GB2461732A - Side loading pen injector - Google Patents

Side loading pen injector Download PDF

Info

Publication number
GB2461732A
GB2461732A GB0821424A GB0821424A GB2461732A GB 2461732 A GB2461732 A GB 2461732A GB 0821424 A GB0821424 A GB 0821424A GB 0821424 A GB0821424 A GB 0821424A GB 2461732 A GB2461732 A GB 2461732A
Authority
GB
United Kingdom
Prior art keywords
cartridge
injector
needle
pen
push rod
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0821424A
Other versions
GB0821424D0 (en
Inventor
Terence Edward Weston
Douglas Arthur Emmott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB0821424D0 publication Critical patent/GB0821424D0/en
Publication of GB2461732A publication Critical patent/GB2461732A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2433—Ampoule fixed to ampoule holder
    • A61M2005/2437—Ampoule fixed to ampoule holder by clamping means
    • A61M2005/244—Ampoule fixed to ampoule holder by clamping means by flexible clip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2496—Ampoule holder connected to rest of syringe via pivot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A side loading pen injector comprises a hinged cartridge cover7and a plunger2wherein there is a mechanism for the retraction of the plunger. The cover7may have a pawl15which engages with teeth12on the outside of a push rod9connected to plunger2. A collet6may be slidable about a middle section of the injector. The collet6engages with a peg28which causes a collet closer17to open, when the cover7is opened, pawl15is disengaged, causing the plunger2to retract under the action of spring13. The push rod9may have an adjustable stroke means for dispensing at least one dose of drugs or a least one dose sequentially from a cartridge. The injector may have a needle, being a passive safety needle attached.

Description

BACKGROUND TO THE INVENTION
Pen injectors are pen-shaped devices widely used as a convenient and accurate method of injecting liquid drugs into patients. They are popular with diabetics and others requiring regular injections of drugs, because less skill is required in adjusting the dose. The drug is normally supplied contained in a tubular cartridge -usually made from glass and having a slidable seal at a proximal end, and a piercable septum at the distal end. (In the present context, proximal means the end nearest to the user, and distal means the end farthest away from the user). Most pen injectors have a manual drive mechanism that advances a rod to push the slidable seal along the drug cartridge, and thus dispense the drug. The drive mechanism usually enables the stroke of the push rod to be adjusted in order to vary the delivered dose, and the drug cartridge remains installed to enable the user to administer consecutive doses until the cartridge is exhausted. In addition to the manually powered dispensing types of injectors, there are injectors having means for automatic injection, such as those used to treat anaphylactic shock and other emergency conditions. Usually these injectors deliver a fixed dose, and do not have dose adjustment means. Yet another variation are injectors that allow the dose to be adjusted and inject automatically. Automatic injectors are powered by the stored energy of a spring.
Good practice requires that a new hypodermic needle is attached to the pen barrel for each injection, or in some cases, the drug cartridge itself has a screw thread and the needle is screwed onto the cartridge.. The needle is supplied fixed into a hub, and has a distal end for piercing the patient's skin, and a proximal end for piercing the septum of the drug cartridge, the hub having a thread for connection to the barrel of the pen or cartridge. When the needle is assembled to the pen, the needle hub first aligns the proximal end of the needle with the centre of the cartridge septum, and by pushing the needle and hub towards the cartridge, the needle pierces the septum. Once the needle has passed completely through the septum, the hub thread becomes in contact with the pen or cartridge thread, and by twisting the needle hub it screws onto the pen to make a secure connection. Removal of the needle is a reverse procedure.
Prior art pen injectors require the cartridge housing part to be unscrewed from the main body of the pen, so that a cartridge may be assembled therein. Apart from the inconvenience, a problem arises when users of limited manual dexterity or without sensitivity as regards good assembly practice, damage the screw thread when re-assembling the pen. Again, those with impaired dexterity, such as those suffering from arthritis or Parkinson's Disease, fmd it quite difficult to manipulate the assembly, and will sometimes fail to secure the hypodermic needle properly.
Another drawback of prior art injectors is that the pushrod that urges the drug cartridge piston must be manually adjusted by screwing it back to a zero position; this requires the injector to be partly dismantled for access. Again, this is inconvenient and not particularly easy for some users. The pens are usually paid for by the user, and are relatively expensive, so any damage or inconvenience in the operating procedure will at least cause irritation, and at worst poor compliance and incorrect dosing.
Whilst the present invention discloses embodiments applicable to injection pens, the invention may be applied to other medical dosing devices which employ a prefluled cartridge of the type described herein, such as automatic dosing pumps..
DESCRIPTION OF THE INVENTION
The present invention is directed to improve the ergonomics and convenience of pen injectors by providing a pen having a variable or fixed dose dispensing mechanism of any known type, manually or automatically operated, wherein there is means for inserting the drug cartridge into the side of the pen, preferably without dismantling the pen. Another objective is to simplify' the push rod re-setting procedure.
In a first embodiment, the pen injector has a hinged panel provided with clip means to temporarily retain a drug cartridge. The hinged panel may be spring-loaded towards the closed position, or be unbiased and have latching means to keep the panel in the closed position. Once the cartridge is assembled onto the panel, the panel is closed, thus aligning the cartridge with the dispensing mechanism. To remove the cartridge, the panel is opened and the cartridge unclipped from the panel. In a second embodiment, the pen again has a hinged panel, which may be simply opened to give access to a chamber into which the drug cartridge is loaded. Again, the hinged panel may be spring-loaded towards the closed position, or be unbiased and have latching means to keep the panel in the closed position.
A third embodiment has at least one longitudinal slot through which the drug cartridge to be pushed into alignment with the dispensing mechanism. When the cartridge is exhausted, it is merely pushed out through a slot. A fourth embodiment has a shuttle which may be partly or fuily ejected sideways from the pen barrel. The drug cartridge is inserted into the shuttle, and the shuttle is pushed back into the pen barrel. In all embodiments, a mechanism for driving the cartridge piston may be set to a zero or start position without disassembling the pen. In all embodiments, it is preferred that an automatic plunger retraction mechanism is interlocked with the side-loading means, so that it is not possible to open the access panel or push the drug cartridge out of the pen unless the push rod is fully withdrawn from the cartridge. It may be preferred that the drug cartridge is visible to enable the user to check the contents, and this may be facilitated by providing a window or transparent element in the construction. Again, there is increasing demand to reduce needle-stick injuries, and this specification includes the use of the present invention with safety needles having so-called "passive" protection (i.e., automatic shielding of the needle tip after withdrawal from the patient).
It may be seen that the invention simplifies the pen construction, and greatly simplifies the operating procedures.
The first two embodiments of the invention are now described with reference to the following drawings. For simplicity, like parts are given like annotation. The second embodiment is very similar to the first, the difference being that the first requires the drug cartridge to be clipped to an openable panel, and in the second embodiment, the cartridge is loaded directly into the body of the injector. The description therefore refers to the first embodiment, with references where necessary to identify the differences.
Figure 1 is a side view of the pen injector, and figure 2 is a section through the injector on the centre line, the Figures 3 and 4 show a thread engaging and disengaging mechanism. Figure 5 shows the injector set to dispense a dose from a medicament cartridge. Figure 6 shows how the cartridge may be removed after use, and figure 7 shows an alternative means of loading and unloading a cartridge.
Referring to figure 1, injector I comprises a body 26 of approximately cylindrical section, having a cartridge carrier 4 hinged at 5 onto the body 26. A rotary dose adjusting knob 2 with calibrations 23 is shown on the proximal end of the injector.
The distal end of the cartridge carrier 4 has a screwed connector 3 to which a needle 24 may be attached.
Referring to figure 2, a drug cartridge 7 is held temporarily within the carrier 4, being retained by clip means 22. In the second embodiment, the clip means is not required.
The dose adjusting knob 2 has an elongated tubular section 8, and is a sliding fit within the body 26. Slidable within the tubular section 8 is a tubular push rod 9.
Located inside the tubular push rod 9 is an extension spring 13, which is attached at one end to the inside of the knob 2, and at the other to the distal end of the push rod 9.
The spring 13 thus holds the push rod 9 and knob 2 in resilient contact. The push rod 9 has a saw-tooth thread 12, which may be engaged with a matching thread at the distal end of the inside of the tubular section 8. This may be seen more clearly in the enlarged section in figures 3 and 4. The distal end of the tubular section 8 is configured as a collet, sprung radially outwards. In the example shown, this would be achieved by a number of slits extending longitudinally from the open end of tubular section 8. The collet thread 18 may be engaged or disengaged with the thread 12 on the push rod 9 by the action of a collet closer 17; again, this may be seen more clearly in figures 3 and 4. The collet closer 17 is sleeve slidable longitudinally along the bore of the body 26. Collet closer 17 has a an internal ridge configured to engage with the detents 19 and 20. Thus, if the collet closer 17 is slid in the direction of arrow B (figure 3), the ridge 29 engages with the detent 20, and will remain engaged to hold the thread 18 of collet 16 closed onto the thread 12 of the push rod 9, until the closer 17 is slid in the opposite direction C as shown in figure 4. This allows the collet 16 to open and disengage the threads 18 from the thread 12 of the push rod 9.
The collet closer 17 has a peg 28 extending radially therefrom, which is engageable by the sliding sleeve 6. The sliding sleeve 6 has a switchable action so that it may push or pull the collet closer 17. This mechanism may be one of many types typically employed in retractable ball point pens mechanisms and the like.
When the sleeve 6 is in the position shown in figures 2 and 3, the dose adjusting knob 2 and tubular extension 8 may be rotated, and this unscrews the knob from the push rod 9. The push rod 9 is prevented from rotating by a paw! 15, which is engaged with the saw tooth thread 12 of the push rod 9. As the knob 2 is screwed out, markings 23 on the knob indicate the dose required to be dispensed from the cartridge 7. At the same time, the spring 13 is stretched, maintaining the components in resilient contact.
The injector will then be set as shown in figure 5, which shows the push rod and pad already in contact with the piston 11 in the drug cartridge 7 from a previous injection.
By acting on the knob 2 in the direction of arrow D, the knob 2 and tubular section 8 push on push rod to urge the piston 11 along the cartridge to dispense the drug therefrom. During this action, the saw tooth thread behaves a ratchet in conjunction with the pawl 15. The ratchet and pawl maintain the incremental adjustments of the knob 2 and the push rod 9, so that subsequent doses may be delivered until the cartridge is empty. The markings 23 on the knob 2 relate to the gap X between the abutment 20 on knob 2 and stop 25 on the body 26, dimension X thus controlling the stroke of the piston.
When the cartridge 7 is empty, the sleeve 6 is slid in the direction C. This moves collet closer to disengage the threads 18 of collet 16 from the saw tooth threads 12, and allows the cartridge carrier 4 to be opened. The initial part of the second action also disengages the paw! 15 from the screw thread 12, and the spring 13 pulls the push rod 9 and the pad 10 towards the knob 2, thus withdrawing the rod and pad from the empty cartridge, and allowing the carrier 4 to be filly opened. The cartridge 7 may then be withdrawn and replaced by a full cartridge.
Figure 7 shows an alternative opening cartridge carrier 31, hinged at 31 to body 26.
Cartridge 7 may be clipped into the carrier 31 or loaded into the body 26 in the second embodiment. The other features of this configuration remain similar to those described.
Figure 8 shows a common alternative fixing for the needle. The cartridge 7a has a fixed threaded part 3a to which the needle 24a is attached. The distal end of the body 26a therefore has an aperture through which the thread 3a of the cartridge 7a projects.
The sliding sleeve 6 and associated collet operating parts provide an interlocking function, and it is preferred that the sequence of interlock is first to disengage the thread 18 of the collet 16 from the thread 12 of push rod 9, followed by disengaging the pawl 15 from the thread 12 of push rod 9. This latter action allows the spring 13 to pull the push rod 9 out of the cartridge. Thereafter the hinged panel 4 or 32 (fig.8) may be opened and the cartridge extracted.
The third and fourth embodiments have not been described in detail, because the construction would be obvious to a skilled person. A similar sliding sleeve and interlocking functions would achieve the same preferred sequence of operation.
The interlocking means disclosed is but one of many that would suffice, and although that used in the present invention has only one component (sleeve 6) operable by the user, further locking buttons and devices may of course be added if necessary.
The main objectives of the invention have been achieved, namely, the drug cartridge may be inserted and removed without dismantling the pen injector, and resetting is achieved also without dismantling. Interlock means prevent the removal of the drug cartridge until the push rod is withdrawn from the cartridge. There are several alternative mechanisms that will provide similar detent and ratchet functions to those described, and these are deemed to form part of this specification. Also there are other devices such as automatic medicament pumps that employ similar cartridges and
such devices are included in this specification.

Claims (6)

  1. CLAIMS1. A pen injector adapted to allow a drug cartridge to be loaded into the side of the injector and having interlocked and automatic means for retracting the plunger from the cartridge before allowing the cartridge to be removed from the pen injector.
  2. 2. A pen injector as in any previous claim having adjustable stroke push rod means for dispensing the drug from the cartridge.
  3. 3. A pen injector as in any previous claim having adjustable stroke push rod means for dispensing more than one dose sequentially from the cartridge.
  4. 4. An injector as in any previous claim which has a hypodermic needle attached to the pen injector and proximal end of said needle being in hydraulic connection with the contents of the drug cartridge and the distal end suitable for piercing a patient's skin.
  5. 5. An injector as in any previous claim ito 3 adapted to receive a drug cartridge having means to attach a hypodermic needle thereto and proximal end of said needle being in hydraulic connection with the contents of the drug cartridge and the distal end suitable for piercing a patient's skin.
  6. 6. An injector as in claims 4 and 5 wherein the hypodermic needle is a passive safety needle.
GB0821424A 2008-07-08 2008-11-24 Side loading pen injector Withdrawn GB2461732A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB0812420A GB2461694A (en) 2008-07-08 2008-07-08 Side-loaded pen injector

Publications (2)

Publication Number Publication Date
GB0821424D0 GB0821424D0 (en) 2008-12-31
GB2461732A true GB2461732A (en) 2010-01-13

Family

ID=39718105

Family Applications (2)

Application Number Title Priority Date Filing Date
GB0812420A Withdrawn GB2461694A (en) 2008-07-08 2008-07-08 Side-loaded pen injector
GB0821424A Withdrawn GB2461732A (en) 2008-07-08 2008-11-24 Side loading pen injector

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB0812420A Withdrawn GB2461694A (en) 2008-07-08 2008-07-08 Side-loaded pen injector

Country Status (1)

Country Link
GB (2) GB2461694A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012126974A1 (en) 2011-03-23 2012-09-27 Sanofi-Aventis Deutschland Gmbh Drug delivery device with pivoting protective cap
WO2013178602A1 (en) * 2012-05-30 2013-12-05 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
WO2013178599A1 (en) * 2012-05-30 2013-12-05 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
WO2015018787A1 (en) * 2013-08-05 2015-02-12 Sanofi-Aventis Deutschland Gmbh Cover biasing means for an apparatus
WO2015018811A3 (en) * 2013-08-06 2015-04-02 Sanofi-Aventis Deutschland Gmbh Drug delivery device
JP2015521920A (en) * 2012-07-05 2015-08-03 ユニトラクト シリンジ プロプライエタリイ リミテッドＵｎｉｔｒａｃｔ Ｓｙｒｉｎｇｅ Ｐｔｙ Ｌｔｄ Automatic injector for injectable cartridge and drive control mechanism therefor
WO2018103338A1 (en) * 2016-12-05 2018-06-14 甘肃成纪生物药业有限公司 Pharmaceutical product delivery device and anti-return mechanism thereof
WO2022171343A1 (en) * 2021-02-15 2022-08-18 Shl Medical Ag Syringe carriers

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125994B2 (en) 2009-06-01 2015-09-08 Sanofi—Aventis Deutschland GmbH Drug delivery device with dose dial sleeve rotational stop

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1012700A (en) * 1910-12-23 1911-12-26 Joseph Payne Syringe.
US3848593A (en) * 1970-10-09 1974-11-19 Affiliated Hospital Prod Side loading disposable carpule syringe
US4407283A (en) * 1981-10-19 1983-10-04 Dale C. Grier Self-injecting syringe
US4915701A (en) * 1989-02-21 1990-04-10 Halkyard Douglas R Protective device and syringe
US5112307A (en) * 1990-04-24 1992-05-12 Habley Medical Technology Corp. Dental syringe having a medication filled carpule and an automatically-detaching piston stem
EP0937474A2 (en) * 1998-02-23 1999-08-25 Becton Dickinson and Company Vial retainer interface to a medication delivery pen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2540461A (en) * 1948-03-01 1951-02-06 Arthur E Smith Combination ampoule syringe
GB2216801A (en) * 1988-04-08 1989-10-18 Malcolm Melville Davies Syringe system
DE4419235C2 (en) * 1994-06-01 1999-03-11 Thomas Braeger Hypodermic syringe with a receptacle
JP3568959B2 (en) * 1995-03-07 2004-09-22 イーライ・リリー・アンド・カンパニー Reusable dosing device
US9486581B2 (en) * 2002-09-11 2016-11-08 Becton, Dickinson And Company Injector device with force lock-out and injection rate limiting mechanisms

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1012700A (en) * 1910-12-23 1911-12-26 Joseph Payne Syringe.
US3848593A (en) * 1970-10-09 1974-11-19 Affiliated Hospital Prod Side loading disposable carpule syringe
US4407283A (en) * 1981-10-19 1983-10-04 Dale C. Grier Self-injecting syringe
US4915701A (en) * 1989-02-21 1990-04-10 Halkyard Douglas R Protective device and syringe
US5112307A (en) * 1990-04-24 1992-05-12 Habley Medical Technology Corp. Dental syringe having a medication filled carpule and an automatically-detaching piston stem
EP0937474A2 (en) * 1998-02-23 1999-08-25 Becton Dickinson and Company Vial retainer interface to a medication delivery pen

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103458944A (en) * 2011-03-23 2013-12-18 赛诺菲-安万特德国有限公司 Drug delivery device with pivoting protective cap
WO2012126974A1 (en) 2011-03-23 2012-09-27 Sanofi-Aventis Deutschland Gmbh Drug delivery device with pivoting protective cap
CN103458944B (en) * 2011-03-23 2015-12-23 赛诺菲-安万特德国有限公司 There is the drug delivery device of the protective cap of pivotable
CN104334216B (en) * 2012-05-30 2017-09-05 赛诺菲-安万特德国有限公司 Drive mechanism and delivery device for delivery device
WO2013178602A1 (en) * 2012-05-30 2013-12-05 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
WO2013178599A1 (en) * 2012-05-30 2013-12-05 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
CN104334216A (en) * 2012-05-30 2015-02-04 赛诺菲-安万特德国有限公司 Drive mechanism for a drug delivery device and drug delivery device
CN104349807A (en) * 2012-05-30 2015-02-11 赛诺菲-安万特德国有限公司 Drive mechanism for drug delivery device and drug delivery device
US9675760B2 (en) 2012-05-30 2017-06-13 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
US9700679B2 (en) 2012-05-30 2017-07-11 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device and drug delivery device
JP2015517857A (en) * 2012-05-30 2015-06-25 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Drug delivery device drive mechanism and drug delivery device
US10894128B2 (en) 2012-07-05 2021-01-19 Unl Holdings Llc Drive control mechanisms and automatic injectors for injectable cartridges
JP2015521920A (en) * 2012-07-05 2015-08-03 ユニトラクト シリンジ プロプライエタリイ リミテッドＵｎｉｔｒａｃｔ Ｓｙｒｉｎｇｅ Ｐｔｙ Ｌｔｄ Automatic injector for injectable cartridge and drive control mechanism therefor
JP2018202214A (en) * 2012-07-05 2018-12-27 ユーエヌエル ホールディングス エルエルシーＵＮＬ Ｈｏｌｄｉｎｇｓ ＬＬＣ Automatic injectors for injectable cartridges and drive control mechanisms therefor
CN105451793A (en) * 2013-08-05 2016-03-30 赛诺菲-安万特德国有限公司 Cover biasing means for an apparatus
JP2016527038A (en) * 2013-08-05 2016-09-08 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Device cover biasing means
US20160184519A1 (en) * 2013-08-05 2016-06-30 Sanofi-Aventis Deutschland Gmbh Cover biasing means for an apparatus
US10322234B2 (en) 2013-08-05 2019-06-18 Sanofi-Aventis Deutschland Gmbh Cover biasing means for an apparatus
WO2015018787A1 (en) * 2013-08-05 2015-02-12 Sanofi-Aventis Deutschland Gmbh Cover biasing means for an apparatus
CN105451794A (en) * 2013-08-06 2016-03-30 赛诺菲-安万特德国有限公司 Drug delivery device
WO2015018811A3 (en) * 2013-08-06 2015-04-02 Sanofi-Aventis Deutschland Gmbh Drug delivery device
CN105451794B (en) * 2013-08-06 2019-03-22 赛诺菲-安万特德国有限公司 Medicine delivery device
WO2018103338A1 (en) * 2016-12-05 2018-06-14 甘肃成纪生物药业有限公司 Pharmaceutical product delivery device and anti-return mechanism thereof
WO2022171343A1 (en) * 2021-02-15 2022-08-18 Shl Medical Ag Syringe carriers

Also Published As

Publication number Publication date
GB0812420D0 (en) 2008-08-13
GB0821424D0 (en) 2008-12-31
GB2461694A (en) 2010-01-13

Similar Documents

Publication Publication Date Title
GB2461732A (en) Side loading pen injector
US9901680B2 (en) Spring driven injection device
US10099017B2 (en) Device for the dosed administration of a fluid product, adapted for the replacement of a container
CA2500195C (en) Injecting device
US5957896A (en) Medication delivery pen
US9901681B2 (en) Medical injector with slidable sleeve activation
US8012131B2 (en) Extractable dose setting knob
USRE47614E1 (en) Drug delivery device and method of manufacturing a drug delivery device
US5584815A (en) Multi-cartridge medication injection device
EP1790366B1 (en) Injection device
MX2010011251A (en) Medication delivery device.
US9199039B2 (en) Pusher with a coupling element
JP2016518232A (en) Forward-loading drug delivery device with moved cartridge holder and piston rod coupler
WO2021165250A1 (en) An injection device with integrated needles
US20230074677A1 (en) Drug injection control device having stable operation structure of injection button through button plate positioned in dose dial
CN113747932B (en) Dosing device for an injection device
US20240066227A1 (en) Keyed connectors for medicament delivery devices

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)