral surface of the device insertion side opening 207a of the cylindrical housing case 207, four engaging recesses 239 that constitute the engaging means 213 are formed along with four locking projections 237 described later. In addition, an annular groove 238 that functions as a positioning and retaining when inserted into the measurement opening 211 of the puncture measurement device 205 to perform puncture and measurement is provided on the outer peripheral surface of the device insertion side opening 7a of the cylindrical housing case 207. It is recessed.

The cylindrical housing case 207 holding the biosensor cartridge 209 is inserted into the measurement opening 211 of the puncture measurement device 5 together with the biosensor cartridge 209 (see FIG. 11B).
The engaging means 213 provided between the cylindrical housing case 207 and the biosensor cartridge 209 is in a state where the rear end portion 23c of the biosensor cartridge 209 is held and fixed to the terminal insertion portion 217, as will be described in detail later. By moving the cylindrical storage case 207 relative to the distal end opening 207b side, the holding of the cylindrical storage case 207 with respect to the biosensor cartridge 209 can be released.

  The cylindrical housing case 207 has a rear end portion 23c protruding from the device insertion side opening 207a for removing the biosensor cartridge 209 during use, and a terminal insertion portion 217 which is a connector portion of the puncture measuring device 205 (see FIG. 11). The biosensor cartridge 209 is attached to the measurement opening 211 of the puncture measuring device 205. Then, the cylindrical housing case 207 itself inserted into the puncture measuring device 205 can be used as the contact portion of the subject.

In other words, the cylindrical storage case 207 and the biosensor cartridge 209 constitute a biosensor set 203.
The biosensor set 203 is individually sealed and packaged in a packaging film (not shown) to hold the biosensor cartridge 209 in a sterile state. Further, by being accommodated in the cylindrical accommodation case 207, the user is not touching the elastic body 19 of the biosensor cartridge 209 or the puncture device N (see FIG. 3), and safety is ensured.

  In the biosensor set 203, the cylindrical housing case 207 also functions as an insertion assisting means for the biosensor cartridge 209, a contact portion with respect to the subject, and a protective cap for the puncture measuring device 205 with the biosensor cartridge 209 inserted. Will be. The biosensor set 203 can also be used as a disposal case after use of the biosensor cartridge 209. The biosensor set 203 is preferably disposable from the viewpoint of hygiene.

The engaging means 213 protrudes from the four engaging recesses 239 provided in the inner peripheral surface of the device insertion side opening 207 a of the cylindrical housing case 207 and the outer peripheral portion of the biosensor cartridge 209. It consists of four locking projections 237 that are press-fitted into the mating recesses 239, respectively.
Therefore, as shown in FIGS. 10 and 11, the biosensor cartridge 209 is engaged with an engaging recess 239 provided in the inner peripheral surface of the cylindrical housing case 207, so as to protrude from the outer peripheral portion of the biosensor cartridge 209. When the protrusion 237 is press-fitted and fitted, movement in the axial direction is restricted, and the protrusion 237 is held in the cylindrical housing case 207.

Then, when the cylindrical housing case 207 is relatively moved toward the front end opening 207b with the rear end portion 23c of the biosensor cartridge 209 held and fixed to the terminal insertion portion 217, as shown in FIG. The locking projection 237 is released from the engaging recess 239, and the movement restriction in the axial direction is released.
That is, the cylindrical housing case is inserted into the measurement opening 211 of the puncture measuring device 205 while the biosensor cartridge 209 is held by the cylindrical housing case 207, and the rear end portion 23c is held and fixed to the terminal insertion portion 217. The holding by the engaging means 213 is released by relatively moving only 207. That is, the biosensor cartridge 209 can be inserted without direct contact.

Then, as shown in FIG. 12 (a), the cylindrical housing case 207 moved relative to the tip opening 207b side has an annular groove 238 recessed in the outer peripheral surface of the device insertion side opening 7a. It fits into an O-ring 284 disposed in the opening of the opening 211 and is positioned and prevented from coming off.
In this state, since the rear end portion 23c of the biosensor cartridge 209 is inserted into the terminal insertion portion 217 of the drive unit 265, the biosensor cartridge 209 released from the engagement with the cylindrical housing case 207 is released. Is relatively moved in the axial direction of the cylindrical housing case 207 so that the puncture device N can be punctured.

Next, the operation of the above-described needle integrated type measuring apparatus 201 will be described.
In order to use the needle-integrated measuring apparatus 201 according to the present embodiment, first, the hermetically packaged biosensor set 203 is taken out of the packaging film, and the side portion of the cylindrical housing case 207 is picked with fingers, as shown in FIG. ), The rear end portion 23c of the biosensor cartridge 209 is inserted into the terminal insertion portion 217 of the driving portion 265. Therefore, the detection electrodes 49a and 49b of the biosensor cartridge 209 are inserted into the terminal insertion portion 217 of the puncture block 279, and the biosensor chip 23 is electrically connected to the control device 71.

Further, by pushing the biosensor set 203 into the measurement opening 211, the compression coil spring 75 of the drive unit 265 is compressed as shown in FIG. 11B, and the puncture block 279 is held in a puncturable state.
Next, when the cylindrical housing case 207 is relatively moved toward the distal end opening 207b, the engaging recess 239 is disengaged from the locking projection 237, and the annular groove 238 is formed into an O-ring as shown in FIG. It is fitted to 284 and positioned and retained. As a result, the biosensor cartridge 209 can move relative to the cylindrical housing case 207 in the axial direction, and can be punctured.

  In this state, as shown in FIG. 12B, the subject M is applied to the tip of the cylindrical housing case 207 to close the tip opening 207 b of the cylindrical housing case 207. The cylindrical storage case 207 inserted into the measurement opening 211 is projected and the tip opening 207b is pressed against the subject M, for example, a finger, for example, when puncturing with the inner biosensor cartridge 209. Used as positioning means.

When the puncture switch 68 is pressed in this state, the puncture block 279 is moved in the puncture direction by the biasing force of the compression coil spring 75, and the biosensor cartridge 209 is pressed by the puncture block 279.
Therefore, as shown in FIG. 12B, the biosensor cartridge 209 is punctured by the relatively projecting puncture instrument N because the elastic body 19 is pressed against the subject M and is compressed and deformed.

The elastic body 19 deformed by the pressing force returns to the original shape by the restoring force. Along with this, the biosensor cartridge 209 is slightly retracted, and the puncture instrument N is removed from the subject M.
When the puncture device N is removed from the subject M, blood (sample) B flowing out from the puncture hole is guided to the sample collection port 29 opened at the tip of the biosensor chip 23, and a hollow reaction is performed from the sample collection port 29. It flows into the part 51.

  Note that the needle-integrated measurement device 201 according to the present embodiment applies a negative pressure to the puncture measurement device 205 from a decompression-type blood collection assisting mechanism (not shown) immediately before pressing the puncture switch 68, and passes through the measurement opening 211. To act on the biosensor cartridge 209. Thereby, the blood B flowing out from the puncture hole is efficiently sucked into the sample collection port 29 of the biosensor chip 23.

That is, according to the needle-integrated measuring apparatus 201 of the present embodiment described above, the biosensor cartridge can be obtained simply by inserting the cylindrical housing case 207 that houses and holds the biosensor cartridge 209 into the measurement opening 211 of the puncture measuring apparatus 205. 209 can be attached to the puncture measuring device 205, and puncture, sampling, and measurement can be performed by a single operation of the puncture switch 68.
Therefore, it is possible to provide the needle-integrated measurement device 201 and the biosensor set 203 that can be easily measured with a simple structure.

Furthermore, the biosensor cartridge 209 held in the cylindrical housing case 207 has the rear end portion 23c including the detection electrodes 49a and 49b exposed, so that it can be inserted into the measurement opening 211 of the puncture measuring device 205. Is easy to insert.
Further, after the biosensor set 203 is pushed into the measurement opening 211 to compress the compression coil spring 75 of the drive unit 265 and the puncture block 279 is held in a puncturable state, the cylindrical housing case 207 is relatively moved toward the distal end opening 207b. It is moved and positioned and retained. Therefore, a sufficient movement stroke can be secured between the distal end portion of the biosensor cartridge 209 held by the puncture block 279 and the distal end opening portion 207b of the cylindrical storage case 207, and a satisfactory puncture operation is possible. It becomes.

In the above embodiment, the puncture block 279 of the drive unit 265 is driven in the puncture direction by pressing the puncture switch 68. However, the tip of the cylindrical housing case 207 is pressed against the subject M. Then, this may be detected and the puncture block 279 of the drive unit 265 may be driven in the puncture direction.
In each of the above embodiments, the needle-integrated measurement devices 1,201 using the biosensor cartridges 9, 209 in which the biosensor chip 23 is integrated with the puncture tool 25 have been described as an example. Alternatively, the present invention can be applied to a puncture device that strikes only the puncture tool accommodated and held in the cylindrical accommodation case. Even in this case, when the puncture device is mounted on the puncture measurement device, it can be mounted without direct contact, and the user can be prevented from being injured by accidentally touching the needle or the like of the puncture device.

It is a lineblock diagram of a needle integrated measuring device and a biosensor set concerning one embodiment of the present invention. It is a disassembled perspective view of the biosensor set shown in FIG. FIG. 3 is an exploded perspective view of the biosensor cartridge shown in FIG. 2. It is a front view of the biosensor set showing the engagement state and the engagement release state of the engagement means. The state before a drive part retreat of a puncture measuring device is shown, (a) is a partial section front view, and (b) is a longitudinal section. It is a longitudinal cross-sectional view after the drive part retreat of a puncture measuring apparatus. It is explanatory drawing showing the procedure of sample collection, (a) is a longitudinal cross-sectional view of a puncture measuring apparatus, (b) is a principal part expanded sectional view. It is explanatory drawing showing the procedure of sample collection, (a) is a longitudinal cross-sectional view of a puncture measuring apparatus, (b) is a principal part expanded sectional view. It is explanatory drawing showing the procedure of sample collection, (a) is a longitudinal cross-sectional view of a puncture measuring apparatus, (b) is a principal part expanded sectional view. It is a schematic block diagram of the needle integrated measuring apparatus and biosensor set which concern on other embodiment of this invention. It is explanatory drawing showing the procedure of the sample collection of the puncture measuring apparatus shown in FIG. 10, (a) shows the state before a drive part backward movement, (b) shows the state after a drive part backward movement. It is explanatory drawing showing the procedure of sample collection of the puncture measuring apparatus shown in FIG. 10, (a) shows the completion state of mounting | wearing of a biosensor set, (b) shows the state after completion of puncture. (A) is a perspective view which shows the conventional biosensor chip. (B) is an exploded perspective view showing a conventional biosensor chip.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Needle integrated measuring device 3 ... Biosensor set 5 ... Puncture measuring device 6 ... Device main body 7 ... Cylindrical storage case 7a ... Device insertion side opening 7b ... Tip opening 9 ... Biosensor cartridge 13 ... Engaging means 15a , 15b ... Sealing sealing material 25 ... Puncture tool 37 ... Engaging groove 39 ... Locking protrusion

Claims (5)

A biosensor cartridge integrally including a puncture device and a biosensor chip;
A cylindrical storage case that holds and holds the biosensor cartridge, and is inserted into a measurement opening of a puncture measurement device together with the biosensor cartridge;
Engagement means provided between the cylindrical housing case and the biosensor cartridge, and capable of releasing the holding of the biosensor cartridge;
A biosensor set comprising: The engaging means is formed along the circumferential direction in a part of the inner peripheral part of the cylindrical housing case, and the engaging groove formed along the circumferential direction in a part of the outer peripheral part of the biosensor cartridge, A locking projection that engages with the engaging groove,
2. The biosensor according to claim 1, wherein the engagement between the engagement groove and the engagement protrusion can be released by rotating the biosensor cartridge and the cylindrical housing case relative to each other about an axis. set. A pair of the engaging grooves are formed on both sides of the biosensor cartridge,
The biosensor set according to claim 2, wherein a pair of the locking protrusions are formed on the opposing inner wall surfaces of the cylindrical housing case.   The biosensor set according to any one of claims 1 to 3, wherein both ends of the cylindrical housing case are sealed with a peelable sealing material. A needle-integrated measurement device having a puncture measurement device that performs puncture and measurement by loading a biosensor cartridge integrally provided with a puncture device and a biosensor chip,
A cylindrical storage case that is inserted into the measurement opening of the puncture measurement device together with the biosensor cartridge so that one of both end openings protrudes out of the device while holding and holding the biosensor cartridge;
Engagement means provided between the cylindrical housing case and the biosensor cartridge, and capable of releasing the biosensor cartridge after the biosensor cartridge is attached to the puncture measurement device;
A needle-integrated measuring apparatus comprising:

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