JP2003104865A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation preventing aging of the skin, having activities for firming the skin and preventing the flap of the skin, and providing a good use feeling. SOLUTION: This skin care preparation contains one or more kinds selected from an extract of Alpinia speciosa (Wendl.) K. Schum., Sanguisorba officinalis L., a plant belonging to the genus Cinchona, a plant belonging to the genus Kigelia, a malt, and a seaweed, and a fraction of the extract, in combination with one or more kinds selected from polysaccharides and the derivative thereof.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which is excellent in the effect of preventing skin aging, particularly the effect of tightening the skin and the effect of preventing sagging, and has a good feeling in use. For more details, see Getto ( Alpinia speciosa (Wendl.) K. S.
chum.), Waremokou ( Sanguisorba officinalis )
L.), Chrysanthemum plant, Sausage cypress plant, malt, and seaweed extract and one or two selected from extracted fractions
The present invention relates to an external preparation for skin, which comprises one or more species and one or more species selected from polysaccharides and derivatives thereof in combination.

[0002]

2. Description of the Related Art It is known that aging of the skin progresses due to aging, exposure to ultraviolet rays, oxidative stress due to active oxygen species generated in skin tissues, contact with drugs and various allergens, and the like. In the field of external preparations for skin, many physiologically active ingredients such as active oxygen species scavengers, anti-inflammatory agents, antiallergic agents and the like have been searched and studied in order to prevent such skin aging. In recent years, there is an increasing tendency to seek such ingredients from plants, reflecting the natural and plant orientations of consumers.

However, among the above-mentioned components of plant origin which have already been reported, since the activity is low, it takes a considerably high concentration to obtain a sufficient action and effect when incorporated into an external preparation for skin, and it is stable. The stability of the formulation when formulated into a skin preparation for external use may cause problems in terms of safety and safety, may impart an undesirable color or odor to the skin preparation for external use, or may impair the feeling of use. At present, there are few things that are satisfactory in terms of safety, usability, and operational effects. Further, skin aging progresses due to various factors intricately involved with each other, and therefore a sufficient effect could not be obtained even if a substance acting only in a part of the above-mentioned reaction was used.

[0004]

SUMMARY OF THE INVENTION Therefore, the object of the present invention is to obtain an external preparation for the skin which is excellent in the effect of preventing skin aging, particularly the effect of tightening the skin and the effect of preventing sagging, and which has a good feeling in use. .

[0005]

It made various studies to solve the above problems [SUMMARY OF INVENTION The present inventors have Alpinia zerumbet (Alpinia
speciosa (Wendl.) K. Schum.), Waremokou ( Sangui
sorba officinalis L.), a plant of the genus Chrysanthemum, a plant of the genus Sausage, a malt, and a seaweed, and one or more selected from the extracted fractions, and one or two selected from a polysaccharide and a derivative thereof. It has been found that the combined use of one or more of these in an external preparation for skin provides a good effect of preventing skin aging, particularly a tightening effect of skin and an effect of preventing sagging, and has a good feeling in use. The invention was completed.

[0006] As a compound of the ghetto extract with an external skin preparation, it has an effect of improving acne and rough skin (Japanese Patent Laid-Open No. 2000-19
1493), a bactericidal effect (JP-A-9-124677), and a hair-growth / hair-growth effect (JP-A-2000-35525).

[0007] Further, as for the extract of Pleurotus cornucopiae, a dry powder water extract has been disclosed to have a collagenase inhibitory action (JP-A-7-196526), and other hydroxy radicals or singlet oxygen scavenging action (JP-A-7-13321).
6), chemical mediator release inhibitory effect
0-36276), improvement of skin strength, morphological improvement of keratinocytes (JP-A-11-29460), dermal collagen fiber bundle improvement (JP-A-11-12122), elastase inhibitory activity (JP2969451) and the like. ing.

[0008] Regarding the extract of the genus Asteraceae, endothelin-converting enzyme inhibitory action (Japanese Unexamined Patent Publication No. 2000-30263)
3), antiallergic action (Japanese Patent Laid-Open No. 10-36276),
Whitening effect (JP-A-8-208451), superoxide scavenging effect (JP-A-3-157334) and the like have been reported.

It is known that a cosmetic containing an extract of a sausage tree plant exhibits a bust-up effect due to a tightening action (French Patent Publication No. 2759910), and a plant having an estrogen-like action. It is also disclosed that the bust size and the farming effect can be obtained by using the extract together (International Patent Application Publication 2000-002531).

Further, malt extract also promotes nitric oxide (NO) production (JP-A-7-324039),
Various physiological actions such as an antioxidant action (Japanese Patent Laid-Open No. 10-140153) and a Tsu liquid action (Japanese Laid-Open Patent Publication No. 11-193238) have been reported.

The seaweed extract has been reported to have various physiological actions such as a moisturizing action, a rough skin preventing action (JP-A-9-301821) and a collagen gel contraction promoting action (JP-A-10-72336). Particularly, as a physiological effect of seaweed belonging to the red algae, an immune function suppressing effect (Japanese Patent Laid-Open No. 6-29866).
1), antibacterial / antiseptic effect (JP-A-11-180813),
Interleukin 4 production inhibitory action (JP-A-10-279
491) is also disclosed.

However, the ghetto ( Alpinia specio
sa (Wendl.) K. Schum.), Waremokou ( Sanguisorba )
officinalis L.), a plant of the genus Chrysanthemum, malt and seaweed, and one or more selected from the extracted fractions, and
The effects of the present invention obtained by using one or more selected from polysaccharides and derivatives thereof in combination have never been suggested so far.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION The ghetto ( Alpinia speciosa (Wendl.) K. Schum.) Used in the present invention is a perennial plant belonging to the ginger family ( Zingiberaceae ).
Although various parts such as flowers and roots can be used, it is preferable to use leaves or flowers.

[0014] Moreover, Sanguisorba officina
lis L.) is a perennial plant belonging to the family Rosaceae , whose leaves,
Although various parts such as stems, flowers, and roots can be used, it is preferable to use root parts.

The plant of the genus Chrysanthemum is not particularly limited, and includes wild chrysanthemums ( Cinchona calysaya Wedd.), Bolivian cypress ( Cinchona ledgeriana (Howard) Moens ex Trimen),
Cinchona officinalis L., Cinchona pubescens Vahl; Cinchona succirubra Pa
v.) and cultivated varieties thereof are exemplified. When obtaining an extract from a plant of the genus Asteraceae, the bark thereof is used as it is or after being dried.

The sausage genus ( Kigelia DC.) Plant is a dicotyledon plant of the family Nostaceae ( Bignoniaceae ),
It is an evergreen or deciduous tree, and more than 10 species are distributed and planted in Africa. In the present invention, it is not particularly limited as long as it is a sausage plant, but from the ease of availability, sausage ( Kigelia africana (Lamk.) Bent
h.) is preferably used. Although various parts such as fruits, bark, seeds and leaves can be used, it is preferable to use fruits from the viewpoint of their effects.

Next, as malt, barley ( Hordeum vu
lgare L.), wheat ( Triticum sativum Lamarck), rye ( Secale cereale L.), oats ( Avena fat )
It is possible to use germinated grains such as ua L.) and oats ( Avena sativa L.). These are Gramineae ( Gr
It is preferable to use malt of barley, which is a first-year or second-year herb belonging to amineae ). As barley, the barley barley ( Hordeum vulgare L. var. He .
xastichon Aschers.), Barley ( Hordeum vu)
lgare L. var. vulgare ), rainbow barley ( Hordeum)
vulgare L. var. distichon Alefeld) and various strains of barley can be used.

In the present invention, any of green algae, red algae and brown algae can be used as the seaweed, but red algae are preferably used, and seaweeds belonging to the order Gigartinales are particularly preferable. .
In the order of Scutellaria, seaweeds such as Scutellariae, Scutellariae, Scutellariae, Scutellariae, Eucalyptus, Pheasantaceae, Acanthaceae, Pleurotus spp. Gigartina tenella Harvey), Kainori ( Gigartin
a intermedia Suringar), Gigartina tee
dii Lamouroux), Ibonori ( Gigartina pacifica Kjel
lman), Squid reed ( Gigartina mamillosa J. Agard
h), tsunomata ( Chondrus ocellatus Holmes), hirakotoji ( Chondrus pinnulatus Okamura), thorny nomata ( Chondrus armatus Okamura), kotojitsunomata ( Chon )
drus elatus Holmes), Black-spotted Ginseng ( Chondrus
yendoi Yamada et Mikami), Nanha Sou ( Rh
odoglossum pulcherum Setchell et Gardner), Ogonori ( Gracilaria verrucosa Papenfuss), Ogonori ( Gracilaria gigas Harvey), Silamo ( Gracilaria bu )
rsa- pastris Silva), Tsurcilamo ( Gracilariopsis ch )
orda Ohmi), Gracilaria incurvata Ok
amura） 、 Cavanori ( Gracilaria textorii Suringa
r), Yumigatatagonori ( Gracilaria arcuata Zanardin
i), Ryukyugogonori ( Gracilaria eucheumoides)
Harvey), Fushikrenori ( Corallopsis opuntia J. Ag
ardh), sperm ( Ceratodictyon spongiosum Zan
ardini), Namiitake ( Tylotus lichenoides Okamur)
a), Isomokka ( Catenella opuntia Greville), Usuginu ( Nemastoma lancifolia Okamura), Honoo ( Platoma japonica Okamura), Venice Nago ( Schizyme )
nia dubyi J. Agardh), Yukari ( Plocamium telfairia )
e Harvey), Soybean ( Plocamium leptophyllum var.
flexuosum J. Agardh), Maki Yukari ( Plocamium recu )
rvatum Okamura), Hime Yukari ( Plocamium oviforme O
kamura), Isodantsu ( Caulacanthus okamurai Yama
da), Kijinoo (Phacelocarpus japonicus Okamur
a), Mirin ( Solieria robusta Kylin), Hosobamirin ( Solieria mollis Kylin), Ezonameshi ( Turnerell )
a mertensiana Schmitz), Tosakanori ( Meristotheca p
apulosa J. Agardh), Meristotheca coac
ta Okamura), Giraffe ( Eucheuma muricatum Weber)
van Bosse), Eucheuma amakusa
nensis Okamura), Togekirinsai ( Eucheuma serra)
J. Agardh), juniper giraffe ( Eucheuma cupres)
oideum Weber van Bosse), Suscarveni ( Halarachni )
on latissimum Okamura), Ibaranori ( Hypnea charoi
des Lamouroux), Kagii Baranori ( Hypnea japonica T
anaka), Saidaibara (Hypnea saidana Holmes), Tachiibaranori (Hypnea variabilis Okamura), Himoibara (Hypnea chordacea Kuetzing), rerun (Ahnfelt
ia concinna J. Agardh), Aegness ( Ahnfeltia pli )
cata F. Fries), Harigane ( Ahnfeltia paradoxa Okam
ura), Okitsunori (Gymnogongrus flabelliformis Har
vey), Maguera ( Trematocarpus pygmaeus Yend
o), Atsuno Nori ( Sarcodia ceylanica Harvey), Lotus japonicus ( Stenogramma interrupta Montagne), Euchakimadara ( Fauchea stipitata Ymamada et Segawa), Weebagsa ( Webberella micans Hauptfleisch) and the like.

Ghetto ( Alpinia speciosa (Wendl.) K.
Schum.), Waremokou ( Sanguisorba officinalis )
L.), Chrysanthemum plants, sausage cypress plants, malt and seaweed may be subjected to extraction as they are, but in consideration of extraction efficiency, extraction is performed after performing processes such as shredding, drying and crushing. It is preferable to carry out. The extraction is performed by immersing it in an extraction solvent.
In order to improve the extraction efficiency, stirring may be performed, homogenization in an extraction solvent, or hydrolysis by enzymatic treatment or the like. As the extraction temperature, it is appropriate to set the temperature to about 5 ° C. to a temperature not higher than the boiling point of the extraction solvent. The extraction time varies depending on the type of extraction solvent and the extraction temperature, but it is suitable to be about 4 hours to 14 days.

As the extraction solvent, in addition to water, methanol,
Lower alcohols such as ethanol, propanol and isopropanol, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as diethyl ether and dipropyl ether, esters such as ethyl acetate and butyl acetate And organic solvents such as ketones such as acetone and ethyl methyl ketone can be used, and one kind or two or more kinds are selected from these and used. Alternatively, physiological saline, phosphate buffer, phosphate buffered saline, etc. may be used.

Getto ( Alpinia speciosa (Wendl.) K.
Schum.), Waremokou ( Sanguisorba officinalis )
L.), Chrysanthemum plant, Sauscinaceae plant, malt and seaweed extract with the above solvent can be contained as it is in the external preparation for skin according to the present invention. It may be used after being redissolved in a polar solvent, or subjected to purification treatment such as decolorization, deodorization, and desalting within a range not impairing these physiological actions, or fractionation treatment such as column chromatography. It can also be used after the extract is further fermented or subjected to a hydrolysis treatment. Especially for malt extract, pH of malt extract
It is preferable to use a fermented malt extract obtained by preparing the above, adding lactic acid bacteria and fermenting the mixture at around the optimum temperature, centrifuging and filtering. The above-mentioned extracts of ghetto, waremoko, malt, and seaweed and their treated products and fractions can be freeze-dried after each treatment and fractionation, and dissolved in a solvent before use. It can also be used by encapsulating it in vesicles such as liposomes or in microcapsules.

In the present invention, one or more selected from polysaccharides and their derivatives are blended in the external preparation for skin. Such polysaccharides and derivatives thereof are not particularly limited as long as they are components that are usually used in external preparations for skin, and specifically, pullulan, fucoidan, hydroxypropyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose. And salts thereof, xanthan gum, dextran, carrageenan, alginic acid and salts thereof, xyloglucan, chitin, chitosan, hyaluronic acid and salts thereof, and the like. Among these polysaccharides, alginic acid and salts thereof are preferably used from the viewpoint of their effects. The amount of these polysaccharides and their derivatives to be added to the external preparation for skin of the present invention includes specific types of polysaccharides and their derivatives, the dosage form of the external preparation for skin of the present invention, and the compatibility with other components. It is possible to select appropriately depending on the
It is preferable to blend in the range of 01 to 10% by weight,
It is particularly preferable to blend in the range of 0.01 to 5% by weight.

In the present invention, the above-mentioned ghetto ( Alpini
a speciosa (Wendl.) K. Schum.) extract and extract fractions, or waremoko ( Sanguisorba officinalis)
L.) extract and extract fraction, Chrysanthemum plant extract and extract fraction, sausage genus plant and extract fraction, malt extract and extract fraction, seaweed extract and extract fraction One or more selected from the products and one or more of polysaccharides and derivatives thereof are contained in the skin external preparation base. The external preparation for skin according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders and granules. In addition, skin lotion, emulsion, cream, beauty essence, skin cosmetics such as packs, makeup base lotion, foundation cosmetics such as makeup base cream, foundations, eye lotions for each formulation such as emulsion, oil, and solid. It can be provided as makeup cosmetics such as colors and cheek colors.

The external preparation for skin according to the present invention includes ghetto ( Alpinia speciosa (Wendl.) K.Schum.), Waremoko ( Sanguisorba officinalis L.), quince plant, sausage plant, malt and seaweed extraction. In addition to substances and extract fractions, polysaccharides, etc., general pharmaceuticals and cosmetics such as oily ingredients, surfactants, moisturizers, pigments, ultraviolet absorbers, antioxidants, fragrances, antibacterial and antifungal agents, etc. Raw materials and physiologically active ingredients such as skin cell activating agents, anti-inflammatory agents, and whitening agents can be contained.

[0025]

EXAMPLES The features of the present invention will be described in detail with reference to Examples.

First, ghetto ( Alpinia speciosa (Wendl.) K. Schum.) To be contained in the external preparation for skin according to the present invention.
Extract of Waremoko ( Sanguisorba officinalis L.)
Extracts and extract fractions of sausage ( Kigelia afr
icana (Lamk.) Benth.) extract, malt extract and extract fraction, seaweed extract, and cucumber extract and extract fraction.

[Ghetto Extract 1] Ghetto ( Alpinia
500g of leaves of speciosa (Wendl.) K. Schum.),
After crushing and immersing in 2 liters of 80% by volume ethanol aqueous solution at 20 ° C. for 7 days, the filtrate was recovered, concentrated and dried, and dissolved in 50% by volume 1,3-butylene glycol aqueous solution. The product was named Geto Extract 1.

[Ghetto Extract 2] Ghetto ( Alpinia
250 g of flowers of speciosa (Wendl.) K. Schum.) are chopped into 20 pieces in 2 liters of 50% by volume aqueous ethanol solution.
The mixture was extracted with stirring at 3 ° C. for 3 days, and the extract was collected by filtration to obtain the title ghetto extract 2.

[Walemkou Extract 1] Waremoko ( Sang
350 g of roots of uisorba officinalis L.) are dried and crushed, immersed in 1.5 liter of 50% by volume ethanol aqueous solution at 20 ° C. for 7 days, and then filtered to collect a filtrate,
This was designated as the title extract 1.

[Walemkou Extract 2] Waremoko ( Sang
uisorba officinalis L.) root (500 g) is dried, crushed, immersed in 2.5 liters of ethanol, and dried at 15 ° C for 1 hour.
The mixture was left standing for 0 days for extraction, and the extract was collected by filtration, concentrated, dried and freeze-dried to obtain the title extract 2.

[Fracture extract fraction 1] 500 g of the root of Warremoko ( Sanguisorba officinalis L.) was dried, crushed and immersed in 2.5 liters of ethanol, and 2
The mixture is allowed to stand at 0 ° C. for 7 days for extraction, filtered, and the filtrate is collected, then concentrated, dried and freeze-dried. This dry powder was dissolved in 0.5 liter of ethanol, and 1.5 liter of purified water was further added to the mixture to prepare 600 ml of DIAION M.
CI gel HP-20 (manufactured by Mitsubishi Kagaku Co., Ltd.) was added and stirred for 1 hour, and then the resin was recovered by filtration, packed in a column, and eluted sequentially with a mixed solvent of water and ethanol in a stepwise manner. . At that time, fractions eluted with a 30% by volume ethanol aqueous solution were collected and freeze-dried to obtain the title extract fraction 1.

[Sausage tree extract] Sausage tree
( Kigelia africana (Lamk.) Benth.) 500g of fruit was crushed, immersed in 5000g of 50% by weight ethanol aqueous solution, stirred and extracted at 25 ° C for 24 hours, and then the extract was filtered to recover a filtrate. And freeze-dry. Lyophilized product 4
g of purified water 198g, 1,3-butylene glycol 198g
It was evenly dispersed in to obtain the title extract.

[Malt extract 1] Wheat ( Triticum sativ
650 g of malt ( um Lamarck) is immersed in 2.5 liters of hot water and extracted for 4 hours, then filtered to collect the filtrate,
This was designated as the title extract 1.

[Malt extract 2] Rye ( Secale cerea
550 g of malt ( le L.) was homogenized in 2 liters of physiological saline at 10 ° C. and then stirred for 5 hours.
The mixture was centrifuged at 3,000 rpm for 10 minutes, and the supernatant was collected to give the title extract 2.

[Malt extract 3] Rye barley ( Hord
500 g of malt of eum vulgare L. var. vulgare ) was immersed in 2.0 liters of purified water and stirred at 40 ° C to 45 ° C for 2 hours, and then the pH was adjusted to 5.5 to 6.0 to obtain lactic acid bacteria. ( Lactobacillus delbruckii ) is added, 45 ℃ -50 ℃
Was fermented anaerobically for 5 days. Then, the mixture was centrifuged at 3,000 rpm for 10 minutes, the supernatant was collected and filtered with a Millipore filter to obtain the title extract 3.

[Malt extraction fractions 1 and 2] Hordeum vulgare L. var. Hexastichon Ascher
500 g of malt (s.) is dried, crushed, immersed in 2.5 liters of a 20% by volume aqueous ethanol solution, allowed to stand at 20 ° C. for 7 days for extraction, and then filtered to collect a filtrate. Add 0.6 liters of DIAION MCI Gel H to the filtrate.
After adding P-20 (manufactured by Mitsubishi Chemical Co., Ltd.) and stirring for 1 hour, the resin was recovered by filtration, packed in a column, and eluted stepwise with a mixed solvent of water and ethanol. At that time, the fractions eluted with the 15% by volume aqueous ethanol solution and the 30% by volume aqueous ethanol solution were collected and freeze-dried to obtain the title extraction fractions 1 and 2.

[Suginori extract, Tsunomata extract, Ogonori extract] Suginori ( Gigartina tenella Harvey),
25 dry powders of Tsunomata ( Chondrus ocellatus Holmes) and Ogonori ( Gracilaria verrucosa Papenfuss)
0 g was immersed in 1.2 liters of a 50% by volume aqueous ethanol solution and extracted at 20 ° C. for 7 days. The extract was filtered and the filtrate was collected and used as each of the title extracts.

[ Giraffe extract, spiny ginkgo extract, Ibaranori extract] Giraffe ( Eucheuma muricat
um Weber van Bosse), Togekirinsai ( Eucheuma ser)
ra J.Agardh), and Ibaranori ( Hypnea charoides La
1.2 kg of each algal cell of mouroux) was cut into fine pieces, immersed in 3 liters of 1,3-butylene glycol, and extracted by stirring at 15 ° C. for 3 days. The extract was filtered and the filtrate was collected and used as each of the title extracts.

[ Saimi Extract] Saimi ( Ahnfeltia conc
2.4 kg of algal cells of ( Inna J. Agardh) were dried, pulverized, immersed in 1.5 liters of purified water, and extracted by stirring at 50 ° C. to 60 ° C. for 10 hours. The extract was filtered and the filtrate was collected as the title extract.

[Cuckon extract] Cuckon ( Puercone
Radix ) 250 g was dried, pulverized and immersed in 2 liters of 50% by volume ethanol aqueous solution at 20 ° C. for 7 days,
The filtrate was collected by filtration to obtain the title extract.

[ Fraccoon Extracted Fraction ]
iae Radix ) 500 g was dried, pulverized, immersed in 2 liters of 50% by volume ethanol aqueous solution, allowed to stand at 20 ° C. for 7 days for extraction, filtered to collect a filtrate, and then concentrated and dried. And freeze-dry. This dry powder (36.0 g) was dissolved in ethanol (500 ml), and purified water (1500) was added.
ml, 0.6 liter of DIAION MCI gel HP-20 (manufactured by Mitsubishi Chemical Co., Ltd.) was added and stirred for 1 hour, and then the resin was recovered by filtration and packed in a column. It was eluted stepwise with a mixed solvent. At that time, a fraction eluted with a 70% by volume aqueous ethanol solution was collected and freeze-dried to obtain a title extraction fraction.

Next, the formulations of the examples of the external preparation for skin according to the present invention will be shown.

[Example 1] Lotion (1) Ethanol 10.0 (wt%) (2) Polyoxyethylene (60 E.O.) hydrogenated castor oil 1.0 (3) Getto extract 1 0.5 ( 4) Methyl paraoxybenzoate 0.1 (5) Dipropylene glycol 5.0 (6) 1,3-Butylene glycol 10.0 (7) Sugi nori extract 5.0 (8) Sodium alginate 0.5 (9) Purified water 67.9 Production method: (2) to (4) are added to (1) and dissolved to obtain an alcohol phase. On the other hand, (5) to (8) are sequentially dissolved in (9) to form an aqueous phase. The alcohol phase is added to the aqueous phase, and the mixture is stirred and mixed.

Example 2 Emulsion (1) Cetanol 1.0 (wt%) (2) Beeswax 0.5 (3) Vaseline 2.0 (4) Squalane 6.0 (5) Dimethylpolysiloxane 2.0 (6) Polyoxyethylene (20 E.O.) sorbitan 1.0 Monostearate (7) Glycerin Monostearate 1.0 (8) Glycerin 4.0 (9) 1,3-Butylene glycol 4.0 (10) Methyl paraoxybenzoate 0.1 (11) Purified water 43.35 (12) Xanthan gum 20.0 (1.0% by weight aqueous solution) (13) Ethanol 5.0 (14) Waremoko extract fraction 10 .05 (15) Tsunomata extract 10.0 Manufacturing method: The oil phase components of (1) to (7) were mixed and dissolved by heating to 75
℃. On the other hand, the water phase components (8) to (11) are mixed and dissolved to 75 ° C. After pre-emulsifying by adding the oil phase to this, add (12) and homogenize with a homomixer and then cool, and dissolve (14) in (13) at 40 ° C. with (15). Add and mix.

[Example 3] Oil-in-water cream (1) Beeswax 6.0 (wt%) (2) Cetanol 5.0 (3) Reduced lanolin 8.0 (4) Squalane 27.5 (5) Glycerin Fatty acid ester 4.0 (6) Lipophilic glycerin monostearate 2.0 (7) Polyoxyethylene (20E.O.) sorbitan 5.0 Monolaurate (8) Propylene glycol 5.0 (9) Paraoxy Methyl benzoate 0.1 (10) Ghetto extract 2 0.5 (11) Waremoko extract 2 0.25 (12) Sodium hyaluronate 0.5 (13) Purified water 36.15 Process: (1) ~ ( Mix and dissolve the oil phase components of 7) to 75 ° C. Meanwhile, mix and dissolve the water phase components (8) to (13) to 75
Heat to ℃. Next, the oil phase component is added to this aqueous phase component to pre-emulsify it, then homogenize with a homomixer and cool.

[Example 4] Gel agent (1) Dipropylene glycol 10.0 (wt%) (2) Sodium alginate 0.4 (3) Carrageenan 0.2 (4) Methyl paraoxybenzoate 0.1 (5) ) Ghetto extract 1 0.5 (6) Malt extract fraction 1 0.2 (7) Ogonori extract 5.0 (8) Purified water 83.6 Production method: (8) to (2) and (3) Dissolve evenly, then add (4) to (1)
~ Dissolve (7), add and mix.

[Example 5] Oil-in-water emulsion type ointment (1) White petrolatum 25.0 (wt%) (2) Stearyl alcohol 25.0 (3) Glycerin 12.0 (4) Sodium lauryl sulfate 1.0 (5) Methyl paraoxybenzoate 0.1 (6) Purified water 25.4 (7) Ghetto extract 1 0.5 (8) Warmoko extract 1 0.5 (9) Malt extract fraction 1. 0 (w / v)% aqueous solution 0.5 (10) Potassium alginate (2% by weight aqueous solution) 10.0 Production method: Mix the oil phase components (1) to (4) and heat to uniformly dissolve them. ℃. On the other hand, mix the water phase components of (5) and (6),
Heat to 75 ° C. The oil phase component was gradually added to this water phase component while stirring to emulsify and cool the mixture.
Add (7) to (10) at ℃ and mix.

Example 6 Beauty Serum (1) 1,3-Butylene Glycol 5.0 (wt%) (2) Methyl Paraoxybenzoate 0.1 (3) Polyglycerin Monoisostearate 1.5 (4) Fragrance 0.015 (5) Sorbitol (70% by weight aqueous solution) 2.0 (6) Polyglycerin 1.0 (7) Diglycerin 3.0 (8) Carboxyvinyl polymer (2% by weight aqueous solution) 40.0 (9 ) Potassium alginate (1 wt% aqueous solution) 30.0 (10) Sodium carboxymethylcellulose (1 wt% aqueous solution) 3.0 (11) Malt extract 3 1.0 (12) Thyme extract 0.5 (13) Poly Oxyethylene (50) Hydrogenated castor oil 0.5 (14) Polyethylene glycol (4000) 1.0 (15) Purified water 1.385 (16) Ethanol 3.0 (17) Quina extract (Maruzen Pharmaceutical Co., Ltd.) 5 18) Sausage tree extract 0.5 (19) L-arginine (20% by weight aqueous solution) 6.0 Production method: After mixing and homogenizing the components (1) to (18), the component (19) is added. To homogenize the mixture.

Example 7 Water-in-oil type emollient cream (1) Liquid paraffin 30.0 (wt%) (2) Microcrystalline wax 2.0 (3) Vaseline 5.0 (4) Diglycerin dioleic acid Ester 5.0 (5) L-Glutamate sodium 1.6 (6) L-serine 0.4 (7) Propylene glycol 3.0 (8) Methyl paraoxybenzoate 0.1 (9) Kacon extract 0.05 (10) Malt extract 1 0.05 (11) Ibaranori extract 7.5 (12) Purified water 44.2 (13) Perfume 0.1 (14) Sodium hyaluronate 1.0 Manufacturing method: (5), ( 6) is dissolved in a part of (12) to 50 ° C., and the mixture is gradually added to (4) preheated to 50 ° C. with stirring. These are mixed in advance and uniformly dispersed in (1) to (3) which are dissolved by heating at 70 ° C. To this, (8) is dissolved in (7) and added to the rest of (12) together with (9) to (11), heated to 70 ° C. and added with stirring, and the mixture is emulsified with a homomixer. After cooling, (13) and (14) are added and mixed at 40 ° C.

[Example 8] Makeup base cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Glycerin tri-2-ethylhexanoate 2.5 (4) Self-emulsification Type Glycerin monostearic acid 2.0 ester (5) Propylene glycol 10.0 (6) Potassium hydroxide 0.3 (7) Methyl paraoxybenzoate 0.1 (8) Malt extract 2 0.2 (9) Kirinsai Extract 3.5 (10) Thyme extract 3.5 (11) Xanthan gum (1% by weight aqueous solution) 61.2 (12) Titanium oxide 2.0 (13) Red iron oxide 0.4 (14) Yellow iron oxide 1 (15) Perfume 0.1 (16) Kacon extract 1 0.1 Production method: The oil phase components (1) to (4) are mixed and dissolved to 75 ° C. On the other hand, the water phase components (5) to (11) are mixed, heated and dissolved,
The pigment components (12) to (14) are added to this and uniformly dispersed by a homomixer to 75 ° C. Next, the oil phase component is added to the aqueous phase component, and the mixture is uniformly emulsified with a homomixer. After cooling, (15) and (16) are added and mixed at 40 ° C.

Example 9 Emulsion foundation (1) Stearic acid 2.0 (wt%) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Decaglycerin monoisopalmitic acid ester 9.0 (6) 1,3-butyleneglycol 6.0 (7) Potassium hydroxide 0.08 (8) Methyl paraoxybenzoate 0.1 (9) Kacon extract fraction 0.02 (10) Purified water 50.95 (11) Titanium oxide 9.0 (12) Talc 7.4 (13) Red iron oxide 0.5 (14) Yellow iron oxide 1.1 (15) Black iron oxide 0.0. 1 (16) Perfume 0.15 (17) 1.0 (W / V)% aqueous solution of malt extract fraction 1 0.1 (18) Sodium hyaluronate 2.5 Process: Oil phase of (1) to (5) The ingredients are mixed and melted to 75 ° C. On the other hand, the water phase components (6) to (10) are mixed, heated and dissolved,
The pigment components (11) to (15) are added to this and uniformly dispersed by a homomixer to 75 ° C. Next, the oil phase component is added to this water phase component, and the mixture is uniformly emulsified with a homomixer. After cooling, (16) to (18) are added and mixed at 40 ° C.

Example 10 Hand Cream (1) Cetanol 4.0 (wt%) (2) Vaseline 2.0 (3) Liquid Paraffin 10.0 (4) Glycerin Monostearate 1.5 (5) Polyoxyethylene (60 E.O.) glycerin 2.5 Isostearate (6) Tocopherol acetate 0.25 (7) Glycerin 20.0 (8) Methyl paraoxybenzoate 0.1 (9) Kacon extract 0.01 (10) Spinach ginseng extract 6.0 (11) Xanthan gum (1% by weight aqueous solution) 53.64 Production method: Mix and dissolve the oil phase components (1) to (6) to 75 ° C. On the other hand, the aqueous phase components (7) to (11) are mixed, heated and dissolved to 75 ° C. Next, the oil phase component is added to the aqueous phase component, and the mixture is uniformly emulsified with a homomixer and cooled.

A use test was conducted on the above-mentioned examples according to the present invention to evaluate the effect of preventing skin aging and sensory evaluation. At that time, the comparative examples were prepared by substituting the examples shown in Table 1 for each example, and simultaneously subjected to a usage test. In the use test, 20 female panelists in their 40s to 60s with aging symptoms such as increased wrinkles, decreased tension, and sagging of the skin were set as one group, and each of the examples and comparative examples was blinded to each group. , Once a day for 1 month.

[0054]

[Table 1]

The effect of preventing skin aging is compared by comparing the conditions of wrinkles, skin elasticity and sagging of the skin before and after the start of use test, and "improved", "slightly improved" and "no change" in these improved conditions. When the number of panelists who answered that it was improved was evaluated by 3 grades of 15 or more, "◎", 10 to 1
"○" for 4 people, "△" for 5-9 people, 1-4
The case of first name is shown in Table 2 as "x". The wrinkles of the skin were evaluated by visual observation and photography, and the skin elasticity was evaluated by the measurement result by a cut meter. The sagging of the skin was evaluated by visual observation.

[0056]

[Table 2]

As is clear from Table 2, in the group used in Examples of the present invention, a clear tendency of improvement in skin aging symptoms was recognized as compared with the corresponding group used in Comparative Examples.

Regarding Examples 1 to 10, 2
No change in condition was observed when stored at 5 ° C for 6 months, and no problem skin irritation reaction was observed in a 48-hour back occlusion patch test conducted by 30 male panelists.

[0059]

As described above in detail, according to the present invention, it is possible to obtain a skin external preparation which is excellent in the effect of preventing skin aging, particularly the effect of tightening the skin and the effect of preventing sagging, and has a good feeling of use. .

   ─────────────────────────────────────────────────── ─── Continued front page    F-term (reference) 4C083 AA082 AA111 AA112 AB032                       AB232 AB242 AB432 AC012                       AC022 AC072 AC102 AC122                       AC132 AC242 AC422 AC432                       AC442 AC482 AC582 AC782                       AD042 AD092 AD162 AD211                       AD272 AD302 AD332 AD352                       AD512 AD662 CC02 CC03                       CC04 CC05 DD23 DD31 DD32                       DD33 DD41 EE12                 4C088 AA14 AB12 AB14 AB51 AB73                       AB81 AC02 AC15 BA08 MA04                       MA07 MA63 ZA89

Claims (6)

[Claims] 1. A ghetto ( Alpinia speciosa (Wendl.)
K. Schum.), Waremokou ( Sanguisorba officinalis )
L.), Chrysanthemum plant, Sausage cypress plant, malt, and seaweed extract and one or two selected from extracted fractions
A skin external preparation containing one or more kinds and one or more kinds selected from polysaccharides and derivatives thereof. 2. The external preparation for skin according to claim 1, wherein the sausage tree is a sausage tree ( Kigelia africana (Lamk.) Benth.). 3. The external preparation for skin according to claim 1 or 2, wherein the malt extract is a fermented malt extract obtained by fermenting a malt extract. 4. The external preparation for skin according to claim 1, wherein the seaweed extract and the extracted fraction are red algae extracts and extracted fractions. 5. The external preparation for skin according to any one of claims 1 to 4, wherein the seaweed extract and the extract fraction are extracts and extract fractions of red algae belonging to the order Lepidoptera. 6. The polysaccharide is alginic acid and a salt thereof.
The external preparation for skin according to claim 1.