GB879629A - Improvements in or relating to stable 6-demethyl-tetracycline antibiotic compositions - Google Patents
Improvements in or relating to stable 6-demethyl-tetracycline antibiotic compositionsInfo
- Publication number
- GB879629A GB879629A GB40566/59A GB4056659A GB879629A GB 879629 A GB879629 A GB 879629A GB 40566/59 A GB40566/59 A GB 40566/59A GB 4056659 A GB4056659 A GB 4056659A GB 879629 A GB879629 A GB 879629A
- Authority
- GB
- United Kingdom
- Prior art keywords
- demethyl
- tetracycline
- hydrogen
- parent specification
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A tetracycline antibiotic is solubilised in aqueous solution according to the parent Specification, but is characterised in that the tetracycline antibiotic is a 6-demethyl tetracycline or a soluble salt thereof. Specified are 6-demethyl tetracycline, 6-demethyl-6-deoxytetracycline and 7-chloro-6-demethyltetracycline. In accordance with the said parent Specification, the 6-demethyl tetracycline is solubilised by addition of a soluble non-toxic source of alkaline earth ions and a pyridine derivative having the formula:- <FORM:0879629/IV (b)/1> wherein R is hydrogen or a N-alkylcarbamyl, N-alkanolcarbamyl, hydrazinocarbonyl, hydroxyl, hydroxyalkyl, alkoxycarbonyl or carboxyl radical or a salt of a carboxyl group with a non-toxic metal; R1 is a hydrogen or methyl group and R11 and R111 are each hydrogen or a hydroxymethyl group.ALSO:A tetracycline antibiotic composition of enhanced solubility and stability according to the parent Specification is characterized in that the tetracycline antibiotic is a 6-demethyl tetracycline or a soluble salt thereof. Specified are 6-demethyl tetracycline, 6-demethyl-6-deoxytetracycline and 7-chloro-6-demethyl tetracycline. In accordance with the said parent Specification the 6-demethyl tetracycline is mixed with a soluble non-toxic source of alkaline earth ions and a pyridine derivative having the formula <FORM:0879629/VI/1> wherein R is hydrogen or a N-alkylcarbamyl, N - alkanolcarbamyl, hydrazinocarbonyl, hydroxyl, hydroxyalkyl alkoxy carbonyl or carboxyl radical or a salt of a carboxyl group with a non-toxic metal; R1 is hydrogen or a methyl group and R11 and R111 are each hydrogen or a hydroxy methyl group. In an example, an aqueous solution of pH 3.3 to 4 is prepared by dissolving 7 - chloro - 6 - demethyltetracycline hydrochloride, magnesium gluconate, nicotinamide, citric acid an xylocaine base in water.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US879629XA | 1958-12-05 | 1958-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB879629A true GB879629A (en) | 1961-10-11 |
Family
ID=22208292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40566/59A Expired GB879629A (en) | 1958-12-05 | 1959-11-30 | Improvements in or relating to stable 6-demethyl-tetracycline antibiotic compositions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB879629A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
-
1959
- 1959-11-30 GB GB40566/59A patent/GB879629A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US9278105B2 (en) | 2010-05-12 | 2016-03-08 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US9744179B2 (en) | 2010-05-12 | 2017-08-29 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US11944634B2 (en) | 2010-05-12 | 2024-04-02 | Melinta Subsidiary Corp. | Tetracycline compositions |
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