GR1001050B - Particular human immunoglobulin receiver of il-2 new type - Google Patents
Particular human immunoglobulin receiver of il-2 new typeInfo
- Publication number
- GR1001050B GR1001050B GR900100009A GR900100009A GR1001050B GR 1001050 B GR1001050 B GR 1001050B GR 900100009 A GR900100009 A GR 900100009A GR 900100009 A GR900100009 A GR 900100009A GR 1001050 B GR1001050 B GR 1001050B
- Authority
- GR
- Greece
- Prior art keywords
- immunoglobulin
- immunoglobulins
- cdr
- donor immunoglobulin
- donor
- Prior art date
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Νέαι μέθοδοι προς κατασκευήν εξανθρωπισμένων ανοσοσφαιρινών εχόντων μία ή περισσοτέρας περιοχάς προσδιορισμού συμπληρωματικότητας (CDR's) εκ μιας δότειρος ανοσοσφαιρίνης και μίαν περιοχήν σκελετού εκ μιας ανθρωπείου ανοσοσφαιρίνης περιλαμβάνουσαι πρώτον σύγκρισιν του σκελετού ή της μεταβλητής περιοχής αλληλουχίας αμινοξέως της δοτείρος ανοσοσφαιρίνης προς τας αντιστοίχους αλληλουχίας εις μιαν συλλογήν αλύσεων ανθρωπείων ανοσοσφαιρινών, και επιλογήν ως ανθρωπείου ανοσοσφαιρίνης μιας εκ των πλέον ομολόγων αλληλουχιών εκ της συλλογής. Εκάστη εξανθρωπισθείσα άλυσις ανοσοσφαιρίνης ημπορεί να περιλαμβάνει περί τα 3 ή περισσότερα αμινοξέα εκ της δότειρος ανοσοσφαιρίνης επιπροσθέτως των CDR's, συνήθως τουλάχιστον μίαν των οποίων είναι αμέσως παραπλεύρως προς μίαν CDR εις την δοτείραν ανοσοσφαιρίνην. Αι βαρείαι και ελαφραί αλύσεις ημπορεί να κατασκευασθούν εκάστη δια της χρησιμοποιήσεως ενός οιουδήποτε ή απάντων των τριών κριτηρίων επιπροσθέτων θέσεων. Οταν αι ανοσοσφαιρίναι της παρούσης εφευρέσεως συνδυασθούν εις εν άθικτον αντίσωμα, αι εξανθρωπισθείσαι ανοσοσφαιρίναι της παρούσης εφευρέσεως θα είναι ουσιαστικώς μη ανοσογονικαί εις ανθρώπους και θα διατηρούν ουσιαστικώς την αυτήν χημικήν συγγένειαν ως η δοτείρ ανοσοσφαιρίνη προς το αντιγόνον, τοιούτον όπως μία πρωτείνη ή ετέρα σύνθεσις περιέχουσα εν επιτόπιον. ωNovel methods for making humanized immunoglobulins having one or more complementarity determining regions (CDR's) from a donor immunoglobulin and a backbone region from a human immunoglobulin comprising first comparing the backbone or variable amino acid sequence region of the donor immunoglobulin to sequence counterparts in a collection of chains human immunoglobulins, and selecting as human immunoglobulin one of the most homologous sequences from the collection. Each humanized immunoglobulin chain may include about 3 or more amino acids from the donor immunoglobulin in addition to the CDR's, usually at least one of which is immediately adjacent to a CDR in the donor immunoglobulin. The heavy and light chains can each be constructed using any or all of the three additional site criteria. When the immunoglobulins of the present invention are combined into an intact antibody, the humanized immunoglobulins of the present invention will be substantially non-immunogenic in humans and will retain substantially the same chemical affinity as the donor immunoglobulin to the antigen, such as a protein or other composition comprising a on the spot. oh
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR90100009 | 1990-01-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GR900100009A GR900100009A (en) | 1992-06-25 |
| GR1001050B true GR1001050B (en) | 1993-04-28 |
Family
ID=10940035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR900100009A GR1001050B (en) | 1990-01-09 | 1990-01-09 | Particular human immunoglobulin receiver of il-2 new type |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR1001050B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU631545B2 (en) * | 1988-04-15 | 1992-12-03 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
| IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
-
1990
- 1990-01-09 GR GR900100009A patent/GR1001050B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR900100009A (en) | 1992-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Right expired |