JP2003313110A - Skin pressure-sensitive adhesive sheet - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin pressure-sensitive adhesive sheet moderately evaporating water and having excellent preventing effects on strike of water, an oil ingredient, or the like, through a support. <P>SOLUTION: The skin pressure-sensitive adhesive sheet has a layer comprising an aqueous gel-like composition on the support subjected to a water-repellent treatment. The support is preferably a nonwoven fabric or a woven fabric. The water-repellent treatment is carried out by, e.g. dipping of the support. The applied skin to which the skin pressure-sensitive adhesive sheet is applied can be maintained in a wet state for a long time. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin pressure-sensitive adhesive sheet, and more particularly to a skin pressure-sensitive adhesive sheet used in the fields of medicine such as poultices and poultices and in the field of skin care such as cosmetic packs.

[0002]

2. Description of the Related Art Skin care products for improving symptoms such as dry skin, rough skin, and cracks and for the purpose of providing beautiful skin include active ingredients such as moisturizing ingredients, softening agents, blood circulation promoters such as vitamin E, anti-inflammatory agents, vitamin C, etc. It contains a skin beautifying component and the like, and exerts its effect by permeating such an active component into the skin. Also, for the treatment of diseases such as poultices and poultices,
It exerts a cooling effect by water, a moisturizing effect by a plaster or the like, and a transdermal absorption of the active ingredient to exert its effect. In order to penetrate the skin with the active ingredient, it is preferable to keep the skin in a wet state and form a wet state (hydrated state) on the skin surface.

Packing agents containing a whitening agent or a moisturizing agent and a water-soluble polymer and having a film-forming ability are commercially available. However, the conventional pack agents have stains on the hands during application or adhesive residue when peeled off. It was easy to occur.

Therefore, the active ingredients such as poultices, poultices, cosmetic packs and the like are mixed with an adhesive and applied to the skin, and the support is impregnated with the adhesive in order to absorb the active ingredient into the body through the skin. Sheet-shaped products for treating diseases and skin care products that have been applied or applied have been developed. Further, as a cooling sheet having an antipyretic effect, a sheet-shaped product in which a support is impregnated with water or the like has been developed. However, in the case of conventional products, the moisture and oil components contained in the adhesive layer may exude from the back surface of the support (strike through) during the manufacture or storage of the product, resulting in stains and stickiness. It was inconvenient to handle and gave the wearer discomfort. In addition, the strike-through may change the water content or the concentration of the active ingredient, or some of the active ingredient may be lost to reduce the effect.

Therefore, sheet-shaped products are being developed in consideration of strike-through prevention. For example, Japanese Patent Laid-Open No. 11-1
Japanese Patent No. 30624 discloses a pack agent sheet obtained by impregnating or applying a pack agent composition containing a high-purity poly (meth) acrylic acid salt from which residual monomers are removed onto a base cloth or the like. There are disadvantages that the effect of preventing the exudation of the components and the like is not sufficient, and that a step of purifying the residual monomer is required, resulting in high cost. JP-A-11-1
Japanese Patent No. 30664 discloses a sheet-like pack obtained by impregnating or applying a patch composition containing a water-soluble polymer substance and water on a support made of a non-woven fabric of ultrafine fibers. The oil component, which is easily wettable, oozes out from the support. Japanese Unexamined Patent Publication No. 11-130665 discloses a sheet-like pack obtained by impregnating or applying a composition containing a poly (meth) acrylate, water and a cross-linking agent on a base cloth. After a lapse of time, water and the like began to seep into the support. Japanese Patent Laid-Open No. 2000-14350
Japanese Unexamined Patent Publication (Kokai) No. 3 discloses an external-use patch in which a pressure-sensitive adhesive layer is laminated on a support made of a porous synthetic resin film having fine pores, but has a drawback that an oil component migrates to the synthetic resin film. . Japanese Unexamined Patent Publication No. 2001-302447 discloses a sheet-like pack agent in which a pressure-sensitive adhesive layer containing a water-soluble polymer, a polyhydric alcohol and water in a predetermined blending amount is provided on a support. However, a gel plaster having appropriate physical properties could not be obtained. Japanese Unexamined Patent Publication No. 2001-321395 discloses a patch for external use, which uses a laminate in which cloths are laminated and a part of the cloths is partially adhered as a support, but the oil component is easily wettable. Is oozing out. JP 20
In the case of using a support laminated with a plastic film such as a cosmetic gel sheet having a hydrogel layer laminated on a polyester film laminated rayon nonwoven fabric disclosed in JP-A-00-119129 Although excellent in the prevention effect, there was a problem that the cooling effect could not be obtained because water evaporation from the support did not occur. Water and oil in the pressure-sensitive adhesive layer have a cooling effect and a transdermal absorption effect of the active ingredient. Therefore, a relatively large amount of water may be contained in the pressure-sensitive adhesive layer, and even in such a case, development of a product having a strike-through prevention effect has been desired.

[0006]

SUMMARY OF THE INVENTION The present invention has been made to solve the above problems, and an object of the present invention is to make it possible to evaporate water to an appropriate degree, and to set water and oil. It is an object of the present invention to provide a skin adhesive sheet having an excellent effect of preventing strike-through of a component such as a support.

[0007]

The skin adhesive sheet of the present invention is characterized in that a layer made of an aqueous gel composition is provided on a water-repellent support. Here, the water repellent treatment can be performed by dipping the support. Further, the water repellent treatment is preferably a fluorine-based water repellent treatment. The support may be a non-woven fabric or a woven fabric. Further, the aqueous gel composition can contain polyacrylic acid and / or polyacrylic acid salt, carboxyvinyl polymer, polyhydric alcohols, water, and a crosslinking agent as essential components. Further, the aqueous gel-like composition may contain at least one selected from the group consisting of anti-inflammatory and analgesic ingredients, fragrances, cell-activating ingredients, skin beautifying ingredients and oil ingredients. Further, the aqueous gel composition may be crosslinked with a polyvalent metal salt.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The skin-adhesive gel sheet of the present invention has a layer made of an aqueous gel composition on a water-repellent support. Here, as the support, a cloth such as a woven cloth or a non-woven cloth is preferably used. The skin-adhesive gel sheet of the present invention may have a release liner or the like on the surface of the layer composed of the gel composition. FIG. 1 shows a layer structure of a skin adhesive sheet according to an embodiment having a release liner. In this embodiment, a layer 2 made of a gel composition is provided on one surface of a support 1 that has been subjected to a water repellent treatment, and a release liner 3 is provided on the layer 2 made of the gel composition. Has been. The release liner 3 may be subjected to a release treatment such as a silicone treatment.

The skin-adhesive sheet of the present invention comprises a water-repellent support and a layered aqueous gel composition comprising, for example, the components described below. As the support to be used, a support having flexibility so as to have conformability to the skin surface is preferable, and it is preferable that the support is thin. For example, cloth or the like can be used, and those having a basis weight of 20 to 200 g / m ² can be preferably used. It is preferable to use a cloth such as a non-woven fabric or a woven fabric in terms of air permeability, anchorability with a gel-like composition or the like, cost, and the like, and knitted fabric or felt can also be used. To apply the skin adhesive sheet to the skin surface and to permeate the applied skin surface with the active ingredient such as the cell activating component contained in the aqueous gel-like composition, sufficiently hydrate the applied skin surface. Is important, and it may be effective to increase the content of water or polyhydric alcohol. Even when the aqueous gel composition containing a large amount of water or the like is used, it is impregnated and held inside the support by using a support such as a cloth, and thus the skin adhesive force is unlikely to decrease.

The material of the support is not particularly limited, but examples thereof include polypropylene, polyethylene, polyester, polyether polyurethane, polyester polyurethane, nylon, rayon, cellulose and cotton. For example, any of natural fibers and artificial fibers can be used, and examples of the natural fibers include cotton, kapok, flax, ramie, cannabis, jute, spiro, Manila hemp, sisal, Coyer fiber, and other plant fibers, domestic silkworms. Animal fibers such as silk, wool, cashmere, camel hair, alpaca hair, mohair, rabbit hair and the like can be mentioned, and artificial fibers include regenerated fibers such as human silk thread, suf and viscose, polyamide fibers, polyester fibers. , Polyacrylic fiber, polyvinyl alcohol fiber, polyalkylene paraoxybenzoate fiber, polyurethane fiber, polyvinylidene chloride fiber, polyacrylonitrile fiber, polyethylene fiber, synthetic fiber such as polypropylene fiber, acetic acid artificial fiber, etc. As mentioned above, a semi-synthetic fiber obtained by copolymerizing a natural substance and a synthetic substance can be used. In addition,
It also includes various composite fibers and split fibers split by a water jet.

The method for producing the non-woven fabric is not particularly limited and can be produced by either a dry method or a wet method. Examples include those in which the fibers are three-dimensionally entangled by water entanglement such as a water jet, and nonwoven fabrics having an ultrafine fiber dense structure such as melt blow.

In the present invention, it is preferable that the support such as the above-mentioned non-woven fabric or woven fabric is subjected to a water repellent treatment. For example, it is preferable that the support is subjected to water repellent treatment by means of dipping or the like instead of mere spraying. Examples of the water repellent treatment include a fluorine-based water repellent treatment, a silicone-based water repellent treatment, a paraffin-based water repellent treatment, and the like. The fluorine-based treatment is particularly preferable because it has an excellent oil repellent effect. By thus subjecting the support to the water repellent treatment, it is possible to prevent the water and oil components of the aqueous gel composition from seeping out to the back surface of the support.

The aqueous gel composition according to the present invention is an aqueous gel composition used for poultices, cooling agents, packs and the like. Considering cooling feeling, adhesive property, softness of gel, prevention of adhesive residue, etc., examples of the above aqueous gel composition include polyacrylic acid and / or polyacrylic acid salt, carboxyvinyl polymer, polyhydric alcohol, water, It is preferable to use an aqueous gel composition containing a crosslinking agent as an essential component.

Polyacrylic acid and / or polyacrylic acid salt forms a basic skeleton of the gel composition, and has a three-dimensional skeleton in a state where a cross-linking structure is formed by an external cross-linking agent described later and other components are incorporated. To form. Therefore, the skin surface can be kept wet and the skin surface can be kept wet (hydrated state) for a long time. As a result, the active ingredient can be effectively penetrated into the skin. As such polyacrylic acid and / or polyacrylic acid salt, those having a weight average molecular weight of 20,000 to 10,000,000 are preferably used, and more preferably a weight average molecular weight of 100.
It is from 10,000 to 7 million. Further, the polyacrylic acid and / or the polyacrylic acid salt is preferably contained in an amount of about 2 to 30% by weight, and about 3 to 30% by weight based on the total amount of the aqueous gel composition.
It is more preferable that the content is within the range of 10% by weight. About 2 to 30% by weight of polyacrylic acid and / or polyacrylate having a weight average molecular weight of 20,000 to 10 million
By containing it, it becomes easy to form a three-dimensional skeleton in the layer composed of the aqueous gel composition.

The salt of the polyacrylic acid salt is not particularly limited as long as it is a pharmacologically acceptable salt, and examples thereof include sodium salt, potassium salt and triethanolamine salt. Of these, sodium polyacrylate is preferably used from the viewpoint of easy availability. Further, in order to exert a keratin softening effect, it is desirable to make the pH of the aqueous gel-like composition weak alkaline of 8 to 9, but when sodium polyacrylate is used, the pH of the aqueous gel-like composition is 8 to 9. It becomes easy to adjust to 9 weak alkaline. When the skin-adhesive sheet of the present invention is used as a cosmetic sheet, it is often attached to skin that is sensitive to irritation, such as the face. It is preferred that the composition does not lean toward acidity. In this case, it is preferable to adjust the mixing ratio of polyacrylic acid and polyacrylic acid salt within the range of 0:10 to 7: 3. In particular, the aqueous gel composition is p
It is preferable to adjust from H5 to 7 weakly acidic to neutral. By adjusting the mixing ratio of polyacrylic acid and polyacrylic acid salt within the range of 3: 7 to 5: 5, it becomes easy to adjust the aqueous gel composition within the above-mentioned pH range. In the present invention, a partially neutralized product of polyacrylic acid may be used instead of the mixture of polyacrylic acid and polyacrylic acid salt. Here, the partially neutralized product of polyacrylic acid means, for example, a product obtained by neutralizing a part of polyacrylic acid with sodium hydroxide or the like.

Examples of the polyhydric alcohols contained in the aqueous gel composition include glycols such as ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol and polypropylene glycol, in addition to glycerin and sorbitol.
Diols such as 1,3-propanediol and 1,4-butanediol can be used. These can be used alone or in combination of two or more. Of these, glycerin is preferably used from the viewpoints of moisturizing power, appropriate gel strength, solubility and uniform dispersibility of the material in terms of production. The polyhydric alcohol acts as a plasticizer for polyacrylic acid and / or polyacrylate,
It retains water and also has a moisturizing effect. The content of the polyhydric alcohol is 10 to 50% by weight in the aqueous gel composition.
Is preferable, and more preferably 20 to 40% by weight.

The water contained in the aqueous gel composition is an important component for hydrating the skin portion to which the skin adhesive sheet of the present invention is applied in a wet state. Water is preferably contained in the aqueous gel composition within the range of 10 to 90% by weight, and more preferably within the range of 30 to 70% by weight. When the water content is less than 10% by weight,
The hydration effect of the skin (stratum corneum) may not be sufficient, and if it exceeds 90% by weight, the mechanical strength of the gel layer may be insufficient when the gel layer is formed on the support. In addition, when the gel layer is formed in the support, there is no problem in strength.

The external cross-linking agent to be added to cross-link polyacrylic acid and / or polyacrylic acid salt is aluminum hydroxide, potassium alum, aluminum sulfate, aluminum glycinate, aluminum acetate, aluminum oxide, metasilicic acid. Examples thereof include polyvalent metal salts such as aluminum, magnesium chloride, calcium hydroxide and calcium carbonate, polyvalent metal hydroxides and polyvalent metal oxides. Dry aluminum hydroxide gel is preferable because it is easily available and the amount of the mixture can be easily determined.

The amount of these cross-linking agents to be blended differs depending on the type of the cross-linking agents and therefore cannot be unconditionally limited, but is usually set to about 0.1 to 5% by weight based on the total amount of the aqueous gel composition. Preferably. If the blending amount of the cross-linking agent is too small, the cross-linking is not sufficiently performed, the retention of other components such as polyhydric alcohols and water is deteriorated, and the mechanical strength of the gel layer itself is lowered. On the other hand, if the blending amount is too large, the crosslinking becomes too strong, the obtained gel layer becomes hard and inferior in flexibility, and the retention of other components tends to decrease.

In the present invention, a carboxyvinyl polymer is further added to the gel composition. The carboxyvinyl polymer is a copolymer in which acrylic acid is mainly used and a small amount of allyl sucrose or the like is arranged therein, and a part of the carboxyvinyl polymer is crosslinked. As the carboxyvinyl polymer, for example, those commercially available under the trade names "Carbopol" (manufactured by BF Goodrich), "Hibiswako" (manufactured by Wako Pure Chemical Industries), Junron (manufactured by Nippon Pure Chemical Co., Ltd.), etc. Can be obtained. The carboxyvinyl polymer may be used in the acid state or in a state where a part or all of the carboxyvinyl polymer is neutralized.

A moisturizing action lasts for a long time and a sufficient effect of the active ingredient is exerted even by an aqueous gel composition comprising polyacrylic acid and / or polyacrylic acid salt, polyhydric alcohol, crosslinking agent and water. Although it is possible to obtain a layer composed of an aqueous gel-like composition that can be used, since the adhesive property to the skin is weak, the cosmetic gel sheet attached to the skin is easily dropped off during daily activities. As a result, the skin may not be sufficiently hydrated or the active ingredient may not be sufficiently released.
On the other hand, if the gel composition is made to be in a soft state in order to increase the adhesive force, dripping may occur or adhesive residue may occur at the time of peeling.

However, if a carboxyvinyl polymer is further added to the aqueous gel composition, such a problem can be solved. This is because a part of the polyacrylic acid and / or the polyacrylic acid salt is replaced with the carboxyvinyl polymer, and the carboxyvinyl polymer itself exerts the function of internal cross-linking to cure the layer composed of the aqueous gel-like composition. Is considered to be. Therefore, the compounding amount of the crosslinking agent can be reduced by compounding the carboxyvinyl polymer with the polyacrylic acid and / or the polyacrylic acid salt. As a result, it is possible to form a layer composed of an aqueous gel composition that does not cause problems such as dripping and adhesive residue at the time of peeling, and does not impair the adhesive force, so that sufficient moisture is replenished to the skin. It is possible to obtain a skin-adhesive sheet that can be carried out and can sufficiently release the active ingredient.

The carboxyvinyl polymer having such a function has a weight average molecular weight of about 1,000,000 to 40.
It is preferable to use one having a capacity of 0,000, and more preferably about 2,000,000 to 3,000,000.
At this time, the amount of carboxyvinyl polymer substituted is generally 10% to 50% of the polyacrylic acid and / or polyacrylic acid salt, and the compounding amount is 0. It is preferably 1 to 10% by weight, more preferably about 1 to 5% by weight. If the amount of the carboxyvinyl polymer compounded is too small, the adhesive force required for the layer composed of the aqueous gel composition cannot be obtained, and if it is too large, the viscosity of the aqueous gel composition becomes high and mixing and stirring becomes difficult.

In the present invention, it is preferable to further add polyvinylpyrrolidone to the aqueous gel composition. By adding polyvinylpyrrolidone, the adhesive strength can be further improved without causing dripping or adhesive residue at the time of peeling. As polyvinylpyrrolidone,
The weight average molecular weight is preferably 5,000 to 5,000,000, more preferably 20,000 to 1,200,000. The blending amount is appropriately set according to the type and blending amount of the cross-linking agent, the polyhydric alcohol, and the active ingredient, and is, for example, 0.1 to 10% by weight in the total amount of the aqueous gel composition. It is preferable that the amount is 1 to 6% by weight. If the blending amount of polyvinylpyrrolidone exceeds 10% by weight, the adhesive strength will be too strong and will give a strong irritation to the skin when peeled off, and the viscosity of the aqueous gel composition will become large, so mixing and stirring becomes difficult. Become.

Further, in order to reinforce the gelation, other water-soluble polymers such as gelatin and carboxymethyl cellulose sodium salt may be blended within a range that does not impair the effects of the present invention.

When the skin adhesive sheet of the present invention is used for skin care, in order to improve each skin condition,
In addition to the aqueous gel composition, cell activating component, oil component,
Any of the skin beautifying components can be blended, and if necessary, two or more of these components can be blended.

Examples of the cell activating component that is preferably used include ginseng extract. The ginseng extract may be a natural product or a culture obtained by tissue culture such as callus induction, but it is preferable to use a cultured ginseng extract that stably contains components such as saponin without variation. preferable. From the viewpoint of effectiveness of the component, the amount of the cell activating component is preferably about 0.01 to 5% by weight, and more preferably about 0.01 to 1% by weight in the aqueous gel composition. .

Examples of the oil component include olive oil, camellia oil, cottonseed oil, liquid paraffin, silicone oil, cetyl alcohol, stearyl alcohol, oleyl alcohol, squalane, lanolin and the like. Of these, from the viewpoint of low irritation to the skin,
Preference is given to using olive oil. The amount of such an oil component added is 5 to 60 in the layer made of the gel composition in order to give a moist feeling to the applied skin surface and to effectively exert an effect on dry skin, rough skin and the like. It is desirable to adjust the content to be in the range of 20% by weight, preferably 20 to 40% by weight.

Further, when the oil component is blended, since the water-based gel composition contains a relatively large amount of water,
Water and oil components are likely to separate. Therefore, in such a case, a surfactant is allowed to coexist with water and an oil component, so-called oil-in-water type (O / W: Oil in W).
It is preferable to emulsify into a state of ater) to obtain a uniform dispersion state. As the surfactant used, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene polyoxypropylene glycol, polyhydric alcohol fatty acid partial ester,
Examples thereof include polyoxyethylene polyhydric alcohol fatty acid partial ester, fatty acid salt, polyoxyethylene alkyl ether sulfate, and alkyl sulfonic acid. They are,
0.1 to 5% by weight based on the total amount of the aqueous gel composition
It is preferable to add a certain amount.

In the present invention, a skin beautifying component may be blended in place of the above-mentioned cell activating component or oil component or together with these active components. As the skin beautifying component, various active substances for skin beautification that have been used in conventional cosmetics can be used, and for example, L-serine and L
-Amino acids such as ascorbic acid, enzymes such as lysozyme chloride, vitamins such as ascorbic acid and tocopherol acetate, placenta extracts, peptides, proteins, organic acids, urea, inorganic ions, various herbal extracts, animal and plant extracts, etc. You can In general, the content of these components is preferably 0.01 to 20% by weight in the aqueous gel composition.

Further, depending on the use, for example, a pack or the like may contain a skin lightening substance. As the skin whitening substance used, various skin whitening substances used in conventional cosmetics and the like can be used, for example, ascorbic acid, ascorbic acid monopalmitate, ascorbic acid dipalmitate, ascorbic acid stearate, ascorbic acid. Acid monoethylhexanoate, ascorbic acid diethylhexanoate, ascorbic acid sodium salt,
Examples include kojic acid, sugar amines, hydroquinones, mercapto group-containing compounds, lecithin and the like.

In the present invention, vitamin E as a blood circulation promoter, glycyrrhizic acid as an anti-inflammatory agent and the like can be appropriately added. Further, in addition to known fillers, dyes, pigments and the like can be added. Furthermore, anti-fungal agents such as para-oxybenzoic acid and its ester, and antioxidants such as BHT can be added.

Depending on the application, the aqueous gel composition may contain a keratin softening agent. As a keratin softener,
Lactic acid, lactate, urea, salicylic acid, salicylate, triethanolamine, sodium hydroxide, potassium hydroxide and the like can be mentioned. Of these, it is preferable to use lactic acid, lactate and / or urea from the viewpoint of low irritation to the skin. From the viewpoint of effectiveness, the amount of the keratin softening agent is 0.1 to 3% by weight in the case of lactic acid or lactate and 1 to 20% in the case of urea with respect to the total amount of the gel composition. %, 0.1 in the case of salicylic acid or salicylate
In the case of 2% by weight, triethanolamine and sodium potassium hydroxide, the pH of the aqueous gel composition is 8 to
It is preferable that the compounding amount be such that 9 exhibits weak alkalinity.

Further, in the present invention, other auxiliary ingredients usually added to cosmetics, for example, hyaluronic acid, placenta extract, moisturizers such as various amino acids, emollients such as squalane, lanolin and ceramide, and ingredients having a slimming effect. As seaweed extracts such as kelp, wakame, hibamatata, and hijiki, sesame oil, hamamelis, ginseng, peppermint, pearl barley, tea, ginkgo leaves, rice bran, vegetable oils such as aloe, animal oils such as mink oil and horse oil, and the deep sea. Animal extracts such as sharks, fungi extracts such as shiitake mushrooms, narcissus, moss, and cordyceps, various animal and plant extracts such as polyamino acids, lipoamino acids, microbial metabolites of sarcphantin, kojic acid, hyaluronic acid, 1-menthol , Cooling agents such as capsicum extract, fragrance, L-menthol, L-isopulegol, 3- ( - menthoxy) propane-1,2
-Diole, paramenthane-3,8-diol, various cooling sensation agents such as peppermint oil and camphor, and various warming sensation agents such as capsicum extract can be blended.

In the aqueous gel composition, preservatives, antioxidants, tackifiers, solubilizers, inorganic fillers, pH adjusters, etc., which have been used in conventional skin care products and the like, are appropriately mixed. It may have been done. Examples of the preservative include ascorbic acid, propyl gallate, butylhydroxyanisole, dibutylhydroxytoluene, and tocopherol acetate. Examples of the tackifier include casein, pullulan, agar, dextran, sodium alginate, soluble starch, carboxymethylcellulose, methylcellulose, polyvinylpyrrolidone and the like. Examples of the solubilizer include benzyl alcohol, peppermint oil, isopropyl myristate, and corotamiton. Examples of the dye include legal dyes such as Red No. 2, Red No. 3, Yellow No. 4, Green No. 3, and Blue No. 1. As an inorganic filler,
Examples thereof include titanium oxide, talc, zinc oxide, hydrous silica, magnesium carbonate, magnesium silicate, bentonite and the like. Examples of the pH adjusting agent include acetic acid, formic acid, lactic acid, tartaric acid, oxalic acid, citric acid, sodium hydroxide, potassium hydroxide, methylamine, ethylamine, triethanolamine and the like.

The thickness of the layer composed of the gel composition formed on the support is preferably in the range of 0.05 to 5 mm, more preferably about 0.3 to 2 mm.
When the thickness of the layer is less than 0.05 mm, the moisture retention effect may be weakened because the layer dries relatively quickly. On the other hand, if the thickness of the layer is thicker than 5 mm, you may feel uncomfortable when sticking,
A large amount of the gel composition may remain on the skin surface at the time of peeling from the skin surface, or the gel sheet may become heavy and may peel off from the surface of the support.

In the present invention, a layer composed of a gel composition and a layer composed of a pressure-sensitive adhesive composition are used in order to prevent the adhesion to the skin from being deteriorated due to the progress of drying due to continuous application for a long time. By arranging them alternately, for example, as shown in FIG.
As shown in (a), the layers 4 composed of the aqueous gel composition and the pressure-sensitive adhesive layers 5 are alternately arranged in a striped pattern, or as shown in FIG. 2 (b), they are alternately arranged in a zigzag pattern. By placing
It is possible to secure stable long-term skin adhesion.
The arrangement of the layer composed of the aqueous gel composition and the pressure-sensitive adhesive layer is not limited to those shown in FIGS. 2 (a) and 2 (b). The layers may be arranged, and the design is appropriately changed.

The adhesive used in the present invention may be a lipophilic adhesive or a hydrophilic adhesive,
When applied to an external patch, such as a poultice or a cold / heat sheet, which has an effect on drug efficacy due to evaporation of water or a problem of exudation of a drug, it is preferable to use a hydrophilic adhesive. Specifically, polyisobutylene rubber, polyisoprene rubber (styrene-isoprene-styrene) block copolymer rubber, synthetic rubber such as acrylic rubber, silicone rubber or rubber-based adhesive such as natural rubber, acrylic adhesive Agent, polyurethane adhesive, polyamide adhesive, polyvinyl chloride adhesive, polyethylene adhesive, ethylene-vinyl alcohol copolymer adhesive, ethylene-vinyl acetate copolymer adhesive, ethylene-methacrylic acid copolymer Adhesives, ethylene-ethyl acrylate copolymer adhesives, hydrophilic acrylic polymer adhesives, polyvinyl acetal adhesives, polyvinyl alcohol adhesives, cellulose adhesives, vinyl acetate adhesives (silicone adhesives ) Etc. can be used.

In the present invention, the layer composed of the gel composition is used until the time of use to prevent contamination, evaporation and volatilization of each component, or the layer composed of the gel composition and the pressure-sensitive adhesive composition is used until the time of use. A release liner can be provided for protection. Examples of the release liner include a polyester film that has been subjected to a release treatment such as a silicone treatment.
Further, in order to surely prevent evaporation and volatilization of each component, it is preferable that the entire sheet be hermetically packed in a packaging material or the like.

[0040]

EXAMPLES The present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples and various applications are possible without departing from the technical idea of the present invention. is there. In the following examples, “part” means “part by weight” and “%” means “% by weight”.

Example 1 First, a water-repellent support is prepared. A trade name "Asahi Guard AG-8025" (manufactured by Asahi Glass Co., Ltd.) as a fluorine-based water repellent treatment agent was diluted with purified water to a concentration of 5%. A polyester non-woven fabric (basis weight: 100 g / m ² ) was immersed as a support in the diluting solution of the fluorine-based water repellent treatment, subjected to dipping treatment, and then excess liquid was squeezed and removed. This was dried at 130 ° C. for 3 minutes to form a release-treated support. Next, a layer composed of the aqueous gel composition is formed. 45 parts of water, partially neutralized polyacrylic acid (weight average molecular weight 400
In the meantime, a mixture of 5 parts of 50% neutralized with sodium hydroxide in a molar ratio) and 30 parts of glycerin is quickly added and dissolved. Next, 1 part of powder of carboxyvinyl polymer (trade name "Hibiswako 104", manufactured by Wako Pure Chemical Industries, Ltd.) is gradually added and dissolved. To this, 1.6 parts of polyoxyethylene alkyl phenyl ether (trade name "Neugen EA-190D", manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd.) was added as an emulsifier, and an oil component containing 0.1 part of methylparaben and 16 parts of squalane. 17 parts were added, and the mixture was stirred and uniformly mixed using a kneader. 0.3 part of dried aluminum hydroxide gel was added to this and uniformly dispersed. This is spread on a fluorine-treated support so that the thickness of the layer made of the aqueous gel composition is 1 mm, and heat-treated at 60 ° C. for 1 day to cause gelation, and the aqueous solution is applied on the support. A layer composed of the gel composition was formed. In this way, a skin adhesive sheet having a layer made of the aqueous gel composition on the water-repellent support was produced. In addition, until use
A release liner may be placed on the layer composed of the aqueous gel composition.

(Example 2) In Example 1, the fluorine-based water repellent agent was traded as "Asahi Guard AG-8025".
(Asahi Glass Co., Ltd.) was diluted with purified water to a concentration of 1% and the same as Example 1 except that an acrylic ultrafine nonwoven fabric (basis weight 100 g / m ² ) was used as a support. Then, a skin adhesive sheet was prepared.

(Example 3) In Example 1, the fluorine-based water repellent agent was traded as "Asahi Guard AG-8025".
Example 1 except that a diluting solution (made by Asahi Glass Co., Ltd.) was diluted with purified water to a concentration of 0.5% and a cotton spunlace nonwoven fabric (basis weight 60 g / m ² ) was used as a support. A skin adhesive sheet was prepared in the same manner as in.

(Example 4) In Example 1, instead of the fluorine-based water repellent agent, a silicone-based water repellent agent (trade name "Silicone for fiber SM8070", manufactured by Toray Dow Corning Silicone Co., Ltd.) was added with purified water. Skin was prepared in the same manner as in Example 1 except that a diluting solution diluted to 5% was used and a polyester non-woven fabric (basis weight 100 g / m ² ) was used as a support with the dipping solution. An adhesive sheet was produced.

(Example 5) In Example 1, instead of the fluorine-based water repellent agent, a paraffin-based water repellent agent (trade name "Santor WP", manufactured by Nika Kagaku Co., Ltd.) was added to the purified water to a concentration of 5%. Use a diluting solution diluted to obtain a polyester nonwoven fabric (basis weight 1
A skin adhesive sheet was produced in the same manner as in Example 1 except that the dipping treatment was applied to 00 g / m ² ).

(Comparative Example 1) In Example 1, the water repellent treatment was not carried out, and an acrylic ultrafine nonwoven fabric (basis weight 1
A skin adhesive sheet was produced in the same manner as in Example 1 except that the amount of 00 g / m ² ) was used.

(Comparative Example 2) In Example 1, the water repellent treatment was not performed, and a polyester nonwoven fabric (basis weight 10
0 g / m ² ) was used, and a skin adhesive sheet was produced in the same manner as in Example 1 except that a polyester film was laminated on this.

The skin adhesive sheets obtained in Examples 1 to 5 and Comparative Examples 1 and 2 were evaluated as shown below. The results are shown in Table 1. (Evaluation method) Support strike-through: The skin adhesive sheet was visually observed from the support side and evaluated according to the following criteria. There was no strike-through and the surface of the support was dry and in a clean state. ○ There was partial strike-through and a cod pattern was formed on the surface of the support. △ There was strike-through entirely and the surface of the support was Sticky x cooling sensation: A skin adhesive sheet was attached to the skin of the monitor and evaluated according to the following criteria. If the cooling sensation lasts for a long time ○ If there is a cooling sensation immediately after application, but it disappears immediately △ If there is no cooling sensation immediately after application × Adhesiveness: Adhere the skin adhesive gel sheet to the skin of the monitor and follow the criteria below. An evaluation was made. The sheet did not fall off, and the good adhesion state was maintained continuously for a long time. ○ The sheet dried and dropped off in a short time. △ The sheet fell off immediately after attaching. × Discomfort: The skin adhesive gel sheet was It was attached to the skin and evaluated according to the writing standard. After attachment, it was comfortable and I did not feel any discomfort during the application. ○ Immediately after attachment, it was comfortable, but the support gradually showed strikethrough. △ After the application, strikethrough occurred immediately and it was uncomfortable during attachment. Was ×

[0049]

[Table 1]

As is clear from Table 1, the skin-adhesive sheets of Examples 1 to 5 of the present invention did not cause strike-through of the support during or after the production of the sheet. In addition, when sticking the skin adhesive sheet, you can work comfortably without stickiness, you can maintain a good sticking state for a long time without dropping off while using the sheet, and a cooling feeling. Was found to last for a long time. In particular, the skin-adhesive sheets of Examples 1 to 3 were excellent in that the backing of the support did not occur even after the sheets were stored for a long period of time. In the skin adhesive sheets of Examples 4 and 5, the backing of the support partly occurred or became sticky after storage for 3 months, but the backing did not occur within a predetermined period after production, and the sheets were cooled. Feeling lasted for a long time. On the other hand, the skin adhesive sheets of Comparative Examples 1 and 2 are
Alternatively, strike-through occurred immediately after the production, and it was sticky and uncomfortable when applied, and the workability was also deteriorated.

[0051]

As described above in detail, according to the present invention, the skin feels good, the pliability is moderate, the moisture can be evaporated appropriately, and the moisture and oil components can be evaporated. It is possible to obtain a skin adhesive sheet having an excellent effect of preventing strike-through to a support such as. As a result, it moisturizes the skin, and a pleasant moisturizing feeling is obtained.In addition, the heat of vaporization is taken away by volatilizing the water to the outside to suppress the burning and irritation of the face and at the same time provide a refreshing feeling and an antipyretic effect. Can be demonstrated. Furthermore, it is satisfactory in terms of handleability, workability, simplicity, etc. without causing contamination of fingers and the like, contamination of clothes and the like, and no adhesive residue during peeling.

[Brief description of drawings]

FIG. 1 is a cross-sectional view showing a layer structure of a skin adhesive sheet according to a first embodiment of the present invention.

FIG. 2 is a perspective view showing an arrangement of an adhesive layer and a layer made of an aqueous gel composition of a skin adhesive sheet according to a second embodiment of the present invention, and (a) is an arrangement of these layers. Is a first specific example, and (b) is a second specific example.

[Explanation of symbols]

1 Water-repellent support Layers composed of 2, 4 aqueous gel composition 3 Release liner 5 Adhesive layer

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Naonori Takahashi             1-2 1-2 Shimohozumi, Ibaraki City, Osaka Prefecture Nitto             Electric Works Co., Ltd. F-term (reference) 4C081 AA03 AA12 BB01 BB02 BB04                       BB06 BC02 CA021 CA081                       CA132 CA161 CA211 CA231                       CC05 CD021 CD32 CD33                       CE02 CE11 DA05 DA12 DB07                       DC03 DC14 EA06                 4C083 AB221 AB222 AC021 AC022                       AC121 AC122 AC182 AC482                       AC811 AC812 AD021 AD022                       AD091 AD092 AD151 AD152                       AD261 AD262 CC01 CC07                       DD12 EE01 EE07 FF01

Claims (7)

[Claims] 1. A skin-adhesive sheet comprising a water-repellent support and a layer comprising an aqueous gel composition on the support. 2. The water repellent treatment is performed by dipping the support.
The skin adhesive sheet described. 3. The skin adhesive sheet according to claim 2, wherein the water repellent treatment is a fluorine-based water repellent treatment. 4. The skin adhesive sheet according to claim 1, wherein the support is a non-woven fabric or a woven fabric. 5. The aqueous gel composition according to claim 1, wherein polyacrylic acid and / or polyacrylic acid salt, carboxyvinyl polymer, polyhydric alcohol, water, and a crosslinking agent are essential components. The skin adhesive sheet according to item 1. 6. The aqueous gel composition according to claim 1, wherein the aqueous gel composition contains at least one selected from the group consisting of an anti-inflammatory and analgesic component, a fragrance, a cell activating component, a beautiful skin component and an oil component. The skin adhesive sheet described. 7. The aqueous gel composition is cross-linked with a polyvalent metal salt, according to any one of claims 1 to 6.
The skin adhesive sheet according to any one of 1.