GB2288061B - Electrospraying method for mass spectrometric analysis - Google Patents

Electrospraying method for mass spectrometric analysis

Info

Publication number
GB2288061B
GB2288061B GB9504660A GB9504660A GB2288061B GB 2288061 B GB2288061 B GB 2288061B GB 9504660 A GB9504660 A GB 9504660A GB 9504660 A GB9504660 A GB 9504660A GB 2288061 B GB2288061 B GB 2288061B
Authority
GB
United Kingdom
Prior art keywords
mass spectrometric
spectrometric analysis
electrospraying method
electrospraying
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9504660A
Other versions
GB2288061A (en
GB9504660D0 (en
Inventor
Jochen Franzen
Matthias Mann
Matthias Wilm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bruker Daltonics GmbH and Co KG
Original Assignee
Bruken Franzen Analytik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4444229A external-priority patent/DE4444229C2/en
Application filed by Bruken Franzen Analytik GmbH filed Critical Bruken Franzen Analytik GmbH
Publication of GB9504660D0 publication Critical patent/GB9504660D0/en
Publication of GB2288061A publication Critical patent/GB2288061A/en
Application granted granted Critical
Publication of GB2288061B publication Critical patent/GB2288061B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
GB9504660A 1994-03-10 1995-03-08 Electrospraying method for mass spectrometric analysis Expired - Lifetime GB2288061B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19944408032 DE4408032A1 (en) 1994-03-10 1994-03-10 Process for the ionization of dissolved atoms or molecules from liquids by electrical spraying
DE4444229A DE4444229C2 (en) 1994-03-10 1994-11-25 Methods and devices for electrospray ionization for storage mass spectrometers

Publications (3)

Publication Number Publication Date
GB9504660D0 GB9504660D0 (en) 1995-04-26
GB2288061A GB2288061A (en) 1995-10-04
GB2288061B true GB2288061B (en) 1997-10-15

Family

ID=25934563

Family Applications (2)

Application Number Title Priority Date Filing Date
GB9504661A Withdrawn GB2287356A (en) 1994-03-10 1995-03-08 Ionizing an analyte by electrospraying
GB9504660A Expired - Lifetime GB2288061B (en) 1994-03-10 1995-03-08 Electrospraying method for mass spectrometric analysis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB9504661A Withdrawn GB2287356A (en) 1994-03-10 1995-03-08 Ionizing an analyte by electrospraying

Country Status (2)

Country Link
DE (1) DE4408032A1 (en)
GB (2) GB2287356A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008617B1 (en) 2007-12-28 2011-08-30 Science Applications International Corporation Ion transfer device
US8071957B1 (en) 2009-03-10 2011-12-06 Science Applications International Corporation Soft chemical ionization source
US8123396B1 (en) 2007-05-16 2012-02-28 Science Applications International Corporation Method and means for precision mixing

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4415480C2 (en) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Device and method for the mass spectrometric analysis of substance mixtures by coupling capillary electrophoretic separation (CE) with electrospray ionization (ESI)
EP1876443A3 (en) 1998-09-17 2008-03-12 Advion BioSciences, Inc. Integrated monolithic microfabricated electrospray and liquid chromatography system and method
US6633031B1 (en) 1999-03-02 2003-10-14 Advion Biosciences, Inc. Integrated monolithic microfabricated dispensing nozzle and liquid chromatography-electrospray system and method
ATE538490T1 (en) 1999-12-30 2012-01-15 Advion Biosystems Inc MULTIPLE ELECTROSPRAY DEVICE, SYSTEMS AND METHODS
US6596988B2 (en) 2000-01-18 2003-07-22 Advion Biosciences, Inc. Separation media, multiple electrospray nozzle system and method
DE10154601B4 (en) * 2000-11-13 2007-02-22 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto A micro device with an integrated protruding electrospray emitter and a method of fabricating the micro device
US7138626B1 (en) 2005-05-05 2006-11-21 Eai Corporation Method and device for non-contact sampling and detection
DE102005061381B4 (en) * 2005-12-22 2017-10-05 Leibniz - Institut Für Analytische Wissenschaften - Isas - E.V. Device for the electrospray ionization of a liquid sample

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5115131A (en) * 1991-05-15 1992-05-19 The University Of North Carolina At Chapel Hill Microelectrospray method and apparatus
EP0565027A1 (en) * 1992-04-10 1993-10-13 Waters Investments Limited Time modulated electrospray

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318028A (en) * 1979-07-20 1982-03-02 Phrasor Scientific, Inc. Ion generator
EP0120633B1 (en) * 1983-03-25 1988-12-14 Imperial Chemical Industries Plc Spraying apparatus
US4531056A (en) * 1983-04-20 1985-07-23 Yale University Method and apparatus for the mass spectrometric analysis of solutions
US4776515A (en) * 1986-08-08 1988-10-11 Froughieh Michalchik Electrodynamic aerosol generator
US4885076A (en) * 1987-04-06 1989-12-05 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US5115971A (en) * 1988-09-23 1992-05-26 Battelle Memorial Institute Nebulizer device
US5344676A (en) * 1992-10-23 1994-09-06 The Board Of Trustees Of The University Of Illinois Method and apparatus for producing nanodrops and nanoparticles and thin film deposits therefrom

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5115131A (en) * 1991-05-15 1992-05-19 The University Of North Carolina At Chapel Hill Microelectrospray method and apparatus
EP0565027A1 (en) * 1992-04-10 1993-10-13 Waters Investments Limited Time modulated electrospray

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8123396B1 (en) 2007-05-16 2012-02-28 Science Applications International Corporation Method and means for precision mixing
US8308339B2 (en) 2007-05-16 2012-11-13 Science Applications International Corporation Method and means for precision mixing
US8008617B1 (en) 2007-12-28 2011-08-30 Science Applications International Corporation Ion transfer device
US8071957B1 (en) 2009-03-10 2011-12-06 Science Applications International Corporation Soft chemical ionization source

Also Published As

Publication number Publication date
GB2287356A (en) 1995-09-13
GB9504661D0 (en) 1995-04-26
DE4408032A1 (en) 1995-09-14
GB2288061A (en) 1995-10-04
GB9504660D0 (en) 1995-04-26

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20150307