HRP20110349T1 - Nova kombinacijska upotreba spoja sulfonamida u liječenju karcinoma - Google Patents

Nova kombinacijska upotreba spoja sulfonamida u liječenju karcinoma Download PDF

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Publication number
HRP20110349T1
HRP20110349T1 HR20110349T HRP20110349T HRP20110349T1 HR P20110349 T1 HRP20110349 T1 HR P20110349T1 HR 20110349 T HR20110349 T HR 20110349T HR P20110349 T HRP20110349 T HR P20110349T HR P20110349 T1 HRP20110349 T1 HR P20110349T1
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Croatia
Prior art keywords
sulfonamide compound
cancer
treatment
substance
inhibitory effect
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HR20110349T
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English (en)
Inventor
Owa Takashi
Ozawa Yoichi
Semba Taro
Wakabayashi T.
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Eisai R&D Management Co.
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Publication of HRP20110349T1 publication Critical patent/HRP20110349T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Farmaceutski pripravak obuhvaća spoj sulfonamida u kombinaciji sa supstancom koja ima inhibicijsko djelovanje EGF, naznačen time, što spoj sulfonamida je: N-(3-klor-1H-indol-7-il)-4-sulfamoilbenzensulfonamid,N-(3-cijano-4-metil-1H-indol-7-il)-3-cijanobenzensulfonamid, ili njegova farmakološki prihvatljiva sol ili njegov solvat, i pri čemu supstanca koja ima inhibicijsko djelovanje EGF je gefitinib, erlotinib ili cetuksimab. Patent sadrži još 9 patentnih zahtjeva.

Claims (10)

1. Farmaceutski pripravak obuhvaća spoj sulfonamida u kombinaciji sa supstancom koja ima inhibicijsko djelovanje EGF, naznačen time, što spoj sulfonamida je: N-(3-klor-1H-indol-7-il)-4-sulfamoilbenzensulfonamid,N-(3-cijano-4-metil-1H-indol-7-il)-3-cijanobenzensulfonamid, ili njegova farmakološki prihvatljiva sol ili njegov solvat, i pri čemu supstanca koja ima inhibicijsko djelovanje EGF je gefitinib, erlotinib ili cetuksimab.
2. Farmaceutski pripravak prema zahtjevu 1, naznačen time, što se farmaceutski pripravak koristi za liječenje karcinoma.
3. Pribor, naznačen time, što obuhvaća skup formulacije koja sadrži spoj sulfonamida definiran u zahtjevu 1 i formulacije koja sadrži supstancu koja ima inhibicijsko djelovanje EGF definiranu u zahtjevu 1.
4. Pribor prema zahtjevu 4, naznačen time, što je za uporabu u liječenju karcinoma.
5. Upotreba spoja sulfonamida definiranog u zahtjevu 1 naznačena time, što za proizvodnju farmaceutskog pripravka za upotrebu u kombinaciji sa supstancom koja ima inhibicijsko djelovanje EGF definiranom u zahtjevu 1 za liječenje karcinoma.
6. Upotreba supstance koja ima inhibicijsko djelovanje EGF definirano u zahtjevu 1 naznačena time, što za proizvodnju farmaceutskog pripravka za upotrebu u kombinaciji sa spojem sulfonamida definirano u zahtjevu 1 za liječenje karcinoma.
7. Spoj sulfonamida definiran u zahtjevu 1 naznačen time, što za upotrebu u kombinaciji sa supstancom koja ima inhibicijsko djelovanje EGF definiranom u zahtjevu 1 za liječenje karcinoma.
8. Supstanca koja ima inhibicijsko djelovanje EGF definirana u zahtjevu 1 naznačena time, što za upotrebu u kombinaciji sa spojem sulfonamida definiranim u zahtjevu 1 za liječenje karcinoma.
9. Farmaceutski pripravak obuhvaća spoj sulfonamida definiran u zahtjevu 1 naznačen time, što za upotrebu u kombinaciji sa supstancom koja ima inhibicijsko djelovanje EGF definiranom u zahtjevu 1 za liječenje karcinoma.
10. Farmaceutski pripravak obuhvaća supstancu koja ima inhibicijsko djelovanje EGF definiranu u zahtjevu 1 naznačen time, što za upotrebu u kombinaciji sa spojem sulfonamida definiranim u zahtjevu 1 za liječenje karcinoma.
HR20110349T 2005-02-28 2011-05-11 Nova kombinacijska upotreba spoja sulfonamida u liječenju karcinoma HRP20110349T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005054111 2005-02-28
PCT/JP2006/304218 WO2006090930A1 (ja) 2005-02-28 2006-02-28 スルホンアミド化合物の新規併用

Publications (1)

Publication Number Publication Date
HRP20110349T1 true HRP20110349T1 (hr) 2011-07-31

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HR20110349T HRP20110349T1 (hr) 2005-02-28 2011-05-11 Nova kombinacijska upotreba spoja sulfonamida u liječenju karcinoma

Country Status (18)

Country Link
US (1) US20090047278A1 (hr)
EP (1) EP1859793B1 (hr)
JP (1) JPWO2006090930A1 (hr)
KR (1) KR20070108270A (hr)
CN (1) CN101163468A (hr)
AU (1) AU2006217692A1 (hr)
CA (1) CA2599115A1 (hr)
CY (1) CY1111579T1 (hr)
DE (1) DE602006021401D1 (hr)
DK (1) DK1859793T3 (hr)
ES (1) ES2362898T3 (hr)
HR (1) HRP20110349T1 (hr)
ME (1) ME01222B (hr)
PL (1) PL1859793T3 (hr)
PT (1) PT1859793E (hr)
RS (1) RS51821B (hr)
SI (1) SI1859793T1 (hr)
WO (1) WO2006090930A1 (hr)

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SI1859793T1 (sl) 2011-08-31
CA2599115A1 (en) 2006-08-31
US20090047278A1 (en) 2009-02-19
WO2006090930A1 (ja) 2006-08-31
CY1111579T1 (el) 2015-10-07
DE602006021401D1 (de) 2011-06-01
KR20070108270A (ko) 2007-11-08
ME01222B (me) 2013-06-20
PL1859793T3 (pl) 2011-09-30
RS51821B (en) 2012-02-29
EP1859793A1 (en) 2007-11-28
EP1859793B1 (en) 2011-04-20
JPWO2006090930A1 (ja) 2008-07-24
PT1859793E (pt) 2011-07-05
AU2006217692A1 (en) 2006-08-31
EP1859793A4 (en) 2008-07-23
ES2362898T3 (es) 2011-07-14
DK1859793T3 (da) 2011-08-01
CN101163468A (zh) 2008-04-16

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