IT1190405B - Derivati del flavone - Google Patents

Derivati del flavone

Info

Publication number
IT1190405B
IT1190405B IT22578/85A IT2257885A IT1190405B IT 1190405 B IT1190405 B IT 1190405B IT 22578/85 A IT22578/85 A IT 22578/85A IT 2257885 A IT2257885 A IT 2257885A IT 1190405 B IT1190405 B IT 1190405B
Authority
IT
Italy
Prior art keywords
flavone derivatives
flavone
derivatives
Prior art date
Application number
IT22578/85A
Other languages
English (en)
Other versions
IT8522578A0 (it
Inventor
Amedeo Leonardi
Renzo Pennini
Pietro Cazzulani
Dante Nardi
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of IT8522578A0 publication Critical patent/IT8522578A0/it
Priority to IT22578/85A priority Critical patent/IT1190405B/it
Priority to IL80229A priority patent/IL80229A0/xx
Priority to GR862546A priority patent/GR862546B/el
Priority to AR86305576A priority patent/AR243883A1/es
Priority to NO864108A priority patent/NO167570C/no
Priority to NZ217964A priority patent/NZ217964A/en
Priority to AT86830300T priority patent/ATE73453T1/de
Priority to ES8602677A priority patent/ES2002425A6/es
Priority to EP86830300A priority patent/EP0223744B1/en
Priority to ZA867941A priority patent/ZA867941B/xx
Priority to DE8686830300T priority patent/DE3684244D1/de
Priority to HU864363A priority patent/HU202863B/hu
Priority to IE276886A priority patent/IE58330B1/en
Priority to JP61251553A priority patent/JPH0772186B2/ja
Priority to TNTNSN86144A priority patent/TNSN86144A1/fr
Priority to CA000520953A priority patent/CA1330994C/en
Priority to FI864260A priority patent/FI89167C/fi
Priority to DK506386A priority patent/DK169408B1/da
Priority to US06/921,397 priority patent/US4806534A/en
Priority to PH34400A priority patent/PH22766A/en
Priority to CN198686107544A priority patent/CN86107544A/zh
Priority to PT83604A priority patent/PT83604B/pt
Priority to EG662/86A priority patent/EG18109A/xx
Priority to KR1019860008836A priority patent/KR910009269B1/ko
Priority to AU64273/86A priority patent/AU596382B2/en
Application granted granted Critical
Publication of IT1190405B publication Critical patent/IT1190405B/it
Priority to SG551/92A priority patent/SG55192G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IT22578/85A 1985-10-22 1985-10-22 Derivati del flavone IT1190405B (it)

Priority Applications (26)

Application Number Priority Date Filing Date Title
IT22578/85A IT1190405B (it) 1985-10-22 1985-10-22 Derivati del flavone
IL80229A IL80229A0 (en) 1985-10-22 1986-10-03 Flavone derivatives,their preparation and pharmaceutical compositions containing them
GR862546A GR862546B (en) 1985-10-22 1986-10-14 Flavone derivatives
AR86305576A AR243883A1 (es) 1985-10-22 1986-10-15 Procedimiento para preparar nuevos derivados de flavona con actividad antogonica de calcio asi como con actividad relajante de la musculatura lisa.
NO864108A NO167570C (no) 1985-10-22 1986-10-15 Analogifremgangsmaate for fremstilling av terapeutisk aktive flavonforbindelser.
NZ217964A NZ217964A (en) 1985-10-22 1986-10-16 Substituted flavone derivatives and pharmaceutical compositions
AT86830300T ATE73453T1 (de) 1985-10-22 1986-10-20 Flavon-derivate.
ES8602677A ES2002425A6 (es) 1985-10-22 1986-10-20 Un procedimiento para preparar nuevos derivados de flavona
EP86830300A EP0223744B1 (en) 1985-10-22 1986-10-20 Flavone derivatives
ZA867941A ZA867941B (en) 1985-10-22 1986-10-20 Flavone derivatives
DE8686830300T DE3684244D1 (de) 1985-10-22 1986-10-20 Flavon-derivate.
IE276886A IE58330B1 (en) 1985-10-22 1986-10-21 Flavone derivatives
HU864363A HU202863B (en) 1985-10-22 1986-10-21 Process for producing flavon derivatives
JP61251553A JPH0772186B2 (ja) 1985-10-22 1986-10-21 フラボン誘導体、その製造法及びそれを含む医薬
TNTNSN86144A TNSN86144A1 (fr) 1985-10-22 1986-10-21 Procede pour la preparation de derives de la flavone
CA000520953A CA1330994C (en) 1985-10-22 1986-10-21 Flavone derivatives
FI864260A FI89167C (fi) 1985-10-22 1986-10-21 Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara flavonyl-1,4-dihydropyridinderivat
CN198686107544A CN86107544A (zh) 1985-10-22 1986-10-22 黄酮衍生物的制备方法
US06/921,397 US4806534A (en) 1985-10-22 1986-10-22 Therapeutically active flavonyl-1,4-dihydrophyridines
PH34400A PH22766A (en) 1985-10-22 1986-10-22 Therapeutically active flavonyl-1,4-dihydropyridines
DK506386A DK169408B1 (da) 1985-10-22 1986-10-22 Terapeutisk aktive 4-(3-methylflavon-8-yl)-1,4-dihydropyridinderivater, fremgangsnmåder til fremstilling heraf samt farmaceutiske midler indeholdende disse
PT83604A PT83604B (pt) 1985-10-22 1986-10-22 Processo para a preparacao de derivados da flavona e de composicoes farmaceuticas que os contem
EG662/86A EG18109A (en) 1985-10-22 1986-10-22 Process for preparing flavone derivatives
KR1019860008836A KR910009269B1 (ko) 1985-10-22 1986-10-22 플라본 유도체의 제조방법
AU64273/86A AU596382B2 (en) 1985-10-22 1986-10-22 Flavone derivatives
SG551/92A SG55192G (en) 1985-10-22 1992-05-23 Flavone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22578/85A IT1190405B (it) 1985-10-22 1985-10-22 Derivati del flavone

Publications (2)

Publication Number Publication Date
IT8522578A0 IT8522578A0 (it) 1985-10-22
IT1190405B true IT1190405B (it) 1988-02-16

Family

ID=11198039

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22578/85A IT1190405B (it) 1985-10-22 1985-10-22 Derivati del flavone

Country Status (26)

Country Link
US (1) US4806534A (it)
EP (1) EP0223744B1 (it)
JP (1) JPH0772186B2 (it)
KR (1) KR910009269B1 (it)
CN (1) CN86107544A (it)
AR (1) AR243883A1 (it)
AT (1) ATE73453T1 (it)
AU (1) AU596382B2 (it)
CA (1) CA1330994C (it)
DE (1) DE3684244D1 (it)
DK (1) DK169408B1 (it)
EG (1) EG18109A (it)
ES (1) ES2002425A6 (it)
FI (1) FI89167C (it)
GR (1) GR862546B (it)
HU (1) HU202863B (it)
IE (1) IE58330B1 (it)
IL (1) IL80229A0 (it)
IT (1) IT1190405B (it)
NO (1) NO167570C (it)
NZ (1) NZ217964A (it)
PH (1) PH22766A (it)
PT (1) PT83604B (it)
SG (1) SG55192G (it)
TN (1) TNSN86144A1 (it)
ZA (1) ZA867941B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912223A (en) * 1988-01-28 1990-03-27 Nelson Research & Development Co. 1,4-Dihydropyridines
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
US5244602A (en) * 1990-12-03 1993-09-14 Ppg Industries, Inc. Photochromic naphthopyrans
DE4321030A1 (de) * 1993-06-24 1995-01-05 Bayer Ag 4-bicyclisch substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimittel
SE9703377D0 (sv) 1997-09-18 1997-09-18 Astra Ab New compounds
KR100392468B1 (ko) * 2000-09-18 2003-07-22 주식회사 엘지생명과학 사이클린 의존 키나아제의 저해제로서 유용한3-히드록시크로멘-4-온 유도체
BR0206512A (pt) 2001-01-16 2004-01-06 Astrazeneca Ab Composto, método de tratamento de um ser humano ou animal que sofre de depressão, ansiedade generalizada, distúrbios da alimentação, demência, distúrbio do p nico, distúrbios do sono, distúrbios gastrointestinais, distúrbios motores, distúrbios endócrinos, vasoespasmo e disfunção sexual, uso de um composto, e, processo para preparar um composto.
DE102005034267A1 (de) * 2005-07-22 2007-01-25 Bayer Healthcare Ag 4-Chromenonyl-1,4-dihydropyridine und ihre Verwendung
DE102005034264A1 (de) 2005-07-22 2007-02-01 Bayer Healthcare Ag 4-Chromenonyl-1,4-dihydropyridincarbonitrile und ihre Verwendung
CN103254122B (zh) * 2013-06-19 2015-04-22 湖南师范大学 一种心血管药物尼伐地平的制备方法
AR121719A1 (es) 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
IL307950A (en) 2021-05-03 2023-12-01 Petra Pharma Corp Allosteric chromanone inhibitors of PHOSPHOINOSITIDE 3-KINASE (PI3K) for the treatment of diseases
BR112023022890A2 (pt) 2021-05-27 2024-01-23 Petra Pharma Corp Inibidores de cromenona alostéricos de fosfoinositídio 3-cinase (pi3k), composições farmacêuticas que os compreendem e usos dos mesmos
TW202329930A (zh) 2021-09-30 2023-08-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑
CN115536644B (zh) * 2022-09-27 2024-09-03 广西民族大学 一种色酮-2-甲酰胺类化合物用于制备降血糖药物的用途及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2921070A (en) * 1957-11-05 1960-01-12 Recordati Lab Farmacologico S Basic esters of 3-methylflavone-8-carboxylic acid
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3311005A1 (de) * 1983-03-25 1984-09-27 Bayer Ag, 5090 Leverkusen Chromon- und thiochromonsubstituierte 1,4-dihydropyridinderivate, mehrere verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Also Published As

Publication number Publication date
GR862546B (en) 1987-03-04
FI864260A0 (fi) 1986-10-21
FI864260A (fi) 1987-04-23
AR243883A1 (es) 1993-09-30
EP0223744A3 (en) 1988-09-14
HU202863B (en) 1991-04-29
EP0223744B1 (en) 1992-03-11
KR910009269B1 (ko) 1991-11-08
US4806534A (en) 1989-02-21
SG55192G (en) 1992-07-24
JPH0772186B2 (ja) 1995-08-02
ATE73453T1 (de) 1992-03-15
NO864108L (no) 1987-04-23
NZ217964A (en) 1990-04-26
PH22766A (en) 1988-12-12
CA1330994C (en) 1994-07-26
IE58330B1 (en) 1993-09-08
NO864108D0 (no) 1986-10-15
KR870004022A (ko) 1987-05-07
EP0223744A2 (en) 1987-05-27
IE862768L (en) 1987-04-22
FI89167C (fi) 1993-08-25
TNSN86144A1 (fr) 1990-01-01
JPS62161781A (ja) 1987-07-17
ES2002425A6 (es) 1988-08-01
DK506386A (da) 1987-04-23
ZA867941B (en) 1987-06-24
FI89167B (fi) 1993-05-14
AU596382B2 (en) 1990-05-03
DE3684244D1 (de) 1992-04-16
IT8522578A0 (it) 1985-10-22
AU6427386A (en) 1987-04-30
CN86107544A (zh) 1987-11-25
PT83604B (pt) 1988-10-14
DK506386D0 (da) 1986-10-22
PT83604A (en) 1986-11-01
EG18109A (en) 1992-08-30
NO167570B (no) 1991-08-12
IL80229A0 (en) 1987-01-30
HUT45525A (en) 1988-07-28
NO167570C (no) 1991-11-20
DK169408B1 (da) 1994-10-24

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970129