IL115854A - Process for purifying and isolating beta-anomer enriched 2'-deoxy-2',2'-difluoro-D-ribofuranosyl-4-aminopyrimidin-2-one - Google Patents

Process for purifying and isolating beta-anomer enriched 2'-deoxy-2',2'-difluoro-D-ribofuranosyl-4-aminopyrimidin-2-one

Info

Publication number
IL115854A
IL115854A IL11585495A IL11585495A IL115854A IL 115854 A IL115854 A IL 115854A IL 11585495 A IL11585495 A IL 11585495A IL 11585495 A IL11585495 A IL 11585495A IL 115854 A IL115854 A IL 115854A
Authority
IL
Israel
Prior art keywords
aminopyrimidin
ribofuranosyl
deoxy
difluoro
purifying
Prior art date
Application number
IL11585495A
Other languages
English (en)
Other versions
IL115854A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23335711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL115854(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL115854A0 publication Critical patent/IL115854A0/xx
Publication of IL115854A publication Critical patent/IL115854A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
IL11585495A 1994-11-17 1995-11-02 Process for purifying and isolating beta-anomer enriched 2'-deoxy-2',2'-difluoro-D-ribofuranosyl-4-aminopyrimidin-2-one IL115854A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/340,972 US5606048A (en) 1992-06-22 1994-11-17 Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (2)

Publication Number Publication Date
IL115854A0 IL115854A0 (en) 1996-01-31
IL115854A true IL115854A (en) 2000-07-16

Family

ID=23335711

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11585495A IL115854A (en) 1994-11-17 1995-11-02 Process for purifying and isolating beta-anomer enriched 2'-deoxy-2',2'-difluoro-D-ribofuranosyl-4-aminopyrimidin-2-one

Country Status (34)

Country Link
US (1) US5606048A (de)
EP (1) EP0712860B1 (de)
JP (1) JPH10509170A (de)
KR (1) KR100424990B1 (de)
CN (1) CN1044119C (de)
AR (1) AR001045A1 (de)
AT (1) ATE210142T1 (de)
AU (1) AU702588B2 (de)
BG (1) BG62737B1 (de)
BR (1) BR9509904A (de)
CA (1) CA2205350C (de)
CO (1) CO4600741A1 (de)
CZ (1) CZ292013B6 (de)
DE (1) DE69524365T2 (de)
DK (1) DK0712860T3 (de)
ES (1) ES2164745T3 (de)
HU (1) HU219019B (de)
IL (1) IL115854A (de)
MX (1) MX9703548A (de)
MY (1) MY115183A (de)
NO (1) NO308305B1 (de)
NZ (1) NZ296712A (de)
PE (1) PE50196A1 (de)
PL (1) PL182052B1 (de)
PT (1) PT712860E (de)
RO (1) RO118296B1 (de)
RU (1) RU2161622C2 (de)
SI (1) SI0712860T1 (de)
SK (1) SK283160B6 (de)
TW (1) TW377356B (de)
UA (1) UA53614C2 (de)
WO (1) WO1996016072A1 (de)
YU (1) YU49446B (de)
ZA (1) ZA959321B (de)

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MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EA007867B1 (ru) * 2000-05-26 2007-02-27 Айденикс (Кайман) Лимитед Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения
US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
CA2472581C (en) * 2002-01-15 2012-06-26 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
BR0312278A (pt) * 2002-06-28 2007-06-19 Idenix Cayman Ltd éster 2'-c-metil-3'-o-l-valina de ribofuranosil citidina para tratamento de infecções por flaviviridae
NZ537662A (en) * 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7265096B2 (en) * 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
KR20050088079A (ko) * 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
WO2004052899A2 (en) * 2002-12-12 2004-06-24 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
EP1912643A2 (de) * 2004-06-23 2008-04-23 Idenix (Cayman) Limited 5-aza-7-deazapurinderivate zur behandlung von infektionen mit flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CN101076535A (zh) * 2004-12-08 2007-11-21 西科尔公司 二氟核苷及其制备方法
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
AU2005320374B2 (en) * 2004-12-30 2009-01-08 Hanmi Science Co., Ltd. Method for the preparation of 2'-deoxy-2',2'-difluorocytidine
CN101203524B (zh) * 2005-03-04 2011-06-15 费森尤斯卡比肿瘤学有限公司 用于制备β-异头物富集的21-脱氧，21，21-二氟-D-呋喃核糖核苷的中间体和方法
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
US7572898B2 (en) * 2005-06-03 2009-08-11 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
WO2007049294A1 (en) * 2005-10-28 2007-05-03 Arch Pharmalabs Limited An improved process for preparation of gemcitabine hydrochloride.
US7781576B2 (en) * 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
AU2007235210A1 (en) * 2006-02-06 2007-10-18 Dr. Reddy's Laboratories Ltd. Preparation of gemcitabine
JP2010510243A (ja) * 2006-11-17 2010-04-02 トラスティーズ オブ ダートマス カレッジ 三環系−ビス−エノン（ｔｂｅ）の合成および生物学的活性
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
WO2008064132A2 (en) * 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
WO2008117955A1 (en) * 2007-03-23 2008-10-02 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
CN100475832C (zh) * 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
WO2009023845A2 (en) * 2007-08-15 2009-02-19 The Board Of Regents Of The University Of Texas System Combination therapy with synthetic triterpenoids and gemcitabine
EP2050757A1 (de) 2007-10-10 2009-04-22 Cilag AG Verfahren zur Herstellung von 2' -deoxy-5-Azacytidin (Decitabin)
JO2778B1 (en) * 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
LT2252283T (lt) 2008-01-11 2019-03-25 Reata Pharmaceuticals, Inc. Sintetiniai triterpenoidai ir jų panaudojimo būdai gydant ligą
LT2276493T (lt) 2008-04-18 2019-01-10 Reata Pharmaceuticals, Inc. Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17
TW201004627A (en) * 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
NZ588709A (en) 2008-04-18 2012-11-30 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: triterpenoid oleanolic acid derivatives with saturation in the c-ring
MX2010011439A (es) 2008-04-18 2011-01-25 Reata Pharmaceuticals Inc Moduladores de inflamacion antioxidantes: derivados del acido oleanolico homologacion c-17.
CN103588678A (zh) 2008-04-18 2014-02-19 里亚塔医药公司 包含抗炎症药效团的化合物以及使用方法
ES2449396T3 (es) 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
JO3197B1 (ar) * 2009-04-06 2018-03-08 Otsuka Pharma Co Ltd (مشتقات 2'-دايوكسي-ريبوفيورانوسيل) 1 , 3 , 4, 7- تترا هيدرو- (1, 3) داي آزيبين- 2 - أون لعلاج السرطان
JP5730854B2 (ja) * 2009-04-06 2015-06-10 大塚製薬株式会社 デシタビンとシチジンデアミナーゼ阻害剤との組合せ、およびがんの治療におけるその使用
ES2628609T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de fármacos antineoplásicos a base de citidina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer
HUE038744T2 (hu) 2012-04-04 2018-11-28 Halozyme Inc Kombinációs terápia hialurodinázzal és egy tumor-targetált taxánnal
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

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US3721664A (en) * 1970-01-27 1973-03-20 Hoffmann La Roche Preparation of 5-cytosine nucleosides
DE2628202A1 (de) * 1976-06-23 1977-12-29 Max Planck Gesellschaft Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
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Also Published As

Publication number Publication date
EP0712860A3 (de) 1996-09-25
BG101485A (en) 1998-03-31
YU49446B (sh) 2006-03-03
TW377356B (en) 1999-12-21
HU219019B (hu) 2001-01-29
SI0712860T1 (en) 2002-04-30
RU2161622C2 (ru) 2001-01-10
NZ296712A (en) 1999-01-28
PL182052B1 (pl) 2001-10-31
ES2164745T3 (es) 2002-03-01
WO1996016072A1 (en) 1996-05-30
NO972214D0 (no) 1997-05-14
UA53614C2 (uk) 2003-02-17
NO972214L (no) 1997-05-14
IL115854A0 (en) 1996-01-31
BG62737B1 (bg) 2000-06-30
CA2205350A1 (en) 1996-05-30
SK283160B6 (sk) 2003-03-04
SK48597A3 (en) 1997-11-05
CZ292013B6 (cs) 2003-07-16
AR001045A1 (es) 1997-09-24
CN1165519A (zh) 1997-11-19
KR970707143A (ko) 1997-12-01
YU70995A (sh) 1998-09-18
DE69524365T2 (de) 2002-08-14
EP0712860A2 (de) 1996-05-22
CN1044119C (zh) 1999-07-14
CO4600741A1 (es) 1998-05-08
MX9703548A (es) 1997-08-30
MY115183A (en) 2003-04-30
DK0712860T3 (da) 2002-03-04
NO308305B1 (no) 2000-08-28
JPH10509170A (ja) 1998-09-08
ATE210142T1 (de) 2001-12-15
KR100424990B1 (ko) 2004-05-20
CA2205350C (en) 2007-09-04
US5606048A (en) 1997-02-25
CZ148197A3 (en) 1997-08-13
PT712860E (pt) 2002-05-31
AU4139396A (en) 1996-06-17
DE69524365D1 (de) 2002-01-17
AU702588B2 (en) 1999-02-25
HUT77926A (hu) 1998-11-30
ZA959321B (en) 1997-05-05
PL320634A1 (en) 1997-10-13
PE50196A1 (es) 1996-11-30
RO118296B1 (ro) 2003-04-30
EP0712860B1 (de) 2001-12-05
BR9509904A (pt) 1997-10-14

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