IT201700039329A1 - BENZOFURAN DERIVATIVES SUCH AS AMPK ACTIVATORS - Google Patents

BENZOFURAN DERIVATIVES SUCH AS AMPK ACTIVATORS

Info

Publication number
IT201700039329A1
IT201700039329A1 IT102017000039329A IT201700039329A IT201700039329A1 IT 201700039329 A1 IT201700039329 A1 IT 201700039329A1 IT 102017000039329 A IT102017000039329 A IT 102017000039329A IT 201700039329 A IT201700039329 A IT 201700039329A IT 201700039329 A1 IT201700039329 A1 IT 201700039329A1
Authority
IT
Italy
Prior art keywords
benzofuran derivatives
ampk activators
ampk
activators
benzofuran
Prior art date
Application number
IT102017000039329A
Other languages
Italian (it)
Inventor
Francesco Angelucci
Luca Quattrini
Vito Coviello
Luca Antonioli
Matteo Fornai
Corrado Blandizzi
Won Keun Oh
Motta Concettina La
Original Assignee
Univ Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pisa filed Critical Univ Pisa
Priority to IT102017000039329A priority Critical patent/IT201700039329A1/en
Priority to PCT/IB2018/052517 priority patent/WO2018189683A1/en
Publication of IT201700039329A1 publication Critical patent/IT201700039329A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT102017000039329A 2017-04-10 2017-04-10 BENZOFURAN DERIVATIVES SUCH AS AMPK ACTIVATORS IT201700039329A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102017000039329A IT201700039329A1 (en) 2017-04-10 2017-04-10 BENZOFURAN DERIVATIVES SUCH AS AMPK ACTIVATORS
PCT/IB2018/052517 WO2018189683A1 (en) 2017-04-10 2018-04-10 Benzofuran derivatives for use as ampk activators

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000039329A IT201700039329A1 (en) 2017-04-10 2017-04-10 BENZOFURAN DERIVATIVES SUCH AS AMPK ACTIVATORS

Publications (1)

Publication Number Publication Date
IT201700039329A1 true IT201700039329A1 (en) 2018-10-10

Family

ID=59700059

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000039329A IT201700039329A1 (en) 2017-04-10 2017-04-10 BENZOFURAN DERIVATIVES SUCH AS AMPK ACTIVATORS

Country Status (2)

Country Link
IT (1) IT201700039329A1 (en)
WO (1) WO2018189683A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL298306A (en) 2020-05-19 2023-01-01 Kallyope Inc Ampk activators
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006020767A2 (en) * 2004-08-13 2006-02-23 Genentech, Inc. Thiazole based inhibitors of atp-utilizing enzymes
EP1710233A1 (en) * 2004-01-28 2006-10-11 Kissei Pharmaceutical Co., Ltd. Novel benzofuran derivative, medicinal composition containing the same, and uses of these

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1710233A1 (en) * 2004-01-28 2006-10-11 Kissei Pharmaceutical Co., Ltd. Novel benzofuran derivative, medicinal composition containing the same, and uses of these
WO2006020767A2 (en) * 2004-08-13 2006-02-23 Genentech, Inc. Thiazole based inhibitors of atp-utilizing enzymes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AMY LEW TSUHAKO ET AL: "The design, synthesis, and biological evaluation of PIM kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 11, 2012, pages 3732 - 3738, XP028423353, ISSN: 0960-894X, [retrieved on 20120411], DOI: 10.1016/J.BMCL.2012.04.025 *

Also Published As

Publication number Publication date
WO2018189683A1 (en) 2018-10-18

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