HUP9902160A2 - Benzil(idén)-laktám-származékok, alkalmazásuk szelektív (ant)agonistaként 5-HT1a és/vagy 5-HT1d-receptorokként, a vegyületeket tartalmazó gyógyászati készítmények - Google Patents
Benzil(idén)-laktám-származékok, alkalmazásuk szelektív (ant)agonistaként 5-HT1a és/vagy 5-HT1d-receptorokként, a vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP9902160A2 HUP9902160A2 HU9902160A HUP9902160A HUP9902160A2 HU P9902160 A2 HUP9902160 A2 HU P9902160A2 HU 9902160 A HU9902160 A HU 9902160A HU P9902160 A HUP9902160 A HU P9902160A HU P9902160 A2 HUP9902160 A2 HU P9902160A2
- Authority
- HU
- Hungary
- Prior art keywords
- ring
- atom
- alkyl
- aryl
- general formula
- Prior art date
Links
- 101150015707 HTR1A gene Proteins 0.000 title 1
- 101100321769 Takifugu rubripes htr1d gene Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
- -1 phenyl- Chemical group 0.000 abstract 4
- 239000000843 powder Substances 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001743 benzylic group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 229910052740 iodine Chemical group 0.000 abstract 1
- 150000003951 lactams Chemical class 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány szerinti új laktámszármazékők (I) általánős képletében R1jelentése (G1), (G2), (G3), (G4) vagy (G5) általánős képletű csőpőrt,amelyekben E jelentése őxigén- vagy kénatőm, szűlfinil- vagyszűlfőnilcsőpőrt, R6 és R7 hidrőgénatőmőt, alkil- vagy őlyan alkil-arilcsőpőrtőt jelent, amelyben az arilrész fenil- vagy naftilcsőpőrt,tővábbá R6 és R7 jelenthet heterőaril-(CH2)q általánős képletűcsőpőrtőt, mely csőpőrtban a heterőarilcsőpőrt piridil-, pirimidil-,benzőxazőlil-, benztiazőlil-, benzizőxazőlil- vagybenzizőtiazőlilcsőpőrt lehet, és q értéke 0, 1, 2, 3 vagy 4, tővábbáaz aril- és heterőarilcsőpőrtők adőtt esetben helyettesítetteklehetnek; vagy R6 és R7 együtt 2-4 szénatőmőt tartalmazó láncőt képez;x értéke 0 és 8 közötti egész szám; mindegyik R13 helyettesítőegymástól függetlenül alkilcsőpőrtőt jelenthet vagy őlyanmetiléncsőpőrtőkból álló hídcsőpőrtőt képezhet, amely (G1) vagy (G2)általánős képletű csőpőrtőkban a piperazin- vagy piperidingyűrűgyűrűbeli szénatőmjainak egyikétől űgyanazőn vagy egy másik gyűrűbeliszénatőmhőz, vagy a piperazin- vagy piperidingyűrű gyűrűbelinitrőgénatőmjáhőz kapcsőlódik, űgyanakkőr elérhető kötési helye van,vagy pedig R6 egyik gyűrűbeli, elérhető kötési helyű szénatőmjáhőzkapcsőlódik; R8 és R9 jelentése hidrőgénatőm vagy alkilcsőpőrt; R8 ésR9 együtt 5-7-tagú gyűrűt alkőt azzal a nitrőgénatőmmal, amelyhezkapcsőlódnak; és p értéke 1, 2 vagy 3; R2 jelentése hidrőgénatőm vagyadőtt esetben helyettesített alkilcsőpőrt; R3 jelentése -(CH2)mBáltalánős képletű csőpőrt, ahől m értéke 0, 1, 2 vagy 3, és Bjelentése hidrőgénatőm vagy adőtt esetben helyettesített fenil-,naftil- vagy 5- vagy 6-tagú heterőarilcsőpőrt; Z jelentése -CR4R5általánős képletű csőpőrt, ahől R4 és R5 hidrőgénatőm vagy alkil- vagytriflűőr-metilcspőrt vagy Z jelentheti a kőrábban megadőttjelentésénél említett aril- vagy heterőarilcsőpőrtők bármelyikét,tővábbá Z két szőmszédős gyűrűtagja az A gyűrű tagja is lehet; Xjelentése hidrőgén-, klór-, flűőr-, bróm- vagy jódatőm vagy cianő-,alkil-, hidrőxi-, triflűőr-metil-, alkőxi-, SOg-alkil (ebben g értéke0, 1 vagy 2), CO2R10 vagy CONR11R12 általánős képletű csőpőrt, ahőlR10, R11 és R12 jelentése azőnős R2 jelentésével, vagy pedig R11 ésR12 5-7 tagú gyűrűt alkőt a nitrőgénatőmmal; n értéke 1, 2, 3 vagy 4;és a szaggatőtt vőnal adőtt esetben jelenlévő kettőskötésre űtal;azzal a megkötéssel, hőgy n értéke 1, ha Z jelentése aril- vagyheterőarilcsőpőrt. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1513496P | 1996-03-29 | 1996-03-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9902160A2 true HUP9902160A2 (hu) | 1999-11-29 |
| HUP9902160A3 HUP9902160A3 (en) | 2001-02-28 |
Family
ID=21769713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902160A HUP9902160A3 (en) | 1996-03-29 | 1997-02-03 | Benzyl(idene)-lactam derivatives, their use as selective (ant)agonists of 5-ht1a-and/or 5-ht1d receptors, pharmaceutical compositions containing these compounds |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US6462048B2 (hu) |
| EP (1) | EP0894085B1 (hu) |
| JP (1) | JP3118467B2 (hu) |
| KR (1) | KR100305071B1 (hu) |
| CN (1) | CN1128788C (hu) |
| AP (1) | AP824A (hu) |
| AR (1) | AR006390A1 (hu) |
| AT (1) | ATE302182T1 (hu) |
| AU (1) | AU706839B2 (hu) |
| BG (1) | BG64176B1 (hu) |
| BR (1) | BR9708581A (hu) |
| CA (1) | CA2249603A1 (hu) |
| CO (1) | CO4650033A1 (hu) |
| CZ (1) | CZ293628B6 (hu) |
| DE (1) | DE69733996T2 (hu) |
| DZ (1) | DZ2198A1 (hu) |
| EA (1) | EA001485B1 (hu) |
| ES (1) | ES2246058T3 (hu) |
| HK (1) | HK1019446A1 (hu) |
| HN (1) | HN1997000023A (hu) |
| HR (1) | HRP970175A2 (hu) |
| HU (1) | HUP9902160A3 (hu) |
| ID (1) | ID17781A (hu) |
| IL (1) | IL125377A (hu) |
| IS (1) | IS4813A (hu) |
| MA (1) | MA26425A1 (hu) |
| MY (1) | MY118498A (hu) |
| NO (1) | NO312957B1 (hu) |
| NZ (1) | NZ325914A (hu) |
| OA (1) | OA10879A (hu) |
| PL (1) | PL329170A1 (hu) |
| SK (1) | SK131498A3 (hu) |
| TN (1) | TNSN97056A1 (hu) |
| TR (1) | TR199801929T2 (hu) |
| TW (1) | TW413679B (hu) |
| UA (1) | UA70284C2 (hu) |
| UY (1) | UY24498A1 (hu) |
| WO (1) | WO1997036867A1 (hu) |
| YU (1) | YU11997A (hu) |
| ZA (1) | ZA972690B (hu) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH041367U (hu) * | 1990-04-13 | 1992-01-08 | ||
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6696448B2 (en) * | 1996-06-05 | 2004-02-24 | Sugen, Inc. | 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors |
| US6423708B1 (en) * | 1996-09-30 | 2002-07-23 | Pfizer Inc | Aralkyl and aralkylidene heterocyclic lactams and imides |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| DE19830201A1 (de) * | 1998-07-07 | 2000-01-13 | Boehringer Ingelheim Pharma | Mittel mit antidepressiver Wirkung |
| CA2301899C (en) * | 1998-07-27 | 2008-11-18 | Boehringer Ingelheim Pharma Kg | Agent with an antidepressant activity |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
| PT1113015E (pt) * | 1999-12-29 | 2004-12-31 | Pfizer Prod Inc | Compostos 3-((2-piperazinilfenil)metil)-1-(4-(trifluorometil)fenil)-2-pirrolidinona opticamente activos, como antagonistas selectivos dos receptores de 5-ht1d |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| MXPA04003385A (es) | 2001-10-10 | 2005-04-11 | Sugen Inc | Derivados de 3-?4-substituido con heterociclilo)-pirrol-2-ilmetilidene?-2-indolinona como inhibidores de cinasa. |
| PL372096A1 (en) | 2002-01-02 | 2005-07-11 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
| TWI263497B (en) * | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| EP1689721B1 (en) * | 2003-11-26 | 2010-07-14 | Pfizer Products Inc. | Aminopyrazole derivatives as gsk-3 inhibitors |
| WO2005082372A1 (en) * | 2004-01-29 | 2005-09-09 | Pfizer Products Inc. | COMBINATION OF γ-AMINOBUTYRIC ACID MODULATORS AND 5-HT 1B RECEPTOR ANTAGONISTS |
| KR20060124770A (ko) | 2004-03-17 | 2006-12-05 | 화이자 프로덕츠 인코포레이티드 | 벤질(이덴)-락탐 유도체 |
| MXPA06013163A (es) * | 2004-05-11 | 2007-02-13 | Pfizer Prod Inc | Combinacion de antipsicoticos atipicos y antagonistas del receptor 5-ht1b. |
| EP1753745A2 (en) * | 2004-05-21 | 2007-02-21 | Pfizer Products Inc. | Pyrazinylmethyl lactam derivatives |
| WO2006000912A2 (en) * | 2004-06-25 | 2006-01-05 | Pfizer Products Inc. | Pyridyl piperazines for the treatment of cns disorders |
| US8012969B2 (en) | 2005-01-13 | 2011-09-06 | Ge Healthcare Limited | 11C-labeled benzyl-lactam compounds and their use as imaging agents |
| WO2006106416A1 (en) * | 2005-04-08 | 2006-10-12 | Pfizer Products Inc. | PYRIDIL-LACTAMS AND THEIR USE 5 -HTl RECEPTORS LIGAN |
| CA2612268A1 (en) * | 2005-06-17 | 2006-12-28 | Pfizer Products Inc. | Metabolites of 1-[6-(1-ethyl-1-hydroxy-propyl)-pyridin-3-yl]-3-[2-(4-methyl-piperazin-1-yl)-benzyl]-pyrrolidin-2-one as seratonin receptor antagonists |
| WO2007012964A1 (en) * | 2005-07-25 | 2007-02-01 | Pfizer Products Inc. | Preparation of alkylpiperazinylphenyl compounds by classical resolution |
| WO2007026224A2 (en) * | 2005-08-31 | 2007-03-08 | Pfizer Products Inc. | 5-ht1b antagonist composition for depression, anxiety and cognition |
| WO2007026219A2 (en) * | 2005-08-31 | 2007-03-08 | Pfizer Products Inc. | Combinations of a 5-ht1b antagonist with a noradrenalin re-uptake inhibitor or a serotonin noradrenalin reutake inhibitor for treating cns conditions |
| US20070096411A1 (en) * | 2005-11-02 | 2007-05-03 | Rempe Gary L Ii | Device for retaining a kneeling rider on a gliding board |
| EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA |
| ES2920130T3 (es) | 2015-09-02 | 2022-08-01 | Trevena Inc | Compuestos moduladores del receptor opioide Delta que contienen heterocíclicos Aza de 6 miembros, métodos de uso y fabricación de los mismos |
| US11225487B2 (en) | 2017-02-17 | 2022-01-18 | Trevena, Inc. | 7-membered aza-heterocyclic containing δ-opioid receptor modulating compounds, methods of using and making the same |
| WO2018152293A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4078062A (en) * | 1976-10-28 | 1978-03-07 | E. R. Squibb & Sons, Inc. | Substituted 2H-1,4-benzothiazin-3(4H)-ones |
| JPS62116557A (ja) | 1985-11-15 | 1987-05-28 | Takeda Chem Ind Ltd | 置換ベンジルラクタム類 |
| US5189179A (en) * | 1990-08-29 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | Serotonin 5ht1a agonists |
| PT533268E (pt) | 1991-09-18 | 2002-02-28 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d |
| EP0607334B1 (en) | 1991-10-11 | 1997-07-30 | The Du Pont Merck Pharmaceutical Company | Cyclic ureas and analogues useful as retroviral protease inhibitiors |
| US5436246A (en) | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
| GB9410512D0 (en) * | 1994-05-25 | 1994-07-13 | Smithkline Beecham Plc | Novel treatment |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6467084B1 (en) * | 1999-12-16 | 2002-10-15 | Emware, Inc. | Systems and methods for reprogramming an embedded device with program code using relocatable program code |
-
1997
- 1997-02-03 US US09/155,215 patent/US6462048B2/en not_active Expired - Fee Related
- 1997-02-03 JP JP09535074A patent/JP3118467B2/ja not_active Expired - Fee Related
- 1997-02-03 DE DE69733996T patent/DE69733996T2/de not_active Expired - Fee Related
- 1997-02-03 KR KR1019980707713A patent/KR100305071B1/ko not_active IP Right Cessation
- 1997-02-03 CZ CZ19983052A patent/CZ293628B6/cs not_active IP Right Cessation
- 1997-02-03 IL IL12537797A patent/IL125377A/xx not_active IP Right Cessation
- 1997-02-03 EP EP97900717A patent/EP0894085B1/en not_active Expired - Lifetime
- 1997-02-03 AT AT97900717T patent/ATE302182T1/de not_active IP Right Cessation
- 1997-02-03 PL PL97329170A patent/PL329170A1/xx unknown
- 1997-02-03 TR TR1998/01929T patent/TR199801929T2/xx unknown
- 1997-02-03 CN CN97193251A patent/CN1128788C/zh not_active Expired - Fee Related
- 1997-02-03 HU HU9902160A patent/HUP9902160A3/hu unknown
- 1997-02-03 ES ES97900717T patent/ES2246058T3/es not_active Expired - Lifetime
- 1997-02-03 SK SK1314-98A patent/SK131498A3/sk unknown
- 1997-02-03 CA CA002249603A patent/CA2249603A1/en not_active Abandoned
- 1997-02-03 EA EA199800771A patent/EA001485B1/ru not_active IP Right Cessation
- 1997-02-03 BR BR9708581A patent/BR9708581A/pt not_active Application Discontinuation
- 1997-02-03 AU AU13170/97A patent/AU706839B2/en not_active Ceased
- 1997-02-03 NZ NZ325914A patent/NZ325914A/en unknown
- 1997-02-03 WO PCT/IB1997/000076 patent/WO1997036867A1/en active IP Right Grant
- 1997-02-04 TW TW086101295A patent/TW413679B/zh active
- 1997-02-06 HN HN1997000023A patent/HN1997000023A/es unknown
- 1997-03-02 UA UA98095077A patent/UA70284C2/uk unknown
- 1997-03-13 CO CO97013714A patent/CO4650033A1/es unknown
- 1997-03-21 UY UY24498A patent/UY24498A1/es not_active IP Right Cessation
- 1997-03-25 AR ARP970101200A patent/AR006390A1/es not_active Application Discontinuation
- 1997-03-26 HR HR60/015,134A patent/HRP970175A2/hr not_active Application Discontinuation
- 1997-03-26 DZ DZ970045A patent/DZ2198A1/fr active
- 1997-03-26 TN TNTNSN97056A patent/TNSN97056A1/fr unknown
- 1997-03-26 MA MA24535A patent/MA26425A1/fr unknown
- 1997-03-27 ZA ZA972690A patent/ZA972690B/xx unknown
- 1997-03-27 AP APAP/P/1997/000955A patent/AP824A/en active
- 1997-03-27 YU YU11997A patent/YU11997A/sh unknown
- 1997-03-27 ID IDP971025A patent/ID17781A/id unknown
- 1997-03-28 MY MYPI97001340A patent/MY118498A/en unknown
-
1998
- 1998-07-29 IS IS4813A patent/IS4813A/is unknown
- 1998-09-16 OA OA9800170A patent/OA10879A/en unknown
- 1998-09-24 BG BG102791A patent/BG64176B1/bg unknown
- 1998-09-28 NO NO19984513A patent/NO312957B1/no unknown
-
1999
- 1999-10-13 HK HK99104493A patent/HK1019446A1/xx not_active IP Right Cessation
-
2002
- 2002-08-15 US US10/219,692 patent/US6924289B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9902160A2 (hu) | Benzil(idén)-laktám-származékok, alkalmazásuk szelektív (ant)agonistaként 5-HT1a és/vagy 5-HT1d-receptorokként, a vegyületeket tartalmazó gyógyászati készítmények | |
| ATE305302T1 (de) | Heterozyklische verbindungen mit sulfonamid- gruppen | |
| HUP9802822A2 (hu) | Halogén-benzimidazol-származékok, intermedierjeik, előállításuk és a vegyületeket hatóanyagként tartalmazó mikrobicid készítmények | |
| HUP0301745A2 (hu) | Ciklopentánindolok, ezeket tartalmazó gyógyszerkészítmények és a vegyületek alkalmazása | |
| ES2188280T3 (es) | Acetales heteroaril-ciclicos. | |
| HUP0402026A2 (hu) | 5,6-Diaril-pirazin-2-amid-származékok mint CB1 antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| CO4650135A1 (es) | Lactamas e imidas heterociclicas de aralquilo y aralquilideno | |
| HUP0003859A2 (hu) | Imidazollal kondenzált heterociklusos vegyületek, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0303183A2 (hu) | Gerinctelen kártevőírtó hatású heterociklusos diamidszármazékok, azokat tartalmazó készítmények és alkalmazásuk | |
| HUP0001243A2 (hu) | Nikotinamidszármazékok és a vegyületeket tartalmazó gyógyszerészeti készítmények | |
| WO2002098857A8 (en) | New indole derivatives with 5-ht6 receptor affinity | |
| UA41251C2 (uk) | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі | |
| WO2002042292A3 (en) | Indol derivative and their use as inhibitors of p38 kinase | |
| HUP0204081A2 (en) | 4-pyrimidinyl-n-acyl-l-phenylalanines, pharmaceutical compositions containing them and their use | |
| HUP9901184A2 (hu) | Antibakteriális hatású benzoxazin- és pirido-oxazin-származékok, intermedierjeik, a vegyületeket tartalmazó gyógyászati készítmények, előállításuk és alkalmazásuk | |
| HUP0104452A2 (hu) | Triciklusos vegyületeket tartalmazó gyógyászati kompozíció | |
| HUP9700159A2 (hu) | Benzil-szulfid-származékok, intermedierjeik, eljárás előállításukra és a vegyületeket hatóanyagként tartalmazó inszekticid készítmények | |
| DE69712084D1 (de) | Aminothiazole derivate, ihre herstellung und sie enthaltenden pharmazeutischen zusammensetzungen | |
| FI954965A (fi) | AMPA-antagonisteja ja hoitomenetelmä, jossa niitä käytetään | |
| HUP9903590A2 (hu) | 3-(Azetidinil-alkil)-piperidin- vagy -pirrolidin-származékok mint tachikinin-antagonisták | |
| HUP0400653A2 (hu) | Benzil(idén)-laktám-származékok és 5HT1-receptor ligandumokként való alkalmazásuk, és ezeket tartalmazó gyógyszerkészítmények | |
| DE69319925D1 (de) | Indol-piperazin-derivate als selektive liganden der 5ht1d und 5ht1b receptoren verwendbar als arzneimittel | |
| HUP9801382A2 (hu) | Neurokinin antagonista piperazinszármazékok és a vegyületeket tartalmazó gyógyászati készítmények | |
| HUP0001165A2 (hu) | NK1 és NK2 antagonista hatású acil-amino-alkil-amid-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra | |
| HUP0001551A2 (hu) | Javított eljárás tiazolidin-dionok előállítására, tiazolidin-dionok és az ezeket tartalmazó gyógyszerkészítmények |